| Patent application number | Description | Published |
|---|
| 20080299580 | Targeted integration into the PPP1R12C locus - Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into the human PPP1R12C locus, for example, for expression of a polypeptide of interest. | 12-04-2008 |
| 20090111119 | Rapid in vivo identification of biologically active nucleases - Disclosed herein are methods and compositions for rapidly identifying and ranking nucleases for specific cleavage of a target sequence. | 04-30-2009 |
| 20090111188 | Optimized non-canonical zinc finger proteins - Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described. | 04-30-2009 |
| 20090203140 | Genomic editing in zebrafish using zinc finger nucleases - Disclosed herein are methods and compositions for genomic editing of one or more genes in zebrafish, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins. | 08-13-2009 |
| 20090205083 | Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes - The present disclosure relates to engineered zinc finger proteins that target 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS) genes in plants and methods of using such zinc finger proteins in modulating gene expression, gene inactivation, and targeted gene modification. In particular, the disclosure pertains to zinc finger nucleases for targeted cleavage and alteration of EPSPS genes. | 08-13-2009 |
| 20090263900 | Linear donor constructs for targeted integration - Disclosed herein are linear donor molecules comprising homology arms of 50-750 base pairs (e.g., 50-100 base pairs) flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell. | 10-22-2009 |
| 20100199389 | Targeted integration into the Zp15 locus - Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into a plant Zp15 locus, for example, for expression of a polypeptide of interest. | 08-05-2010 |
| 20100218264 | Genome editing in rats using zinc-finger nucleases - Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins. | 08-26-2010 |
| 20100323424 | Targeted modification of chromatin structure - Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences. | 12-23-2010 |
| 20110027235 | Targeted integration into stem cells - Disclosed herein are methods and compositions for targeted integration of sequences of interest such as lineage-specific or cell fate reporter constructs or protein encoding sequences into stem cells. | 02-03-2011 |
| 20110136895 | Methods and compositions for modulating PD1 - Disclosed herein are methods and compositions for modulating expression of a PD1 gene. | 06-09-2011 |
