Patent application number | Description | Published |
20110211073 | OBJECT DETECTION AND SELECTION USING GESTURE RECOGNITION - Object detection and selection for use in a device having digital camera functionality is described. The mechanism detects the occurrence of a gesture by a pointing member in an image frame captured by an IR image sensor. The gesture is then recognized and an object pointed to is detected. The object detected is then selected as a result of the gesture recognition. | 09-01-2011 |
20110212687 | COMMUNICATIONS DEVICE RESPONSIVE TO NEAR FIELD COMMUNICATIONS (NFC) TO ENTER LOCKED OR UNLOCKED OPERATING MODES - A communications device includes a housing and radio frequency (RF) circuitry and a processor carried by the housing and operative with each other. A Near Field Communications (NFC) circuit is carried by the housing and connected to the processor. This circuit is configured to detect an NFC enabled tag using an NFC communications protocol when the device is positioned near the tag. The circuit generates a disable signal to the processor upon detecting the NFC enabled tag. The processor is configured to cause the device to enter a locked, operating mode upon receiving the disable signal and to enter or remain in an unlocked, operating mode if the NFC circuit does not generate a disable signal indicative that the NFC circuit has not detected the NFC enabled tag. | 09-01-2011 |
20120086847 | CONVERGENCE FEEDBACK INDICATOR, PROVIDED WHEN TAKING A PICTURE IN A CAMERA APPLICATION - An apparatus, and an associated method, facilitates capturing an image in an electronic camera without the image being completely focused. A “most-in-focus” indicator is provided to an operator of the camera to notify the operator that a reasonably good image is available for capture, without having to wait for the camera to finish a fine focus adjustment. | 04-12-2012 |
20120147243 | SYSTEM AND METHOD OF CAPTURING LOW-LIGHT IMAGES ON A MOBILE DEVICE - A system and method of capturing low-light images on a mobile device include a camera module, an image sensor, an infrared filter, and a visible light filter. The image sensor can detect a color spectrum of ambient light passed through a lens of the camera module. The visible light filter can cover a first portion of the image sensor, and the infrared filter can cover a second portion of the image sensor. A processor can be coupled to the image sensor to receive visible light data and infrared data. Visible light data can be formed from ambient light passed through the visible light filter and image sensor. Infrared data can formed from ambient light passed through the infrared filter and the image sensor. The visible light data and the infrared data are combined to form a low-light image data having enhanced brightness while maintaining color accuracy. | 06-14-2012 |
Patent application number | Description | Published |
20090307215 | NETWORK RESOURCE ANNOTATION AND SEARCH SYSTEM - A method and system for annotation of network resources existing within an electronic network. Further provided for is a method for increasing, or decreasing the relevance of network resources forming part of a search result of a network through use of annotations associated with network resources. | 12-10-2009 |
20100174708 | SYSTEMS AND METHODS FOR DETECTING NETWORK RESOURCE INTERACTION AND IMPROVED SEARCH RESULT REPORTING - Systems and methods are described for intercepting user interactions without network-provided content. The intercepted information can be used for prioritizing search results by statistical and other analyses of user interactions with a network resource and/or network content. A server connected to a network can receive captured information from an agent that is installed in a device connected to the network. The captured information can be related to an interaction of a user with a network resource. An aggregator may be provided to aggregate the captured information with other captured information related to a plurality of network resources and maintains a repository of aggregated captured information. A prioritizer can determine the relevance of network content based on characteristics of the aggregated captured information. The prioritizer determines relevance for a plurality of search results based on frequency of prior user interactions with the content of the search results. | 07-08-2010 |
20110082850 | NETWORK RESOURCE INTERACTION DETECTION SYSTEMS AND METHODS - Systems and methods are described for intercepting user interactions without network-provided content. The intercepted information can be used for prioritizing search results by statistical and other analyses of user interactions with a network resource and/or network content. A server connected to a network can receive captured information from an agent that is installed in a device connected to the network. The captured information can be related to an interaction of a user with a network resource. An aggregator may be provided to aggregate the captured information with other captured information related to a plurality of network resources and maintains a repository of aggregated captured information. A prioritizer can determine the relevance of network content based on characteristics of the aggregated captured information. The prioritizer determines relevance for a plurality of search results based on frequency of prior user interactions with the content of the search results. | 04-07-2011 |
