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Frankel, US

Arthur Frankel, Temple, TX US

Patent application numberDescriptionPublished
20110189209FOLD-BACK DIABODY DIPHTHERIA TOXIN IMMUNOTOXIN AND METHODS OF USE - Provided are methods and compositions related to diphtheria toxin diabody immunotoxins.08-04-2011

Arthur E. Frankel, Temple, TX US

Patent application numberDescriptionPublished
20090232767METHODS AND COMPOSITIONS BASED ON DIPHTHERIA TOXIN-INTERLEUKIN-3 CONJUGATES - The present invention provides methods for inhibiting interleukin-3 receptor-expressing cells, and, in particular, inhibiting the growth of such cells by using a diphtheria toxin-human interleukin-3 conjugate (DT-IL3) that is toxic to cells expressing the interleukin-3 receptor. In preferred embodiments, the DT-IL3 conjugate is a fusion protein comprising amino acids 1-388 of diphtheria toxin fused via a peptide linker to full-length, human interleukin-3. In certain embodiments, the methods of the present invention relate to the administration of a DT-IL3 conjugate to inhibit the growth of cancer cells and/or cancer stem cells in humans, which cells express one or more subunits of the interleukin-3 receptor. Exemplary cells include myeloid leukemia cancer stem cells. In other embodiments, the methods of the present invention relate to ex vivo purging of bone marrow or peripheral blood to remove cells that express one or more subunits of the interleukin-3 receptor such that the purged bone marrow or peripheral blood is suitable, e.g., for autologous stem cell transplantation to restore hematopoietic function.09-17-2009

Bruce Frankel, Marlton, NJ US

Patent application numberDescriptionPublished
20120030102FACILITATING A NETWORK COMMUNICATION SERVICE FOR A SUBSCRIBER LINKED TO A PLURALITY OF ACCOUNTS - There is provided a method that includes (a) receiving a notification of an event concerning a network communication service involving a subscriber, in which the subscriber is linked to a first account having first account terms, and a second account having second account terms, (b) making a decision of whether to handle the network communication service in accordance with the subscriber being linked to the first account or in accordance with the subscriber being linked to the second account, and (c) issuing a communication to a device to facilitate the network communication service, pursuant to the decision. There is also provided a system that performs the method, and a storage medium that contains instructions for controlling a processor to perform the method.02-02-2012
20120041853FACILITATION OF A NETWORK COMMUNICATION SERVICE FOR WHICH PAYMENT MAY BE MADE BY ANY OF A PLURALITY OF PAYMENT MODES - There is provided a method that includes (i) receiving a notification of an event concerning a network communication service, (ii) querying a database, in response to the notification, to obtain a payment mode for the service, in which the payment mode is selectable from a set that includes (a) pre-payment and (b) post-payment, (iii) determining, in accordance with the payment mode, whether a balance to fund the service satisfies a balance criterion, and (iv) issuing, in accordance with whether the balance to fund the service satisfies the balance criterion, a communication to a device to affect a provision of the service. There is also provided a system that employs the method, and a storage medium that contains instructions for controlling a processor to perform the method.02-16-2012
20120047057CONTROLLING A SHARED SERVICE - A method includes obtaining a liability limit indicative of an available funding, determining whether a first amount of liability contributed by a first subscriber during a provision of a service to the first subscriber exceeds a first balance indicative of a first portion of the available funding that may be consumed by the first subscriber, determining whether a second amount of liability contributed by a second subscriber during a provision of a service to the second subscriber exceeds a second balance indicative of a second portion of the available funding that may be consumed by the second subscriber, issuing a first communication to a device to affect the provision of a service to the first subscriber if the first amount of liability exceeds the first balance, and issuing a second communication to the device to affect the provision of a service to the second subscriber if the second amount of liability exceeds the second balance.02-23-2012

Bruce Frankel, Mount Pleasant, SC US

Patent application numberDescriptionPublished
20110202095ANTI-SPLAY APPARATUS - An anti-splay apparatus having a bridge and frangible connection points for use with mechanical fasteners having a shank portion and a receiving member with opposing arms is provided. The bridge may take a number of forms including a ring, a notched ring, a tube, or a notched tube and the connection points join the opposing arms of the receiving member with the bridge. Also provided is the anti-splay apparatus also having tabs connected between frangible connection points.08-18-2011

