Patent application number | Description | Published |
20090158755 | SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS - A system for using freezing, storing and thawing biopharmaceutical materials which includes a holder and a container for holding biopharmaceutical materials therein. The holder has a cavity and the container is received in the cavity. The holder includes a first portion and second portion. The container is received between the first portion and the second portion to connect the container to the holder. The holder includes an interior cradle having a bottom and edges extending from the bottom. The cradle bounds the cavity. An outer rim is connected to the cradle and separated from the cavity. The bottom includes an inner surface facing the cavity receiving the container and an outer surface. The outer surface of the bottom is recessed relative to an outer surface of the outer rim. | 06-25-2009 |
20100072216 | SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS - A system for use in storing biopharmaceutical materials includes a holder and a container for holding biopharmaceutical materials therein. The container includes a storage portion and a sampling portion connected to each other by a connecting portion. The holder has a storage cavity receiving the storage portion and a sampling cavity receiving the sampling portion. The holder includes a first portion and second portion. The container is received between the first portion and the second portion to connect the container to the holder. The holder includes an interior storage cradle bounding the storage cavity of the holder. The holder includes an interior sampling cradle bounding the sampling cavity. The sampling cradle is separated from the storage cradle and connected to the storage cradle by a passage receiving the connecting portion connecting the storage portion to the sampling portion. An outer rim of the holder is connected to the cradle and separated from the cavity. | 03-25-2010 |
20110005984 | PRESTERILIZABLE FILTRATION SYSTEM TO BE DISPOSED OF AFTER A SINGLE USE - A presterilizable filtration system is provided and is to be disposed of after a single use. The system has a recirculation tank and a filtration module that are connected to each other in a circuit via a hose system that can be regulated by at least one valve. The valve has a disposable separate valve part that can be integrated in the hose system and a reusable actuator. | 01-13-2011 |
20110013473 | METHOD OF MIXING - A method of mixing including providing a flexible container which comprises at least two components, assembling the components from outside the flexible container to form a centrally disposed magnetic driven shaft with at least one impeller, whereby the integrity of the flexible container is maintained, filling the flexible container having the centrally disposed magnetic driven shaft with one or more ingredients of the contents to be mixed; engaging a magnetic element of the centrally disposed magnetic driven shaft with an external magnetic drive element; analyzing the contents of the flexible container using at least one sensor or a sampling line on the flexible container; and draining the contents of the flexible container through a drain port at the bottom of the flexible container. | 01-20-2011 |
20110013474 | DISPOSABLE MIXING VESSEL - A disposable mixing vessel comprising a flexible container, a centrally disposed shaft having first and second ends with one or more impellers thereon and a magnetic element associated with a first shaft end, a first flange adapted to rotatably engage the first shaft end and a second flange adapted to rotatably engage the second shaft end. | 01-20-2011 |
20110120151 | SYSTEMS AND METHODS FOR USE IN FREEZING, THAWING, AND STORING BIOPHARMACEUTICAL MATERIALS - A system for use in freezing, thawing, transporting or storing biopharmaceutical materials which includes a container, a holder and plurality of heat transfer members. The container is configured to hold biopharmaceutical materials therein. The holder has a cavity for receiving the container and includes an interior surface bounding the cavity. A plurality of pockets contact outer surfaces of the container and is received in the cavity. Each pocket of the plurality of pockets includes a pocket cavity. A heat transfer member actively controls the temperature of biopharmaceutical materials held in the container and is received in the pocket cavity. | 05-26-2011 |
20110120667 | SYSTEMS AND METHODS FOR USE IN FREEZING, THAWING, AND STORING BIOPHARMACEUTICAL MATERIALS - A system for use in freezing, thawing, transporting or storing biopharmaceutical materials which includes a container, a holder and plurality of heat transfer members. The container is configured to hold biopharmaceutical materials therein. The holder has a cavity for receiving the container and includes an interior surface bounding the cavity. A plurality of pockets contact outer surfaces of the container and is received in the cavity. Each pocket of the plurality of pockets includes a pocket cavity. A heat transfer member actively controls the temperature of biopharmaceutical materials held in the container and is received in the pocket cavity. | 05-26-2011 |
