Fogh
Jens Fogh, Lynge DK
Patent application number | Description | Published |
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20120308549 | PROCESS FOR PRODUCTION AND PURIFICATION OF RECOMBINANT LYSOSOMAL ALPHA-MANNOSIDASE - The present invention relates to a process for purification of recombinant alpha-mannosidase, a process for production of alpha-mannosidase, a composition comprising alpha-mannosidase, use of the composition as a medicament, use as a medicament for the treatment of alpha-mannosidosis and a method of treating alpha-mannosidosis and/or alleviating the symptoms of alpha-mannosidosis. | 12-06-2012 |
20140072548 | PRODUCTION AND PURIFICATION OF RECOMBINANT ARYLSULFTASE - The present invention pertains to a process for production of recombinant arylsulfatase A in a cell culture system, the process comprising culturing a mammalian cell capable of producing rASA in liquid medium in a system comprising one or more bio-reactors; and concentrating, purifying and formulating the rASA by a purification process comprising one or more steps of chromatography. Other aspects of the invention provides a pharmaceutical composition comprising rASA, which is efficiently endocytosed via the mannose-6-phosphate receptor pathway in vivo as well as a rhASA a medicament and use of a rhASA for the manufacture of a medicament for reducing the galactosyl sulphatide levels within target cells in the peripheral nervous system and/or within the central nervous system in a subject. A final aspect of the invention provides a method of treating a subject in need thereof, said method comprising administering to said subject a pharmaceutical composition comprising a rhASA and thereby obtaining a reduction in the galactosyl sulphatide levels in target cells within said subject. | 03-13-2014 |
Rune Fogh, Copenhague DK
Patent application number | Description | Published |
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20140132555 | METHOD FOR MAKING SECURE A CONTROL ON A VISUALIZATION DEVICE WITH A TACTILE SURFACE, AND ASSOCIATED SYSTEM - The general field of the invention is that of methods providing a secure control for an appliance by means of a visualization device having a tactile surface capable of detecting several simultaneous touches. The method according to the invention comprises: | 05-15-2014 |
Thomas M. Fogh, Stanford, KY US
Patent application number | Description | Published |
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20100252535 | Contact tip for an electrode of a resistance welder - A contact tip used with the electrode of a resistance welder. The contact tip includes a bore that has an insert of blended tungsten and copper inserted therein. Prior to insertion of the insert into the bore, the bore is lined with a composition containing silver. A brazing process can be utilized to enhance attachment of the insert to the contact tip. | 10-07-2010 |
20100252536 | Contact tip for an electrode of a resistance welder - A contact tip used with the electrode of a resistance welder. The contact tip includes a bore that has an insert of blended tungsten and copper inserted therein. Prior to insertion of the insert into the bore, the bore is lined with a composition containing silver. A brazing process can be utilized to enhance attachment of the insert to the contact tip. | 10-07-2010 |