Bruce M. Frankel, Mount Pleasant, SC US

Patent application numberDescriptionPublished
20110077525Ultrasound Systems and Methods For Orthopedic Applications - Medical diagnostic instruments and systems are provided that include (i) a proximal handle configured and dimensioned to permit an operator to manually grasp the instrument; (ii) an ultrasound probe including a longitudinal shaft extending distally from the handle and terminating in a distal end, and an ultrasound transducer mounted with respect to the longitudinal shaft proximate the distal end thereof, the ultrasound transducer including an array of ultrasonic energy generation elements; and (iii) a tactile feeler probe mounted with respect to the ultrasound probe, the tactile feeler probe including a longitudinal shaft mounted with respect to the longitudinal shaft of the ultrasound probe and extending distally beyond the distal end thereof, and a feeler probe tip (e.g., a ball tip) defined at a distal end of the longitudinal shaft of the tactile feeler probe. Advantageous methods for use of the disclosed instruments and systems are also provided, e.g., for detecting breaches in cortical bones in connection with pedicle screw placement.03-31-2011
20110208062Ultrasound Systems and Methods For Orthopedic Applications - Medical diagnostic instruments/systems are provided that include (i) a proximal handle configured and dimensioned to permit an operator to manually grasp the instrument; (ii) an ultrasound probe including a longitudinal shaft extending distally from the handle and terminating in a distal end, and an ultrasound transducer mounted with respect to the longitudinal shaft, the ultrasound transducer including an array of ultrasonic energy generation elements (iii) a tactile feeler probe mounted with respect to the ultrasound probe; and (iv) at least one hollow receiver member mounted with respect to the longitudinal shaft of the ultrasound probe, the at least one hollow receiver member configured to receive a K-wire to permit the instrument to be slidably mounted thereto for purposes of guiding the ultrasound and tactile feeler probes axially relative to a desired anatomical location. Advantageous methods for use of the disclosed instruments/systems are also provided.08-25-2011
20110313282Ultrasound for Surgical Cranial Applications - The present disclosure relates generally to equipment and procedures in the field of surgery and/or diagnostics and, more particularly, to instruments, systems, and methods for undertaking surgical and/or diagnostic procedures that involve and/or are in proximity to the brain, e.g., cranial procedures and/or surgery. The disclosed devices generally include a handle member and an elongated probe that includes an ultrasound transducer. The devices may be used in conjunction with K-wires/guidewires, tubular members, e.g., EVD catheters and/or ventricular drains, endoscopes/cameras, and accessory items such as curettes, probes, knives, suction devices, scissors, cautery units, forceps, grasping devices and the like.12-22-2011

Bruce Michael Frankel, Mount Pleasant, SC US

Patent application numberDescriptionPublished
20100119592CYTARABINE FOR TREATMENT OF GLIOMA - Provided are methods and compositions for the treatment of a subject with glioma. An exemplary method can comprise administering cytarabine to the subject. For example, DepoCyt® can be administered to the subject. An exemplary composition can comprise cytarabine. For example the composition can comprise DepoCyt®.05-13-2010

Charles H. Frankel, Denver, CO US

Patent application numberDescriptionPublished
20090219245DIGITAL PICTURE FRAME - A method, apparatus and system for display of digital images that provides for duplicate file detection, dynamic simultaneous and sequential display of multiple images, user modifiable image display sequences, operating mode transition based upon motion sensing and automatic and selective transfer of images from external devices without requiring user or other human intervention.09-03-2009

David A. Frankel, Kirkwood, MO US

Patent application numberDescriptionPublished
20080296513Integrating ultraviolet exposure detection devices - Devices or formulations incorporating photochromic agents and methods of using them are provided. The compositions are useful in connection with personal care, light and/or ultraviolet radiation detection, imaging and printing applications.12-04-2008

Patent applications by David A. Frankel, Kirkwood, MO US

David Joseph Frankel, Orono, ME US

Patent application numberDescriptionPublished
20100181869Ultra-thin film electrodes and protective layer for high temperature device applications - An ultra-thin film electrode including at least one electrically conductive layer disposed upon an adhesive layer that is carried by a substrate.07-22-2010

David P. Frankel, Los Gatos, CA US

Patent application numberDescriptionPublished
20080259824IDENTITY-BASED CONFERENCING SYSTEMS AND METHODS - Described in this paper are systems and methods of providing conferencing services where a conference participant is identified by the conferencing system when calling into the system. The system and methods focus on individual users instead of groups of participants. Instead of using a conference identity as the driver, embodiments herein invoke a user identity, and services are personalized for each user. The user has far fewer codes to juggle and all participants enjoy a quicker, richer, and more secure experience.10-23-2008
20110112833REAL-TIME TRANSCRIPTION OF CONFERENCE CALLS - Described herein are embodiments of systems, methods and computer program products for real-time transcription of conference calls that employ voice activity detection, audio snippet capture, and multiple transcription instances to deliver practical real-time or near real-time conference call transcription.05-12-2011