20110247349 | SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS - A system for using freezing, storing and thawing biopharmaceutical materials which includes a holder and a container for holding biopharmaceutical materials therein. The holder has a cavity and the container is received in the cavity. The holder includes a first portion and second portion. The container is received between the first portion and the second portion to connect the container to the holder. The holder includes an interior cradle having a bottom and edges extending from the bottom. The cradle bounds the cavity. An outer rim is connected to the cradle and separated from the cavity. The bottom includes an inner surface facing the cavity receiving the container and an outer surface. The outer surface of the bottom is recessed relative to an outer surface of the outer rim. | 10-13-2011 |
20120267367 | TIGHT CONNECTION AND TIGHT TRANSFER BETWEEN TWO HOUSINGS IN VIEW OF AN ASEPTIC TRANSFER THEREBETWEEN - A device for a tight connection between a first housing ( | 10-25-2012 |
20120292311 | HOUSING FOR TIGHT CONNECTION DEVICE AND ASEPTIC TRANSFER DEVICE - The invention relates to a housing ( | 11-22-2012 |
20120312415 | METHOD AND UNIT FOR THE STERILE FILLING OF A FINAL BASIC CONTAINER WITH CONTENT INTENDED FOR THE BIOPHARMACEUTICAL FIELD - A method for the sterile filling of at least one final basic container, includes: providing at least one sterile chamber having at least one sterile entrance port and providing a source container containing the content, located outside the chamber; providing a communication element, a dispensing element and at least one filling member, to form when all are assembled, a sterile fluid filling and transfer line; inserting at least one final container into the chamber; structurally combining at least one final container with at least one filling member; providing inner members and elements in sterile condition for a single-use; inserting the inner element and members which were previously outside the chamber in the chamber in a sterile manner, such that after filling, a new filling process can be performed without sterilizing the inside of the chamber; transferring in a filling step content from the source container into the final container. | 12-13-2012 |
20130086871 | STERILIZABLE BIOPHARMACEUTICAL PACKAGING - A sterilizable biopharmaceutical packaging includes an opening for inserting biopharmaceutical contents to be sterilized, the opening being separate from a sterilization gas conveyance channel so that the opening can be closed independently and before closing the sterilization gas conveyance channel. The opening is directly adjacent to an inner space for receiving the biopharmaceutical contents so that the contents to be sterilized are inserted directly into the inner space from outside the packaging. The elements for controlling the distribution of the sterilization gas open/close the sterilization gas conveyance channel independently of the opening or closing of the insertion opening. After sterilization, the outer wall, the sterilization gas conveyance channel, and the opening/closing element are capable of remaining rigidly connected therebetween so as to form a sterilized biopharmaceutical packaging that contains the sterilized biopharmaceutical contents and can be subjected to one or more integrity tests at any desired time after the sterilization. | 04-11-2013 |
20140165707 | TEST METHOD AND APPARATUS FOR BIOREACTOR CONTAINERS AND USE - A method for testing the integrity of a bioreactor container includes providing a bioreactor container having a fluid-tight, at least locally flexible wall and having at least one container opening and providing a test apparatus having a bioreactor container compartment and a fluid-permeable and/or structured reception sheet arranged replaceably on the bioreactor container compartment. The method continues by arranging the bioreactor container in the bioreactor container compartment so that the bioreactor container wall contacts the reception sheet in the bioreactor container compartment, connecting the container opening of the bioreactor container to a fluid source filling the bioreactor container with a fluid from the fluid source to generate a predetermined positive pressure Pi in the bioreactor container at a first time Ti and determining whether the bioreactor container is sufficiently leaktight. | 06-19-2014 |
20140193897 | BIOREACTOR CONTAINER AND INTEGRITY CHECK METHOD FOR BIOREACTOR CONTAINERS - A bioreactor container comprising has an at least locally flexible wall and at least one container opening. The wall of the bioreactor container has a fluid-tight inner sheet, and an at least locally fluid-permeable or structured outer sheet. A method for testing the integrity of the bioreactor container also is provided. | 07-10-2014 |
Patent application number | Description | Published |
20110038222 | MIXING VESSEL - A mixing vessel includes a flexible container, elements for mixing its contents, aeration elements, a drain/lower bearing port having a rigid flange provided with a drain passage, attached in a tight manner to the lower portion of the container wall, supporting a lower bearing that is adjacent to the drain passage. The vessel includes an extended element for dispensing aeration gas and is spaced essentially radially from the drain/bearing port; at least one tubular element for dispensing aeration gas extends from the extended dispensing element, in the inside space, along the inside surface of the lower portion and the side portion of the wall of the container and extends on the outside of the container from the upper portion; at least one mixing element is spaced essentially from the lower portion of the container wall, from the lower bearing, and from at least one extended element for dispensing aeration gas. | 02-17-2011 |
