Francisca
Francisca Alcayaga-Miranda, Las Condes CL
Francisca Bejarano Garcia, Madrid ES
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20150312387 | METHODS AND APPARATUS FOR RESOLVING DATA INCONSISTENCIES IN AN IMS NETWORK - A Serving Call Session Control Function, S-CSCF, within an IP Multimedia Subsystem, IMS, core network. Notifications are sent to a Home Subscriber Server, HSS, of the IMS core network, indicating IMS registration state changes of users. Delivery failure of a notification of an IMS registration state change sent to a HSS and relating to a given user is detected. An association between an identifier of the given user and an indication of said delivery failure is stored in order to indicate a loss of IMS registration state synchronization for the given user between the S-CSCF and the HSS. An event requiring an IMS registration state change for the user is detected. A determination is made that a delivery failure indication associated with the user's identifier is stored. The HSS is notified indicating the required IMS registration state change and of a previous loss of the IMS registration state synchronization. | 10-29-2015 |
Francisca Bronfman Caceres, Santiago De Chile CL
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20100240674 | USE OF COMPOUNDS DERIVED FROM BENZAMIDINE METHANESULPHONATE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, FOR EXAMPLE IMATINIB MESYLATE, FOR THE PREPARATION O F A DRUG FOR THE TREATMENT OF NEURODEGENERATIVE NIEMANN-PICK C DISEASE (NPC) - This invention relates to the use of imatinib mesylate for the treatment of metabolism disorders characterized by neurodegeneration, in particular a metabolism disorder characterized by an inability to metabolize lipids such as in persons with Niemann-Pick Type C disease. More specifically, this invention relates to a method of treating neurodegenerative disease, comprising administering a therapeutically effective amount of a compound derived from imatinib mesylate or a pharmaceutically acceptable salt thereof. | 09-23-2010 |
Francisca Coll Herrero, Getafe (madrid) ES
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20130334370 | SYSTEM AND METHOD FOR THE CALCULATION OF THE APPROACH SPEED DURING AIR TO AIR REFUELLING OPERATIONS - Systems and methods for the calculation of the approach speed during air to air refuelling manoeuvres. The systems comprise: a) capturing means of a sequence of digital photograms of the approach operation scenario calibrated in order to determine the real distance corresponding to a pixel of a photogram; b) computational means configured for obtaining the coordinates of the relative trajectory of the receiver aircraft with respect of the tanker aircraft, by means of a sequence of photograms of the approach operation obtained by said capturing means and calculating the speed difference between receiver aircraft and tanker aircraft based on the trajectory defined by the coordinates recorded in said process b1). The invention also refers to the methods for calculating the approach speed. | 12-19-2013 |
Francisca Delgado-Jiménez, Toledo ES
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20130102618 | 3-AMINO-5,6-DIHYDRO-1H-PYRAZIN-2-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER FORMS OF DEMENTIA - The present invention relates to novel 3-amino-5,6-dihydro-1H-pyrazin-2-one derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid. | 04-25-2013 |
20130190318 | 4,7-DIHYDRO-PYRAZOLO[1,5-a]PYRAZIN-6-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) - The present invention relates to novel 4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid. | 07-25-2013 |
20130274266 | 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) - The present invention relates to novel 5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, cerebrovascular amyloid angiopathy, multi-infarct dementia, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid. | 10-17-2013 |
Francisca Delgado-Jiménez, Madrid ES
Patent application number | Description | Published |
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20090281099 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE - The present invention concerns substituted pyrazinone derivatives according to the general Formula (I) | 11-12-2009 |
20100105694 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE - The present invention concerns substituted pyrazinone derivatives according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in claim | 04-29-2010 |
20100137368 | PYRIDINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to (1-benzyl-piperidin-4-yl)-(pyridin-2-yl)-amines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 06-03-2010 |
20110112107 | SUBSTITUTED 6-(1-PIPERAZINYL)-PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS - The present invention is concerned with novel substituted 6-(1-piperazinyl)-pyridazines of Formula (I) | 05-12-2011 |
