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Gash, US

Alexander Gash, Brentwood, CA US

Patent application numberDescriptionPublished
20090012297Ionic liquids as solvents - A method in one embodiment includes contacting a strongly hydrogen bonded organic material with an ionic liquid having a fluoride anion for solubilizing the strongly hydrogen bonded organic material; and maintaining the ionic liquid at a temperature of about 90° C. or less during the contacting. A method in another embodiment includes contacting a strongly hydrogen bonded organic material with an ionic liquid having an acetate or formate anion for solubilizing the strongly hydrogen bonded organic material; and maintaining the ionic liquid at a temperature of less than about 90° C. during the contacting. A method for purifying a strongly hydrogen bonded organic material according to one another embodiment includes dissolving a strongly hydrogen bonded organic material, selected from a group consisting of 1,3,5-triamino-2,4,6-trinitrobenzene and 2,6-diamino-3,5-dinitropyrazine-1-oxide, in a solution comprising an ionic liquid, the ionic liquid having an anion selected from a group consisting of a fluoride anion, an acetate anion, and a formate anion; maintaining the solution at a temperature of about 70° C. or less during the contacting; and recrystallizing the strongly hydrogen bonded organic material.01-08-2009

Alexander E. Gash, Brentwood, CA US

Patent application numberDescriptionPublished
20100139823PYROPHORIC METAL-CARBON FOAM COMPOSITES AND METHODS OF MAKING THE SAME - A method for creating a pyrophoric material according to one embodiment includes thermally activating a carbon foam for creating micropores therein; contacting the activated carbon foam with a liquid solution comprising a metal salt for depositing metal ions in the carbon foam; and reducing the metal ions in the foam to metal particles. A pyrophoric material in yet another embodiment includes a pyrophoric metal-carbon foam composite comprising a carbon foam having micropores and mesopores and a surface area of greater than or equal to about 2000 m06-10-2010
20100162913Energetic composite and system with enhanced mechanical sensitivity to initiation of self-sustained reaction - An energetic composition and system using amassed energetic multilayer pieces which are formed from the division, such as for example by cutting, scoring, breaking, crushing, shearing, etc., of a mechanically activatable monolithic energetic multilayer(s) (e.g. macro-scale sheets of multilayer films), for enhancing the sensitivity of the energetic composite and system to mechanical initiation of self-sustained reaction. In particular, mechanical initiation of the energetic composition may be achieved with significantly lower mechanical energy inputs than that typically required for initiating the monolithic energetic multilayers from which it is derived.07-01-2010
20100190639HIGH SURFACE AREA, ELECTRICALLY CONDUCTIVE NANOCARBON-SUPPORTED METAL OXIDE - A metal oxide-carbon composite includes a carbon aerogel with an oxide overcoat. The metal oxide-carbon composite is made by providing a carbon aerogel, immersing the carbon aerogel in a metal oxide sol under a vacuum, raising the carbon aerogel with the metal oxide sol to atmospheric pressure, curing the carbon aerogel with the metal oxide sol at room temperature, and drying the carbon aerogel with the metal oxide sol to produce the metal oxide-carbon composite. The step of providing a carbon aerogel can provide an activated carbon aerogel or provide a carbon aerogel with carbon nanotubes that make the carbon aerogel mechanically robust.07-29-2010
20100212787ORGANIZED ENERGETIC COMPOSITES BASED ON MICRO AND NANOSTRUCTURES AND METHODS THEREOF - An ordered energetic composite structure according to one embodiment includes an ordered array of metal fuel portions; and an oxidizer in gaps located between the metal fuel portions. An ordered energetic composite structure according to another embodiment includes at least one metal fuel portion having an ordered array of nanopores; and an oxidizer in the nanopores. A method for forming an ordered energetic composite structure according to one embodiment includes forming an ordered array of metal fuel portions; and depositing an oxidizer in gaps located between the metal fuel portions. A method for forming an ordered energetic composite structure according to another embodiment includes forming an ordered array of nanopores in at least one metal fuel portion; and depositing an oxidizer in the nanopores.08-26-2010
20110203714NANO-LAMINATE-BASED IGNITORS - Sol-gel chemistry is used to prepare igniters comprising energetic multilayer structures coated with energetic materials. These igniters can be tailored to be stable to environmental aging, i.e., where the igniters are exposed to extremes of both hot and cold temperatures (−30 C to 150 C) and both low (0%) and high relative humidity (100%).08-25-2011

