Patent application number | Description | Published |
20080240543 | Calibration and normalization method for biosensors - Calibration and normalization methods for a grating-based sensor design are disclosed. The sensor may be constructed in a manner optimized for both label-free and luminescence, e.g. fluorescence, amplification detection in a single device. Such a sensor, based on grating or another periodical structure with appropriate coating, dramatically increases the diversity of applications and allows realizing novel concepts that provide qualitative and quantitative information/data for each location or capture element in the sensor surface. The invention takes advantage of these different modes to carry out a quality control (QC) step and a calibration of each individual location of the sensor. Thus, the assay data can be flagged according to their quality and local density variations, batch variations and variations in the printed deposition of probes or the materials to the surface can be compensated. | 10-02-2008 |
20090252980 | GREASE-RESISTANT FILMS AND COATINGS - Compositions and methods for rendering a substrate more grease-resistant are disclosed. Treatments, such as aqueous-based treatments and/or emulsions, can be applied to the surface of a substrate, such as paper-based materials, which can be dried to form a treatment layer imparting grease resistant properties. In some instances, the treatment includes an acrylic-based polymer, which can impart grease-resistance, and one or more complementary components (e.g., a polymer and/or oligomer) that can make a layer less brittle (e.g., lowering the T | 10-08-2009 |
20090282931 | Simultaneous aspirator and dispenser for multiwell plates and similar devices - A method of making a measurement of binding affinity of a sample comprises the steps of: introducing the sample into a well having a bottom formed as a photonic crystal biosensor, wherein a portion of the sample becomes bound to the biosensor; making a measurement of the change in the shift in peak wavelength value as a function of time (k | 11-19-2009 |
20100003743 | Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor - A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used. | 01-07-2010 |
20100043571 | Simultaneous aspirator and dispenser for multiwell plates and similar devices - A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate. | 02-25-2010 |
20100143959 | GRATING BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESNCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR - A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. Various applications for the biosensors are described, including cell-based assays for assessing the effect of drug compounds, proteins, peptides and other materials on cell function. A biosensor embodiment optimized for a luminescent response at two different wavelengths is also described. Such luminescent response could be produced by fluorescence (either native or from an attached fluorophore), phosphorescence, chemi-luminescence, or other luminescence technology. Two different luminescence technologies could be combined on the same biosensor chip. | 06-10-2010 |
20100202923 | Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor - A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. Various applications for the biosensors are described, including cell-based assays for assessing the effect of drug compounds on cell function. A biosensor embodiment optimized for a luminescent response at two different wavelengths is also described. Such luminescent response could be produced by fluorescence (either native or from an attached fluorophore), phosphorescence, chemi-luminescence, or other luminescence technology. Two different luminescence technologies could be combined on the same biosensor chip. | 08-12-2010 |
20100227769 | GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR - A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used. | 09-09-2010 |
20100263818 | Retention Systems and Methods for Papermaking - Compositions and methods of producing an optically-enhanced paper-based material are disclosed. The composition can include an optical brightening agent and an additive having an aromatic portion, where the aromatic portion is associated with an optical brightening agent. The paper-based material can exhibit a higher capacity for the optical brightening agent relative to a paper-based material that lacks the additive. Techniques for increasing optical brightening agent retention in a paper-based material are also disclosed. The techniques include using an additive having an aromatic portion, where the aromatic portion associates with an optical brightening agent so that the retention of the optical brightening agent is improved. | 10-21-2010 |
20100329933 | Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor - A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is in the form of an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used. | 12-30-2010 |
