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Fowlkes, US

Brian Fowlkes, Ann Arbor, MI US

Patent application numberDescriptionPublished
20090054763SYSTEM AND METHOD FOR SPECTROSCOPIC PHOTOACOUSTIC TOMOGRAPHY - A system and method for spectroscopic photoacoustic tomography of a sample include at least one light source configured to deliver light pulses at two or more different wavelengths to the sample. An ultrasonic transducer is disposed adjacent to the sample for receiving photoacoustic signals generated due to optical absorption of the light pulses by the sample. A control system is provided in communication with the ultrasonic transducer for reconstructing photoacoustic tomographic images from the received photoacoustic signals, wherein upon application of light pulses of two or more different wavelengths to the sample, the control system is configured to determine the local spectroscopic absorption of substances at any location in the sample. The system may further provide for one or more of ultrasound imaging. Doppler ultrasound imaging, and diffuse optical imaging of the sample.02-26-2009

Dana M. Fowlkes, Chapel Hill, NC US

Patent application numberDescriptionPublished
20080268475YEAST CELLS EXPRESSING MODIFIED G PROTEINS AND METHODS OF USE THEREFOR - The present invention pertains to novel yeast cells which are useful for the expression of heterologous G protein coupled receptors. The yeast cells of the present invention can be used in screening assays which can be used to screen for modulators of G protein coupled receptors. Specifically, the invention provides novel yeast cells which express a heterologous G protein coupled receptor and mutant and/or chimeric G protein subunit molecules which serve to functionally integrate the heterologous into the pheromone signaling pathway of the yeast cell. The invention also provides for the expression of heterologous G protein coupled receptors which are functionally integrated into the yeast cell membrane using a yeast α factor leader sequence. Drug discovery assays using the subject yeast cells are also provided.10-30-2008
20090264303Polypeptides having a functional domain of interest and methods of identifying and using same - Novel polypeptides having functional domains of interest are described, along with DNA sequences that encode the same. A method of identifying these polypeptides by means of a sequence-independent (that is, independent of the primary sequence of the polypeptide sought), recognition unit-based functional screen is also disclosed. Various applications of the method and of the polypeptides identified are described, including their use in assay kits for drug discovery, modification, and refinement.10-22-2009

Patent applications by Dana M. Fowlkes, Chapel Hill, NC US

Donald Fowlkes, San Jose, CA US

Patent application numberDescriptionPublished
20100200979Power Transistor Package with Integrated Bus Bar - According to one embodiment, a power transistor package includes an electrically conductive flange configured to be connected to a source of a power transistor device. The package further includes a first terminal mechanically fastened to the flange and configured to be electrically connected to a gate of the power transistor device and a second terminal mechanically fastened to the flange and configured to be electrically connected to a drain of the power transistor device. The package also includes a bus bar mechanically fastened to the flange which extends between and connects at least two different DC bias terminals mechanically fastened to the flange. The bus bar is configured to be electrically connected to the drain via one or more RF grounded connections.08-12-2010
20100283134High Power Ceramic on Copper Package - According to an embodiment of a high power package, the package includes a copper heat sink, a ceramic lead frame and a semiconductor chip. The copper heat sink has a thermal conductivity of at least 350 W/m K. The ceramic lead frame is attached to the copper heat sink with an epoxy. The semiconductor chip is attached to the copper heat sink on the same side as the lead frame with an electrically conductive material having a melting point of about 280° C. or greater.11-11-2010
20110089529Open Cavity Leadless Surface Mountable Package for High Power RF Applications - An RF semiconductor package includes a substrate having generally planar top and bottom surfaces. The substrate includes a metallic base region and one or more metallic signal terminal regions extending from the top surface to the bottom surface, and an insulative material separating the metallic regions from one another. The bottom surface of an RF semiconductor die is surface-mounted to the base region at the top substrate surface. The RF semiconductor die has a terminal pad disposed at a top surface of the RF semiconductor die. The terminal pad is electrically connected to one of the signal terminal regions at the top substrate surface. A lid is attached to the top substrate surface so that the RF semiconductor die is enclosed by the lid to form an open-cavity around the RF semiconductor die. The base and signal terminal regions are configured for surface-mounting at the bottom substrate surface.04-21-2011
20110147921Flange for Semiconductor Die - A semiconductor package includes a curved body and a plurality of semiconductor die. The curved body includes first and second opposing end regions and an intermediate center region. The curved body has a first inflection point at the center region, a second inflection point at the first end region and a third inflection point at the second end region. The center region has a convex curvature with a minimal extremum at the first inflection point, the first end region has a concave curvature with a maximal extremum at the second inflection point and the second end region has a concave curvature with a maximal extremum at the third inflection point. The plurality of semiconductor die are attached to an upper surface of the curved body between the maximal extrema.06-23-2011