Eric Frankel, Los Angeles, CA US

Patent application numberDescriptionPublished
20120130821POINT-OF-SALE PURCHASE PERSONALIZED MESSAGE - A method, apparatus, system, article of manufacture, and computer program product provide a personalized promotional message. A request is received for the message. The request includes a keyword that denotes personalized attributes and a token that denotes a name of a consumer and is a component position in a script product. Based on the request, media components are concatenated to produce the personalized promotional message that is transmitted and received by the consumer.05-24-2012

Fred R. Frankel, Philadelphia, PA US

Patent application numberDescriptionPublished
20100189739Immunogenic compositions comprising dal/dat double mutant, auxotrophic attenuated strains of Listeria and their methods of use - The invention includes auxotrophic attenuated mutants of 07-29-2010

Glenn Frankel, Redmond, WA US

Patent application numberDescriptionPublished
20110137992SHARING CALENDAR INFORMATION - Sharing calendar information may be provided. Calendar information may be shared with individuals that may or may not be associated with a local exchange server in order to coordinate schedules. A determination is conducted to decide whether a sender is authorized to send calendar information to another by examining registration rights. Next, if the registration rights are valid, input may be received from the sender associated with sending the calendar information to another using one or more entry points. Next, calendar information settings are received from the sender, which are used when sending the calendar information to another. Next, calendar information is published to the Internet based on the calendar information settings established by the sender, and provided to others for viewing.06-09-2011

Glenn Frankel, Seattle, WA US

Patent application numberDescriptionPublished
20100251093Automated Document Formatting Tool - A formatting tool enables “smart” copy and paste functions. The “smart” copy and paste functions can be invoked in a context-sensitive manner, depending on the conditions under which the copy and paste functions are implemented. The present invention will automatically include in a selection a paragraph marker at the end of a selected paragraph, if every other textual character in the paragraph has been selected. The present invention will discard a paragraph mark that is included in pasted text if the pasted text is pasted into the middle of another paragraph, indicating that the user prefers the formatting of the pasted-into paragraph. The present invention also reduces inconsistencies in formatting styles that may exist between source and target documents automatically redefining a style in the target document to conform to a corresponding style in the source document. The present invention also automatically adjusts paragraph spacing, in response to text being pasted into a target document. In response to various scenarios, the present invention will determine the most likely paragraph spacing intended by the user and will apply the most probable paragraph spacing to the pasted paragraph. The present invention also automatically adjusts list, table, and spreadsheet formatting, in response to such document elements being pasted into a differently-formatted target document. Finally, the present invention provides a convenient recovery dialog that may be invoked to alter any automatically-implemented formatting decisions.09-30-2010

Glenn L. Frankel, Seattle, WA US

Patent application numberDescriptionPublished
20100223575User Interface for Providing Task Management and Calendar Information - An electronic “To-Do” bar is provided in which displayed upcoming tasks, meetings, appointments and the like. The electronic To-Do bar is displayed in a lightweight menu of tasks, meetings and appointments and is displayed persistently in addition to other software functionality or user interfaces displayed on a user's computer display screen according to other software applications or other software functionality in use. A user is presented with an always-visible list of upcoming tasks, meetings and appointments without the need to launch a separate tasks application or calendar application to view upcoming tasks, meetings or appointments.09-02-2010

Glenn L. Frankel, Atlanta, GA US

Patent application numberDescriptionPublished
20100318924Method and System for Improved Electronic Task Flagging and Management - An improved method and system are provided for creating tasks and for inputting information associated with created tasks according to an electronic task management application or system. Electronic correspondence items may be flagged as tasks. Upon flagging an individual electronic correspondence item, a corresponding task is created for the flagged item, and the created task is then populated into and exposed by one or more applications used for displaying tasks such as a tasks application, calendar application, or electronic to-do list application. Properties such as task start dates and task categories may be applied to the created task, as desired.12-16-2010

