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Gales
Céline Gales, Toulouse FR
| Patent application number | Description | Published |
|---|---|---|
| 20090298162 | BIOSENSORS FOR MONITORING RECEPTOR-MEDIATED G-PROTEIN ACTIVATION - The present invention relates to novel biosensors that are based on bioluminescence resonance energy transfer (BRET). These biosensors may be used to monitor rapid interaction and conformational changes within G protein-coupled receptor/G protein complexes and, in this way, reflect the activation status of the receptor. Advantageously, the biosensors may be used as a highly sensitive and quantitative assay for the identification of ligands (agonists, antagonists, inverse agonists, partial agonists, etc.) targeting G protein-coupled receptors (GPCRs) as well as for the analysis of the activation status of these receptors. Moreover, multiplexing different biosensors within receptors/G protein complexes allows for mapping ligand textures. Additionally, the biosensors permit the direct, real-time examination of interactions between receptors and G protein in their natural environment, the living cell. | 12-03-2009 |
Charles C. Gales, Lancaster, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100219042 | PRODUCT INVERTING MECHANISM - The invention is directed to an inverting device which takes one or more articles from a first device, inverts the article(s), and discharges the article(s) onto a second device that may be at essentially the same relative height as the first device. The inverting device has a rotating device with two opposed surfaces that are spaced apart a distance slightly greater than the height of the article. Once the article(s) has been moved into position in the rotating device, the rotating device rotates 180 degrees about a transverse axis, resulting in the inversion of the article. The new orientation of the article may facilitate further processing in a manufacturing environment, such as cleaning, filling, labeling, stacking or any other activity that relies on a specific product disposition. | 09-02-2010 |
Mark Gales, Wauwatosa, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20100230199 | MOTORCYCLE HAVING A MULTI-FUNCTIONAL REAR BRAKE CALIPER BRACKET - A motorcycle includes a rear brake caliper bracket coupled to the swingarm. In some constructions, the rear brake caliper bracket includes a caliper mounting portion and a license plate mounting portion. In some constructions, the rear brake caliper bracket includes an axle engaging portion secures and retains the axle relative to the swingarm in a desired position along the axis of rotation. In some constructions, the rear brake caliper bracket is disposed at a laterally outward side of the swingarm and includes a caliper mounting portion, first and second swingarm engaging portions, and an axle engaging portion. In such constructions, the motorcycle may further include an axle adjusting member engaged with the rear brake caliper bracket and operable to adjust the position of the axle relative to the swingarm. | 09-16-2010 |
Mark John Francis Gales, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20110015925 | SPEECH RECOGNITION SYSTEM AND METHOD - A speech recognition method, comprising: | 01-20-2011 |
Nicolas Gales, Pontchateau FR
| Patent application number | Description | Published |
|---|---|---|
| 20090121540 | HYDRAULIC BRAKE SYSTEM - Embodiments of a hydraulic brake system are disclosed. In one embodiment, a priority flow control valve for supplying operating pressure has a first orientation in which operating pressure is provided at a controlled flow port and a second orientation in which operating pressure is provided at the controlled flow port and an excess flow port. A steering control unit has an inlet port for receiving operating pressure and an outlet port for communicating a steering control load sense signal. A brake control unit has an inlet port for receiving operating pressure and an outlet port for communicating a braking control load sense signal. The inlet port of the brake control unit and the inlet port of the steering control unit are connected to the controlled flow port. | 05-14-2009 |