Patent application number | Description | Published |
20100291602 | CLINICAL DIAGNOSIS OF HEPATIC FIBROSIS USING A NOVEL PANEL OF LOW ABUNDANT HUMAN PLASMA PROTEIN BIOMARKERS - The inventors have proposed a novel panel of human plasma protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Plasma from patients with hepatic cirrhosis induced by infection with the hepatitis C virus (HCV) were analysed. Several proteins associated with liver scarring and potentially also related to viral infection were identified. These proteins include 14-3-3 protein zeta/delta, adiponectin, afamin, alpha-1-antitrypsin, alpha-2-HS-glycoprotein, apolipoprotein C-III, apolipoprotein E, C4b-binding protein beta chain, intact/cleaved complement C3dg, corticosteroid-binding globulin, fibrinogen gamma chain, beta haptoglobin at pH 5.46-5.49, haptoglobin-related protein, hemopexin, immunoglobulin J chain, leucine-rich alpha-2-glycoprotein, lipid transfer inhibitor protein, retinol-binding protein 4, serum paraoxonase/arylesterase 1, sex hormone-binding globulin and zinc-alpha-2-glycoprotein. These biomarkers can be used in conjunction with polypeptides in WO/2008/031051. The concentrations of these novel biomarkers can be determined using an immunoassay where the concentrations would reflect the extent of fibrosis. A fibrosis scoring scale for each of the novel biomarkers is proposed. The additive result from the scores of all the novel biomarkers would give a more reliable indication of the degree of fibrosis rather than examining individual biomarkers. | 11-18-2010 |
20150105293 | CLINICAL DIAGNOSIS OF HEPATIC FIBROSIS USING A NOVEL PANEL OF LOW ABUNDANT HUMAN PLASMA PROTEIN BIOMARKERS - The inventors have proposed a novel panel of human plasma protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Plasma from patients with hepatic cirrhosis induced by infection with the hepatitis C virus (HCV) were analysed. Several proteins associated with liver scarring and potentially also related to viral infection were identified. These proteins include 14-3-3 protein zeta/delta, adiponectin, afamin, alpha-1-antitrypsin, alpha-2-HS-glycoprotein, apolipoprotein C-M, apolipoprotein E, C4b-binding protein beta chain, intact/cleaved complement C3dg, corticosteroid-binding globulin, fibrinogen gamma chain, beta haptoglobin at pH 5.46-5.49, haptoglobin-related protein, hemopexin, immunoglobulin J chain, leucine-rich alpha-2-glycoprotein, lipid transfer inhibitor protein, retinol-binding protein 4, serum paraoxonase/arylesterase 1, sex hormone-binding globulin and zinc-alpha-2-glycoprotein. | 04-16-2015 |
20160077109 | CLINICAL DIAGNOSIS OF HEPATIC FIBROSIS USING A NOVEL PANEL OF HUMAN SERUM PROTEIN BIOMARKERS - The inventors have proposed a novel panel of human serum protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Serum from patients with varying degrees of hepatic scarring induced by infection with the hepatitis C virus (HCV) was analysed. Several proteins associated with liver scarring and/or viral infection were identified. These proteins include the inter-α-trypsin inhibitor heavy chain H4 fragments, complement factor H-related protein 1, CD5L, Apo L1, and β2GPI. Increased and decreased thiolester cleavage of a2M and Complement C3, respectively, was also detected. The concentrations of these novel biomarkers can be determined using an immunoassay where the concentrations would reflect the extent of fibrosis. A fibrosis scoring scale for each of the novel biomarkers is proposed. The additive result from the scores of all the novel biomarkers would give a more reliable indication of the degree of fibrosis rather than examining individual biomarkers. | 03-17-2016 |
Patent application number | Description | Published |
20140130009 | SYSTEM AND METHOD FOR COMPOSING A TELECOMMUNICATION APPLICATION BY ORCHESTRATING APPLICATION COMPONENTS - In accordance with various embodiments, systems and methods are provided which facilitate composing a telecommunication application by orchestrating application components. Embodiments of the invention enhance the use of simplified programming constructs for user activities in a telecommunications network providing an invocation manager which invokes event functions in an order identified by an orchestrator. The orchestrator holds all specified event functions each with trigger chance and priority value. The event functions can be defined in Communication Beans with annotations and may be updated and selected by an XML file. | 05-08-2014 |
20140156728 | SYSTEM AND METHOD FOR PROVIDING SIMPLIFIED PROGRAMMING CONSTRUCTS FOR USER ACTIVITIES IN A TELECOMMUNICATIONS APPLICATION - In accordance with embodiments of the invention, the converged application framework of a converged application server is extended by providing a set of easily usable artifacts which enable easy creation of programs effecting user activities without detailed knowledge of the underlying SIP level protocol and events. In particular embodiments the present invention provides new communication beans implementing particular user activities including, for example, subscribing to the status of a user mailbox. | 06-05-2014 |
20140222893 | SYSTEM AND METHOD FOR EXTENDING IP MULTIMEDIA SUBSYSTEM TO HTML5 ENVIRONMENTS - The present invention provides a system and method for real-time communication signaling between HTML5 endpoints and the IMS Core of a telecommunication network. The method adapts complex signaling on the server-side into simple operations towards the Web. In an embodiment the system includes a network-side controller communicating over an Internet domain protocol with a client-side controller. The client-side controller provides a JavaScript API to encapsulate the signaling layer. The network-side controller includes session border control functionality, terminates Internet domain communications with the client-side, parses, and normalizes the Internet domain communications into an internal protocol suitable for communication with telecommunications network systems. The system thereby provides a dedicated signaling channel with session border control for applications on the client to interact with telecommunications network services. | 08-07-2014 |