Patent applications by Alexander E. Gash, Brentwood, CA US

Alexander E. Gash, Livermore, CA US

Patent application numberDescriptionPublished
20100267541Nano-ceramics and method thereof - A method for producing ceramic materials utilizing the sol-gel process enables the preparation of intimate homogeneous dispersions of materials while offering the ability to control the size of one component within another. The method also enables the preparation of materials that densify at reduced temperatures. Applications of the compositions include filters, solid-oxide fuel cells, membranes, ceramic cutting tools and wear and auto parts. In one example, 10 g of AlCl10-21-2010

Alex E. Gash, Brentwood, CA US

Patent application numberDescriptionPublished
20100221667Catalyst For Microelectromechanical Systems Microreactors - A microreactor comprising a silicon wafer, a multiplicity of microchannels in the silicon wafer, and a catalyst coating the microchannels. In one embodiment the catalyst coating the microchannels comprises a nanostructured material. In another embodiment the catalyst coating the microchannels comprises an aerogel. In another embodiment the catalyst coating the microchannels comprises a solgel. In another embodiment the catalyst coating the microchannels comprises carbon nanotubes.09-02-2010

Diana N. Gash, Tucker, GA US

Patent application numberDescriptionPublished
20080212486Checking of broadband network components - Systems and methods for checking broadband network components are provided in which an automated interactive system permits a field technician to check various conditions of a communication line or other broadband network components without the assistance of a support technician. While options to request assistance from a support technician are provided, the automated interactive system permits the field technician to perform various functions on a communication line without additional assistance, especially for routine tasks. The automated interactive system, therefore, removes efficiencies that may be associated with conventional approaches for checking broadband network components.09-04-2008

Don M. Gash, Lexington, KY US

Patent application numberDescriptionPublished
20100035820AMIDATED DOPAMINE NEURON STIMULATING PEPTIDES FOR CNS DOPAMINERGIC UPREGULATION - The present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or “Amidated Dopamine Neuron Stimulating peptides (ADNS peptides)”), that are useful for treating brain diseases and injuries that result in dopaminergic deficiencies.02-11-2010
20100184692Amidated Dopamine Neuron Stimulating Peptides for CNS Dopaminergic Upregulation - The present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or “Amidated Dopamine Neuron Stimulating peptides (ADNS peptides)”), that are useful for treating brain diseases and injuries that result in dopaminergic deficiencies.07-22-2010
20110178025Amidated Dopamine Neuron Stimulating Peptides for CNS Dopaminergic Upregulation - The present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or “Amidated Dopamine Neuron Stimulating peptides (ADNS peptides)”), that are useful for treating brain diseases and injuries that result in dopaminergic deficiencies.07-21-2011

Patent applications by Don M. Gash, Lexington, KY US

Don M. Gash, Lexington-Fayette, KY US

Patent application numberDescriptionPublished
20110245798Method of Treating Parkinson's Disease in Humans by Convection-Enhanced Infusion of Glial Cell-Line Derived Neurotrophic Factor to the Putamen - A method of treating Parkinson's disease in humans is disclosed, wherein glial cell-line derive neurotrophic factor (GDNF) is chronically administered directly to one or both putamen of a human in need of treatment thereof via convection-enhanced infusion using at least one implantable pump and at least one catheter. In one aspect of the present invention the GDNF is infused directly into one or both putamen through one or more indwelling intraparenchymal mutitiport brain catheters connected to one or moreimplantable pumps wherein the flow rate is pulsed.10-06-2011

Don Marshall Gash, Lancaster, KY US

Patent application numberDescriptionPublished
20120116360TREATMENT OF NEUROLOGICAL DISORDERS - This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment composition can contain a labeled interfering RNA (iRNA) agent capable of decreasing expression of a target RNA associated with the neurological disorder. The methods of the invention include determining an effective amount of a therapeutic composition by introducing a solution containing a tracer into the brain of a mammal. The tracing solution is monitored until a target volume of distribution at steady state distribution is substantially achieved, and the rate of delivery of the therapeutic composition is determined. The therapeutic composition can then be administered at the rate determined by use of the tracing solution.05-10-2012