20110082897 | SYSTEMS AND METHODS FOR DETERRING TRAVERSAL OF DOMAINS CONTAINING NETWORK RESOURCES - The present invention provides for a novel method and system for the monitoring of actions by users likely to precede said user leaving the domain of a network resource. Also provided for is a method and system for the deterring users from leaving the domain of a network resource, a method and system for increasing user traffic to a network resource and a method and system for monitoring trends within a population using network resources. | 04-07-2011 |
20110082898 | SYSTEM AND METHOD FOR NETWORK OBJECT CREATION AND IMPROVED SEARCH RESULT REPORTING - Systems and methods are described that may be used for the creation of user defined objects arising from the implicit interaction of a user with a network resource. The objects are made generally available within the network. A network resource in communication with a network maintains content accessible by a plurality of users of the network. An agent provided to a user device identifies an implicit interaction with a portion of the content and transmits information associated with the implicit interaction to another computing system communicatively connected to the network. The information includes a URL identifying the network resource and the portion of the content and is provided in a user-defined object on the network. Frequency of occurrence of a URL in a plurality of the objects can be used to determine relevance of a network resource and its content. | 04-07-2011 |
20110276626 | SYSTEM AND METHOD FOR DETERRING TRAVERSAL OF DOMAINS CONTAINING NETWORK RESOURCES - The present invention provides for a novel method and system for the monitoring of actions by users likely to precede said user leaving the domain of a network resource. Also provided for, is a method and system for the deterring users from leaving the domain of a network resource, a method and system for increasing user traffic to a network resource and a method and system for monitoring trends within a population using network resources. | 11-10-2011 |
20120226659 | SYSTEM AND METHOD FOR MONITORING ELEMENTS AND CATEGORIZING USERS WITHIN A NETWORK - Systems and methods for monitoring user interactions with keywords associated with a brand or words and phrases within the brand, present within a network resource and for enhancing user experience related to access of a network resource are described. A first computing device maintains a network resource and provides the resource and an agent to a second computing device. The agent monitors user interactions with the network resource when the network resource is displayed on the second computing device. The user interactions include implicit interaction. | 09-06-2012 |
Patent application number | Description | Published |
20090264768 | Scanning mechanisms for imaging probe - The present invention provides scanning mechanisms for imaging probes using for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and/or optical coherence tomography. The imaging probes include adjustable rotational drive mechanism for imparting rotational motion to an imaging assembly containing either optical or ultrasound transducers which emit energy into the surrounding area. The imaging assembly includes a scanning mechanism having including a movable member configured to deliver the energy beam along a path out of said elongate hollow shaft at a variable angle with respect to said longitudinal axis to give forward and side viewing capability of the imaging assembly. The movable member is mounted in such a way that the variable angle is a function of the angular velocity of the imaging assembly. | 10-22-2009 |
20120220869 | SYSTEMS, METHODS, AND COMPUTER READABLE MEDIA FOR HIGH FREQUENCY CONTRAST IMAGING AND IMAGE-GUIDED THERAPEUTICS - Systems, methods, and computer readable media for high-frequency contrast imaging and image-guided therapeutics are disclosed. According to one aspect a method for high frequency contrast imaging and image-guided therapeutics includes: providing ultrasound of a first frequency bandwidth, directed toward the volume to be imaged, the volume containing a carrier having non-linear acoustical properties, wherein the ultrasound of the first frequency bandwidth causes the carrier to generate ultrasound of a second frequency bandwidth that is different from the first frequency bandwidth; receiving, from the volume to be imaged, ultrasound of the second frequency bandwidth; and using the received ultrasound of the second frequency bandwidth to generate an image of the volume to be imaged, wherein the components of the second frequency bandwidth that are detected are of a frequency greater than 20 MHz. According to another aspect, ultrasound at a first frequency bandwidth enables imaging of a target, and ultrasound at a second frequency bandwidth mediates drug or gene delivery to a portion of the target, as guided by the image provided by the first frequency. | 08-30-2012 |
