Patent application number | Description | Published |
20080269161 | Compositions and Methods Relating to Mitochondrial Hyperpolarization in Neurological Disease - Provided is a method of protecting a neuron from dysfunction induced by an HIV neurotoxin comprising contacting the cell with a therapeutically effective dose of an inhibitor of mitochondrial hyperpolarization. | 10-30-2008 |
20090081318 | TREATMENT OF NEUROADS USING INHIBITORS OF GLYCOGEN SYNTHASE KINASE (GSK)-3 - Provided is a method of treating or preventing neurological disease in a subject in need of such treatment or prevention, comprising administering to the subject a therapeutically effective dose of a GSK-3 inhibitor. | 03-26-2009 |
20090221651 | CHEMICAL PRECONDITIONING AS A PREVENTATIVE OR TREATMENT FOR EXCITOTOXIC SYNAPTIC DAMAGE - A method of preventing HIV-1 associated dendritic pathology in a brain cell, comprising contacting the cell with a therapeutically effective dose of a mitochondrial ATP-sensitive potassium channel agonist. A method of preventing HIV-1 associated dendritic pathology in a brain cell, comprising contacting the cell with a therapeutically effective dose of an inhibitor of succinate dehydrogenase. A method of preventing HIV-1 associated dendritic pathology in a brain cell, comprising contacting the cell with a therapeutically effective dose of a stimulator of production of reactive oxygen species. A model for the study of HIV-1 associated dendritic pathology, comprising a) contacting a hippocampal slice with platelet-activating factor; and b) stimulating the hippocampal slice of a) with high frequency stimulation. | 09-03-2009 |
20130203755 | BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE - Provided are compounds having an inhibitory effect on kinases including Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders that comprise the inhibition of Mixed Lineage Kinases. | 08-08-2013 |
20140256733 | MIXED LINEAGE KINASE INHIBITORS AND METHOD OF TREATMENTS - Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions. | 09-11-2014 |
20150105401 | MLK INHIBITORS AND METHODS OF USE - Provided are compounds having an inhibitory effect on Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders which comprise the inhibition of Mixed Lineage Kinases. | 04-16-2015 |
20150297587 | MIXED LINEAGE KINASE INHIBITORS FOR HIV/AIDS THERAPIES - Disclosed are methods for treating an individual infected with a retrovirus that comprise administering to the individual effective amounts of a mixed lineage kinase inhibitor and antiretroviral drug. In further aspects, disclosed are methods for treating an individual infected with a retrovirus that comprises administering an antiretroviral drug formulated into a crystalline nanoparticle comprising a surfactant, and a MLK inhibitor. Still further disclosed are methods for treating an individual infected with a retrovirus that comprises administering a composition comprising both an antiretroviral and MLK inhibitor formulated into a crystalline nanoparticle, which comprises a surfactant. Still further disclosed are compositions that comprise an antiretroviral drug, a MLK inhibitor, and a surfactant, wherein the composition is a crystalline nanoparticle. Compostions comprising MLK inhibitors with other drugs in nanoparticulate form, and methods of there use, are also disclosed. | 10-22-2015 |
Patent application number | Description | Published |
20090210446 | Method for Efficient Association of Multiple Distributions - An association method for analyzing a dataset and grouping its objects in homogeneous groups. Multiple grouping algorithms of the art are performed against the dataset, each producing its own grouping results. All the distributions (groupings) are ordered in a matrix, where each distribution suggested by a specific algorithm and/or parameters is presented in a column of the matrix, and each object is presented in a row of the matrix. The association method is applied to the grouping results and associates similar groups among different grouping methods. The best grouping of the objects is determined according to one or more quality criteria. The various grouping results are represented by colors in the matrix such that similar colors, even on different rows, represent similar grouping recommendations. | 08-20-2009 |
20110113249 | METHOD AND SYSTEM FOR SHARING TRUSTED CONTACT INFORMATION - A method and system for sharing trusted contact information between trusted, known and unknown parties, without revealing the contact information itself, thus protecting the party defined in the contact from possible unsolicited messages known as “Spam”. Addresses of trusted senders are encrypted using a one-way encryption and stored in a whitelist repository that can be shared by different users. When a message is received, its senders address is extracted, encrypted using the same encryption method, and compared if it is found in the whitelist repository. | 05-12-2011 |
20120254192 | METHOD AND SYSTEM FOR EXTENDED BITMAP INDEXING - A system and method for enhancing bitmap indexing representation of a dataset, which comprises a plurality of cases and features, each case characterized by one or more values of each feature. Currently, the bins vector for each case in the dataset, is a binary array, which is a bitmap indexing representation of each respective feature of the case. The system and method enhance the bitmap indexing by padding each bins vector. The padding is carried out by identifying all target bit locations with a ‘1’ value and replacing at least one ‘0’ bit adjacent to a target bit location with a non-zero numerical value, thereby creating a padded bitmap index. The padding factor may be based on any mathematical or statistical factor concerning population or subpopulation relevant to each of the features of the dataset. | 10-04-2012 |