20140222894 | JAVASCRIPT API FOR WEBRTC - The present invention provides a system and method for real-time communication signaling between HTML5 endpoints and the IMS Core of a telecommunication network. The system includes a WebRTC Session Controller (WSC) that terminates Web communications with the client-side, parses, and normalizes the Web communications into an internal protocol suitable for communication with telecommunications network systems. The client-side controller provides a JavaScript API which encapsulates the signaling aspect of a communication session of the HTML5 application, including gathering media description, establishing signaling channels, and exchanging media descriptions with the WSC, populating the relevant WebRTC objects, managing the call after it has been established. The JavaScript API, which is more flexible than widgets that provide rigid capabilities, thereby simplifies development and implementation of real-time communication Web applications, enabling the developers to concentrate on the business logic implementation and innovate on user interface designs. | 08-07-2014 |
20140222930 | BROWSER/HTML FRIENDLY PROTOCOL FOR REAL-TIME COMMUNICATION SIGNALING - The present invention provides a protocol for use in a system for real-time communication signaling in a telecommunication network and communication in web-only internet The protocol facilitates adapting complex signaling on the server-side into simple operations towards the Web. In an embodiment the protocol is used to communicate between a server-side web signaling engine and a client-side communication controller. The client-side communication controller provides a JavaScript API to encapsulate the signaling layer. The web signaling engine includes a controller which terminates communications using the protocol, and normalizes communications into an internal protocol suitable for communication with telecommunications network systems. In an embodiment, the protocol utilizes JSON and a WebSocket connection and can be defined as a WebSocket subprotocol. | 08-07-2014 |
20140222957 | JAVA API FOR PROGRAMMING WEB REAL-TIME COMMUNICATION APPLICATIONS - The present invention provides a system and method for programming server-side real-time web communication applications. In an embodiment of the invention, a JAVA application programming interface (API) is provided for web application developers to write JAVA applications on a server to control, manage, and mediate HTML5 endpoints that communicate with the JAVA applications. Each JAVA application can be a JAVA component that are annotated with a plurality of JAVA objects provided by a JAVA API, thus enabling the JAVA component to be instantiated by a software container and get ready for accepting the signaling messages. The plurality of annotated JAVA objects can also establish communication between HTML5 applications endpoints, and holding the state of the communication. The container can integrate with other enterprise technologies such as JMS, JTA, JPA, JDBC etc, thus enabling the JAVA applications to integrate with applications and services exposed by other providers, e.g., FACEBOOK, GOOGLE, and TWITTER. The JAVA API can be used to write applications that can connect with legacy IMS systems and services using existing JAVA APIs such as SIP servlets, thus enabling protocol translation and creating a gateway with IMS services. | 08-07-2014 |
20140222963 | INTEGRATED WEB-ENABLED SESSION BORDER CONTROLLER - The present invention provides a system and method for real-time communication signaling between HTML5 endpoints and between HTML5 endpoints and the IMS Core of a telecommunications network. The method adapts complex signaling on the server-side into simple operations towards the Web. In an embodiment the system includes an integrated web-enable session border controller (WSBC) including a network-side controller/a signaling engine, a media gateway and a client-side controller. The client-side controller provides a JavaScript API to encapsulate the signaling layer. The WSBC also includes session border control functionality, terminates Internet domain communications with the client-side, parses, and normalizes the Internet domain communications into an internal protocol suitable for communication with telecommunications network systems. The system thereby provides a dedicated signaling channel with the network-side controller for applications on the client to interact with telecommunications network services. | 08-07-2014 |
Patent application number | Description | Published |
20110009188 | CONTROLLING WAGERING TRANSACTIONS FOR MULTI-PROVIDER GAME CONTENT - Described herein are processes and devices that control wagering transactions for multi-provider game content. One of the devices described is a wagering game system. The wagering game system can process a plurality of wagering games from multiple wagering game providers on a single wagering game machine during a single wagering game session. The system can communicate wagering transaction information for the plurality of wagering games between the wagering game machine and an account server. The wagering game system can synchronize a session funds balance on the wagering game machine with an account balance on the account server. The system can utilize different modes of synchronizing the account information for the multiple wagering games. | 01-13-2011 |