Patent applications by Glenn L. Frankel, Atlanta, GA US

Jason L. Frankel, Hopewell Junction, NY US

Patent application numberDescriptionPublished
20120125677CROSSTALK REDUCTION BETWEEN SIGNAL LAYERS IN A MULTILAYERED PACKAGE BY VARIABLE-WIDTH MESH PLANE STRUCTURES - A first selection of mesh line segments of a mesh layer are of a first width and a second selection of mesh line segments of the mesh layer are of a second width, wherein the second width is greater than the first width. The second selection of mesh line segments of the second width are positioned in parallel to a selection of signal lines in a signal layer that are likely to introduce crosstalk, wherein the widening of the mesh line segments shadowing the selection of signal lines increases the likelihood that the return current associated with the signal will flow in the wider mesh line segment, thereby increasing the likelihood of containing the electromagnetic fields associated with the signal such that crosstalk to other signals is reduced or contained.05-24-2012

Jason L. Frankel, Wappingers Falls, NY US

Patent application numberDescriptionPublished
20090145973STRUCTURE FOR IMPLEMENTING SECURE MULTICHIP MODULES FOR ENCRYPTION APPLICATIONS - A tamper resistant, integrated circuit (IC) module includes a ceramic-based chip carrier; one or more integrated circuit chips attached to a top surface of the chip carrier; a ceramic-based cap structure attached to the top surface of the chip carrier, and covering the one or more integrated circuit chips; and a conductive grid structure embedded within the chip carrier and the cap structure, the conductive grid structure having a plurality of meandering lines disposed in an x-direction, a y-direction, and a z-direction; wherein the conductive grid structure is configured so as to detect an attempt to penetrate the IC module.06-11-2009

Patent applications by Jason L. Frankel, Wappingers Falls, NY US

Joan M. Frankel, Woodbury, MN US

Patent application numberDescriptionPublished
20090251776MULTILAYER POLARIZING FIBERS AND POLARIZERS USING SAME - A polarizing film is made of multilayer polarizing fibers embedded within a matrix. The fibers are formed with layers of at least a first and a second polymer material. Layers of the first polymer material are disposed between layers of the second polymer material. At least one of the first and second polymer materials is birefringent. In some embodiments the thickness of the layers of at least one of the materials varies across the fiber, and may include layers are selected as quarter-wavelength thickness for light having a wavelength of more than 700 nm.10-08-2009
20110096395COLOR SHIFTING MULTILAYER POLYMER FIBERS AND SECURITY ARTICLES CONTAINING COLOR SHIFTING MULTILAYER POLYMER FIBERS - Polymer fibers are formed with concentric alternating layers of different polymer materials. The layers pairs have cross-sectional thicknesses selected for reflecting light at a selected visible wavelength. A cross-sectional dimension of the core is at least ten times an average of the selected thicknesses of the alternating layers. Some articles formed by the fibers are formed by attaching one fiber to another: the color of the fibers at the point of attachment is different from the colors of the fibers elsewhere. The fibers may be deformed to change its color properties by elongating the cross-section of the polymer fiber along a first cross-sectional axis. In some embodiments, the fibers are polarization sensitive.04-28-2011

Patent applications by Joan M. Frankel, Woodbury, MN US

Jordan Frankel, Atlanta, GA US

Patent application numberDescriptionPublished
20110011137SECURITY DOOR BRACE SYSTEM AND METHOD OF USE THEREOF - A security door brace is provided for bearing against an inside surface of a barrier door in order to prevent non-permitted, inward opening of the door. The security door brace carries one or more elongated pin means for cooperative engagement with one or more slotted receiving means formed within a cooperating mounting plate that is firmly affixed, preferably via conventional screw fastener means, to a portion of the floor underlying the intended operable position of the security door brace.01-20-2011

Joseph G. Frankel, Beaverton, OR US

Patent application numberDescriptionPublished
20100164305MONOLITHIC STAGE POSITIONING SYSTEM AND METHOD - A magnetically levitated monolithic stage positioning system includes linear three phase motors and coil windings connected to the monolithic stage that interact with a ferromagnetic base. The linear three phase motors may be excited to provide motion in an X-axis direction, motion in a Y-axis direction, and rotation about a Z-axis. The monolithic stage is levitated on an air bearing. The plurality of coil windings connected to the monolithic stage may serve to magnetically preload the air bearing. The plurality of coil windings may be excited to provide motion in a Z-axis direction and rotation of the monolithic stage about the X-axis and about the Y-axis.07-01-2010