20110247772 | FIBROUS PRODUCTS AND METHODS OF MANUFACTURE - Fibrous materials made from multiple populations of fibers, and compositions related to preparing such, are disclosed. In some instances, fiber populations can have different native surfaces, in which at least one of the populations can be surface modified, for example by the use of a polycation (e.g., a polyamine), secondary polymers, complementary polymers, and/or other agents. These populations can be combined to form a fibrous composition, where the surface treatments can enhance properties of the end product. Populations of fibers can also have other physically varying characteristics (e.g., shapes and sizes). Such compositions can be utilized in a variety of applications such as paper products, filters, fire-retardant fibrous products, protein adsorbing fibrous materials, and fibrous sheets having conducting properties. Methods of preparing portions or the entirety of such fibrous materials are also disclosed. | 10-13-2011 |
20110272325 | FORMULATIONS AND METHODS FOR REMOVING HYDROCARBONS FROM SURFACES - The invention provides formulations for facilitating the removal of oil from a surface using a chisel composition, wherein the chisel composition includes a polymer having one or more binding points with a high affinity for the surface, and one or more hydrophilic segments that form a hydrophilic coating on the surface, rendering the surface water-wet and thereby facilitating the removal of oil from the surface. The invention also provides for methods of use of such formulations. | 11-10-2011 |
20120006499 | Debonders for Use in Papermaking - Debonding compositions and methods are disclosed for use in fibrous compositions such as paper-based products. In some instances, debonding agents can be combined with fibers (e.g., cellulose-based fibers) to produce a material having substantial wicking properties while decreasing fiber-fiber interactions that can require substantial energy to overcome in materials processing. In some instances, the debonding agent can act to create a paper-based product exhibiting a transition temperature in which the agent has a higher affinity for the fibers at temperatures above the transition temperature, and the product exhibiting enhanced wicking properties at temperatures below the transition temperature. As an example, a debonding agents can include polymers or other material exhibiting a lower critical solution temperature. The disclosed debonding agents can provide benefits over existing debonding agent formulations such as ammonium salts. | 01-12-2012 |
20120152476 | HIGH STRENGTH PAPER - Disclosed herein are systems and methods for attaching particulate additives to a population of cellulose fibers dispersed in an aqueous solution. The cellulose fibers are treated with an activator that forms complexes with them. The particulate additive is attached to a tether that is capable of interacting with the activator, thereby forming a tether-bearing particulate additive. The tether-bearing particulate additive can be added to the activated suspension of cellulose fibers. The resulting interaction between the tether and the activator forms durable complexes that attach the particulate additive to the cellulose fibers. Using these systems and methods, useful additives like starches can be attached to cellulose fibers, imparting advantageous properties such as increased strength to paper products formed thereby. These systems and methods are particularly useful for papermaking involving virgin pulp fibers, recycled fibers, or any combination thereof. | 06-21-2012 |
20120264603 | ATTACHMENT AND RETENTION FORMULATIONS FOR BIOLOGICALLY ACTIVE ORGANIC COMPOUNDS - The invention encompasses formulations for increased attachment and retention systems of biologically active organic compounds and methods for the preparation and use thereof. | 10-18-2012 |
20130068407 | VOLATILE DEBONDER FORMULATIONS FOR PAPERMAKING - Formulations and methods for papermaking are disclosed herein using one or more volatile debonders, where the volatile debonder forms a solution or an emulsion with water in a paper precursor, and where the volatile debonder is evaporable from the paper precursor before the paper precursor is completely dried to form a paper sheet during papermaking. Two volatile debonders having different boiling points can be used, where they are miscible in water and in each other, and where one volatile debonder has a higher molecular weight and the other volatile debonder has a lower boiling point. | 03-21-2013 |
20130160958 | BULK AND STIFFNESS ENHANCEMENT IN PAPERMAKING - The present invention provides formulations for papermaking and methods for their use. In embodiments, the formulations include a treatment agent and a fluid carrier, where the treatment agent includes a volatile debonder or a polymer composition exhibiting a lower critical solution temperature. Methods for treating a paper product to increase its bulk or its stiffness are also disclosed, in addition to paper products formed from such methods. | 06-27-2013 |
