Patent application number | Description | Published |
20080207730 | Methods of using (+)-2-[1-(3-Ethoxy-4 methoxyphenyl)-2-methylsulfonylethyl]-4 acetylaminoisoindoline 1,3-dione - Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4. | 08-28-2008 |
20080234359 | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2- methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof - Solid forms comprising (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their use are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4. | 09-25-2008 |
20080242719 | Methods of Using (+)-2-[1-(3-Ethoxy-4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-Acetylaminoisoindoline- 1,3-Dione - Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4. | 10-02-2008 |
20100160405 | METHODS OF USING (+)-2-[1-(3-ETHOXY-4-METHOXYPHENYL)-2-METHYLSULFONYLETHYL]-4-ACETYLAMINOI- SOINDOLINE 1,3-DIONE - Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4. | 06-24-2010 |
20100168475 | PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS - Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of isoindoline based PDE 4 modulators. | 07-01-2010 |
20110087033 | Processes for the Preparation of 2-(1-Phenylethyl)isoindolin-1-one Compounds - Methods for preparation of isoindolin-1-one compounds are described. | 04-14-2011 |
20110112307 | SOLID FORMS COMPRISING (+)-2-[1-(3-ETHOXY-4-METHOXYPHENYL)-2-METHYLSULFONYLETHYL]-4-ACETYLAMINOI- SOINDOLINE-1,3-DIONE, COMPOSITIONS THEREOF, AND USES THEREOF - Solid forms comprising (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their use are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4. | 05-12-2011 |
20110224440 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS - The present invention provides new processes for the preparation of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds which are useful, for example, for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-α. The invention can provide improved and/or efficient processes for the commercial production of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds, including, but not limited to, unsubstituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione. | 09-15-2011 |
20120101144 | SOLID FORMS COMPRISING (+)-2-[1-(3-ETHOXY-4-METHOXYPHENYL)-2-METHYLSULFONYLETHYL]-4-ACETYLAMINOI- SOINDOLINE-1,3-DIONE, COMPOSITIONS THEREOF, AND USES THEREOF - Solid forms comprising (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their use are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4. | 04-26-2012 |
20140024695 | METHODS OF TREATING ARTHRITIC CONDITIONS USING (+)-2-[1-(3-ETHOXY-4-METHOXYPHENYL)-2-METHYLSULFONYLETHYL]-4-ACETYLAMINOI- SOINDOLINE 1,3-DIONE - Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4. | 01-23-2014 |
20140100259 | SOLID FORMS COMPRISING (+)-2-[1-(3-ETHOXY-4-METHOXYPHENYL)-2-METHYLSULFONYLETHYL]-4-ACETYLAMINOI- SOINDOLINE-1,3-DIONE, COMPOSITIONS THEREOF, AND USES THEREOF - Solid forms comprising (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their use are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4. | 04-10-2014 |
20140256950 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS - The present invention provides new processes for the preparation of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds which are useful, for example, for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-α. The invention can provide improved and/or efficient processes for the commercial production of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds, including, but not limited to, unsubstituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione. | 09-11-2014 |
20140371287 | METHODS OF USING (+)-2-[1-(3-ETHOXY-4-METHOXYPHENYL)-2-ETHYLSULFONYLETHYL]-4-ACETYLAMINOIS- OINDOLINE-1,3-DIONE - Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4. | 12-18-2014 |
Patent application number | Description | Published |
20090253673 | Substituted Pyrazoles as Ghrelin Receptor Antagonists - Certain novel N-acylated spiropiperidine derivatives are ligands of the human ghrelin receptor(s) and, in particular, are antagonists/inverse agonists of the human ghrelin receptor. They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of the ghrelin receptor, such as obesity, diabetes, and metabolic syndrome. | 10-08-2009 |
20090312303 | Antidiabetic Bicyclic Compounds - Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia. | 12-17-2009 |
20100105725 | ANTIDIABETIC BICYCLIC COMPOUNDS - Diaryl ethers in which one of the aryl groups is a phenyl fused to a cycloalkyl or heterocyclic ring, to which is attached an acetic acid group, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that often accompany this disease, including insulin resistance, obesity and lipid disorders. | 04-29-2010 |
Patent application number | Description | Published |
20110231704 | METHODS, APPARATUS AND ARTICLES OF MANUFACTURE TO PERFORM ROOT CAUSE ANALYSIS FOR NETWORK EVENTS - Example methods, apparatus and articles of manufacture to perform root cause analysis for network events are disclosed. An example method includes retrieving a symptom event instance from a normalized set of data sources based on a symptom event definition; generating a set of diagnostic events from the normalized set of data sources which potentially cause the symptom event instance, the diagnostic events being determined based on dependency rules; and analyzing the set of diagnostic events to select a root cause event based on root cause rules. | 09-22-2011 |