Mark E. Frankel, Lowergwynedd, PA US

Patent application numberDescriptionPublished
20110184765System and Method for a Healthcare Provider to Obtain, Distribute, and Track Pharmaceutical Samples - A system and method of supplying prepackaged pharmaceutical samples to healthcare providers in the employ of a healthcare organization. A vending machine is provided. The healthcare organization preauthorizes various types of pharmaceutical samples to be stocked within the vending machine. The vending machine is stocked only with the pharmaceutical samples that were preauthorized by the healthcare organization. Although the vending machine is accessible to healthcare providers in a particular office, not all of the prepackaged pharmaceutical samples can be vended by all of the healthcare providers. Rather, each healthcare provider has a sample dispensing authorization that depends upon the healthcare provider's knowledge of the pharmaceuticals. A trackable history is maintained about what pharmaceutical samples were vended, what healthcare provider took the pharmaceutical samples, and what patient was given the pharmaceutical samples.07-28-2011

Mark E. Frankel, Lower Gwynedd, PA US

Patent application numberDescriptionPublished
20090184510Method and System for Preparing a Set of Paired Identification Labels - A system and method for preparing a set of paired identification label based a plurality of characters that identify an inventory item. The method includes a step of assigning a predetermined numerical value to each of the plurality of characters. Mathematical operations are performed on the assigned numerical values to obtain a mapping of the plurality of characters to a corresponding non-textual visual indicator. A label is generated which label includes the plurality of characters and the visual indicator. The visual indicator may be a color or a graphic indicator such as an alignment designation bar or a combination and variation thereof.07-23-2009
20110226412Method and System for Preparing a Set of Paired Identification Labels - A system and method for preparing a set of paired identification label based a plurality of characters that identify an inventory item. The method includes a step of assigning a predetermined numerical value to each of the plurality of characters. Mathematical operations are performed on the assigned numerical values to obtain a mapping of the plurality of characters to a corresponding non-textual visual indicator. A label is generated which label includes the plurality of characters and the visual indicator. The visual indicator may be a color or a graphic indicator such as an alignment designation bar or a combination and variation thereof.09-22-2011

Patent applications by Mark E. Frankel, Lower Gwynedd, PA US

Meir Frankel, Woodmere, NY US

Patent application numberDescriptionPublished
20110084185Protective Device and Method of Manufacturing The Same - A protective device and its method of manufacture is disclosed where the device includes a spherical portion that has an incision in its upper surface and a sleeve portion that fits snugly over the spherical portion in such a manner so that the device can be placed on a furniture leg to protect the furniture and reduce noise associated therewith.04-14-2011

Michael Frankel, Linthicum, MD US

Patent application numberDescriptionPublished
20090103921OPTICAL RECEIVER SYSTEMS AND METHODS FOR POLARIZATION DEMULTIPLEXING, PMD COMPENSATION, AND DXPSK DEMODULATION - A simplified optical receiver architecture capable of tracking and demultiplexing polarization-multiplexed signals, dynamically compensating for PMD using a variety of polarization controller technologies, and reducing the number of delay line demodulators by two for both DPSK and DQPSK modulation is illustrated. Once polarization is stabilized at the first stage of the cascaded system of the present invention, subsequent stages can be simplified and cost reduced.04-23-2009
20110076021OPTICAL RECEIVER SYSTEMS AND METHODS FOR POLARIZATION DEMULTIPLEXING, PMD COMPENSATION, AND DXPSK DEMODULATION - A simplified optical receiver architecture capable of tracking and demultiplexing polarization-multiplexed signals, dynamically compensating for PMD using a variety of polarization controller technologies, and reducing the number of delay line demodulators by two for both DPSK and DQPSK modulation is illustrated. Once polarization is stabilized at the first stage of the cascaded system of the present invention, subsequent stages can be simplified and cost reduced.03-31-2011

Michael Y. Frankel, Linthicum, MD US

Patent application numberDescriptionPublished
20110268436SECURE FIBER OPTIC COMMUNICATION SYSTEMS AND METHODS - The present disclosure relates to fiber optic networks carrying sensitive information such as classified government communications, sensitive financial information, proprietary corporate information, and associated systems and methods for secure transmission where fiber tampering is easily detected. The present invention provides improved security systems and methods for fiber optic communication links. Specifically, a hollow-core photonic bandgap fiber is deployed as a transmission medium. A secure fiber optic communication link is established over the hollow-core photonic bandgap fiber with a monitoring mechanism. The monitoring mechanism is configured to detect large losses and large spectral variability each indicative of loss introduced by malicious intrusion attempts. Further, the monitoring mechanism allows easy differentiation of intrusion relative to normal system variations thereby reducing false positives and missed intrusions.11-03-2011