20130248132 | VOLATILE DEBONDER FORMULATIONS FOR PAPERMAKING - Formulations and methods for papermaking are disclosed herein using one or more volatile debonders, where the volatile debonder forms a solution or an emulsion with water in a paper precursor, and where the volatile debonder is evaporable from the paper precursor before the paper precursor is completely dried to form a paper sheet during papermaking. Two volatile debonders having different boiling points can be used, where they are miscible in water and in each other, and where one volatile debonder has a higher molecular weight and the other volatile debonder has a lower boiling point. | 09-26-2013 |
20140000828 | RETENTION SYSTEMS AND METHODS FOR PAPERMAKING | 01-02-2014 |
20140106964 | SEED COATING FORMULATION SYSTEMS - The present invention provides seed coating systems and methods for their use, where a seed coating system comprises encapsulated active ingredient particles that comprise an active ingredient and an encapsulation layer with a preselected release profile, and a polymeric seed coating, wherein the polymeric seed coating releasably affixes the encapsulated active ingredient particle in proximity to a surface of a seed. In embodiments, the seed coating system comprises a plurality of active ingredient layers, wherein a first active ingredient layer comprises a first encapsulated active ingredient, wherein the first encapsulated active ingredient is encapsulated in a first polymer, and wherein the polymer comprises a first binding site that binds the active ingredient and a second binding site for binding to a delivery area, and a binder to releasably affix the encapsulated active ingredient to at least one of a seed surface or a second active ingredient layer, and wherein a second active ingredient layer comprises a second encapsulated active ingredient, wherein the second encapsulated active ingredient is encapsulated in a second polymer which may be the same as or different from the first polymer, and a binder to releasably affix the encapsulated active ingredient to at least one of the first active ingredient layer and a subsequent active ingredient layer. | 04-17-2014 |
20140170313 | HIGH-PERFORMANCE FIBROUS PRODUCTS - The invention relates to formulations and methods for coating a fibrous web, comprising an emulsion capable of deposition on the fibrous web, the emulsion comprising an aqueous continuous phase and a discontinuous internal phase comprising a surface-modifying agent. The fibrous web may comprise a population of fibers that are pretreated with a pretreatment polymer, such as a polycationic polymer. The fibrous web may contain cellulose fibers, or two populations of dissimilar fibers. The surface-modifying agent may contain a polymeric system that forms a coating polymer on fibers of the fibrous web following evaporation of the aqueous continuous phase of the emulsion. | 06-19-2014 |
20140360690 | DEBONDERS FOR USE IN PAPERMAKING - Debonding compositions and methods are disclosed for use in fibrous compositions such as paper-based products. In some instances, debonding agents can be combined with fibers (e.g., cellulose-based fibers) to produce a material having substantial wicking properties while decreasing fiber-fiber interactions that can require substantial energy to overcome in materials processing. In some instances, the debonding agent can act to create a paper-based product exhibiting a transition temperature in which the agent has a higher affinity for the fibers at temperatures above the transition temperature, and the product exhibiting enhaced wicking properties at temperatures below the transition temperature. As an example, a debonding agents can include polymers or other material exhibiting a lower critical solution temperature. The disclosed debonding agents can provide benefits over existing debonding agent formulations such as ammonium salts. | 12-11-2014 |
20150068657 | FUNCTIONAL PULP-CONTAINING COMPOSITES FOR DRYWALL APPLICATIONS - The present invention provides composite materials comprising a population of cellulose fibers complexed with an activator, and an additive comprising synthetic fibers complexed with a tethering agent, wherein the tethering agent has an affinity for the activator, and wherein an interaction between the tethering agent and the activator attaches the synthetic fibers to the cellulose fibers to form the composite material. The present invention also provides methods of manufacture for such composite materials, and methods for their use, for example in forming gypsum board composites. | 03-12-2015 |
20150075740 | PROCESSES FOR CLAY EXFOLIATION AND USES THEREOF - The present invention provides methods for producing exfoliated clay platelets from a swellable clay material. In embodiments, the method for producing exfoliated clay platelets includes providing an exfoliating agent comprising an anionic extractant, and exposing the swellable clay material to the exfoliating agent, wherein the exfoliating agent produces exfoliated clay platelets from the swellable clay material. Methods for treating paper precursors and paper sheets are also disclosed, as are paper products formed from such paper precursors or paper sheets. | 03-19-2015 |