20130345556 | SCANNING MECHANISMS FOR IMAGING PROBE - The present invention provides scanning mechanisms for imaging probes using for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and/or optical coherence tomography. The imaging probes include adjustable rotational drive mechanism for imparting rotational motion to an imaging assembly containing either optical or ultrasound transducers which emit energy into the surrounding area. The imaging assembly includes a scanning mechanism having including a movable member configured to deliver the energy beam along a path out of said elongate hollow shaft at a variable angle with respect to said longitudinal axis to give forward and side viewing capability of the imaging assembly. The movable member is mounted in such a way that the variable angle is a function of the angular velocity of the imaging assembly. | 12-26-2013 |
20140323860 | IMAGING PROBE WITH COMBINED ULTRASOUND AND OPTICAL MEANS OF IMAGING - The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (IVUS) and optical imaging methods such as optical coherence tomography (OCT) and to accurate co-registering of images obtained from ultrasound image signals and optical image signals during scanning a region of interest. | 10-30-2014 |
20140323877 | MEDICAL IMAGING PROBE WITH ROTARY ENCODER - The present invention provides minimally invasive imaging probe having an optical encoder integrated therewith for accurately measuring or estimating the rotational velocity near the distal end of the medical device, such as an imaging probe which undergoes rotational movement during scanning of surrounding tissue in bodily lumens and cavities. | 10-30-2014 |
Patent application number | Description | Published |
20090108710 | High Frequency Piezocomposite And Methods For Manufacturing Same - A transducer with triangular cross-sectional shaped pillars is described for suppressing lateral modes within a composite, and a method for producing the same. According to one aspect of the present application, a plurality of triangular cross-sectional shaped pillars extends outwardly from a substrate and form an array of pillars. The resulting array of pillars is configured to suppress the lateral modes of the transducer at higher operating frequencies, such as, at or above 15 MHz, at or above 20 MHz, or at or above 30 MHz. | 04-30-2009 |
20110273059 | HIGH FREQUENCY PIEZOCOMPOSITE AND METHODS FOR MANUFACTURING SAME - A transducer with triangular cross-sectional shaped pillars is described for suppressing lateral modes within a composite, and a method for producing the same. According to one aspect of the present application, a plurality of triangular cross-sectional shaped pillars extends outwardly from a substrate and form an array of pillars. The resulting array of pillars is configured to suppress the lateral modes of the transducer at higher operating frequencies, such as, at or above 15 MHz, at or above 20 MHz, or at or above 30 MHz. | 11-10-2011 |
20130193805 | HIGH FREQUENCY PIEZOCOMPOSITE AND METHODS FOR MANUFACTURING SAME - A transducer with triangular cross-sectional shaped pillars is described for suppressing lateral modes within a composite, and a method for producing the same. According to one aspect of the present application, a plurality of triangular cross-sectional shaped pillars extends outwardly from a substrate and form an array of pillars. The resulting array of pillars is configured to suppress the lateral modes of the transducer at higher operating frequencies, such as, at or above 15 MHz, at or above 20 MHz, or at or above 30 MHz. | 08-01-2013 |
20140073929 | NOSEPIECE CONFIGURED FOR USE WITH ULTRASOUND PROBES - A system for producing an ultrasound image comprises a scan head having a transducer capable of generating ultrasound energy at a frequency of at least 20 megahertz (MHz), and a processor for receiving ultrasound energy and for generating an ultrasound image at a frame rate of at least 15 frames per second (fps). | 03-13-2014 |
20140221842 | System and Method for Frequency Domain Photoacoustic Intravascular Imaging - A photoacoustic device capable of performing both intravascular photoacoustic (“IVPA”) imaging and intravascular ultrasound imaging is provided. The device includes one or more optical fibers coupled to a transducer assembly that includes an photoacoustic transducer and optionally an ultrasound transducer. The one or more optical fibers and photoacoustic transducer are arranged such that the illumination field generated by the one or more optical fibers is co-aligned with the sensitive region of the photoacoustic transducer. When both are present, the photoacoustic transducer and ultrasound transducer are arranged such that ultrasound generated by the ultrasound transducer avoids interfering with the sensitive region of the photoacoustic transducer. Frequency domain imaging may be achieved using an intensity-modulated continuous wave (“CW”) laser coupled to the one or more optical fibers. | 08-07-2014 |