20110044567 | 3D CONTAINER WITH RIGID FRAME, DEFORMABLE CONTAINER, AND FUNCTIONAL MEANS FOR PROCESSING THE CONTENT, AND INCLUDING AN INTERNAL MEMBER FOR BIOPHARMACEUTICAL APPLICATIONS - A frame delimits an inside space and includes a peripherally closed side wall and two transverse openings or one transverse opening and a transverse end wall. It is capable of allowing the airtight engagement of the open free edge of a side wall in film form of a receptacle that is at least partially deformable. It is specially designed for the creation of a 3D container. The frame is also able to act as a support for at least one functional port or attachment port of a functional element. Its axial size is adequate for delimiting a space of a size that is at least equal to the axial dimension of the functional element, so that the latter can be completely housed within the inside space. | 02-24-2011 |
20110284776 | PINCHING CLOSED A COLLAPSIBLE TUBE FOR BIOPHARMACEUTICAL USE - The pinching device includes two cross-sections, each having a hollow part with a male indentation and a female indentation, and locking elements, whereby the surfaces of the indentations form a positive pinching passage of the tube; the male indentation has a U shape with a core and two wings; the female indentation has a U shape with a core and two wings; and the pinching passage has a U shape with a core and two wings; the two opposite wings will draw together toward their ends that are opposite to the cores of the indentations, and each of the two wings of the pinching passage has an opening whose width will diminish towards its end that is opposite to the core of the pinching passage; the width of the opening of the pinching passage is at most slightly smaller than twice the thickness of the wall of the flexible tube to be pinched, and, designed to constitute a pinching closing device, it is disposable, performing a function of closing the tube on itself in the pinching region, preventing any passage of fluid into the tube. | 11-24-2011 |
20120017733 | CUTTING A COLLAPSIBLE TUBE FOR BIOPHARMACEUTICAL USE - Process for closing and cutting into sections a flexible tube, with a cutting element and a pinching closing device for cutting into sections with two cross-sections, each with two parts with indentations that can be placed in removable extension by combination elements and that make a passage with an access, whereby the pinching closing device is in the open or closed state where the cross-sections are closed by locking members and where the surfaces form a pinching closing passage of the tube; the pinching region of the tube is positioned in the indentation of a cross-section; the other cross-section is brought opposite the preceding one and the pinching closing device in the closed state, with cooperation of the locking elements, the tube being positively pinched and closed in two positive pinching zones, and thus held in place; the tube is cut into sections between the parts in the closed state, using the cutting element by passing it into the passage without it interfering with the pinching closing device; and the parts are dissociated. | 01-26-2012 |
Patent application number | Description | Published |
20120022831 | METHOD AND TOOLING FOR CONFIGURING A NETWORK OF UNATTENDED GROUND WIRELESS SENSORS - The method for configuring a network of deposited wireless sensors. In certain aspects, these methods include defining performance criteria forming constraints, with associated threshold values, and at least one performance criterion to be optimized, for at least one zone to be equipped with nodes, each performance criterion being defined by a model; defining for said or each zone; the allocation to said or each zone to be equipped, a number of nodes; applying an optimization process per zone on said or each zone; increasing the number of nodes or modifying the performance criteria defined in said or each zone where the performance criteria are not met and reproducing in these zones the optimization process per zone with the new number of nodes or the new performance criteria, and applying the configuration determined at each node in said or each zone. | 01-26-2012 |
20140098708 | METHOD AND TOOLING FOR CONFIGURING A NETWORK OF UNATTENDED GROUND WIRELESS SENSORS - The method for configuring a network of deposited wireless sensors. In certain aspects, these methods include defining performance criteria forming constraints, with associated threshold values, and at least one performance criterion to be optimized, for at least one zone to be equipped with nodes, each performance criterion being defined by a model; defining for said or each zone; the allocation to said or each zone to be equipped, a number of nodes; applying an optimization process per zone on said or each zone; increasing the number of nodes or modifying the performance criteria defined in said or each zone where the performance criteria are not met and reproducing in these zones the optimization process per zone with the new number of nodes or the new performance criteria, and applying the configuration determined at each node in said or each zone. | 04-10-2014 |