Patent applications by Donald Fowlkes, San Jose, CA US

J. Brian Fowlkes, Ann Arbor, MI US

Patent application numberDescriptionPublished
20080287799Method and apparatus for measuring volumetric flow - An ultrasound system comprises an ultrasound probe, a user interface and a processor. The ultrasound probe comprises a transducer face emitting ultrasound beams into a patient. The probe acquires a volume of ultrasound data comprising a blood vessel. The user interface defines a surface on an image that is based on the volume. The surface bisects the blood vessel and further comprises a plurality of points where at least some of the points are located at unequal distances with respect to the transducer face. The processor is configured to steer a subset of the ultrasound beams to intersect the surface at a 90 degree angle and calculate volumetric flow information through the blood vessel based on the ultrasound data corresponding to the surface.11-20-2008
20080319356PULSED CAVITATIONAL ULTRASOUND THERAPY - Therapy methods using pulsed cavitational ultrasound therapy can include the subprocesses of initiation, maintenance, therapy, and feedback of the histotripsy process, which involves the creation and maintenance of ensembles of microbubbles and the use of feedback in order to optimize the process based on observed spatial-temporal bubble cloud dynamics. The methods provide for the subdivision or erosion of tissue, liquification of tissue, and/or the enhanced delivery of therapeutic agents. Various feedback mechanisms allow variation of ultrasound parameters and provide control over the pulsed cavitational process, permitting the process to be tuned for a number of applications. Such applications can include specific tissue erosion, bulk tissue homogenization, and delivery of therapeutic agents across barriers.12-25-2008
20100069797PULSED CAVITATIONAL ULTRASOUND THERAPY - Therapy methods using pulsed cavitational ultrasound therapy can include the subprocesses of initiation, maintenance, therapy, and feedback of the histotripsy process, which involves the creation and maintenance of ensembles of microbubbles and the use of feedback in order to optimize the process based on observed spatial-temporal bubble cloud dynamics. The methods provide for the subdivision or erosion of tissue, liquification of tissue, and the enhanced delivery of therapeutic agents. Various feedback mechanisms allow variation of ultrasound parameters and provide control over the pulsed cavitational process, permitting the process to be tuned for a number of applications. Such applications can include specific tissue erosion, bulk tissue homogenization, and delivery of therapeutic agents across barriers.03-18-2010
20110054315MICROMANIPULATOR CONTROL ARM FOR THERAPEUTIC AND IMAGING ULTRASOUND TRANSDUCERS - A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.03-03-2011
20110054363DEVICES AND METHODS FOR USING CONTROLLED BUBBLE CLOUD CAVITATION IN FRACTIONATING URINARY STONES - A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can deliver Lithotripsy therapy to a patient, so as to fractionate urinary stones. Another feature of the device is that it can deliver Histotripsy therapy to a patient, so as to erode urinary stones. In some embodiments, the medical imaging and therapy device is configured to target and track urinary stones in the patient during therapy. Methods associated with use of the medical imaging and therapy device are also covered.03-03-2011

Patent applications by J. Brian Fowlkes, Ann Arbor, MI US

Monta Fowlkes, Laveen, AZ US

Patent application numberDescriptionPublished
20110147322LUBRICANT SUPPLY FILTRATION SYSTEM AND METHOD - A system and method of filtering lubricant in a lubricant supply system are provided. Lubricant from a lubricant source is directed into and through a coarse filter that is configured to remove, from the lubricant, particulate of at least a first dimension. A fraction of the lubricant discharged from the coarse filter is directed into and through a fine filter that is configured to remove, from the fraction of lubricant, particulate having at least a second dimension that is less than the first dimension. Lubricant discharged from the fine filter is directed back to the lubricant source.06-23-2011

William Y. Fowlkes, Pittsford, NY US

Patent application numberDescriptionPublished
20090169277ON-DEMAND PRINT FINISHING SYSTEM USING SURFACE DETECTION AND REPLICATION - An on-demand printing system and more specifically to a printing system that includes both scanner and printer functionality in one integrated unit. The printing system further including both image and gloss detection devices in the one integrated unit as well as a finishing system that is capable of printing with some specified level of gloss in one or more areas of the final product.07-02-2009
20100156085BOOK COVER AND USES - An instant book binding system and book cover for rapidly binding single- or double-sided documents, photographs, pages, and other forms of hardcopy media into soft or hard cover books is disclosed. The book binding method using the book cover or system can be performed without special skills or training, and does not require the use of ancillary equipment. The book cover and system can be used in conjunction with output on a wide variety of media types, finishes, and stock weights from any type of printer or copier, or with photographs. The finished books retain the appearance and function of conventional mass produced soft and hard covered books.06-24-2010
20100158637BOOK AND A METHOD OF MAKING SAME - An instant book binding system and book cover for rapidly binding single- or double-sided documents, photographs, pages, and other forms of hardcopy media into soft or hard cover books is disclosed. The book binding method using the book cover or system can be performed without special skills or training, and does not require the use of ancillary equipment. The book cover system can be used in conjunction with output on a wide variety of media types, finishes, and stock weights from any type of printer or copier, or with photographs. The finished books retain the appearance and function of conventional mass produced soft and hard covered books.06-24-2010
20100158639INSTANT MEDIA BINDING SYSTEM - An instant book binding system and book cover for rapidly binding single- or double-sided documents, photographs, pages, and other forms of hardcopy media into soft or hard cover books is disclosed. The book binding method using the book cover or system can be performed without special skills or training, and does not require the use of ancillary equipment. The book cover system can be used in conjunction with output on a wide variety of media types, finishes, and stock weights from any type of printer or copier, or with photographs. The finished books retain the appearance and function of conventional mass produced soft and hard covered books.06-24-2010

Patent applications by William Y. Fowlkes, Pittsford, NY US