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Gaillard
Elizabeth R. Gaillard, Dekalb, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20090005349 | THERAPEUTIC USES OF GLUTATHIONE MIMICS - A prodrug having antioxidant activity, including a phosphorylated compound having a thiol group. A method of treating oxidative stress by administering a prodrug of a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug, and treating oxidative stress. A method of increasing bioavailability of a thiol compound by creating a prodrug by phosphorylating a thiol compound, administering the prodrug, preventing first pass metabolism of the prodrug, removing a phosphate group from the prodrug, and providing active drug to a site in need of therapy from oxidative stress. A method of preventing radiation damage to healthy tissue by administering a prodrug comprising a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug to provide active drug, and preventing radiation damage to healthy tissue. | 01-01-2009 |
| 20110244504 | BIOMARKERS OF INFLAMMATION IN BRUCH'S MEMBRANE OF THE HUMAN RETINA - A method of diagnosing a patient with age-related macular degeneration (AMD), by detecting biomarkers in the patient's Bruch's membrane, and diagnosing the patient with AMD. A method of detecting the presence of AMD in a patient, by detecting biomarkers in the patient's Bruch's membrane. A method of detecting inflammation in a patient, by detecting biomarkers in the patient's Bruch's membrane. A method of determining the progression of AMD in a patient. A method of determining efficacy of a treatment for AMD in a patient. A method of determining the presence of AMD in an animal model. A kit for detecting the presence of disease in a patient, including an assay for biomarkers 3-nitrotyrosine and nitro-A2E. An assay of the biomarkers. | 10-06-2011 |
Jean-Paul Gaillard, Cully CH
| Patent application number | Description | Published |
|---|---|---|
| 20110271844 | CAPSULE FOR PREPARING A BEVERAGE, AND DEVICE - The invention relates to a capsule for preparing a beverage, for example coffee, including a hollow element ( | 11-10-2011 |
| 20120031279 | DEVICE FOR PREPARING A BEVERAGE EXTRACTED FROM A CAPSULE - Device for preparing a beverage that is extracted from a capsule comprising a capsule support and a capsule cage inside which there are at least a water inlet and means for piercing the capsule, characterized in that it further comprises interaction means intended to impart a mechanical, thermal, electrical or electromagnetic factor to said capsule when this capsule is introduced into the cage. | 02-09-2012 |
Joel Gaillard, Nassau BS
| Patent application number | Description | Published |
|---|---|---|
| 20100038434 | PORTABLE ELECTRONIC DEVICE CAPABLE OF ALTERNATE DATA CONVEYANCE OPERATIONS RESPONSIVE TO AN INVARIABLE ACTIVATION COMMAND - The portable electronic device comprises an electronic circuit, a control device operatively linked to the electronic circuit with an invariable activation command being issued when the control device is triggered, first and second data conveyance functions programmed in the electronic circuit, a cue receiver for receiving a selectively emitted activation cue from a source external to the portable electronic device and power means, for providing power to the portable electronic device. Upon the control device being selectively triggered to issue the invariable activation command, the electronic circuit will accomplish the first data conveyance function if an activation cue was received by the cue receiver and the second data conveyance function if no activation cue was received by the cue receiver. | 02-18-2010 |
| 20100038436 | PORTABLE ELECTRONIC DEVICE AND METHOD FOR ALTERNATE DATA CONVEYANCE OPERATIONS RESPONSIVE TO AN INVARIABLE ACTIVATION COMMAND - The portable electronic device includes an electronic circuit, a control device operatively linked to the electronic circuit, first and second data transceivers operatively linked to the electronic circuit, a cue receiver operatively linked to the electronic circuit, a data conveyance switching element operatively linked to the electronic circuit and capable of being in either one of a first and a second state, and power means for providing power to the portable electronic device. The method of data conveyance includes awaiting for an activation cue to be received at the cue receiver; if an activation cue is received at the cue receiver, assigning its first state to the switching element, while if no activation cue is received at the cue receiver, assigning its second state to the switching element; and selectively triggering the control device to issue an invariable activation command. Upon the control device being triggered, if the switching element is in its first state, first data will be forwarded to the first data transceiver for initiating a data exchange operation with a first external data exchange device; while if the switching element is in its second state, second data will be forwarded to the second data transceiver for initiating a data exchange operation with a second external data exchange device. | 02-18-2010 |
