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Francine
Francine Behar-Cohen, Paris FR
| Patent application number | Description | Published |
|---|---|---|
| 20090088721 | Enhanced retinal delivery of a nucleic acid through iontophoresis - The present invention provides a device and a method for the enhanced retinal delivery of nucleic acid therapeutics utilizing iontophoresis to evoke a transient elongation of the Müller Cells of a mammalian eye. The enhanced retinal deposition can be achieved by either a topical application, subconjunctival, or an intravitreal injection of the nucleic acid composition followed by, preceded by, or administered simultaneously with the iontophoretic application. The present invention thus provides a particularly advantageous method for the treatment of ocular diseases comprising the in vivo administration of a nucleic acid capable of alleviating the symptoms of a disease, the delivery of the nucleic acid being enhanced by using iontophoresis. This method can be applied particularly to the diseases of the retina resulting from an alteration of a gene expression and/or the over-expression of particular growth factors. The diseases include, but are not limited to, human ocular retinopathies including, neovascular diseases (Age-Related Macular Edema, Diabetic Retinopathies, Diabetic Macular Edema, etc.) and inherited retinopathies such as retinitis pigmentosa. | 04-02-2009 |
| 20110098632 | DEVICE DELIVERING MEDICINES BY TRANSPALPEBRAL ELECTROPHORESIS - The invention concerns a device for ocular application of an active principle ( | 04-28-2011 |
| 20110152749 | EYE INJECTION DEVICE - An injection device for injecting a product into an eye, said device comprising an injection needle and a support on which the injection needle is fixed, said device being characterized in that it comprises a locating mark disposed in such a way that the latter can be placed in contact with a defined bearing region of the surface of the eye, before any contact of the injection needle with said surface, and can then be kept in contact with said bearing region during a stage of penetration of said injection needle through said surface of the eye. | 06-23-2011 |
Francine Cand, Saint Martin D'Heres FR
| Patent application number | Description | Published |
|---|---|---|
| 20100120171 | CIRCULATING VE-CADHERIN AS A PREDICTIVE MARKER OF SENSITIVITY OR RESISTANCE TO ANTI-TUMORAL TREATMENT AND IMPROVED METHOD FOR THE DETECTION OF SOLUBLE PROTEINS - The application relates to improved means for the detection of soluble protein(s), such as soluble angiogenesis-related protein(s), more particularly circulating VE-cadherin. These means notably comprise the dilution of the fluid sample (e.g., serum or plasma sample), before submitting it to protein detection. Said dilution is advantageously diluted in a surfactant-containing solution. The improved means of the invention enabled to determine that circulating VE-cadherin is a reliable prognostic marker of the sensitivity or resistance to anti-tumoral treatment. It is believed that prior art sVE-cadherin detection means did not enable such determination. | 05-13-2010 |
Francine Connan, Deuil La Barre FR
| Patent application number | Description | Published |
|---|---|---|
| 20080248044 | POLYEPITOPIC PROTEIN FRAGMENTS OF THE E6 AND E7 PROTEINS OF HPV, THEIR PRODUCTION AND THEIR USE PARTICULARLY IN VACCINATION - Polyepitopic peptides of E6 and E7 proteins of Human Papillomavirus, their production, and methods of treating pathologies in which a polyepitopic peptide of the E6 and E7 protein of Human Papillomavirus is recognized by the cellular immune system. | 10-09-2008 |
Francine Denizeau, Montreal CA
| Patent application number | Description | Published |
|---|---|---|
| 20080254439 | Plant Extract and Use Thereof as a Cryoprotective Agent - A cryopreservation medium comprising a protein-containing plant extract is disclosed. Methods, compositions, uses and kits for cryopreservation of biological material, such as a molecule, organelle, cell, embryo, tissue or organ, are also disclosed. | 10-16-2008 |
Francine Farouz, Mercer Island, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100216820 | THIENOPYRIMIDIONES FOR TREATMENT OF INFLAMMATORY DISORDERS AND CANCERS - The current invention provides compounds of formula (1): wherein: one of Q | 08-26-2010 |
| 20110021541 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA - Compounds that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3Kδ plays a role in leukocyte function, using the compounds also are disclosed. | 01-27-2011 |
Francine Jotereau, Carquefou FR
| Patent application number | Description | Published |
|---|---|---|
| 20090081226 | Soluble HLA-E Molecules And Their Use For Diagnosing And Treating Pathologies - The present invention relates to a purified soluble HLA-E molecule, characterized in that: | 03-26-2009 |
| 20110195045 | Methods, agents and peptides for inducing an immune response to matrix metalloproteinase-2 expressing tumors - The present invention relates to enhancing, modulating or stimulating the immune response to MMP-2 expressing tumors, including melanoma, and to the modulation and application of immune modulators and MMP-2 peptides for melanoma or other MMP-2 expressing tumor vaccines. The invention provides methods and means to activate an effective response to MMP-2 expressing tumors and modulate the ability of MMP-2 to skew CD4+ T cell responses toward that of T | 08-11-2011 |
Francine Lyle, London GB
| Patent application number | Description | Published |
|---|---|---|
| 20110209261 | BABY TOY - An improved baby toy is described. The toy is a bib-shaped garment that may be adapted to be worn by a carer for a baby. The garment comprises a main portion that may cover the chest of the carer and neck portions that can be wrapped around the neck of the carer and detachably fastened at the back of the neck. The garment also includes one or more toy fixing structures that are integral to the main portion and that allow toys to be attached to the garment in a way that they can subsequently be removed, if required. There may also be a reflective element on the rear face of the main portion. In addition to being worn by the carer, the garment may alternatively be worn around the waist of the baby or be attached to an object such as a table, car window or cot rail. | 09-01-2011 |
Francine Mondou, Blainville CA
| Patent application number | Description | Published |
|---|---|---|
| 20110256305 | Turbine Coating Apparatus And Spray Gun Assembly Therefor - The present invention generally relates to a turbine coating apparatus and a spray gun assembly therefor. More specifically, the present invention relates to a spray gun assembly comprising a gun support mountable to the turbine coating apparatus and at least one spray gun mounted to the gun support. The spray gun is adapted for providing a spray of a coating substance onto a cluster of solid forms to be coated in the apparatus, where the spray defines a spray angle of less than 90 degrees relative to the coating plane defined by the cluster of solid forms in movement. | 10-20-2011 |
Francine Rendu, Paris FR
| Patent application number | Description | Published |
|---|---|---|
| 20100330605 | TEST DEVICE FOR PLATELET AGGREGATION DETECTION - The invention relates to the test device for platelet aggregation detection comprising:—an element ( | 12-30-2010 |