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Fraser
Graeme Fraser, Rixensart BE
| Patent application number | Description | Published |
|---|---|---|
| 20110105389 | Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same - The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (GRLN, growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and/or variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as antagonists or inverse agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, obesity and obesity-associated disorders, appetite or eating disorders, addictive disorders, cardiovascular disorders, gastrointestinal disorders, genetic disorders, hyperproliferative disorders, central nervous system disorders and inflammatory disorders. | 05-05-2011 |
Graeme L. Fraser, Rixensart BE
| Patent application number | Description | Published |
|---|---|---|
| 20080287371 | MACROCYCLIC ANTAGONISTS OF THE MOTILIN RECEPTOR FOR MODULATION OF THE MIGRATING MOTOR COMPLEX - The present invention relates to novel conformationally-defined macrocyclic compounds that bind to and/or are functional modulators of the motilin receptor including subtypes, isoforms and/or variants thereof. These macrocyclic compounds are useful as therapeutics for a range of gastrointestinal disorders, in particular those in which suppression or inhibition of the migrating motor complex (MMC) is effective or malfunction of gastric motility or increased motilin secretion is observed, such as hypermotilinemia, imitable bowel syndrome, dyspepsia, including gallbladder dyspepsia, diarrhea, cancer treatment-related diarrhea, cancer-induced diarrhea, chemotherapy-induced diarrhea, radiation enteritis, radiation-induced diarrhea, stress-induced diarrhea, chronic diarrhea, AIDS-related diarrhea, | 11-20-2008 |
| 20090275648 | MACROCYCLIC GHRELIN RECEPTOR ANTAGONISTS AND INVERSE AGONISTS AND METHODS OF USING THE SAME - The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and/or variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as antagonists or inverse agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, cardiovascular disorders, obesity and obesity-associated disorders, gastrointestinal disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders. | 11-05-2009 |
| 20090312540 | SPATIALLY-DEFINED MACROCYCLES INCORPORATING PEPTIDE BOND SURROGATES - Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target, in particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor. | 12-17-2009 |
| 20100093720 | MACROCYCLIC ANTAGONISTS OF THE MOTILIN RECEPTOR FOR TREATMENT OF GASTROINTESTINAL DYSMOTILITY DISORDERS - The present invention provides conformationally-defined macrocyclic compounds that bind to and/or are functional modulators of the motilin receptor including subtypes, isoforms and/or variants thereof. These macrocyclic compounds, at a minimum, possess adequate pharmacological properties to be useful as therapeutics for a range of disease indications. In particular, these compounds are useful for treatment and prevention of disorders characterized by hypermotilinemia and/or gastrointestinal hypermotility, including, but not limited to, diarrhea, cancer treatment-related diarrhea, cancer-induced diarrhea, chemotherapy-induced diarrhea, radiation enteritis, radiation-induced diarrhea, stress-induced diarrhea, chronic diarrhea, AIDS-related diarrhea, | 04-15-2010 |
John Fraser, Queensland AU
| Patent application number | Description | Published |
|---|---|---|
| 20090130070 | METHOD OF TREATMENT - The present invention discloses the use of fetuin and fetuin producing agents in methods and compositions for treating burn injuries in animals. | 05-21-2009 |
John David Fraser, Auckland NZ
| Patent application number | Description | Published |
|---|---|---|
| 20090215195 | Set1 proteins and uses thereof - The invention relates to methods of use of SET1 proteins or functional equivalents thereof. More particularly the invention relates to the use of SET1 proteins or functional equivalents thereof in procedure, for identification and/or isolation of IgA and the scrum complement factor C5. | 08-27-2009 |
| 20110027907 | SSL7 MUTANTS AND USES THEREFOR - The invention relates to SSL7 mutants which have no, or at least reduced, ability to bind to IgA. The mutants have significant application in the purification or isolation of C5 from samples and in the identification or detection, including quantitation, of C5 in samples. Use of the mutants has the benefit of minimising or preventing simultaneous isolation and/or detection of IgA in a sample, simplifying and improving methods relying on wild type SSL7. | 02-03-2011 |
Michael Grant Fraser, New South Wales AU
| Patent application number | Description | Published |
|---|---|---|
| 20100056237 | Betting System and Method | 03-04-2010 |
Michael James Fraser, Bruxelles BE
| Patent application number | Description | Published |
|---|---|---|
| 20090122832 | MEASUREMENT, COATING AND MONITORING SYSTEM AND METHOD - A measurement system for and method of measuring thicknesses of coatings as applied to objects and a coating system and method for coating objects, in particular three-dimensional objects, with coatings, in particular thermal barrier coatings (TBCs), and a monitoring system for and method of monitoring a state of a thermal barrier coating (TBC) as applied to an object which is exposed to a high-temperature environment, and a TBC for use with the same. | 05-14-2009 |
| 20090202864 | LUMINESCENT MATERIAL COMPOSITIONS AND STRUCTURES INCORPORATING THE SAME - Luminescent material compositions, in particular for use in high-temperature environments, and structures, such as thermal barrier coatings (TBCs), which incorporate the same. | 08-13-2009 |
Paul Fraser, Estepona Malaga ES
| Patent application number | Description | Published |
|---|---|---|
| 20110105224 | System And Process For Stacking Electronic Game Tables - A system and process for aggregating and displaying information about a plurality of gaming tables to a user comprising a stacking component and a console area. The console area displays one or more active tables, while the stacking component displays changing information about each table the user has open. The stacking component may include one or more sub-components or dialogs, including a table list dialog, a player information dialog, a hand information dialog and/or an action area dialog. | 05-05-2011 |