Joël Gaillard, Nassau BS
| Patent application number | Description | Published |
|---|---|---|
| 20100038436 | PORTABLE ELECTRONIC DEVICE AND METHOD FOR ALTERNATE DATA CONVEYANCE OPERATIONS RESPONSIVE TO AN INVARIABLE ACTIVATION COMMAND - The portable electronic device includes an electronic circuit, a control device operatively linked to the electronic circuit, first and second data transceivers operatively linked to the electronic circuit, a cue receiver operatively linked to the electronic circuit, a data conveyance switching element operatively linked to the electronic circuit and capable of being in either one of a first and a second state, and power means for providing power to the portable electronic device. The method of data conveyance includes awaiting for an activation cue to be received at the cue receiver; if an activation cue is received at the cue receiver, assigning its first state to the switching element, while if no activation cue is received at the cue receiver, assigning its second state to the switching element; and selectively triggering the control device to issue an invariable activation command. Upon the control device being triggered, if the switching element is in its first state, first data will be forwarded to the first data transceiver for initiating a data exchange operation with a first external data exchange device; while if the switching element is in its second state, second data will be forwarded to the second data transceiver for initiating a data exchange operation with a second external data exchange device. | 02-18-2010 |
Julien Gaillard, La Conversion CH
| Patent application number | Description | Published |
|---|---|---|
| 20080317931 | Beverage Ingredient Containing Capsule Having Several Compartments - A method for producing a beverage or liquid comestible from a single capsule by subdividing the interior of the capsule into a plurality of compartments, at least two compartments containing beverage-forming ingredients, introducing a liquid into one of the compartments of the capsule and starting to produce and drain a first beverage component on the basis of the ingredient contained in the first compartment, and opening a fluid communication between the first and the second compartment such that after the start of the production of the first beverage compartment, a production of a beverage component on the basis of the ingredient contained in the second compartment commences. The capsule is preferably used to make cappuccino-style beverages. | 12-25-2008 |
Mathieu Gaillard, Lausanne CH
| Patent application number | Description | Published |
|---|---|---|
| 20110110390 | LASER DIODE STRUCTURE WITH INTEGRATED TEMPERATURE-CONTROLLED BEAM SHAPING ELEMENT AND METHOD FOR GAS DETECTION BY MEANS OF A LASER DIODE STRUCTURE - The invention relates to a laser diode structure, specifically for use in gas detection, with a hermetically sealed housing with electrical connections having a bottom and a window. A laser diode chip and a temperature control system for the laser diode chip are provided in the housing. A thermo element in the form of a Peltier element forms the temperature control system, and is connected via a lower flat surface to the bottom of the housing and via an upper flat surface to the laser diode chip, with a temperature-controlled beam shaping element as collimator provided between the laser diode chip and the window of the housing that acts on a laser beam emerging from a laser aperture of the laser diode chip before it passes through the window. The beam shaping element is in contact with the laser diode chip and is preferably connected via a boundary surface to the laser aperture with surface-to-surface contact or adhesively, or is made in one piece together with the laser aperture. | 05-12-2011 |
