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Fryer, US
Andrew M. Fryer, Erie, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20080242656 | N-Substituted-N-Sulfonylaminocyclopropane Compounds and Pharmaceutical Use Thereof - The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1) | 10-02-2008 |
| 20080261994 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF - The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 10-23-2008 |
| 20080306258 | Cyclopropane compounds and pharmaceutical use thereof - The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 12-11-2008 |
| 20090047246 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 02-19-2009 |
| 20100105894 | Cyclopropane compounds and pharmaceutical use thereof - The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 04-29-2010 |
Andrew M. Fryer, Austin, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20100234378 | ALKYLSULFONAMIDE-SUBSTITUTED TRIAZOLES AS MATRIX METALLOPROTEASE INHIBITORS - Provided are MMP-2, MMP-3, MMP-9, MMP-12 and/or MMP-13 inhibitors having the Formula (I): wherein R | 09-16-2010 |
Benjamin Fryer, Skillman, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20090215177 | METHODS, SURFACE MODIFIED PLATES AND COMPOSITIONS FOR CELL ATTACHMENT, CULTIVATION AND DETACHMENT - The present invention relates to the field of mammalian cell culture, and provides methods and compositions for cell attachment to, cultivation on and detachment from a solid substrate surface containing from at least about 0.5% N, a sum of O and N of greater than or equal to 17.2% and a contact angle of at least about 13.9 degrees, lacking a feeder cell layer and lacking an adlayer. In one embodiment of the present invention, the cells are treated with a compound capable of inhibiting Rho kinase activity. In another embodiment, the cells are treated with a compound capable of inhibiting Rho activity. | 08-27-2009 |
| 20100087002 | Methods, Surface Modified Plates and Compositions for Cell Attachment, Cultivation and Detachment - The present invention relates to the field of mammalian cell culture, and provides methods and compositions for cell attachment to, cultivation on and detachment from a solid substrate surface containing from at least about 0.5% N, a sum of O and N of greater than or equal to 17.2% and a contact angle of at least about 13.9 degrees, lacking a feeder cell layer and lacking an adlayer. In one embodiment of the present invention, the cells are treated with a compound capable of inhibiting Rho kinase activity. In another embodiment, the cells are treated with a compound capable of inhibiting Rho activity. | 04-08-2010 |
| 20100112693 | Differentiation of Human Embryonic Stem Cells - The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependant kinase inhibitor to cause an increase in expression of MAFA. | 05-06-2010 |
| 20100124783 | Methods and Compositions for Cell Attachment and Cultivation on Planar Substrates - The present invention is directed to methods for the growth, expansion and differentiation of pluripotent stem cells on planar substrates lacking an adlayer and a feeder cell layer. | 05-20-2010 |
| 20110104805 | Pluripotent Stem Cells - The present invention provides methods to produce pluripotent stem cells from adult cells. In particular, the present invention provides methods to produce pluripotent stem cells from somatic cells without the use of a feeder-cell layer or an agent that increases efficiency of retroviral transfection. | 05-05-2011 |
Colleen Fryer, Towson, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100234841 | System and Method for Magnetic Tissue Ablation - Herein it is described a magnetic medical device, and a system and method in which the magnetic medical device is implemented, that enables bipolar, minimally invasive, tissue ablation. The magnetic medical device may include magnetic means for magnetically coupling the medical device to a second medical device, wherein the magnetic medical devices may be separated by the tissue to be ablated. The magnetic medical device may also include electrical means for transferring electrical energy between the magnetic medical device and the second medical device. The magnetic medical device may further include control means whereby the physical location of the magnetic medical device may be controlled and thereby, as a result of the magnetic coupling, the physical location of the second magnetic medical device may also be controlled. | 09-16-2010 |
David Fryer, Hillsboro, OR US
| Patent application number | Description | Published |
|---|---|---|
| 20090002706 | Wafer level alignment structures using subwavelength grating polarizers - In one embodiment, a wafer alignment system, comprises a radiation source to generate radiation, a radiation directing assembly to direct at least a portion of the radiation onto a surface of a wafer, the radiation having a polarization state, an optical analyzer to collect at least a portion of the radiation reflected from the wafer, the wafer including at least a first region having a first grating pattern oriented in a first direction and at least a second region having a second grating pattern oriented in a second direction, different from the first direction. | 01-01-2009 |
