Furnari
Frank Furnari, La Jolla, CA US
Patent application number | Description | Published |
---|---|---|
20100092475 | TREATMENT METHOD USING EGFR ANTIBODIES AND SRC INHIBITORS AND RELATED FORMULATIONS - The present invention relates to the treatment of EGFR-mediated disease, particularly cancer by inhibiting or blocking EGFR and src in combination or simultaneously. The invention relates to treatment, prevention, or modulation of cancer, particularly EGFR-mediated disease, with one or more EGFR modulator and src inhibitor in combination. The invention further relates to the treatment of cancer with anti-EGFR antibodies and src inhibitors. Methods and compositions for treatment of cancer with the antibody anti-EGFR mAb806 in combination or series with a src inhibitor or src inhibitors are described. | 04-15-2010 |
20120022132 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MUTANT EGFR GENE - The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a mutant Epidermal Growth Factor Receptor (EGFR), and methods of using the dsRNA to inhibit expression of mutant EGFR. | 01-26-2012 |
20120165340 | PTEN PHOSPHORYLATION-DRIVEN RESISTANCE TO CANCER TREATMENT AND ALTERED PATIENT PROGNOSIS - Indicators that can guide clinical decisions in cancer, particularly posttranslational modification of proteins which result in altered prognosis and differential sensitivity to targeted cancer therapy, are provided. In particular, monitoring of phosphorylation of PTEN may be utilized to predict or assess drug response, drug sensitivity, and clinical outcome. Modulation of PTEN phosphorylation may be utilized to alter sensitivity and outcome in cancer patients. Posttranslational modification of PTEN, particularly phosphorylation, is correlated with resistance to targeted cancer therapy, including EGFR inhibitors, and with reduced survival prognosis. Methods and assays for determining phosphorylation of PTEN, particularly Y240 phosphorylation, are provided. Methods for sensitizing tumors to inhibition and targeted therapy by modulating PTEN phosphorylation are provided. | 06-28-2012 |
20130184329 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MUTANT EGFR GENE - The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a mutant Epidermal Growth Factor Receptor (EGFR), and methods of using the dsRNA to inhibit expression of mutant EGFR. | 07-18-2013 |
Joseph Furnari, Washington, MI US
Patent application number | Description | Published |
---|---|---|
20130233269 | Exhaust Valve Assembly - An exhaust valve assembly for use in an exhaust system includes a body region and an auxiliary region. The body region has first and second ends and defines a longitudinal axis defined between the ends. The body region has an interior surface terminating at the ends and defines a flow path along the axis and an opening. The auxiliary region is coupled to the body region about the opening. The auxiliary region has at least one wall that defines a space in communication with the opening outside the flow path. The exhaust valve assembly further includes a shaft coupled to the wall of the auxiliary region and a vane coupled to the shaft. The vane is movable between an open position with the vane disposed entirely within the auxiliary region and a closed position with at least a portion of the vane disposed in the body region intersecting the axis. | 09-12-2013 |
Joseph Vincent Furnari, Washington, MI US
Patent application number | Description | Published |
---|---|---|
20140060056 | Rotational Engine - The rotational engine assembly includes a housing defining a rotor interior. The housing defining an inlet and an outlet extending into the rotor interior. The housing further defining a vane cavity between the inlet and the outlet. A vane movably mounted to the housing to move into and out of the vane cavity. A crankshaft extending through the rotor interior. A rotor radially fixed to the crankshaft in the rotor interior. The rotor defining a working chamber in the rotor interior between the rotor and the housing. The rotor includes at least one thruster extending from the rotor surface transverse to the crankshaft and dividing the working chamber. A compressor in fluid communication with the inlet for supplying compressed air to be mixed with the fuel. An ignition source mounted to the housing and having access to the working chamber for igniting the compressed air fuel charge. | 03-06-2014 |
Mark Furnari, Indian Harbor Beach, FL US
Patent application number | Description | Published |
---|---|---|
20110294476 | EXTENDABLE VOICE COMMANDS - A mobile device, such as a cellular telephone includes a voice interface that includes one part that may not be specific to a particular carrier, and a second part that provides an interface to services that are specific to a carrier or to service or information providers that are not necessarily available with all carriers. A voice command interface provides easy access to the carrier services. The set of carrier services is optionally extendible by the carrier. | 12-01-2011 |