20140336512 | HIGH FREQUENCY, HIGH FRAME-RATE ULTRASOUND IMAGING SYSTEM - A system for producing an ultrasound image comprises a scan head having a transducer capable of generating ultrasound energy at a frequency of at least 20 megahertz (MHz), and a processor for receiving ultrasound energy and for generating an ultrasound image at a frame rate of at least 15 frames per second (fps). | 11-13-2014 |
20140354113 | HIGH FREQUENCY PIEZOCOMPOSITE AND METHODS FOR MANUFACTURING SAME - A transducer with triangular cross-sectional shaped pillars is described for suppressing lateral modes within a composite, and a method for producing the same. According to one aspect of the present application, a plurality of triangular cross-sectional shaped pillars extends outwardly from a substrate and form an array of pillars. The resulting array of pillars is configured to suppress the lateral modes of the transducer at higher operating frequencies, such as, at or above 15 MHz, at or above 20 MHz, or at or above 30 MHz. | 12-04-2014 |
20150148711 | METHOD, SYSTEM AND USE FOR THERAPEUTIC ULTRASOUND - The described embodiments relate to methods, systems and uses for therapeutic ultrasound, and in particular, to methods, systems and uses for therapeutic ultrasound and contact lenses for treating or alleviating eye conditions. The described embodiments relate to methods, systems and uses that involve an ultrasound device configured for treatment of an eye condition and a contact lens protects ocular tissue of the eye and forms a chamber of air. | 05-28-2015 |
Patent application number | Description | Published |
20100138931 | METHOD AND SYSTEM FOR REAL TIME CLASSIFICATION OF EVENTS IN COMPUTER INTEGRITY SYSTEM - Method and system using a designated known secure computer for real time classification of change events in a computer integrity system are disclosed. In the embodiment of the invention, the known secure computer is dedicated for providing permissible change events, which are compared with change events generated on client operational computers. An alert is raised when the change event at the client operational computer and the respective permissible change event provided by the known secure computer differ. | 06-03-2010 |
20110099543 | METHOD AND SYSTEM FOR VERSION INDEPENDENT SOFTWARE RELEASE MANAGEMENT - A method for assembling an update for a software release is described, comprising defining classes of software components, each class comprising one or more instances of the class, each instance having a unique identifier, each instance representing a software component, which has one or more version; for each version of a software component, assigning time stamps and indicators identifying status of the version; introducing a flexible coupling between versions of components and instances of classes by providing a pointer between a version of a component and a unique identifier of an instance of a class; selecting versions of software components from which pointers originate; for each instance of the class, to which the pointer points at, selecting one version of the software component based on the assigned indicators; and assembling the selected versions of software components into the update of the software release. A corresponding system is also provided. | 04-28-2011 |
20120084764 | METHOD AND SYSTEM FOR VERSION INDEPENDENT SOFTWARE RELEASE MANAGEMENT - A system for assembling an update for a software release is described, comprising a processor and memory configured to define classes of software components, each class having a plurality of instances, each instance having a unique identifier (UID) and representing a software component having a plurality of versions; for each version of the software component, assign time stamps and indicator identifying release status of the version; introduce a flexible coupling between versions of software components and instances of classes using a pointer between a version of the software component and a UID associated with the version; select versions of software components from which pointers originate; for each instance of the class, to which the pointer points, select one version of the software component based on the assigned indicator; and assemble the selected versions of software components into the update of the software release. A corresponding method is also provided. | 04-05-2012 |
