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Gall, WA
Alexander Gall, Woodinville, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20080249097 | PRODRUGS OF HETEROARYL COMPOUNDS - The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents. | 10-09-2008 |
| 20090192099 | PRODRUGS OF HETEROARYL COMPOUNDS - The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents. | 07-30-2009 |
| 20090209505 | PRODRUGS OF HETEROARYL COMPOUNDS - The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents. | 08-20-2009 |
| 20100279968 | Mutagenic Nucleoside Analogs for the Treatment of Viral Disease - The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs. | 11-04-2010 |
| 20110224434 | Prodrugs of Heteroaryl Compounds - The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents. | 09-15-2011 |
Alexander A. Gall, Woodinville, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100137614 | NEGATIVELY CHARGED MINOR GROOVE BINDERS - The present invention provides a negatively charged minor groove binding compound, oligonucleotide conjugates comprising the same, and methods for using the same. The negatively charged minor groove binding compounds of the present invention comprises an acidic moiety that is capable of being ionized under physiological conditions. In particular, the negatively charged minor groove binding compound of the present invention comprises a binding moiety that binds preferentially into a minor groove of a double, triple or higher stranded DNA, RNA, PNA or hybrids thereof. The binding moiety comprises at least one aryl moiety and an acidic moiety which is covalently attached to a phenyl portion of the aryl moiety or to a heteroatom of a heteroaryl portion of the aryl moiety. | 06-03-2010 |
| 20100174058 | FLUORESCENT QUENCHING DETECTING REAGENTS AND METHODS - Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group. | 07-08-2010 |
| 20110053155 | POLAR DYES - The present invention relates to novel polar fluorescent and quenchers dyes, and minor groove binder with enhanced polarity. The present invention further relates to methods of preparing oligonucleotide probes labeled with polar arsonate dyes under the condition of automated synthesis and method of using such probes. | 03-03-2011 |
Andrew Gall, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110277875 | COOLANT VACUUM FILL APPARATUS AND METHOD - An apparatus, system, and method are provided for bypassing a coolant reservoir with a fill tool connecting a source of vacuum pressure and a source of coolant (e.g., a vacuum coolant filler) to a vehicular cooling system inlet port. The fill tool bypass allows the coolant reservoir to be manufactured from a relatively structurally weak polymer material, which is subject to failure under vacuum pressure, while still allowing vacuum coolant filling to be used to charge the vehicular cooling system. Without the use of the bypass fill tool, the coolant reservoir would rupture under the vacuum pressures applied during vacuum coolant filling. | 11-17-2011 |
Anna Gall, Woodinville, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090062353 | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders - Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions. | 03-05-2009 |
| 20090170841 | Styrenyl Derivative Compounds for Treating Ophthalmic Diseases and Disorders - The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease. | 07-02-2009 |
| 20090326074 | Alkoxy compounds for disease treatment - The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease. | 12-31-2009 |
| 20110281934 | MICELLES OF HYDROPHILICALLY SHIELDED MEMBRANE-DESTABILIZING COPOLYMERS - Provided herein are micelles comprising a plurality of copolymers. In certain instances, micelles provided herein are pH sensitive particles. | 11-17-2011 |
Anna S. Gall, Woodinville, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110123636 | MICELLIC ASSEMBLIES - Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles. | 05-26-2011 |
| 20110129921 | TARGETED POLYMER BIOCONJUGATES - Polymer bioconjugate having a RNAi agent covalently coupled to the alpha or omega end of a pH-dependent membrane-destabilizing polymer. | 06-02-2011 |
| 20110142951 | MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS - Composition comprising a polymeric micelle and an associated polynucleotide. | 06-16-2011 |
| 20110143434 | DIBLOCK COPOLYMERS AND POLYNUCLEOTIDE COMPLEXES THEREOF FOR DELIVERY INTO CELLS - Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic. | 06-16-2011 |
| 20110143435 | POLYMERIC CARRIER - Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell. | 06-16-2011 |