Robert Fraser, Myrtle Bank AU
| Patent application number | Description | Published |
|---|---|---|
| 20110004253 | SPINAL FIXATION PLATE - Spinal fixation plates for maintaining adjacent vertebrae in and fixed position are provided. In an exemplary embodiment, the plate includes opposed superior and inferior portions that are angled in a direction anterior to an anterior face of a mid-portion of the plate. The plate also includes a curvature formed therein about a longitudinal axis in a sagittal plane thereof. In use, when the plate is attached to adjacent vertebrae, the angle of the superior and inferior portions and the curvature in the plate are effective to position one or more thru-bores formed in the superior and inferior portions at the anterior rims of the adjacent vertebrae. In another embodiment, a spinal fixation plate is provided that is adapted to engage and mate to a fusion cage or other vertebral implant disposed between adjacent vertebra. The present invention also provides spinal fixation kits or assemblies, and methods for implanting the same. | 01-06-2011 |
Robert Coulter Fraser, Melbourne AU
| Patent application number | Description | Published |
|---|---|---|
| 20100161100 | COMPONENT REPAIR USING REVERSE ENGINEERING - A method for modifying a component may comprise measuring the component using a modifying tool, and recording position data for the component based on the measuring. A path for the modifying tool may be provided using the position data, and the component may be modified by moving the same modifying tool based on the provided path. | 06-24-2010 |
Sheena Janet Fraser, Sea Point ZA
| Patent application number | Description | Published |
|---|---|---|
| 20100015660 | Production of Recombiant Products Using Capillary Membranes - The invention provides for a method of producing at least one recombinant product under aerated conditions. The method includes providing a porous substrate having a first side and a second side and which has a biofilm of microorganisms attached to the first side thereof, the substrate being configured to allow passage of a nutrient solution therethrough and to prevent the passage of microorganism cells therethrough. The method further includes causing a nutrient solution to flow through the substrate and the biofilm in a direction from the second side thereof to the first side thereof under aerated conditions, at a rate which is sufficiently low for a nutrient gradient having a concentration differential to be established across the biofilm, and the microorganisms being induced to produce recombinant product. | 01-21-2010 |
| 20100021990 | HIGH THROUGHPUT BIOPROCESS APPARATUS - The invention relates to a multiple bioreactor system comprising a plurality of bioreactors, a source of pressurised fluid, and distribution means for distributing the fluid to the bioreactors, wherein the bioreactor system includes backpressure creating means presented by, before or after each bioreactor and the source of pressurised fluid such that each backpressure creating means provides a resistance to the flow of the pressurised fluid which is greater than the resistance to flow between each backpressure creating means. The invention further relates to A method of operating a multiple bioreactor system comprising providing a plurality of bioreactors, a source of pressurised fluid, and distribution means for distributing the fluid to the bioreactors, wherein the bioreactor system includes backpressure creating means presented by each bioreactor or located between each bioreactor and the source of pressurised fluid such that each backpressure creating means provides a resistance to the flow of the pressurised fluid which is greater than the resistance to flow between each backpressure creating means and operating the system. | 01-28-2010 |
| 20100159555 | PRODUCTION OF SECONDARY METABOLITES USING CAPILLARY MEMBRANES - The invention provides methods of producing secondary metabolites and under recombinant products oxygen-limited or anaerobic culture conditions. The methods include providing a porous substrate having a first side and a second side and which has a biofilm of microorganisms attached to the first side thereof, and causing a nutrient solution to flow through the biofilm and the substrate in a direction from the first side thereof to the second side thereof under oxygen-limited or anaerobic culture conditions. The microorganisms include | 06-24-2010 |
Sheena Janet Fraser, Cape Town ZA
| Patent application number | Description | Published |
|---|---|---|
| 20110124078 | SCALABLE CELL CULTURE BIOREACTOR AND CELL CULTURE PROCESS - The present invention relates to a scaleable bioreactor comprising at least one cassette comprising a manifold and an arrangement of hollow fibre membranes; an upper headplate; and a lower headplate, wherein the cassette(s) are modular components adapted to co-operate with each other and the headplates to define an internal extracapillary culture space (ECS) and wherein the arrangement of hollow fibre membranes includes a discrete inlet and outlet. The invention further relates to a kit for such a bioreactor, a cassette for use in such a bioreactor and a process for exploiting the metabolism of cells and/or microorganisms, the process including the step of utilising a bioreactor according to the invention. | 05-26-2011 |
Todd Fraser, Kensington AU
| Patent application number | Description | Published |
|---|---|---|
| 20090274800 | PET FOOD PRODUCT WITH FLAVORING - A commercial packeted pet food product, having: an edible substrate, said substrate including at least one surface adapted to receive a suspension of flavorsome materials in a paste, gum or gel; and flavorsome materials, adhering to said surface, which substantially contribute to producing the flavor profile of said pet food product when consumed. | 11-05-2009 |