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Gao, MA
Hong Gao, Allston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080241883 | Recombinant expression vector elements (rEVEs) for enhancing expression of recombinant proteins in host cells - Compositions and methods comprising recombinant expression vector elements (rEVEs) to enhance the level of expression of recombinant proteins are described. Other compositions and methods for lowering, substantially suppressing, or essentially silencing expression of a recombinant protein are also described. | 10-02-2008 |
| 20110201053 | Recombinant Expression Vector Elements (REVES) for Enhancing Expression of Recombinant Proteins in Host Cells - Compositions and methods comprising recombinant expression vector elements (rEVEs) to enhance the level of expression of recombinant proteins are described. Other compositions and methods for lowering, substantially suppressing, or essentially silencing expression of a recombinant protein are also described. | 08-18-2011 |
| 20110300549 | Treatment of Development-Related Disorders - Disclosed are composition and methods for treating development-related disorders. Also disclosed are diagnosis methods, prognosis methods, and drug screening methods. | 12-08-2011 |
Huai Gao, Lincoln, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090088445 | Deazapurines useful as inhibitors of Janus kinases - The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 04-02-2009 |
| 20100280026 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES - The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. | 11-04-2010 |
Huai Gao, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100184980 | Process for Preparing 5-Fluoro-1H-Pyrazolo [3,4-b] Pyridin-3-amine and Derivatives Thereof - The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof. | 07-22-2010 |
| 20110020376 | AMINOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES - The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention. | 01-27-2011 |
| 20110020377 | AMINOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES - The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention. | 01-27-2011 |
| 20110118255 | PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JAK2 INHIBITORS - The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. The invention also provides processes for preparing the compounds of the invention. | 05-19-2011 |
Jia Gao, Winchester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120126347 | PACKAGES AND METHODS FOR PACKAGING - Packaged integrated devices and methods of forming the same are provided. In one embodiment, a packaged integrated device includes a package substrate, a package lid, and an integrated circuit or microelectromechanical systems (MEMS) device. The package lid is mounted to a first surface of the package substrate using an epoxy, and the package lid and the package substrate define a package interior. The package lid includes an interior coating suited to good adhesion with the epoxy, and an exterior coating suited to RF shielding, where the materials of the interior and exterior coatings are different. In one example, the interior lid coating is nickel whereas the exterior lid coating is tin. | 05-24-2012 |
Jianxin Gao, Dorchester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090242756 | INTENSIFIED NEUTRAL LOSS TAGS AND USE THEREOF IN MASS SPECTROMETRY - Ultrasensitive detection of a chemical substance (analyte) by mass spectrometry is achieved by employing a molecular tag that yields an intense parent ion and then an intense daughter ion in a multi-stage mass spectrometer. | 10-01-2009 |
Lichao Gao, Amherst, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120041221 | FIBRILLAR, NANOTEXTURED COATING AND METHOD FOR ITS MANUFACTURE - A fibrillar, nanotextured coating is deposited on a substrate by contacting the substrate with a reaction mixture comprising a reagent which is hydrolyzable to produced a cross-linked reaction product, and a first solvent which solvates the reagent and the reaction product. The reagent is hydrolyzed so as to provide a cross-linked reaction product which is bonded to the substrate. The substrate is then contacted with a second solvent which is a non-solvent for the reaction product so as to cause nanoscopic phase separation of the reaction product, resulting in the formation of a fibrillar nanotextured coating which is bonded to the substrate. The thus produced coating may be subjected to further chemical modification. The method may be utilized to produce superhydrophobic coatings. Also disclosed are coatings made by the method of the present invention. | 02-16-2012 |
Qing-Sheng Gao, Belmont, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110003884 | Viral Vectors and Methods of Use - This invention relates to viral vectors and methods employing these vectors. The vectors of the invention can be base on flaviviruses, such as chimeric flavi viruses, which may be used to deliver heterologous antigens, such as influenza virus antigens. | 01-06-2011 |
Robert X. Gao, Amherst, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090222228 | MULTI-SCALE ENVELOPING SPECTROGRAM SIGNAL PROCESSING FOR CONDITION MONITORING AND THE LIKE - A signal processing technique that decomposes complex, dynamically changing non-stationary signals from machine components such as bearings into different scales by means of a continuous wavelet transform. The envelope signal in each scale is then calculated from the modulus of the wavelet coefficients. Subsequently, Fourier transform is performed repetitively on the envelope of the signal at each scale, resulting in an “envelope spectrum” of the original signal at the various scales. The final output is a three-dimensional scale-frequency map that indicates the intensity and location of the defect-related frequency lines. The technique is generic in nature, and applicable not only to machine condition monitoring, but also to the health monitoring of a wide range of dynamic systems, including human beings. | 09-03-2009 |
Songping Gao, Southborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100110420 | Inspecting a Workpiece Using Polarization of Scattered Light - A surface inspection system, as well as related components and methods, are provided. The surface inspection system includes a beam source subsystem, a beam scanning subsystem, a workpiece movement subsystem, an optical collection and detection subsystem, and a processing subsystem. The system features a variable polarization a polarizing relay assembly arranged to selectively permit the scattered light having a selected polarization orientation to pass along a detector optical axis to a light detection unit in the detection subsystem. They system also features a collector output width varying subsystem for varying the width of an output slit in response to changes in the location of the location scanned on the workpiece. | 05-06-2010 |
