| Patent application number | Description | Published |
|---|
| 20090041850 | Process for preparation of swellable and degradable microspheres - A process for producing microspheres was developed that provides microspheres that are swellable and degradable. The process is reliable and high yielding, and makes use of a low temperature azo initiator, a small molecule chlorinated solvent as the organic phase, and a heat treatment step, and is carried out in absence of a crosslinking agent. The microsphere preparation made using the process is particularly useful as a degradable embolic material. | 02-12-2009 |
| 20090054535 | METHOD FOR EMBOLIZATION USING LIQUID EMBOLIC MATERIALS - A method for embolization using liquid embolic materials is described. The method comprises the use of two liquid components. The first liquid component is an aqueous solution or dispersion comprising at least one oxidized polysaccharide. The second liquid component is either an aqueous solution or dispersion comprising at least one water-dispersible, multi-arm amine, or a water-dispersible multi-arm amine in the form of a neat liquid. The two components crosslink in situ to form a hydrogel that should act as an effective embolic agent. | 02-26-2009 |
| 20100086678 | BRANCHED END REACTANTS AND POLYMERIC HYDROGEL TISSUE ADHESIVES THEREFROM - Branched end reactants having two or three functional groups at the ends are disclosed. The branched end reactants are used to prepare crosslinked hydrogel tissue adhesives, which have a good balance of mechanical properties in an aqueous environment. Kits comprising the branched end reactants and methods for applying a coating to an anatomical site on tissue of a living organism are also disclosed. | 04-08-2010 |
| 20100112063 | METHOD FOR PREPARING A HYDROGEL ADHESIVE HAVING EXTENDED GELATION TIME AND DECREASED DEGRADATION TIME - A method for extending the gelation time of an oxidized polysaccharide to react with a water-dispersible, multi-arm amine to form a hydrogel is disclosed. The extension of the gelation time is accomplished by using a chemical additive. The method also extends the time for the hydrogel to become tack-free, and may also be used to decrease the degradation time of the hydrogel. The chemical additive reacts with the functional groups of the oxidized polysaccharide or the water-dispersible, multi-arm amine, thereby reducing the number of groups available for crosslinking. The use of the resulting hydrogel for medical and veterinary applications is described. | 05-06-2010 |
| 20110009520 | DIMENSIONALLY STABLE, SHAPED ARTICLES COMPRISED OF DRIED, AGGREGATED, WATER-SWELLABLE HYDROGEL MICROSPHERES AND METHOD OF MAKING SAME - Dimensionally stable, shaped articles comprised of dried, aggregated, water-swellable hydrogel microspheres are described. The microspheres are aggregated together without the use of a binding agent. When exposed to an aqueous medium in a container, the dimensionally stable, shaped article swells slowly and disaggregates, forming at least partially swollen hydrogel microspheres, which take the shape of the container. The dimensionally stable, shaped articles disclosed herein have many potential applications, including medical applications such as a medical implant. | 01-13-2011 |
| 20110033608 | PROCESS FOR MAKING COATED, WATER-SWELLABLE HYDROGEL MICROSPHERES - A process for coating water-swellable hydrogel microspheres with various coating materials is described. The coating process described herein is a fluidized bed process, which utilizes inert, cofluidization particles to aid the fluidization of the microspheres. The use of the cofluidization particles increases the efficiency of the coating process and improves the quality of the coating obtained. | 02-10-2011 |
| 20110097299 | SWELLABLE AND DEGRADABLE MICROSPHERES - Swellable and degradable microspheres are described. The microspheres are prepared by a process that is reliable and high yielding, and makes use of a low temperature azo initiator, a small molecule chlorinated solvent as the organic phase, and a heat treatment step, and is carried out in absence of a crosslinking agent. The microsphere preparation made using the process is particularly useful as a degradable embolic material. | 04-28-2011 |
| 20110269916 | TISSUE ADHESIVES WITH MODIFIED ELASTICITY - An embodiment of the invention is a water soluble chain-extended polyamine product made by a process comprising reacting a multi-arm polyether amine with a bifunctional crosslinker of the formula: X | 11-03-2011 |