Michael Y. Frankel US

Patent application numberDescriptionPublished
20090169208SYSTEMS AND METHODS FOR THE POLARIZATION INSENSITIVE COHERENT DETECTION AND THE POLARIZATION DIVISION MULTIPLEXED TRANSMISSION OF OPTICAL COMMUNICATION SIGNALS - The present invention relates generally to the transport and processing of optical communication signals. More specifically, the present invention relates to systems and methods for the polarization insensitive coherent detection of optical communication signals with Brillouin amplification of the associated signal carrier and the polarization division multiplexed transmission of optical communication signals without polarization tracking at the associated receiver(s).07-02-2009

Oliver Frankel, New York, NY US

Patent application numberDescriptionPublished
20090043712DYNAMIC REALLOCATION HEDGE ACCOUNTING - A hedged exposure and an associated hedging instrument can be accounted for to reduce periodic earnings volatility associated with the hedged exposure. The accounting to reduce the earnings volatility includes designating a portion of the value of the financial exposure as being hedged by the hedging instrument. The designated portion is determined based on a price sensitivity of the hedging instrument with respect to changes in market value of an underlying instrument. In each of a number of sequential periods, the portion of the financial exposure is redesignated based on changed price sensitivity of the hedging instrument. Periodic earnings volatility associated with a hedged exposure also can be reduced by dividing (for accounting purposes) the hedging instrument into a first part (also referred to as a designated part) and a second part (also referred to as a residue part). This division is made in a way that ensures that changes in the value of the first part substantially offset changes in value of the financial exposure. The method also includes designating a portion of the first part as a hedge of the financial exposure such that the remainder of the first part offsets the delta of the second part. In each of a plurality of sequential periods, the portion of the first part is redesignated to maintain the relationship between the first part and the second part whereby the remainder of the first part offsets the delta of the second part.02-12-2009

Oliver L. Frankel, New York, NY US

Patent application numberDescriptionPublished
20110161224METHOD AND APPARATUS FOR LISTING AND TRADING A FUTURES CONTRACT THAT PHYSICALLY SETTLES INTO A SWAP - According to some embodiments, a futures contract is listed on a futures trading exchange. The futures contract physically settles upon expiration into a reference swap. The reference swap is cleared by a clearing house so that the physical settlement requires that the holder of a position in the futures contract upon expiration takes a specified side of the reference swap against the clearing house. The reference swap may for example be a credit default index swap, a single-name credit default swap, an interest rate swap or a yield curve swap.06-30-2011

Richard Frankel, San Francisco, CA US

Patent application numberDescriptionPublished
20120089455SYSTEM AND METHOD FOR REAL-TIME ADVERTISING CAMPAIGN ADAPTATION - A technique for adapting an advertising campaign based on real-time campaign metrics, such as a composition of the target audience among advertising recipients or an impact on brand metrics. As the advertising campaign runs, parameters of the campaign are updated to boost performance of a portion of the advertising campaign determined to be particularly effective by the campaign metrics. The campaign metrics utilize real-time, single-question surveys across segmented portions of the target audience, and then adapt the advertising campaign to target a particular segment based on desired brand and audience metrics.04-12-2012

Robert D. Frankel, Rochester, NY US

Patent application numberDescriptionPublished
20100238438Method and system for stimulated Raman microscopy beyond the diffraction limit - Systems and methods for probing a Raman signature of a sample with a resolution exceeding the diffraction limit are described. These systems, called GASSE (Gain Saturated Stimulated Emission) and iGASSE (interferometric GASSE), are detecting a Raman signal produced in a sample located at the focal spot of a Gaussian pump pulse. Two additional pulsed laser beams (Stokes beams), a central Stokes beam having a Gaussian beam profile and another Stokes beam having an annular beam profile, are also focused to the focal spot. The spatial and temporal phases of the laser pulses are adjusted to produce destructive interference over most of the temporal width of Stokes pulses, which causes emission from the central Stokes beam to narrow well below the diffraction limit. A two-dimensional image of the sample is produced by scanning the combined beams across the sample. The system may find applications in biomedical and semiconductor technology.09-23-2010
20120069332METHOD AND SYSTEM FOR RAMAN, FLUORESCENCE, LITHOGRAPHIC, STIMULATED EMISSION AND PHOTOCHEMICAL IMAGING BEYOND THE DIFFRACTION LIMIT - Systems and methods for hyper-resolution beyond the diffraction limit of optical microscopes for applications in spectroscopy, absorption and lithographic photochemical patterning are described. These systems are based on interference of a pump pulse and a Stokes laser pulse which interfere to localize the population of an excited vibrational state in an area that is smaller than the scanning resolution of the microscope. Another (interfering) Stokes pulse has an annular shape at focus and destructively interferes with the the Stokes laser pulse. This destructive interference causes narrowing of the population distribution of the vibrational excited state well below the diffraction limit, which in turn localizes the population of the central electronic excited state by a separate actinic laser pulse having a lower energy than the ground state excitation energy of the molecule.03-22-2012

