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Frijlink
Henderik Willem Frijlink, Eelde NL
| Patent application number | Description | Published |
|---|---|---|
| 20090181089 | PH-Controlled Pulsatile Delivery System, Methods for Preparation and Use Thereof - The invention relates to delivery systems that allow for the pulsatile release of a substance, such as a drug, in response to a change in pH. More specifically, it relates to drug administration to the GI tract, in particular to site-specific intestinal drug delivery via the oral route. Provided is a pH-controlled pulsatile release system (PPRS) comprising a core surrounded by a coating layer, wherein said core comprises an active substance and wherein said coating layer comprises a pH-sensitive coating material wherein a swellable agent is embedded. Said swellable agent is capable of taking up at least 1.1 times, preferably at least 5 times, more preferably at least 10 times its weight in water. Also provided is a pharmaceutical composition comprising a PPRS, in particular a colon-specific PPRS. | 07-16-2009 |
| 20110237508 | Peptide Formulations and Uses Thereof - The present invention relates to the field of preventive and therapeutic medicine, in particular to peptide formulations. Provided is a pH-buffered aqueous formulation comprising oxytocin, vasopressin or an analogue thereof and at least one non-toxic source of divalent metal ions in a concentration of at least 2 mM, and the use of the formulation for the manufacture of a medicament for therapeutic and/or prophylactic treatments. Also provided is a method for treating or preventing haemorrhage in a subject in need thereof, comprising administering to said subject an effective dosage amount of an oxytocin formulation according to the invention. Further provided is a method for treating or preventing diabetes insipidus or vasodilatory shock in a subject in need thereof, comprising administering to said subject an effective dosage amount of a vasopressin formulation according to the invention. | 09-29-2011 |
Martin Egbert Frijlink, Rotterdam NL
| Patent application number | Description | Published |
|---|---|---|
| 20080200815 | Intravascular Ultrasound Techniques - Intravascular ultrasound techniques provide for intravascular imaging using contrast agents and nonlinear techniques. An ultrasound imaging device for detecting internal properties of a target body comprises an ultrasound transducer positioned at a distal end portion of a catheter, for transmitting excitation pulses and for receiving echo signals. A signal processor analyses echo signals at harmonics and/or subharmonics of the transmit frequency. The catheter may include a contrast agent delivery conduit extending along the catheter, the delivery conduit having an exit orifice proximal to the ultrasound transducer. The device may discriminate between echo signals respectively arising from interaction with tissue and from the interaction with contrast agent. The device may generate an image of the site of interest using non-linear components of the received ultrasound echo signals. | 08-21-2008 |
Naud Frijlink, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20120089644 | AUTOMATIC CONTACT LINKING FROM MULTIPLE SOURCES - Linking data items describing a person into a single, unified contact entry without merging the data items. The data items include, for example, contact data, social network data, and other data describing the person. The contact entry is a single representation of the person that, in some embodiments, combines a plurality of personas of the person without merging the underlying data items. Metadata representing one or more contact entries is capable of being shared across a plurality of devices and applications such that a user is presented with a consistent contact list on different devices and from within different applications. In some embodiments, the user annotates one or more of the contact entries with notes or other data that is stored with the metadata. | 04-12-2012 |
Wilhelm Klaas Frijlink, Zwolle NL
| Patent application number | Description | Published |
|---|---|---|
| 20090124723 | PROCESS FOR THE MODIFICATION OF BIODEGRADABLE POLYMERS - Process for the modification of a polymer or copolymer having the following general structure for one or more of the repeating units: (1) wherein n is an integer, m is an integer in the range 0 to 6, and R is selected from hydrogen, substituted or unsubstituted C | 05-14-2009 |
| 20110104812 | PROCESS FOR TREATING POLYMERS CONTAINING RESIDUAL CATALYST - Process for thermally stabilizing a polymer containing residues of a Sn(II), Sb(III), Pb(II), Bi(III), Fe(II), Ti(II), Ti(III), Mn(II), Mn(III), or Ge(II)-containing catalyst by treating the polymer at a temperature above its melting temperature with a peroxide selected from the group consisting of ketone peroxides, hydroperoxides, peracids, hydrogen peroxide, and mixtures thereof, wherein said peroxide is used in an amount less than 0.2 wt % based on the weight of the polymer and wherein the molar ratio of peroxy functionalities from said peroxide (p) to metal (M) ranges from 1 to 100; said metal (M) being selected from the group consisting of Sn(II), Sb(III), Pb(II), Bi(III), Fe(II), Ti(II), Ti(III), Mn(II), Mn(III), and Ge(II). The invention further relates to a method for determining the metal residue content of a polymer. | 05-05-2011 |