20120216278 | METHOD AND SYSTEM FOR REAL TIME CLASSIFICATION OF EVENTS IN COMPUTER INTEGRITY SYSTEM - Method and system using a designated known secure computer for real time classification of change events in a computer integrity system are disclosed. In the embodiment of the invention, the known secure computer, having only inbound connection, is dedicated for providing permissible change events, which are compared with change events generated on client operational computers. An alert is generated when the change event at the client operational computer and the respective permissible change event provided by the known secure computer mismatch. | 08-23-2012 |
20120266154 | METHOD AND SYSTEM FOR VERSION INDEPENDENT SOFTWARE RELEASE MANAGEMENT - A system for assembling an update for a software release is described, comprising a processor and memory configured to define classes of software components, each class having a plurality of instances, each instance having a unique identifier (UID) and representing a software component having a plurality of versions; for each version of the software component, assign time stamps and indicator identifying release status of the version; introduce a flexible coupling between versions of software components and instances of classes using a pointer between a version of the software component and a UID associated with the version; select versions of software components from which pointers originate; for each instance of the class, to which the pointer points, select one version of the software component based on the assigned indicator; and assemble the selected versions of software components into the update of the software release. A corresponding method is also provided. | 10-18-2012 |
20130318601 | METHOD AND SYSTEM FOR REAL TIME CLASSIFICATION OF EVENTS IN COMPUTER INTEGRITY SYSTEM - Method and system using a designated known secure computer for real time classification of change events in a computer integrity system are disclosed. In the embodiment of the invention, the known secure computer, having only inbound connection, is dedicated for providing permissible change events, which are compared with change events generated on client operational computers. An alert is generated when the change event at the client operational computer and the respective permissible change event provided by the known secure computer mismatch. | 11-28-2013 |
Patent application number | Description | Published |
20140158514 | METHODS OF SEPARATING SALTS AND SOLVENTS FROM WATER - Methods and apparatus for separation of one or more salts from water are described. The methods include addition of a water miscible solvent to the water, followed by separation of the precipitated salt in a slurry, and evaporation of the water miscible solvent from the slurry. The apparatus include a novel design for a wetted wall separator tube that allows the solids in the slurry to pass through while providing efficient evaporation of the water miscible solvent from the water. | 06-12-2014 |
20140158616 | SYSTEMS, APPARATUS, AND METHODS FOR SEPARATING SALTS FROM WATER - A system, method, and apparatus for precipitating a water soluble salt or water soluble salts from water, including adding a water-miscible solvent to a water solution including an inorganic salt. The system, method and apparatus also allow for the separation of the precipitated salt, and for separation of the solvent from the water. In doing so, reclamation of water is provided. | 06-12-2014 |
20140158631 | SEPARATION OF NEUTRALLY BUOYANT MATERIALS FROM WATER - Described herein are methods of separating phase separated, neutrally buoyant materials from liquids and apparatuses for carrying out the methods. The methods and apparatuses employ nanobubbles. In certain embodiments, the nanobubbles may be formed in solutions of hydrophobically modified water soluble polymers. The methods result in removal of 90% by weight or more of neutrally buoyant materials from liquids. The methods are useful in certain embodiments for separating neutrally buoyant oily mixtures from water produced by mining operations. | 06-12-2014 |
20140158632 | SELECTIVE SEPARATION OF A SALT FROM WATER - Described herein are methods of separating a first soluble salt from water that contains the first soluble salt and a second soluble salt, by (a) adding a composition to a water product containing a first soluble salt and a second soluble salt, the composition comprising seed crystals composed substantially of a target insoluble salt to be formed from the first soluble salt; and (b) collecting the target insoluble salt. These methods may be used, for example, to separate strontium from water that includes at least one soluble strontium salt and a second soluble salt (such as one soluble calcium salt). | 06-12-2014 |
20140299529 | Systems, Apparatus, and Methods for Separating Salts from Water - A system, method, and apparatus for desalinating water, such as seawater. The system, method, and/or apparatus includes an electrodialysis cell that can separate monovalent ionic species from multivalent ionic species, so they may be separately treated. Each separate treatment may include precipitation of salt via the use of an organic solvent, followed by processing of precipitated salts and membrane treatment of water to remove solvent and remaining salts. | 10-09-2014 |
