Patent application number | Description | Published |
20080200513 | Pyridine N-Oxides As Antiviral Agents - The present invention relates to pyridinone derivatives of formula (I): | 08-21-2008 |
20080214522 | Antiviral indoles - Compounds of the formula (I): | 09-04-2008 |
20080261944 | Indole Derivatives as Antiviral Agents - The present invention relates to indole compounds of the formula (I): wherein R | 10-23-2008 |
20100022468 | NUCLEOSIDE CYCLIC PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION - The present invention provides nucleoside cyclic phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as pre-cursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside cyclic phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside cyclic phosphoramidates of the present invention. | 01-28-2010 |
20100035835 | NUCLEOSIDE ARYL PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION - The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention. | 02-11-2010 |
20100076046 | Antiviral Indoles - Compounds of the formula (I) wherein A, B, D, M, Ar, W, X, Y, Z and R | 03-25-2010 |
20100234316 | Nucleoside Aryl Phosphoramidates for the Treatment of RNA-Dependent RNA Viral Infection - The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention. | 09-16-2010 |
Patent application number | Description | Published |
20090048239 | Therapeutic compounds - A class of macrocyclic compounds of formula (I), wherein R | 02-19-2009 |
20090149526 | Tetracyclic Indole Derivatives as Antiviral Agents - The present invention relates to tetracyclic indole derivatives of formula (I): wherein Ar, A, R | 06-11-2009 |
20100009959 | Pentacyclic Indole Derivatives as Antiviral Agents - The present invention relates to pentacyclic indole derivatives of formula (I): wherein A, Ar, R | 01-14-2010 |
20100120760 | BENZOFURAN-CARBOXAMIDE DERIVATIVES AS ANTIVIRAL AGENTS - A compound of the formula (I): as defined herein, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing a compound of the formula (I) for use in inhibiting hepatitis C virus polymerase and/or of treating or preventing an illness due to hepatitis C virus, | 05-13-2010 |
20100152128 | Antiviral Agents - A compound of formula (I) and pharmaceutically acceptable salts thereof; compositions containing it and its use in medicine, particularly for the treatment or inhibition of HCV infections, and processes for making it are disclosed. | 06-17-2010 |