20120069747 | Method and System for Detecting Changes In Network Performance - A system and method are provided for identifying a change point in a set of data. The system performs the method by receiving a set of data. The data indicates a plurality of performance measurements from a measurement point in a network. Each of the plurality of measurements represents a single type of performance measurement made at the measurement point at each of a corresponding plurality of points in time. The method also includes dividing the set of data into a plurality of data points in a chronological order. Each data point has a value corresponding to the performance measurements. The method also includes ranking the data points in an ascending order, calculating a cumulative sum for each of the data points, calculating a change score for the set of data points. A change point is identified in the data set if the change score exceeds a predetermined confidence level. | 03-22-2012 |
20120072556 | Method and System for Detecting Network Upgrades - A system and method identify a network upgrade from a data set including a plurality of configuration sessions. The system performs the method by receiving a plurality of configuration sessions. Each of the configuration sessions comprises a plurality of configuration commands. The configuration commands are generated by a same user identifier and within a time threshold. The method further includes identifying one of the configuration sessions as a network upgrade session. The identification is based on a rareness of the configuration session or a skewness of the configuration session. | 03-22-2012 |
20120072574 | Method and System for Detecting Common Attributes of Network Upgrades - A system and method identify a set of rules for determining a commonality of attributes across different behavior changes for a network. The system performs the method by receiving a set of data correlating network triggers to performance changes of one or more network devices. The set of data further includes an indication of a sign of the performance change for each of the network devices based on the triggers. The method further includes extracting a set of rules relating to a set of relationships between the triggers and the performance changes. The rules identify a commonality of the performance changes for multiple network devices based on the triggers. | 03-22-2012 |
20130051248 | HIERARCHICAL ANOMALY LOCALIZATION AND PRIORITIZATION - Methods, apparatus and articles of manufacture for hierarchical anomaly localization and prioritization are disclosed. An example method disclosed herein comprises obtaining reported status for a plurality of nodes of a hierarchical topology, the reported status for a particular node being at least one of normal, abnormal or indeterminate, and determining a subset of root cause abnormal nodes, a root cause abnormal node included in the subset of root cause abnormal nodes having a total number of abnormal direct descendent nodes and indeterminate direct descendent nodes that is greater than a number of normal direct descendent nodes of the root cause abnormal node. | 02-28-2013 |
20130054783 | PASSIVE AND COMPREHENSIVE HIERARCHICAL ANOMALY DETECTION SYSTEM AND METHOD - A technique for monitoring performance in a network uses passively monitored traffic data at the server access routers. The technique aggregates performance metrics into clusters according to a spatial hierarchy in the network, and then aggregates performance metrics within spatial clusters to form time series of temporal bins. Representative values from the temporal bins are then analyzed using an enhanced Holt-Winters exponential smoothing algorithm. | 02-28-2013 |
20130185591 | METHODS, APPARATUS AND ARTICLES OF MANUFACTURE TO PERFORM ROOT CAUSE ANALYSIS FOR NETWORK EVENTS - Example methods, apparatus and articles of manufacture to perform root cause analysis for network events are disclosed. An example method includes retrieving a symptom event instance from a normalized set of data sources based on a symptom event definition; generating a set of diagnostic events from the normalized set of data sources which potentially cause the symptom event instance, the diagnostic events being determined based on dependency rules; and analyzing the set of diagnostic events to select a root cause event based on root cause rules. | 07-18-2013 |
20130198767 | METHOD AND APPARATUS FOR MANAGING QUALITY OF SERVICE - A system that incorporates teachings of the present disclosure may include, for example, obtaining regression coefficients that quantify a relationship between premises feedback and first network and premises performance indicators, obtaining second network performance indicators for the network elements, obtaining second premises performance indicators for the customer premises equipment, and predicting customer complaints by applying the obtained regression coefficients to at least the second network performance indicators and the second premises performance indicators. Other embodiments are disclosed. | 08-01-2013 |