20110028203 | PRESENTING WAGERING GAME CONTENT IN MULTIPLE WINDOWS - Described herein are processes and devices that present wagering game content in multiple windows. One of the devices described is a wagering game system. The wagering game system can receive wagering game content and control information from more than one content provider. The wagering game system can present the content from the various content providers in one or more windows, such as by presenting content from one provider in a main window while presenting content from a second provider in one or more auxiliary windows. The wagering game system can also determine priority information for content displayed in the windows and control the appearance and actions of the windows, or content displayed within the windows, based on the priority information. | 02-03-2011 |
20120122567 | LOGIN APPLICATION FOR A WAGERING GAME PORTAL - Systems described herein include wagering game systems having a portal container with one or more portal applications running within the portal container. The portal container includes a login application that receives player credentials and logs into various servers using the login credentials. The login application serves as a proxy for the portal applications that communicate with the servers. | 05-17-2012 |
20130244761 | PRESENTING WAGERING GAME CONTENT IN MULTIPLE WINDOWS - In some embodiments, a method including determining a first wagering game content and a second wagering game content, wherein the first wagering game content is related to a first wagering game, and wherein the second wagering game content is related to a second wagering game. The method can also include determining, based on priority rules, a first display priority for the first wagering game content, and a second display priority for the second wagering game content. The method can also include presenting, based on the first display priority, the first wagering game content. The method can also include presenting, based on the second display priority, the second wagering game content after the presenting of the first wagering game content, and detecting player inputs. The method can also include assigning priority values to the player inputs, and responding to the player inputs in an order related to the priority values. | 09-19-2013 |
20140106865 | Funding concurrent wagering games - Described herein are processes and devices that perform operations that, in some embodiments, include receiving a request for concurrent presentation of a first wagering game and a second wagering game via a display device of a wagering game machine. The first wagering game includes first content that originates from a first content source, and the second wagering game includes second content that originates from a second content source. The operations further include accessing funds associated with the first wagering game. The operations further include funding one or more wagers for the second wagering game using at least a portion of the accessed funds associated with the first wagering game. | 04-17-2014 |
Patent application number | Description | Published |
20160003763 | METHODS FOR GENERATING pH/IONIC CONCENTRATION GRADIENT NEAR ELECTRODE SURFACES FOR MODULATING BIOMOLECULAR INTERACTIONS, AND BUBBLE DETECTION USING ELECTRODES - Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample. | 01-07-2016 |
20160003766 | METHODS FOR GENERATING pH/IONIC CONCENTRATION GRADIENT NEAR ELECTRODE SURFACES FOR MODULATING BIOMOLECULAR INTERACTIONS - Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample. | 01-07-2016 |
20160025671 | METHODS FOR GENERATING pH/IONIC CONCENTRATION GRADIENT NEAR ELECTRODE SURFACES FOR MODULATING BIOMOLECULAR INTERACTIONS - Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample. | 01-28-2016 |
Patent application number | Description | Published |
20080301598 | METHOD FOR CHECKING CONSTRAINTS EQUIVALENCE OF AN INTEGRATED CIRCUIT DESIGN - The equivalence of two or more constraint files of an integrated circuit (IC) design are checked. The comparison is performed between files at the same stage of design, files that correspond to different stages of the design flow, or between top-level and block-level constraint files. | 12-04-2008 |
20130014068 | COMPUTER-AIDED DESIGN SYSTEM AND METHODS THEREOF FOR MERGING DESIGN CONSTRAINT FILES ACROSS OPERATIONAL MODES - In the field of integrated circuit (IC) design it is common to use a plurality of design constraints files to provide the appropriate operational mode when checking the design. Designers typically use the Synopsis® design constraint (SDC) format to describe the constraints in each operational mode. Each time an operational mode is tested a corresponding SDC is used. By merging a plurality of SDCs into a single most pessimistic SDC, designers are able to ensure that the device will properly operate in all the defined operational modes. Only a single run of the merged SDC in the hypothetical mode is required thereby saving time as well as avoiding potential errors from conflicting constraints in different operational modes. | 01-10-2013 |
20140101630 | COMPUTER SYSTEM FOR GENERATING AN INTEGRATED AND UNIFIED VIEW OF IP-CORES FOR HIERARCHICAL ANALYSIS OF A SYSTEM ON CHIP (SOC) DESIGN - In order to realize some of the advantages described above, there is provided a computer system for verification of an intellectual property (IP) core in a system-on-chip (SoC). The system generates a plurality of verification specific abstracted views of the IP core, each of the plurality of verification specific abstracted views having a plurality of verification specific attributes at an input/output (I/O) interface of each of the abstracted view of the IP-core. A unified abstracted view'of the IP-core is generated. | 04-10-2014 |
20150234959 | METHOD AND APPARATUS USING FORMAL METHODS FOR CHECKING GENERATED-CLOCK TIMING DEFINITIONS - A generated-clock checker compares timing definitions against a register transfer level description of the design using formal methods. The generated-clock checker derives generated-clock timing waveform models from the timing definitions, derives generated-clock waveform models from the register level design and then compares the waveform models using formal methods. | 08-20-2015 |