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| 20090004298 | Use of S-Nitrosothiol Signaling to Treat Disordered Control of Breathing - The present invention is directed to a method of treating disordered control of breathing including the treatment of apnea and hypoventilation associated with congenital or acquired brain stem abnormalities. Specifically the invention is directed to treating disordered control of breathing by administering an S-nitrosylating agent selected from the group consisting of ethyl nitrite, glutathione, nitric oxide, S-nitrosocysteine, S-nitrosoglutathione, S-nitroso-L-cysteinyl glycine, N-acetyl cysteine and S-nitroso-N-acetyl cysteine. As shown in FIG. | 01-01-2009 |
| 20090054384 | AIRWAY ALKALINIZATION AS THERAPY FOR AIRWAY DISEASES - The present invention relates to a method of treating asthma by raising the pH of the airways of an individual. The effect can be mediated directly by administering a pharmaceutically acceptable basic solution or alternatively, the effect can be mediated by enhancing the activity of glutaminase. | 02-26-2009 |
| 20110177000 | Use of S-Nitrosothiol Signaling to Treat Disordered Control of Breathing - The present invention is directed to a method of treating disordered control of breathing including the treatment of apnea and hypoventilation associated with congenital or acquired brain stem abnormalities. Specifically the invention is directed to treating disordered control of breathing by administering an S-nitrosylating agent selected from the group consisting of ethylnitrite, glutathione, nitric oxide, S-nitrosocysteine, S-nitrosoglutathione, S-nitroso-L-cysteinyl glycine, N-acetyl cysteine and S-nitroso-N-acetyl cysteine. As shown in FIG. | 07-21-2011 |
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| 20080227571 | Tennis backboard - The invention provides a new tennis backboard design. The backboard includes a firm backing layer underlying a soft deadening layer. The rebound of a tennis ball from the backboard is reduced as compared to rebound from a rigid hard-surface backboard. This allows a player to stand fairly close to the backboard, which reduces misses. The player can stand fairly close and hit balls hard against the backboard. Because the rebound is reduced, the ball simply bounces back softly and easily to the player, allowing the player to hit hard again from a fairly short distance. Thus, long rallies without missing are easily achieved. Since the bounce is reduced, the player can stand closer to the backboard, and therefore the backboard can be smaller than conventional backboards without the player missing the backboard. This allows the backboard to be light, portable, and easily stored. Because of the addition of a soft deadening layer, the firm backing layer of the backboard can also be thin and made of lighter and weaker material than a conventional backboard, reducing the weight of the backboard. | 09-18-2008 |
| 20080234627 | PIVOTALLY ENGAGED MULTIPLE PART ELECTROTRANSPORT DRUG DELIVERY DEVICE - An electrotransport device for delivering a therapeutic agent through a body surface of a patient. The device has an electronic module that can be coupled with an agent module to form the electrotransport device. The agent module has a compartment containing the therapeutic agent for delivery through the body surface by electrotransport. The agent module has a first end, and includes first agent module (AM) coupler about the first end. The electronic module has a first end and a second end corresponding to the first end and second end of the agent module. The electronic module has a first electronic module (EM) coupler about the first end of the electronic module for coupling with the first AM coupler such that as the first AM coupler matingly engages with the first EM coupler the electronic module and the agent module can be pressed together pivoting about where the first AM coupler engages the first EM coupler. The electronic module includes circuitry for electrically driving the therapeutic agent for electrotransport. | 09-25-2008 |
| 20080234628 | MULTIPLE PART ELECTROTRANSPORT DRUG DELIVERY DEVICE - An electrotransport device for delivering a therapeutic agent through a body surface of a patient. The device has an electronic module that can be coupled with a reservoir module to form the electrotransport device. The reservoir module has a reservoir that contains the therapeutic agent for delivery through the body surface by electrotransport. The reservoir module also has a cutout forming a channel having a narrow channel portion and a less narrow channel portion with channel walls. The electronic module has circuitry for electrically driving the therapeutic agent for electrotransport and having a body with a narrow portion and a less narrow portion corresponding to the narrow channel portion and the less narrow channel portion. The narrow portion of the electronic module can be guided into the narrow channel portion through the less narrow channel portion of the reservoir module. | 09-25-2008 |