| 20110216793 | LASER DIODE STRUCTURE WITH REDUCED INTERFERENCE SIGNALS - A laser diode structure for generating a collimated or divergent laser beam, preferably for application in gas detection, with a laser diode arranged in a closed housing, with the housing comprising a housing bottom, an exit window, electrical connections, a temperature control device for the laser diode, and an optical element for influencing the laser beam. The temperature control device carrying the laser diode is arranged on the housing bottom and the optical element is positioned at a distance from the laser diode. The invention proposes an electrically controllable power device for the cyclic alteration of the position and/or alignment of the optical element in relation to the laser diode so that the optical path length for the laser beam in the housing changes periodically. The oscillating motion of the optical element has the effect of time-averaging the etalon and/or self-mixing effects caused by the back-reflections of the laser beam in the housing, thereby reducing the optical noise of the laser diode structure. | 09-08-2011 |
Olivier Gaillard, Suchy CH
| Patent application number | Description | Published |
|---|---|---|
| 20120038098 | LOADING STATION FOR PLATE ELEMENTS AND MACHINE FOR PROCESSING SUCH ELEMENTS - A station for loading plate elements ( | 02-16-2012 |
Patrice Fabien Gaillard, Milton, VT US
| Patent application number | Description | Published |
|---|---|---|
| 20090057593 | Staggered Cylinders in a Valve Gate Apparatus - A valve gate piston assembly, in an injection molding system, is positioned in a staggered arrangement such that one piston assembly overlaps that of another valve gate piston assembly thereby minimizing an overall centerline pitch between said piston assemblies. Such a superposed layout of piston assemblies enables larger diameter pistons to occupy a smaller footprint than would be realized should the same piston assemblies be positioned side by side. The use of relatively larger diameter pistons results in an increased force available, for the same input air pressure, to actuate the pistons and valve stems attached thereto, resulting in a higher valve stem closing force. A staggered piston assembly layout also allows independent air circuits to control each piston separately. A combination of multiple piston assemblies may be configured in such a staggered, overlapping array. | 03-05-2009 |
| 20090191300 | Flexible Plate Slot for a Hot Runner Injection Molding System - A flexible plate system for a hot runner assembly includes a backing plate; a manifold plate detachably connected to the backing plate; a manifold positioned between the backing plate and the manifold plate and having at least one nozzle associated therewith; and wherein the manifold plate has at least one plate slot that allows the nozzle to extend through the manifold plate and having at least a first lateral dimension substantially larger than the outside diameter of the nozzle. The manifold plate and the backing plate may be configured to have at least one manifold plate cavity and at least one backing plate cavity to accept at least one nozzle insert and at least one piston cylinder insert respectively, the nozzle insert having a nozzle bore or a plurality of insert slots therethrough for installation of the nozzle, and the piston cylinder insert having a cylinder bore for a piston cylinder. | 07-30-2009 |
| 20090191302 | Reconfigurable Hot Runner - A hot runner system having a melt distribution system that is reusable and reconfigurable to vary drop or nozzle locations to meet various design requirements. The melt distribution system includes a melt distributor in fluid communication with a melt source, at least one melt conduit in fluid communication with the melt distributor, and at least one nozzle in fluid communication with the at least one melt conduit. The hot runner system also includes a backing plate; a manifold plate detachably connected to the backing plate; a melt distribution system positioned between the backing plate and the manifold plate and having at least one nozzle associated therewith. The hot runner system may be configured and reconfigured to accommodate various drop or nozzle locations. | 07-30-2009 |
| 20090236774 | Melt Distribution Apparatus for Use in a Hot Runner and a Related Method for a Balancing of Melt Flow - Disclosed, amongst other things, is a melt distribution apparatus of a hot runner and a related method for balancing melt flow to a plurality of drops. The melt distribution apparatus includes a plurality of chokes with each choke of the plurality of chokes being associated with a corresponding one of a drop of a plurality of drops. Each choke of the plurality of chokes being configured to contribute, during an injection of a molding material therethrough, a choke melt-pressure loss such that the plurality of chokes contribute an aggregate choke melt-pressure loss that is generally between 10% and 75% of an aggregate hot runner melt-pressure loss. | 09-24-2009 |
| 20110183030 | Hot-Runner System having Nano-Structured Material - Disclosed is a hot-runner system of an injection molding system, the hot-runner system comprising a hot-runner component, including: a material, and a nano-structured material being combined with the material. | 07-28-2011 |