Patent applications by Robert D. Frankel, Rochester, NY US

Scott Frankel, Gilbert, AZ US

Patent application numberDescriptionPublished
20090154906System and Method for Controlling Multiple DC Fans - A system and method for controlling multiple cooling fans is presented. The circuitry for directly driving each of the motors is removed from the motor casings, thus increasing air flow and reducing replacement costs should a motor fail. The system includes a common processor for centrally controlling the speeds of the motors and monitoring the performance of each of the multiple motors.06-18-2009
20090309435Integrated Air Mover and Angular Position Sensor on Electric Motor - Embodiments of the present invention provide an integrated air-mover and position sensor for an electric motor. One or more fins may be attached to a position sensor and adapted to generate a movement of air when the position sensor rotates with a rotor shaft. Such an arrangement not only allows the position sensor to sense positions of the electric motor, but also provides air-cooling functions for cooling the motor driver efficiently, thus improving product reliability. The position sensor may be an optical encoder or a capacitive sensor. Alternatively, one or more fins may be disposed within the electric motor and attached directly onto a rotor shaft of the electric motor to create a movement of air for cooling the motor driver directly and efficiently.12-17-2009
20100066279Method and Apparatus of Fan Motor Brake - An electronic system for controlling a fan motor includes a microcontroller and a drive circuit. The microcontroller draws power from a first voltage source and generates control signals for sending drive current to stator coils of a fan motor via the drive circuit. The electronic system further includes a second voltage source to provide the microcontroller with an amount of energy sufficient to operate for a short period of time when the voltage of the first voltage source drops below a predetermined level. The microcontroller is configured to detect when the voltage level of the first voltage source drops below a given level and generates control signals for the drive circuit to discharge energy in the stator coils of the fan motor to quickly stop operation of the fan motor within a short period of time.03-18-2010

Patent applications by Scott Frankel, Gilbert, AZ US

Scott Frankel, Los Angeles, CA US

Patent application numberDescriptionPublished
20110035275METHOD AND APPARATUS FOR EMBEDDED GRAPHICAL ADVERTISING - A method of electronic advertising includes determining a plurality of portions of an image that are to be designated as mouse-clickable portions. The mouse-clickable portions each correspond to a single item to be offered for sale. The method includes designating each of the plurality of portions as mouse-clickable portions and providing a hyper-link in conjunction with each of the mouse-clickable portions. When a given mouse-clickable portion is clicked on by a user, the hyper-link causes a web browser to display a site offering the item shown in the mouse-clickable portion for sale.02-10-2011

Seth Frankel, Los Angeles, CA US

Patent application numberDescriptionPublished
20080202976Adjustable Utensil Tray - An adjustable storage tray has a first tray part that defines at least one first compartment therein. A second tray part of the storage tray defines at least one second compartment therein. The second tray part is slidably connected to the first tray part such that a length of the adjustable storage tray can be adjusted. The storage tray has a ratcheting mechanism to retain a selected adjusted length and has a retention mechanism that can inhibit vertical separation of the first and second tray parts.08-28-2008

Stanley R. Frankel, Yardley, PA US

Patent application numberDescriptionPublished
20080221138Method of using SAHA and Erlotinib for treating cancer - The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor such as suberoylanilide hydroxamic acid (SAHA), or a pharmaceutically acceptable salt or hydrate thereof, and a second amount of one or more anti-cancer agents, including Erlotinib. The HDAC inhibitor and the anti-cancer agent may be administered to comprise therapeutically effective amounts. In various aspects, the effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.09-11-2008
20080269182Method of treating cancers with SAHA and Pemetrexed - The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof, and a second amount of an anti-cancer agent. The HDAC inhibitor and the anti-cancer agent may be administered to comprise therapeutically effective amounts. In various aspects, the effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.10-30-2008
20090105329Methods of Treating Cancers with SAHA, Carboplatin, and Paclitaxel and Other Combination Therapies - The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof an amount of a histone deacetylase (HDAC) inhibitor, e.g., suberoylanilide hydroxamic acid (SAHA), or a pharmaceutically acceptable salt or hydrate thereof, and an amount of one or more anticancer agents such as Carboplatin or Paclitaxel. The HDAC inhibitor and the anticancer agents may be administered to comprise therapeutically effective amounts.04-23-2009
20090247549Methods of using saha and bortezomib for treating cancer - The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor such as suberoylanilide hydroxamic acid (SAHA), or a pharmaceutically acceptable salt or hydrate thereof, and a second amount of one or more anti-cancer agents, including Bortezomib. The HDAC inhibitor and the anti-cancer agent may be administered to comprise therapeutically effective amounts. In various aspects, the effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.10-01-2009