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| 20080255101 | NITRIC OXIDE DONATING DIURETIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE - The invention describes novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or pharmaceutically acceptable salts thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating conditions resulting from excessive water and/or electrolyte retention; (b) treating cardiovascular diseases; (c) treating renovascular diseases; (d) treating diabetes; (e) treating diseases resulting from oxidative stress; (f) treating endothelial dysfunctions; (g) treating diseases caused by endothelial dysfunctions; (h) treating cirrhosis; (j) treating pre-eclampsia; (k) treating osteoporosis; (l) treating nephropathy; (m) treating peripheral vascular diseases; (n) treating portal hypertension; (o) treating central nervous system disorders; (p) treating metabolic syndrome; (q) treating sexual dysfunctions; and (r) hyperlipidemia. The nitric oxide enhancing diuretic compounds comprise at least one nitric oxide enhancing group linked to the diuretic compound through one or more sites such as carbon, oxygen and/or nitrogen via a bond or moiety that cannot be hydrolyzed. | 10-16-2008 |
| 20090088366 | NITROSATED AND NITROSYLATED PROSTAGLANDINS, COMPOSITIONS AND METHODS OF USE - The invention describes novel nitrosated and/or nitrosylated prostaglandins, and novel compositions comprising at least one nitrosated and/or nitrosylated prostaglandin, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and/or at least one vasoactive agent. The invention also provides novel compositions comprising at least one prostaglandin and at least one S-nitrosothiol compound, and, optionally, at least one vasoactive agent. The prostaglandin is preferably a prostaglandin E | 04-02-2009 |
| 20100093671 | NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE - The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders. | 04-15-2010 |
| 20100093708 | NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE - The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders. | 04-15-2010 |
| 20100137291 | NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE - The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders. | 06-03-2010 |
| 20110098253 | Nitrosated Nonsteroidal Antiinflammatory Compounds, Compositions and Methods of Use - The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders comprising administration of novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. | 04-28-2011 |
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| 20090062410 | METHOD OF FORMING EXTRUDED POLYSTYRENE FOAMS AND THE PRODUCTS MADE THEREFROM - The invention a method of forming complex shape of styrenic polymer foams in which a pressing surface is created, for example, by planing/machining a layer of an as formed extruded styrenic polymer plank, contacting said plank with a contoured die face and pressing the foam to form the complex shape. | 03-05-2009 |
| 20100237453 | OPTOELECTRONIC DEVICE - The invention is an optoelectronic device comprising an active portion which converts light to electricity or converts electricity to light, the active portion having a front side for the transmittal of the light and a back side opposite from the front side, at least two electrical leads to the active portion to convey electricity to or from the active portion, an enclosure surrounding the active portion and through which the at least two electrical leads pass wherein the hermetically sealed enclosure comprises at the front side of the active portion a barrier material which allows for transmittal of light, one or more getter materials disposed so as to not impede the transmission of light to or from the active portion, and a contiguous gap pathway to the getter material which pathway is disposed between the active portion and the barrier material. | 09-23-2010 |
| 20110094560 | DIRECT MOUNTED PHOTOVOLTAIC DEVICE WITH IMPROVED SIDE CLIP - The present invention is premised upon a photovoltaic assembly system for securing and/or aligning at least a plurality of vertically adjacent photovoltaic device assemblies to one another. The securing function being accomplished by a clip member that may be a separate component or integral to one or more of the photovoltaic device assemblies. | 04-28-2011 |
| 20110094568 | DIRECT MOUNTED PHOTOVOLTAIC DEVICE WITH IMPROVED FRONT CLIP - The present invention is premised upon a photovoltaic assembly system for securing and/or aligning at least a plurality of vertically adjacent (overlapping) photovoltaic device assemblies to one another. The securing function being accomplished by a clip member that may be a separate component or integral to one or more of the photovoltaic device assemblies. | 04-28-2011 |
| 20110100438 | BUILDING INTEGRATED PHOTOVOLTAIC HAVING INJECTION MOLDED COMPONENT - The invention is a photovoltaic device comprising a photovoltaic cell assembly with an injection molded portion connected to at least one edge of the photovoltaic cell assembly where the body portion has properties and a composition enabling robust function over a period of years when the photovoltaic device is mounted on the exterior of a building. | 05-05-2011 |
| 20110183540 | CONNECTOR DEVICE FOR BUILDING INTEGRATED PHOTOVOLTAIC DEVICE - The present invention is premised upon a connector device and method that can more easily electrically connect a plurality of PV devices or photovoltaic system components and/or locate these devices/components upon a building structure. It also may optionally provide some additional sub-components (e.g. at least one bypass diode and/or an indicator means) and may enhance the serviceability of the device. | 07-28-2011 |
