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Fruehauf, US
Diane Fruehauf, Streetsboro, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20100032577 | RADIATION DETECTOR INCLUDING ELONGATED ELEMENTS - A detector includes a housing defining a cavity; a scintillator material disposed within the cavity and having a front face, a rear face, and a side face; a reflective material disposed between the housing and the side face of the scintillator material; and a tolerance ring disposed between the housing and the reflective material. | 02-11-2010 |
Diane L. Fruehauf, Streetsboro, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20090283688 | SCINTILLATOR DEVICE - A detector includes a scintillator crystal having a front face and a rear face, a backplate disposed proximal to the rear face of the scintillator crystal, and a biasing member disposed proximal to the backplate and applying a biasing force to the backplate. In turn, the backplate applies a biasing force to the scintillator crystal in a direction toward the front face. The biasing member comprises a single-turn, round-section wire wave spring. | 11-19-2009 |
| 20100072398 | METHOD OF FORMING A SCINTILLATOR DEVICE - A method of forming a scintillator device includes inserting a window into a lumen of a window support ring. The window support ring has an annular structure defining the lumen. The lumen extends between first and second ends of the window support ring. The method also includes inserting a scintillator material into a cavity of a housing defined by an annular sidewall of the housing. The housing has an anterior end and a posterior end. The sidewall defines an opening at the anterior end of the housing. The scintillator material is inserted into the cavity via the opening. The method further includes adhering the window to a front face of the scintillator material and coupling the first end of the window support ring to the annular sidewall of the housing at the anterior end to close the opening. | 03-25-2010 |
Johannes Fruehauf, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080311081 | Bacteria mediated gene silencing - Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium or BTP. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating viral diseases and disorders. The bacterium or BTP includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells. | 12-18-2008 |
| 20100092438 | Bacteria Mediated Gene Silencing - Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium or BTP. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating viral diseases and disorders. The bacterium or BTP includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells. | 04-15-2010 |
Johannes Fruehauf, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090123426 | Compositions for Bacterial Mediated Gene Silencing and Methods of Using the Same - Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating cancer off cell proliferative disorders. The bacterium includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells. | 05-14-2009 |
Johannes H. Fruehauf, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100189691 | E. Coli Mediated Gene Silencing of Beta-Catenin - Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium or BTP. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating viral diseases and disorders. The bacterium or BTP includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells. | 07-29-2010 |
Johannes Heinrich. Fruehauf, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100239546 | BACTERIAL MEDIATED TNF ALPHA GENE SILENCING - Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating an inflammatory disease or disorder. The bacterium includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells. | 09-23-2010 |
John Fruehauf, Tustin, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090280508 | Methods and Reagents for Preparing and Using Immunological Agents Specific for P-Glycoprotein - This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a component of clinically-important multidrug resistance in cancer patients undergoing chemotherapy. The invention provides methods for developing and using immunological reagents specific for certain mutant forms of Pgp and for wild-type Pgp in a conformation associated with substrate binding or in the presence of ATP depleting agents. The invention also provides improved methods for identifying and characterizing anticancer compounds. | 11-12-2009 |