| 20100149527 | System and Method for Controlling a Beam Source in a Workpiece Surface Inspection System - A surface inspection system, as well as related components and methods, are provided. The surface inspection system includes a beam source subsystem, a beam scanning subsystem, a workpiece movement subsystem, an optical collection and detection subsystem, and a processing subsystem. The system features a variable scan speed beam scanning subsystem, preferably using an acousto-optic deflector, with beam compensation, so that variable scanning speeds can be achieved. Also included are methods and systems for improving the signal to noise ratio by use of scatter reducing complements, and a system and method for selectively and repeatedly scanning a region of interest on the surface in order to provide additional observations of the region of interest. | 06-17-2010 |
| 20120013898 | Inspecting a Workpiece Using Polarization of Scattered Light - A surface inspection system, as well as related components and methods, are provided. The surface inspection system includes a beam source subsystem, a beam scanning subsystem, a workpiece movement subsystem, an optical collection and detection subsystem, and a processing subsystem. The system features a variable polarization a polarizing relay assembly arranged to selectively permit the scattered light having a selected polarization orientation to pass along a detector optical axis to a light detection unit in the detection subsystem. The system also features a collector output width varying subsystem for varying the width of an output slit in response to changes in the location of the location scanned on the workpiece. | 01-19-2012 |
Weiwei Gao, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110065807 | PH SENSITIVE BIODEGRADABLE POLYMERIC PARTICLES FOR DRUG DELIVERY - The present invention generally relates to polymers and particles, such as nanoparticles. The particles and polymers generally include one or more buffering components. Additionally, the particles and polymers may include two or more components that impart useful properties (functionalities). The particles and polymers, for example, may include a buffering component and a degradable component. As described herein, the particles and polymers may also include a hydrophilic component and/or a cleavable bond component. The particles and polymers described herein have been found to be particularly effective when used for delivery of one or more agents, such as one or more pharmaceutical agents. Other aspects of the invention are directed to methods of using or administering such particles or polymers, kits involving such particles or polymers, and the like. The present invention also relates to particles containing a cleavable bond component and one or more fluorescence resonance energy transfer (FRET) pairs as well as methods of detecting the cleavage of the cleavable bond component of such particles. | 03-17-2011 |
Xuan Gao, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100152057 | HIGH-SENSITIVITY NANOSCALE WIRE SENSORS - The present invention generally relates to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample. The invention provides a nanoscale wire that has improved sensitivity, as the carrier concentration in the wire is controlled by an external gate voltage, such that the nanoscale wire has a Debye screening length that is greater than the average cross-sectional dimension of the nanoscale wire when the nanoscale wire is exposed to a solution suspected of containing an analyte. This Debye screening length (lambda) associated with the carrier concentration (p) inside nanoscale wire is adjusted by adjusting the gate voltage applied to an FET structure, such that the carriers in the nanoscale wire are depleted. | 06-17-2010 |
Xuri Gao, Watertown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100196316 | CYCLOSPORIN ANALOGUES FOR PREVENTING OR TREATING HEPATITIS C INFECTION - The present invention relates to cyclosporin analogues having antiviral activity against HCV and useful in the treatment of HCV infections. More particularly, the invention relates to novel cyclosporin analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds. | 08-05-2010 |
Xuri Gao, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110008284 | NOVEL CLYCLOSPORIN ANALOGUES - The present invention provides novel cyclosporin analogue compounds, pharmaceutical compositions comprising these compounds and methods of using these compounds for the treatment of disorders and diseases, including immune disorders, inflammatory disorders and viral infections. | 01-13-2011 |
| 20110008285 | NOVEL CYCLOSPORIN ANALOGUES - The present invention provides novel cyclosporin analogue compounds, pharmaceutical compositions comprising these compounds and methods of using these compounds for the treatment of disorders and diseases, including immune disorders, inflammatory disorders and viral infections. | 01-13-2011 |
| 20110008286 | NOVEL PROLINE SUBSTITUTED CYCLOSPORIN ANALOGUES - The present invention provides novel proline substituted cyclosporinanalogue compounds, pharmaceutical compositions comprising these compounds and methods of using these compounds for the treatment of disorders and diseases, including immune disorders, inflammatory disorders and viral infections. | 01-13-2011 |
| 20110218175 | ANTIVIRAL AGENTS - The present invention relates to antiviral compounds of formula (I), | 09-08-2011 |
Yijie Gao, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090221035 | SYSTEMS AND METHODS FOR PROTEIN PRODUCTION - The invention relates to systems and methods for producing proteins of interest. The invention employs genetically-engineered animal or plant cells that have modified protein folding or processing capacities. In one aspect, the invention features genetically-engineered cells comprising one or more recombinant expression cassettes which encode (1) a protein of interest and (2) a polypeptide that is functional in the unfolded protein response (UPR) pathway of the cells. Co-expression of the polypeptide significantly increases the yield of the protein of interest in the genetically-engineered cells. In one example, the genetically-engineered cells are animal cells, and the co-expressed polypeptide is a component or modulator of an XB1- or ATF6-mediated UPR pathway. | 09-03-2009 |
Zhong Gao, Quincy, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080272728 | ROBOTIC JOINT - A driven joint for coupling two structural members is angularly adjustable in two polar or orthogonal dimensions and provides a pair of nonparallel, crossed axles, each having a middle section located between a pair of opposed side sections, wherein the pair of axles are mounted to each other along their respective middle sections and each axle of the pair of axles is rotationally mounted at its respective side sections to a respective structural member, a separate arcuate drive member orthogonally affixed to each respective axle and adapted to enable rotation of its respective axle and a separate drive mechanism mounted to each structural member and adapted to engage and rotate the respective arcuate drive member and the respective axle rotationally mounted to said each structural member. | 11-06-2008 |