Patent application number | Description | Published |
20130212648 | Automatic System Replication and Server Access Using Authentication Credentials and Data Files Supplied by a Local Handheld Device and Common Session Level Software - In certain embodiments, the system of the invention automatically replicates a user's personal computing environment and provides associated remote server access using authentication credentials and data files supplied by a local handheld device as coordinated by session level software common to the handheld device, the replicated system, the system on which the replication occurs, and the remote servers. The application enables a handheld computing device to transfer a user's various online account credentials to a user's other computing devices securely and automatically. Thereafter the other computing device accesses a user's cloud-based storage and various on-line accounts and also pulls selected documents, bookmarks and related information directly from a user's handheld. The other computing device thereby essentially becomes a clone of a user's primary personal computer, complete with bookmarks, email account access, documents in a user's desktop and My Documents folder, pictures, music, and on-line content subscription access. | 08-15-2013 |
20130317678 | VEHICULAR DUAL MODE MASTER/SLAVE INTERFACE - A vehicular interface may include an electromechanical interface between a hand-held electronic device and subsystems on a vehicular bus or network. In selected embodiments the interface may operate in a “master mode” when a handheld device, such as a tablet computer or smart-phone, is not inserted therein. In this mode the interface may serve as a master controller and accesses and controls various subsystems on a vehicle (such as engine control subsystems, media controllers, navigation systems, sensors and transducers) as a master controller. In one embodiment, when a tablet device is inserted into the interface, the interface may automatically switch to “slave mode” in which it acts as an adapter or interface between the tablet device and the vehicular subsystems. In this mode of operation the user's exclusive interface is through the tablet computer and the tablet computer serves as the master controller for the system. | 11-28-2013 |
20140208395 | System and Method for Access of User Accounts on Remote Servers - In certain embodiments, the system of the invention automatically replicates a user's personal computing environment and provides associated remote server access using authentication credentials and data files supplied by a local handheld device as coordinated by session level software common to the handheld device, the replicated system, the system on which the replication occurs, and the remote servers. The application enables a handheld computing device to transfer a user's various online account credentials to a user's other computing devices securely and automatically. Thereafter the other computing device accesses a user's cloud-based storage and various on-line accounts and also pulls selected documents, bookmarks and related information directly from a user's handheld. The other computing device thereby essentially becomes a clone of a user's primary personal computer, complete with bookmarks, email account access, documents in a user's desktop and My Documents folder, pictures, music, and on-line content subscription access. | 07-24-2014 |
20150100658 | Dual Mode Master/Slave Interface - In an illustrative embodiment, a dual mode controller switches between a master mode in which the controller is the primary controller of external display devices and a slave mode wherein the controller functions mainly as a conduit for data, such as video data, sent from an external control and display device (ECD). | 04-09-2015 |
Patent application number | Description | Published |
20090264365 | CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONE (PTH) ANALOGS - The present invention relates to conformationally constrained parathyroid hormone (PTH) analogs, and methods of preparing and using the PTH analogs. The invention provides novel PTH polypeptide derivatives containing amino acid substitutions at selected positions in the polypeptides. The invention provides derivatives of PTH(1-34), PTH(1-21), PTH(1-20), PTH(1-19), PTH(1-18), PTH(1-17), PTH(1-16), PTH(1-15), PTH(1-14), PTH(1-13), PTH(1-12), PTH(1-11), and PTH(1-10) polypeptides, wherein at least one residue in each polypeptide is a helix, preferably an α-helix, stabilizing residue. The invention also provides methods of making such peptides. Further, the invention encompasses compositions and methods for use in limiting undesired bone loss in a vertebrate at risk of such bone loss, in treating conditions that are characterized by undesired bone loss or by the need for bone growth, e.g., in treating fractures or cartilage disorders and for raising cAMP levels in cells where deemed necessary. | 10-22-2009 |
20100081612 | POLYPEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) - The present invention is related to novel parathyroid hormone polypeptide derivatives, and to pharmaceutical composition containing the polypeptides, as well as synthetic and recombinant methods for producing the polypeptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing the polypeptides of the present invention. The present invention further provides diagnostic and therapeutic methods using the polypeptide derivatives. | 04-01-2010 |
20110009328 | Polypeptide Derivatives of Parathyroid Hormone (PTH) - Novel parathyroid hormone (PTH) polypeptide derivatives are disclosed, as are pharmaceutical compositions containing said polypeptides, and synthetic and recombinant methods for producing said polypeptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said polypeptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds. | 01-13-2011 |
20110172153 | SCREENING METHODS USING G-PROTEIN COUPLED RECEPTORS AND RELATED COMPOSITIONS - The present invention provides screening methods for GPCRs based on the discovery that the affinity of a receptor agonist for a GPCR (such as the parathyroid hormone receptor) when not bound to a G-protein is correlated with the length of time over which the agonist is effective, independently of its pharmacokinetic properties. The invention also provides PTH- and PTHrP-derived polypeptides. | 07-14-2011 |
20120083448 | Parathyroid Hormone Peptides And Parathyroid Hormone-Related Protein Peptides And Methods Of Use - Provided herein are Parathyroid hormone (PTH) peptides and parathyroid hormone-related protein (PTHrP) peptides (e.g., PTH analogs, PTHrP analogs), and related variants, chemical derivatives, fusion polypeptides, multimeric polypeptides, and peptidomimetics, peptoids, the like. Also provided are their use in methods for activating the PTH receptor in a cell (e.g., an osteoblast), methods of treating a subject with bone loss (e.g., by administration of a PTH peptide or PTHrP peptide (e.g., a PTH analog or PTHrP analog)), methods of ameliorating a symptom associated with osteoporosis in a subject, methods of retarding the progression of osteoporosis in a subject, and methods of regenerating bone in a subject. | 04-05-2012 |
20130116180 | PARATHYROID HORMONE ANALOGS AND USES THEREOF - Disclosed are two PTH analog ligands, SP-PTH-AAK and Aib-SP-PTH-AAK, that have long-acting activity at the PTH receptor, as demonstrated both in vitro and in vivo. These polypeptides are thus particularly useful in the treatment of diseases, such as hypoparathyroidism, in which long-acting activity is desired. The method of making the analog polypeptides is also disclosed. | 05-09-2013 |
20140086842 | SCREENING METHODS USING G-PROTEIN COUPLED RECEPTORS AND RELATED COMPOSITIONS - The present invention provides screening methods for GPCRs based on the discovery that the affinity of a receptor agonist for a GPCR (such as the parathyroid hormone receptor) when not bound to a G-protein is correlated with the length of time over which the agonist is effective, independently of its pharmacokinetic properties. The invention also provides PTH- and PTHrP-derived polypeptides. | 03-27-2014 |
20140378382 | ALPHA-/BETA-POLYPEPTIDE ANALOGS OF PARATHYROID HORMONE (PTH) AND METHOD OF USING SAME - Described are polypeptide analogs of parathyroid hormone (PTH) that include at least two non-adjacent β-amino acid residues in place of a naturally occurring α-amino acid residues. Also described are pharmaceutical compositions useful for treating hypoparathyroidism that contain the analogs and methods of using the analogs to treat hypoparathyroidism. | 12-25-2014 |