Francisca Delgado-Jiménez, Madrid ES
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20090111801 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE - The present invention concerns substituted pyrazinone derivatives according to the general Formula (I), a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim | 04-30-2009 |
20090281099 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE - The present invention concerns substituted pyrazinone derivatives according to the general Formula (I) | 11-12-2009 |
20100105694 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE - The present invention concerns substituted pyrazinone derivatives according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in claim | 04-29-2010 |
20100137368 | PYRIDINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to (1-benzyl-piperidin-4-yl)-(pyridin-2-yl)-amines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 06-03-2010 |
20110112107 | SUBSTITUTED 6-(1-PIPERAZINYL)-PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS - The present invention is concerned with novel substituted 6-(1-piperazinyl)-pyridazines of Formula (I) | 05-12-2011 |
Francisca Delgado-Jiménez, Toledo ES
Patent application number | Description | Published |
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20130102618 | 3-AMINO-5,6-DIHYDRO-1H-PYRAZIN-2-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER FORMS OF DEMENTIA - The present invention relates to novel 3-amino-5,6-dihydro-1H-pyrazin-2-one derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid. | 04-25-2013 |
20130190318 | 4,7-DIHYDRO-PYRAZOLO[1,5-a]PYRAZIN-6-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) - The present invention relates to novel 4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid. | 07-25-2013 |
20130274266 | 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) - The present invention relates to novel 5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, cerebrovascular amyloid angiopathy, multi-infarct dementia, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid. | 10-17-2013 |
20130345228 | 3,4-DIHYDRO-PYRROLO[1,2-a]PYRAZIN-1-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) - The present invention relates to novel 3,4-dihydro-pyrrolo[1,2-a]pyrazin- | 12-26-2013 |
20140005200 | 6,7-DIHYDRO-PYRAZOLO[1,5-a]PYRAZIN-4-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | 01-02-2014 |
Francisca Fuster Ramon, Betera ES
Patent application number | Description | Published |
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20120329988 | METHOD FOR THE EXTRACTION AND HYDROLYSIS OF ANY PROTEIN SUBSTANCE, NATURAL AUXINS AND POLYPHENOLS FROM SOURCES OF PLANT ORIGIN AND THEIR DERIVATIVES - Method for the extraction and hydrolysis of any protein substance, natural auxins and polyphenols from sources of plant origin and their derivatives, which from a any vegetable matter (roots, stems including bark, leaves, fruits, seeds and derivatives) and by an hydrolysis in acid alcohol which is added alcohols and mineral acids, the resulting mass is subjected to a thermodynamic treatment, with subsequent utilization of physical systems of separate solid/liquid plant extract is obtained a hydro alcoholic. | 12-27-2012 |
Francisca Garcia Rivera, Sevilla ES
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20100134280 | TRACKING SYSTEM WITH REDUNDANT SECURITY AND RETRANSMISSION FEATURES - The invention relates to a tracking system with redundant security and retransmission features. The invention comprises one or more positioning devices ( | 06-03-2010 |
Francisca Godoy Santin, Santiago CL
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20150067916 | GENERATION OF GRAPEVINE ROOTSTOCKS THAT PROVIDE RESISTANCE AND SANITATION IN RELATION TO GRAPEVINE FANLEAF VIRUS (GFLV) - The invention discloses a vector plasmid called “GFLV silencing construct” that confers resistance and sanitation against the grapevine fanleaf virus (GFLV); plant cells transformed with said vector plasmid and a method to impart resistance and sanitation against the grapevine fanleaf virus (GFLV) in non-transgenic grapevines when being grafted onto seedlings generated from cells transformed with said plasmid vector. The “GFLV silencing construct” plasmid vector of the invention comprises inverted sequence duplicates coding for the grapevine fanleaf virus (GFLV) capsid protein. | 03-05-2015 |
Francisca Izquierdo Torres, Esplugues De Llobregat (barcelona) ES
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20110212932 | AQUEOUS CLEAR SOLUTIONS OF FLUOCINOLONE ACETONIDE FOR TREATMENT OF OTIC INFLAMMATION - A pharmaceutical otic sterile preservative-free composition in the form of a clear aqueous solution comprising 0.01-0.10% (w/v) of Fluocinolone Acetonide, optionally accompanied by 0.1-0.8% of Ciprofloxacin or a pharmaceutically acceptable salt thereof, a nonionic surfactant, a tonicity adjusting agent and a viscosity increasing agent. It is useful for the prevention and/or treatment of otic inflammation, optionally accompanied by bacterial infection, and for administration from single-use containers. | 09-01-2011 |