Patent application number | Description | Published |
20090054311 | Novel Cyclosporin Analog Formulations - The present invention relates to formulations containing cyclosporin analogs that are structurally similar to cyclosporin A, in particular isomeric mixtures of cyclosporin analogs that are structurally similar to cyclosporin A. The formulations form stable microemulsion preconcentrates and may provide superior drug bioavailability and/or may reduce one or more adverse effects associated with the administration of cyclosporin. Also disclosed are methods for using and preparing the formulations. | 02-26-2009 |
20090318336 | Deuterated Cyclosporine Analogs and Methods of Making the Same - Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) Chemical substitution and optionally deuterium substitution of amino acid 1; and (2) deuterium substitution at key sites of metabolism of the cyclosporine A molecule such as amino acids 1, 4, 9. Also disclosed are methods of producing the cyclosporine derivatives and method of producing immunosuppression with reduced toxicity with the disclosed cyclosporine derivatives. | 12-24-2009 |
20100062976 | Synthesis of Cyclosporin Analogs - The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISA | 03-11-2010 |
20110092669 | SYNTHESIS OF CYCLOSPORIN ANALOGS - The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISA | 04-21-2011 |
20110136744 | CYCLOSPORIN ANALOG FORMULATIONS - The present disclosure relates to formulations containing cyclosporin analogs that are structurally similar to cyclosporin A, in particular isomeric mixtures of cyclosporin analogs that are structurally similar to cyclosporin A. The formulations form stable microemulsion preconcentrates and may provide superior drug bioavailability and/or may reduce one or more adverse effects associated with the administration of cyclosporin. Also disclosed are methods for using and preparing the formulations. | 06-09-2011 |
20110166080 | DEUTERATED CYCLOSPORINE ANALOGS AND METHODS OF MAKING THE SAME - Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporin and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) Chemical substitution and optionally deuterium substitution of amino acid 1; and (2) deuterium substitution at key sites of metabolism of the cyclosporine A molecule such as amino acids 1, 4, 9. Also disclosed are methods of producing the cyclosporine derivatives and method of producing immunosuppression with reduced toxicity with the disclosed cyclosporine derivatives. | 07-07-2011 |
20120214745 | Deuterated Cyclosporine Analogs and Methods of Making the Same - Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporin and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) Chemical substitution and optionally deuterium substitution of amino acid 1; and (2) deuterium substitution at key sites of metabolism of the cyclosporine A molecule such as amino acids 1, 4, 9. Also disclosed are methods of producing the cyclosporine derivatives and method of producing immunosuppression with reduced toxicity with the disclosed cyclosporine derivatives. | 08-23-2012 |
20130078280 | CYCLOSPORINE ANALOGUE MIXTURES AND THEIR USE AS IMMUNOMODULATING AGENTS - The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISA | 03-28-2013 |
20140142277 | CYCLOSPORINE ANALOGUE MIXTURES AND THEIR USE AS IMMUNOMODULATING AGENTS - The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISA | 05-22-2014 |
20140235819 | Deuterated Cyclosporine Analogs and Methods of Making the Same - Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) Chemical substitution and optionally deuterium substitution of amino acid 1; and (2) deuterium substitution at key sites of metabo-lism of the cyclosporine A molecule such as amino acids 1, 4, 9. Also disclosed are methods of producing the cyclosporine derivatives and methods of producing immunosuppression with reduced toxicity using the disclosed cyclosporine derivatives. | 08-21-2014 |
20140249092 | CYCLOSPORIN ANALOG FORMULATIONS - The present disclosure relates to formulations containing cyclosporin analogs that are structurally similar to cyclosporin A, in particular isomeric mixtures of cyclosporin analogs that are structurally similar to cyclosporin A. The formulations form stable microemulsion preconcentrates and may provide superior drug bioavailability and/or may reduce one or more adverse effects associated with the administration of cyclosporin. Also disclosed are methods for using and preparing the formulations. | 09-04-2014 |
20140288266 | Synthesis of Cyclosporin Analogs - The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISA | 09-25-2014 |
20140370082 | CYCLOSPORINE ANALOGUE MIXTURES AND THEIR USE AS IMMUNOMODULATING AGENTS - The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISA | 12-18-2014 |