Patent applications by Stanley R. Frankel, Yardley, PA US

Steven H. Frankel, Indianapolis, IN US

Patent application numberDescriptionPublished
20110257462ACTIVE OR PASSIVE ASSISTANCE IN THE CIRCULATORY SYSTEM - Apparatus and methods for assisting flow of a fluid in a conduit. In some embodiments, a viscous impeller rotating within a protective cage provides a boost and total pressure to blood within the circulatory system of an animal.10-20-2011

Thomas E. Frankel, Poughkeepsie, NY US

Patent application numberDescriptionPublished
20100032851Fluorinated elastomeric gas diffuser membrane - The present invention relates generally to a structure for a diffused aeration system. More particularly, the invention encompasses a diffuser membrane where at least a portion of the surface has been treated with at least one layer of fluorine, to form a fluorinated elastomeric gas diffuser membrane. The invention also includes the deposition of fluorine atoms on the surface of a non-fluorine containing membrane to create a permanent fluoro-elastomeric surface layer. Tubular and disc diffuser members are also disclosed that have at least a portion of them treated with at least one layer of fluorine. A process of making the inventive diffuser membrane is also disclosed.02-11-2010
20110132847METHODS AND APPARATUS FOR WASTEWATER TREATMENT - Wastewater is treated by providing a distribution conduit and providing a diffuser assembly. An aperture is created in the distribution conduit having an initial minimum diameter. The diffuser assembly, in turn, comprises a diffuser membrane in fluidic communication with a mating tube. The mating tube has an initial outside diameter at a location along its length greater than the initial minimum inside diameter of the aperture. The mating tube is inserted into the aperture until the location on the mating tube that, before insertion, had the initial outside diameter is encircled by the aperture where the aperture, before insertion, had the initial minimum inside diameter. This forms an airtight interference fit between the distribution conduit and diffuser assembly.06-09-2011
20110198763DIFFUSER MEMBRANES WITH MODIFIED ELECTRICAL PROPERTIES - A diffuser membrane for use in a wastewater treatment application comprises an additive or coating operative to substantially reduce the ability of at least a portion of the diffuser membrane to buildup static charge. Aeration efficiency and contamination resistance are thereby improved.08-18-2011

Patent applications by Thomas E. Frankel, Poughkeepsie, NY US

Timothy L. Frankel, New York, NY US

Patent application numberDescriptionPublished
20120015888T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE - The invention provides T cell receptors (TCRs) having antigenic specificity for a cancer antigen, e.g., tyrosinase. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.01-19-2012

Yair Frankel, Ridgewood, NJ US

Patent application numberDescriptionPublished
20080221914Computer-based method and system for aiding transactions - A method for providing a warranty relating to a transaction between two parties, each party having a data communications device, in a system which includes an infrastructure composed of a plurality of locations each associated with a respective institution which provides services to clients, each location having a computer system, a database coupled to the computer system and storing information about each client of the institution and a data communications device coupled to the computer system for communication with the data communications device of any one party, each party being a client of at least one of the institutions, the method containing the steps of:09-11-2008

Yair Frankel, New York, NY US

Patent application numberDescriptionPublished
20100011208CRYPTOGRAPHIC CONTROL AND MAINTENANCE OF ORGANIZATIONAL STRUCTURE AND FUNCTIONS - Methods, systems and devices for cryptographic control and maintenance of organizational structure and functions are provided. A method for control and maintenance of an operational organizational structure, the method includes associating entities with cryptographic capabilities; organizing entities within the organizational structure as roles; and maintaining roles within the organizational structure. The system may involve at least a Public Key Infrastructure operation. Elements in said organizational structure may be assigned to roles and/or groups within said organizational structure.01-14-2010