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Frasch, US
Carl E. Frasch, Martinsburg, WV US
| Patent application number | Description | Published |
|---|---|---|
| 20120076817 | POLYSACCHARIDE-PROTEIN CONJUGATE VACCINES - Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products. | 03-29-2012 |
E. Walter Frasch, Perkasie, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080197171 | BOND HEAD LINK ASSEMBLY FOR A WIRE BONDING MACHINE - A bond head assembly for use with a bonding machine includes a wire bonding tool and a link mechanism coupled between the wire bonding tool and the wire bonding machine. The link mechanism includes a frame, a plurality of arm links pivotably connected to the frame, and a tool support member supporting the wire bonding tool and pivotably connected to each of the arm links. | 08-21-2008 |
| 20100108744 | CLOSED LOOP WIRE BONDING METHODS AND BONDING FORCE CALIBRATION - A method of applying bonding energy to form a bond between a portion of a wire and a contact of a bonding location using a wire bonding machine is provided. The method includes: (1) moving a bonding tool towards the contact; (2) detecting when a portion of the contact ( | 05-06-2010 |
| 20100230476 | REDUCED OXIDATION SYSTEM FOR WIRE BONDING - A wire bonding machine is provided. The wire bonding machine includes (1) a bond site area for holding a semiconductor device during a wire bonding operation, and (2) a gas supply line configured to provide a gas at the bond site area from above the bond site area. | 09-16-2010 |
James Frasch, Hollis, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20080313873 | Highloft needlepunched nonwovens - The present disclosure relates to a highloft needlepunched fabric wherein said fabric may be formed by needlepunching a web at a penetration density of less than or equal to about 150 penetrations per square centimeter and a penetration depth of about 5-20 mm, wherein the needles are spaced apart 5 mm or greater. | 12-25-2008 |
| 20090233075 | Flame Blocking Liner Materials - A fire blocking non-woven textile containing a first carded web of char-forming fibers containing aramid or melamine/formaldehyde fiber and a second carded web of oxygen-depleting fibers comprising a blend of polyacrylonitrile copolymer with a halogen comonomer and a polyester polymer. The webs may be needled-punched or thermally bonded and remain as separate layers separating the action of the char forming and oxygen depleting layers to optimize char strength, provide a light weight product, which may satisfy 16 CFR 1633 at thicknesses of up to 3.0 mm. | 09-17-2009 |
Wayne Frasch, Phoenix, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20090035751 | Single Molecule Detection Using Molecular Motors - The present invention provides methods and compositions for highly sensitive nucleic acid detection, down to the single nucleic acid molecule level. In one aspect, the present invention provides methods for detecting a target nucleic acid comprising: (a) providing first and second target-specific nucleic acids, wherein the first and second target-specific nucleic acids each comprise sequences complementary to the target nucleic acid; wherein the first target specific nucleic acid is bound to a first affinity tag and the second target-specific nucleic acid is bound to a second affinity tag, wherein the first affinity tag is capable of binding to a molecular motor, and wherein the second affinity tag is capable of binding to a detection probe; (b) contacting the first and second target-specific nucleic acids to a sample under conditions whereby the first and second target-specific nucleic acids will hybridize to the target nucleic acid if the target nucleic acid is present in the sample, wherein upon hybridization to the target nucleic acid the first and second target-specific nucleic acids are directly adjacent to each other; (c) ligating the first and second target-specific nucleic acids together; (d) binding the molecular motor t˜ the first affinity tag and the detection probe to the second affinity tag; (e) inducing movement of the molecular motor; and (f) detecting movement of the molecular motor through the detection probe, wherein the movement of the molecular motor serves to detect the target nucleic acid in the sample. | 02-05-2009 |
| 20090047677 | METHODS FOR GENERATING A DISTRIBUTION OF OPTIMAL SOLUTIONS TO NONDETERMINISTIC POLYNOMIAL OPTIMIZATION PROBLEMS - The present invention overcomes problems in prior art DNA-based computing methods for solving non-deterministic polynomial optimization problems, by providing methods that derive the most probable answers in a statistically significant manner that makes the methods scalable with increases in the number of data inputs, and thus makes the methods practical. | 02-19-2009 |
| 20100015616 | High Speed, High Fidelity, High Sensitivity Nucleic Acid Detection - The present invention provides methods, compositions, and kits for nucleic acid detection. | 01-21-2010 |
Wayne D. Frasch, Phoenix, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20110212450 | Polarization-enhanced detector with gold nanorods for detecting nanoscale rotational motion and method therefor - A nanoscale motion detector attaches a gold nanorod ( | 09-01-2011 |
| 20110212510 | Polarization-enhanced detector with gold nanorods for detecting nanoscale rotational motion and method therefor - A nanoscale motion detector attaches a gold nanorod ( | 09-01-2011 |
Zoltan Frasch, Hooksett, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20100237944 | Amplifier System With Digital Adaptive Power Boost - An amplifier system with digital adaptive power boost includes a charge pump for providing a power supply to an amplifier. The charge pump may switch between a fixed input DC voltage and a boosted value for a certain period of time in response to an increase in an input signal to the amplifier. The charge pump may use a switching transistor which is switched on only when the input signal to the amplifier exceeds a threshold. The amplifier system may be used for envelope tracking, especially for envelope tracking of low duty cycle signals, e.g., xDSL or vDSL. | 09-23-2010 |