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Fox, MA
Andrew D. Fox, Westborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090036922 | SYSTEMS AND METHODS FOR CLOSING A TISSUE OPENING - The present invention is directed to tissue closure devices for closing a tissue opening, including one or more closure components, each closure component having a first member and a second member, each of the first and second members having a first surface that adheres to a tissue surface proximate to the tissue opening, each of the first and second members having a second surface substantially orthogonal to the first surface, and each of the first and second members having a transitional region between the first surface and the second surface which is contoured to evert an edge of the tissue opening upon the drawing together of the first and second members. The present invention is also directed to systems and kits, dressing systems, and methods for tissue repair and closure. | 02-05-2009 |
Barbara S. Fox, Wayland, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100068222 | Hapten-carrier conjugates for use in drug abuse therapy and methods for preparation of same - Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs. | 03-18-2010 |
| 20100105672 | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same - Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs. | 04-29-2010 |
| 20100183632 | Antibody Therapy For Modulating Function Of Intestinal Receptors - The present invention provides pharmaceutical compositions formulated for direct delivery to the GI tract of a patient comprising an antibody specific for a target apical intestinal receptor. The present invention further provides methods of treating diseases and conditions in a patient comprising administering directly to the GI tract of the patient, compositions of the present invention wherein modulation of the target apical intestinal receptor by the antibody treats the condition. | 07-22-2010 |
| 20100209449 | HAPTEN-CARRIER CONJUGATES FOR USE IN DRUG-ABUSE THERAPY AND METHODS FOR PREPARATION OF SAME - Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs. | 08-19-2010 |
| 20100266607 | ANTIBODY THERAPY FOR USE IN THE DIGESTIVE TRACT - In accordance with the invention, the development and use of antibodies within the digestive tract is provided. Antibodies are described that are used to treat disorders associated with altered permeability of the digestive tract. Antibodies are described with increased stability within the environment of the digestive tract. Antibodies are described with enhanced permeability to a compromised digestive tract. | 10-21-2010 |
Edward Fox, Maynard, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090186394 | Crystallizable JNK complexes - The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of JNK3. A computer comprising such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to JNK3 or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets. | 07-23-2009 |
Edward A. Fox, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110257036 | Methods and Compositions for the Diagnosis of Cancer Susceptibilities and Defective DNA Repair Mechanisms and Treatment Thereof - Methods and compositions for the diagnosis of cancer susceptibilities, defective DNA repair mechanisms and treatments thereof are provided. Among sequences provided here, the FANCD2 gene has been identified, and probes and primers are provided for screening patients in genetic-based tests and for diagnosing Fanconi Anemia and cancer. The FANCD2 gene can be targeted in vivo for preparing experimental mouse models for use in screening new therapeutic agents for treating conditions involving defective DNA repair. The FANCD2 polypeptide has been sequenced and has been shown to exist in two isoforms identified as FANCD2-S and the monoubiquinated FANCD-L form. Antibodies including polyclonal and monoclonal antibodies have been prepared that distinguish the two isoforms and have been used in diagnostic tests to determine whether a subject has an intact Fanconi Anemia/BRCA pathway. | 10-20-2011 |
Julia L. Fox, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120088300 | COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF DEFINITIVE ENDODERM - Certain embodiments disclosed herein are directed to a method of producing endoderm cells, such as definitive endoderm cells by exposing stem cells such as embryonic stem cells or induced pluripotent stem (iPS) cells to an effective amount of at least one compound described herein to differentiate the stem cells into the endoderm cells such as definitive endoderm cells. Differentated endoderm cells produced by the methods disclosed herein can be differentiated into pancreatic epithelium, and other endoderm derivatives such as thymus, liver, stomach, intestine and lung. Another aspect of the present invention relates to a method of producing pancreatic progenitor cells, such as Pdx1-positive pancreatic progenitor cells by exposing endoderm cells, such as definitive endoderm cells to an effective amount of at least one compound described herein to differentiate the definitive endoderm cells into Pdx1-positive pancreatic progenitor cells. Kits and compositions comprising Pdx1-positive pancreatic progenitor produced using the methods are also described. | 04-12-2012 |
Kevin Fox, Jamaica Plain, MA US
Levi G. Fox, Charlestown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100109917 | PULSED ANTENNA CAPACITIVE TOUCH SWITCH - A capacitive touch switch suitable for use in areas with high environmental and electrical contamination employs a complex excitation signal that is demodulated to better distinguish it from environmental effects. Improved discrimination allows these sensed signals to be offset against a signal developed by a reference electrode to allow the system to operate robustly with contamination on the electrodes that would otherwise trigger or obscure pulses. | 05-06-2010 |
Marsha J. Fox, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100309467 | Single-Shot Spectral Imager - A single-shot spectral imager or imaging system which acquires multiplexed spatial and spectral data in a single snapshot with high optical collection efficiency and with the speed limited only by the readout time of the detector circuitry. The imager uses dispersive optics together with spatial light modulators to encode a mathematical transform onto the acquired spatial-spectral data. A multitude of encoded images is recorded simultaneously on a focal plane array and subsequently decoded to produce a spectral/spatial hypercube. | 12-09-2010 |
Nicole Fox, Lowell, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080245736 | Crosslinked cellulosic nanofiltration membranes - The present invention relates to a nanofilter formed by using a porous ultrafiltration membrane as a precursor, and carefully controlling reaction conditions so as to maintain sufficient hydrophilic nature of the membrane while causing the pore structure to close to a nanofilter range (less than 400 Daltons). This produces a solvent stable cellulose nanofiltration membrane capable of operating at satisfactory flux in aqueous solutions, and being low binding to organic biomaterials. | 10-09-2008 |
Robert Fox, Mashpee, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090165334 | Customizable insole - An insert for a shoe includes an insole for fitting into a shoe and a molded support structure fitted within the insole and a plurality of arch carriers, each of which is shaped to fit in a matting relationship with the molded support structure, where a user selects one of the plurality of arch carriers and inserts the arch carrier into the molded support structure. | 07-02-2009 |
Stephen Fox, Leicester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090159114 | Photovoltaic Panel and Cell with Fine Fingers and Method of Manufacture of the Same - A photovoltaic cell has a photosensitive substrate and a plurality of fingers in ohmic contact with the substrate. At least one of the fingers has an average width of less than about 95 microns. The cell also has a plurality of busbars in ohmic contact with the fingers. At least two of the busbars that are spaced less than about 38 millimeters apart intersect the at least one finger (i.e., the finger(s) having an average width of less than about 95 microns). | 06-25-2009 |
| 20100000602 | Photovoltaic Cell with Efficient Finger and Tab Layout - A photovoltaic cell has a photosensitive substrate, a plurality of fingers in ohmic contact with the substrate, and a plurality of pads on the substrate. The plurality of pads effectively form a plurality of discontinuous busbars. Two of the fingers extend from a first pad of the plurality of pads. Specifically, a given one of the two fingers (“given finger”) may connect with a second pad of the plurality of pads. This given finger may have an inter-pad portion between the first and second pads. The cell further has a tab at least partially covering the inter-pad portion of the given finger. | 01-07-2010 |
Stephen E. Fox, Worcester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110131888 | BONDED ABRASIVE ARTICLE AND METHOD OF FORMING - An abrasive article includes an abrasive body having abrasive grains within a bond material, the abrasive body further including a spinel material disposed at an interface between the abrasive grains and the bond matrix. | 06-09-2011 |
Steven N. Fox, Weymouth, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100192384 | Flexible pin for connecting a finger ring to a shank of a cutting device - The present invention is directed to a hair cutting device ( | 08-05-2010 |