Francisca Swist, Edmonton CA
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20130061414 | Methods and Devices for Cleaning Implements - A cleaning system is provided comprising a compliant pad and a consumable pad for use in conjunction with a variety of cleaning implements. The compliant pad may according to embodiments of the invention provide for both compliance to the contour of the surface being cleaned but also allows for the compliant pad to provide for controlled release of fragrance, solvents, cleaning agents etc within the matrix or matrices provided in its construction. Likewise the consumable pad may provide elements providing dust attraction/retention, abrasion, as well as controlled release of fragrance, solvents, cleaning agents etc within the materials provided in its construction. According to embodiments of the invention the compliant pad and/or consumable pad are water soluble to provide this release wherein the water is provided either from within one or both of the compliant pad and consumable pad or from the cleaning implement to which they are attached. | 03-14-2013 |
Francisca Tan, West Lake Village, CA US
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20140257458 | EXPANDABLE STENT DELIVERY SYSTEM WITH OUTER SHEATH - According to aspects described herein, there is disclosed an improved hot balloon catheter delivery system for shape memory tubular stents. An outer sheath is provided on the delivery system that facilitates stent placement on a balloon during delivery through an endoscope. In one embodiment, the stent may be positioned between radiopaque markers/electrodes and the balloon may be heated. The stent may be prevented from moving proximally relative to the catheter as the delivery system is tracked through the patient's anatomical passageways. The outer sheath may be positioned to ride over the proximal cone of the hot balloon catheter and abut the proximal end of the stent to facilitate proper alignment of the balloon for deployment. Upon deployment of the stent in an appropriate position, the sheath may be pulled away from the stent to expose the proximal cone of the balloon and thereby allow balloon and stent expansion. | 09-11-2014 |
Francisca Tan-Malecki, Westlake Village, CA US
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20140288511 | Injector and Method of Assembly - An injector ( | 09-25-2014 |
Francisca Tan-Malecki, West Lake Village, CA US
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20130072941 | Cement Injector and Cement Injector Connectors, and Bone Cement Injector Assembly - An assembly for injecting bone cement into a vertebral body, comprising a bone cement dispenser, an introducer needle, a cement injection needle attached to the cement dispenser and slidably received in the introducer needle, and a Touhy-Borst adapter that locks and unlocks the cement injection needle from the introducer needle. | 03-21-2013 |
20130165942 | Length-Adjustable Vertebral Body Balloon - A length-adjustable vertebral body balloon catheter in which the location of the balloon can now be manipulated once an access cannula has been placed in the vertebral body. The device includes a collet such as a Touhy-Borst valve that allows the clinician | 06-27-2013 |
Francisca Tan-Malecki, Waltham, MA US
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20080208320 | Delivery Apparatus and Methods for Vertebrostenting - The invention relates to a method of delivering and deploying a stent into a curvilinear cavity within a vertebral body or other bony or body structure. The invention also relates to devices that may be used to perform the steps to deliver and deploy a stent. | 08-28-2008 |
20100114111 | DELIVERY APPARATUS AND METHODS FOR VERTEBROSTENTING - The invention relates to a method of delivering and deploying a stent into a curvilinear cavity within a vertebral body or other bony or body structure. The invention also relates to devices that may be used to perform the steps to deliver and deploy a stent. | 05-06-2010 |
20140121667 | Delivery of Apparatus and Methods for Vertebrostenting - The present invention generally is directed toward a spinal fixation system whereby a coupling element allows the physician to selectively lock or unlock either the connection between the coupling element and a fastener, such as to allow for repositioning of the coupling element, or the connection between the coupling element and an elongate rod. The locking or unlocking of these connections may be made independently and as desired by the physician. | 05-01-2014 |