Pierre-Alain Gaillard, Sion CH
| Patent application number | Description | Published |
|---|---|---|
| 20110253586 | Medication container and dosing monitor - A patient-portable medication event monitor is disclosed which is capable of detecting the dispensing of doses of a particular medication from the monitor, comparing the dispensing detected with information concerning the desired dosing regimen for the certain medication and displaying graphically to the patient at least one feedback indication of the patient's degree of compliance or deviation with the desired regimen. | 10-20-2011 |
Pieter Jaap Gaillard, Valkenburg NL
| Patent application number | Description | Published |
|---|---|---|
| 20080213179 | Differentially Expressed Nucleic Acids in the Blood-Brain Barrier Under Inflammatory Conditions - The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced changes in blood-brain barrier functionality. Such polypeptides are referred to as lipopolysaccharide-sensitive (LPSS) polypeptides herein. These nucleic acids and polypeptides may be useful in methods for controlling blood-brain barrier properties in mammals in need of such biological effects. This includes the diagnosis and treatment of disturbances in the blood-brain/retina barrier, brain (including the eye) disorders, as well as peripheral vascular disorders. Additionally, the invention relates to the use of anti-LPSS polypeptide antibodies or ligands as diagnostic probes, as blood-brain barrier targeting agents or as therapeutic agents as well as the use of ligands or modulators of expression, activation or bioactivity of LPSS polypeptides as diagnostic probes, therapeutic agents or drug delivery enhancers. | 09-04-2008 |
| 20110274749 | METHODS AND COMPOSITIONS FOR TARGETING AGENTS INTO AND ACROSS THE BLOOD-BRAIN BARRIER AND OTHER ENDOTHELIAL CELL MICROVASCULAR BARRIERS - The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced changes in blood-brain bather functionality. Such polypeptides are referred to as lipopolysaccharide-sensitive (LPSS) polypeptides. These nucleic acids and polypeptides may be useful in methods for controlling blood-brain bather properties in mammals in need of such biological effects. This includes the diagnosis and treatment of disturbances in the blood-brain/retina barrier, brain (including the eye) disorders, as well as peripheral vascular disorders. Additionally, the invention relates to the use of anti-LPSS polypeptide antibodies or ligands as diagnostic probes, as blood-brain barrier targeting agents or as therapeutic agents as well as the use of ligands or modulators of expression, activation or bioactivity of LPSS polypeptides as diagnostic probes, therapeutic agents or drug delivery enhancers. | 11-10-2011 |
Pieter Jaap Gaillard, Oegstgeest NL
| Patent application number | Description | Published |
|---|---|---|
| 20100129437 | TARGETED INTRACELLULAR DELIVERY OF ANTIVIRAL AGENTS - The invention relates to methods of targeted drug delivery of antiviral compounds, including, chemical agents (like nucleoside analogs or protease inhibitors) and nucleic acid based drugs (like DNA vaccines, antisense oligonucleotides, ribozymes, catalytic DNA (DNAzymes) or RNA molecules, siRNAs or plasmids encoding thereof). Furthermore, the invention relates to targeted drug delivery of antiviral compounds to intracellular target sites within cells, tissues and organs, in particular to target sites within the central nervous system (CNS), into and across the blood-brain barrier, by targeting to internalizing uptake receptors present on these cells, tissues and organs. Thereto, the antiviral compounds, or the pharmaceutical acceptable carrier thereof, are conjugated to ligands that facilitate the specific binding to and internalization by these receptors. | 05-27-2010 |
| 20110305751 | GLUTATHIONE-BASED DRUG DELIVERY SYSTEM - The invention relates to methods of targeted drug delivery of compounds, including, chemical agents, (poly)peptides and nucleic acid based drugs (like DNA vaccines, antisense oligonucleotides, ribozymes, catalytic DNA (DNAzymes) or RNA molecules, siRNAs or plasmids encoding thereof). Furthermore, the invention relates to targeted drug delivery of compounds to extravascular and intracellular target sites within cells, tissues and organs, in particular to target sites within the central nervous system (CNS), into and across the blood-brain barrier, by targeting to glutathione transporters present on these cells, tissues and organs. Thereto, the compounds, or the pharmaceutical acceptable carrier thereof, are conjugated to glutathione-based ligands that facilitate the specific binding to and internalization by these glutathione transporters. | 12-15-2011 |