David Thomas Fryer, Fleetwood, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080271324 | Spring biased nipper with replaceable blades - A nipper is disclosed having light-weight alloy handles which are ergonomically shaped narrowly to accommodate smaller hands or one-handed use, and biased outwardly by a torsion type spring which additionally limit the open handle width. The nipper utilizes carbide tool steel blades affixed with fasteners for easy replacement. The nipper has a friction reducing bushing at the pivot for ease of movement. | 11-06-2008 |
Don T. Fryer, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090140505 | Shopping Cart Security Device - A device and method for temporarily maintaining and securing valuables in a shopping cart is disclosed. The device is manufactured to fit in the upper basket area of standard shopping carts. The device can be modified to fit in alternative shopping cart designs and sizes. The device is generally manufactured from a flat panel which forms a lid enclosure over the small basket of a shopping cart. The device is secured to the back side of a shopping cart basket and can flip up so that valuables may be stored inside the small basket. The device is then flipped down and is secured in the front of the small basket of the cart nearest to the shopper. | 06-04-2009 |
Jack M. Fryer, Huntington Beach, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110100603 | MICROCHANNEL COOLING DEVICE FOR SMALL HEAT SOURCES - According to the invention, an apparatus for transferring heat with a target is disclosed. The apparatus may include a body which defines a surface, inlet and outlet ports, inlet and outlet manifold passages, and heat transfer passages. The surface may couple the target with the body. The inlet port may be configured to receive and direct a fluid into inlet manifold passages. The outlet port may be configured to receive and output the fluid. The inlet and outlet manifold passages may be configured to receive and direct the fluid to and from the heat transfer passages. The heat transfer passages may be configured to receive and direct all of the fluid from the inlet manifold passages in one or more directions substantially parallel to the surface and substantially perpendicular the input manifold passages. At least one heat transfer passages may have a plurality of fins on at least one surface. | 05-05-2011 |
Jack Merrill Fryer, Huntington Beach, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100205933 | Regeneratively cooled porous media jacket - The fluid and heat transfer theory for regenerative cooling of a rocket combustion chamber with a porous media coolant jacket is presented. This model is used to design a regeneratively cooled rocket or other high temperature engine cooling jacket. Cooling jackets comprising impermeable inner and outer walls, and porous media channels are disclosed. Also disclosed are porous media coolant jackets with additional structures designed to transfer heat directly from the inner wall to the outer wall, and structures designed to direct movement of the coolant fluid from the inner wall to the outer wall. Methods of making such jackets are also disclosed. | 08-19-2010 |
Luke Fryer, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110251489 | ULTRASOUND MONITORING SYSTEMS, METHODS AND COMPONENTS - Ultrasound monitoring systems and components used in ultrasound monitoring systems, such as Transcranial Dopper (TCD) systems, are disclosed. Components include framework systems for mounting, locating and maintaining one or more ultrasound probes in contact with an anatomical surface, adjustable probe mounting systems, and probe interface components providing an acoustically transmissive interface between a probe mounting system and the emissive face of the ultrasound probe. | 10-13-2011 |
Nate Fryer, Broomfield, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20100009818 | Multi Axes Exercise Apparatus - An apparatus and method for an exercise apparatus is disclosed that includes a base structure, a multiple axes pivotal mechanism disposed adjacent to the base structure, and an arm. The arm further includes a distal end portion and a proximal end portion with a longitudinal axis spanning therebetween. The distal and proximal end portions are each adapted to provide independent resistive force to muscle exertion, with the proximal end portion being adjacent to the mechanism such that operationally at least two independent axes of movement occur in the arm relative to the structure. Also included in the exercise apparatus is an assemblage for creating selectable variable resistance forces to the movement of the arm relative to the structure, such that each axis of movement has an independent selectable variable resistance force to the arm movement. | 01-14-2010 |
