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Garigapati

Venkat Garigapati, Southborough, MA US

Patent application numberDescriptionPublished
20080234727Novel Carriers For Coating Growth Factors Onto Sutures - A suture coated with a composition comprising: 09-25-2008

Venkata Garigapati, Southborough, MA US

Patent application numberDescriptionPublished
20090318343Protein Formulations for Use at Elevated Temperatures - Liquid formulations of bone morphogenetic proteins are provided for prolonged use at elevated temperatures. More specifically, the invention relates to liquid formulations comprising rhGDF-5, trehalose, and one or more biocompatible excipients that provide stability to the protein for at least 30 days at temperatures up to body temperature.12-24-2009
20100130730PROTEIN FORMULATIONS FOR USE AT ELEVATED TEMPERATURES - Liquid formulations of bone morphogenetic proteins are provided for prolonged use at elevated temperatures. More specifically, the invention relates to liquid formulations comprising rhGDF-5, trehalose, and one or more biocompatible excipients that provide stability to the protein for at least 30 days at temperatures up to body temperature.05-27-2010

Venkata R. Garigapati, Southborough, MA US

Patent application numberDescriptionPublished
20110237506PROTEIN STABILIZATION FORMULATIONS - The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants.09-29-2011

Venkat R. Garigapati, Southborough, MA US

Patent application numberDescriptionPublished
20100121459Tetra Calcium Phosphate Based Organophosphorus Compositions and Methods - Compositions and methods of their use to adhere a variety of materials together are disclosed herein. The compositions include at least tetra calcium phosphate, an effective amount of a compound that is structurally similar to phosphoserine, and can be mixed with an aqueous solution. The compositions provide adhesive and cohesive strength in both wet and dry environments and exhibit significant bond strength upon curing.05-13-2010
20110152195POST IRRADIATION SHELF-STABLE DUAL PASTE DIRECT INJECTABLE BONE CEMENT PRECURSOR SYSTEMS AND METHODS OF MAKING SAME - The present invention relates to a bone cement precursor system that is presented in the form of two shelf-stable pastes which have been terminally sterilized and are held in separate containers during product transport and storage. When the product is used during surgery, these pastes inject to a site of application through a static mixing device by the action of applied injection force. When the two pastes are mixed, they start to react to each other while injecting out. The resulting composition is highly biocompatible, osteoconductive, injectable, rapid setting and bioresorbable, and is useful in connection with bone repair procedures, for example, in the craniomaxillofacial, trauma and orthopedic areas.06-23-2011