20140059208 | Methods, Systems, and Products for Monitoring Domain Name Servers - Methods, systems, and products infer performance of a domain name system. Queries to, and responses from, the domain name system are logged and categorized. Each category is associated with a different performance issue related to the domain name system. The number of entries in each category may be used to infer the performance of the domain name system | 02-27-2014 |
20140181968 | Monitoring Operational Activities In Networks And Detecting Potential Network Intrusions And Misuses - Concepts and technologies disclosed herein are for monitoring operational activities in networks and detecting potential network intrusions and misuses. According to one aspect disclosed herein, an intrusion detection system can collect logs from an authentication, authorization, and accounting system. The intrusion detection system can extract information from the logs, update intrusion detection information utilized by an intrusion detection rule based upon the information extracted from the logs, update a profile utilized by the intrusion detection rule, compare the profile and the intrusion detection rule against a running state of an on-going session, tag corresponding log entries with a threat score, calculate the threat scores from the corresponding log entries to create an aggregated threat score, and present the aggregated threat score. The intrusion detection system can also present an alarm if the aggregated threat score triggers an alarm condition. | 06-26-2014 |
Patent application number | Description | Published |
20090262650 | METHOD AND APPARATUS FOR PROVIDING STATISTICAL EVENT CORRELATION IN A NETWORK - A method and apparatus for providing event correlation in a network are disclosed. For example, the method extracts a plurality of events of interest from a database, and creates one or more event time series from the plurality of events of interest, wherein each of the one or more event time series comprises a set of events of a same type and of a same location that occur within a given time period. The method forms one or more composite events from the one or more event time series, and performs one or more pair-wise correlations for at least one of: the event time-series, or the one or more composite events. The method then identifies one or more pair-wise correlations that are statistically significant. | 10-22-2009 |
20100014420 | Lightweight Application Classification for Network Management - Managing network traffic to improve availability of network services by classifying network traffic flows using flow-level statistical information and machine learning estimation, based on a measurement of at least one of relevance and goodness of network features. Also, determining a network traffic profile representing applications associated with the classified network traffic flows, and managing network traffic using the network traffic profile. The flow-level statistical information includes packet-trace information and is available from at least one of Cisco NetFlow, NetStream or cflowd records. The classification of network flows includes tagging packet-trace flow record data based on defined packet content information. The classifying of network flows can result in the identification of a plurality of clusters based on the measurement of the relevance of the network features. Also, the classification of network traffic can use a correlation-based measure to determine the goodness of the network features. | 01-21-2010 |
20100034102 | Measurement-Based Validation of a Simple Model for Panoramic Profiling of Subnet-Level Network Data Traffic - A system and method for profiling subnet-level aggregate network data traffic is disclosed. The system allows a user to define a collection of features that combined characterize the subnet-level aggregate traffic behavior. Preferably, the features include daily traffic volume, time-of-day behavior, spatial traffic distribution, traffic balance in flow direction, and traffic distribution in type of application. The system then applies machine learning techniques to classify the subnets into a number of clusters on each of the features, by assigning a membership probability vector to each network thus allowing panoramic traffic profiles to be created for each network on all features combined. These membership probability vectors may optionally be used to detect network anomalies, or to predict future network traffic. | 02-11-2010 |
20110307913 | Modeling User Activity Information Associated with a Network System - Systems and methods to model user activity information associated with a network system are provided. A particular method includes receiving, at a computing device, a request for user activity information associated with selected channels of a television access network that provides multimedia content to users. The method includes executing a model of user activity associated with the television access network at the computing device. The model estimates the user activity information as user multimedia access demands during particular time periods within a day. The method also includes storing the user activity information at a computer-readable non-transitory storage medium. | 12-15-2011 |