Samuel M. Fryer, Fairport, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090030952 | GLOBAL ASSET MANAGEMENT - A system and a method for managing data among devices, servers and systems by providing a logically unified and aggregated view of a user's digital assets including metadata from any system node or device. This invention describes a method supporting the aggregated view by using manifests. A manifest is a file/database that includes data about all media assets within a user's virtual collection. | 01-29-2009 |
| 20090094518 | METHOD FOR IMAGE ANIMATION USING IMAGE VALUE RULES - A method for image presentation are provided, in which at least one theme for image presentation is obtained; at least one set of images is acquired for presentation in association with each theme; and a presentation area image is generated for presentation on a display with a plurality of separate presentation objects in the presentation area image; an image value for each of the acquired images is determined; an emphasis score is determined for each of the acquired images. The presentation area image is presented with one of the acquired images in each of the presentation objects; and the presentation objects are animated by moving the presentation objects relative to each other in a manner that attracts more attention to presentation objects that are used to present images having a higher emphasis score than presentation objects that are used to simultaneously present images having a lower emphasis score. | 04-09-2009 |
| 20100245625 | IDENTIFYING COLLECTION IMAGES WITH SPECIAL EVENTS - A method for associating event times or time periods with digital images in a collection for determining if a digital image is of interest, includes storing a collection of digital images each having an associated capture time; comparing the associated capture time in the collection with a special event time to determine if a digital image in the collection is of interest, wherein the comparing step includes calculation of a special event time associated with a special event based on the calendar time associated with the special event and using such information to perform the comparison step; and associating digital images of interest with the special event. | 09-30-2010 |
| 20110099478 | IDENTIFYING COLLECTION IMAGES WITH SPECIAL EVENTS - A method for associating event times or time periods with digital images in a collection for determining if a digital image is of interest, includes storing a collection of digital images each having an associated capture time; comparing the associated capture time in the collection with a special event time to determine if a digital image in the collection is of interest, wherein the comparing step includes calculation of a special event time associated with a special event based on the calendar time associated with the special event and using such information to perform the comparison step; and associating digital images of interest with the special event. | 04-28-2011 |
Thomas Michael Fryer, Lancaster, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080289045 | Method and device for encoding software to prevent reverse engineering, tampering or modifying software code, and masking the logical function of software execution - This invention prevents software from being reverse engineered. The random nature and multiple uses of atoms prevent the analysis of key processes within the software. If an attempt is made to try and duplicate or bypass the program and/or key processes, then this invention will cause the failure of the execution of the software code thereby preventing unauthorized release and/or execution of the code. | 11-20-2008 |
| 20080289046 | Method and device for the prevention of piracy, copying and unauthorized execution of computer-readable media - Piracy is a growing concern for digital content and intellectual property holders. Prior art technology and Digital Rights Management (DRM) have failed to provide content holders with an effective solution. Too often, DRM is compromised within days of release offering little or no protection to content owners. This invention offers a unique process and/or method for protecting computer-readable media that is fast, efficient, and economical to implement, and can be implemented with all types of content. This invention provides the means to prevent piracy, copying, and unauthorized use of content on all computer-readable media (physical or memory-based). | 11-20-2008 |
Todd Fryer, Liberty, MO US
| Patent application number | Description | Published |
|---|---|---|
| 20100023992 | Method and Apparatus for Managing Presentation of Media Content - A system that incorporates teachings of the present disclosure may include, for example, a set top box having a controller to monitor for a triggering event that is associated with viewing of media content, retrieve a screen saver from a remote server when the triggering event is detected, and apply the screen saver to a display device connected with the set top box. Other embodiments are disclosed. | 01-28-2010 |