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Flores, PA

Broc A. Flores, Ardmore, PA US

Patent application numberDescriptionPublished
201103194097-AZA-QUINAZOLINE PDE10 INHIBITORS - The present invention is directed to 7-aza-quinazoline compounds of general structural formula I12-29-2011

Christopher Flores, Lansdale, PA US

Patent application numberDescriptionPublished
20080287398COLD MENTHOL RECEPTOR-1 ANTAGONISTS - The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.11-20-2008

Patent applications by Christopher Flores, Lansdale, PA US

Christopher M. Flores, Spring House, PA US

Patent application numberDescriptionPublished
20090264474SULFONAMIDES AS TRPM8 MODULATORS - Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:10-22-2009
20100048589Cold Menthol Receptor Antagonists - Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:02-25-2010
20100048619Cold Menthol Receptor Antagonists - Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows:02-25-2010

Christopher M. Flores, Lansdale, PA US

Patent application numberDescriptionPublished
20080234347METHOD FOR TREATING CB2 RECEPTOR MEDIATED PAIN - The present invention is directed to a method for treating, ameliorating or preventing CB2 receptor mediated pain in a subject in need thereof comprising administering to the subject an effective amount of a compound of formula (I):09-25-2008
20090165151CANINE TRANSIENT RECEPTOR POTENTIAL V2 (CTRPV2) AND METHODS OF SCREENING FOR TRPV2 CHANNEL MODULATORS - A recombinant canine TRPV2 channel which has been prepared by cDNA cloning and polymerase chain reaction techniques is disclosed. Expression systems for these channels and an assay using the expression systems are also disclosed. The recombinant TRPV2 channel can be used in assays to evaluate compounds which directly or indirectly interact with or bind to TRPV2 channel.06-25-2009
20090215850METHOD FOR TREATING CB2 RECEPTOR MEDIATED PAIN - The present invention is directed to a method for treating, ameliorating or preventing CB2 receptor mediated pain in a subject in need thereof comprising administering to the subject an effective amount of a compound of formula (I):08-27-2009
20090275649Compositions And Methods For Identifying Modulars Of TRPV2 - It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.11-05-2009
20110178274CANINE TRANSIENT RECEPTOR POTENTIAL V2 (CTRPV2) AND METHODS OF SCREENING FOR TRPV2 CHANNEL MODULATORS - A recombinant canine TRPV2 channel which has been prepared by cDNA cloning and polymerase chain reaction techniques is disclosed. Expression systems for these channels and an assay using the expression systems are also disclosed. The recombinant TRPV2 channel can be used in assays to evaluate compounds which directly or indirectly interact with or bind to TRPV2 channel.07-21-2011
20110319400PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN - Disclosed are compounds, compositions and methods for treating pain, including inflammatory, visceral, and acute pain. Such compounds are represented by Formula (I) as follows:12-29-2011
20110319418PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN - Disclosed are compounds, compositions and methods for treating pain, including inflammatory, visceral, and acute pain. Such compounds are represented by Formula (I) as follows:12-29-2011

Patent applications by Christopher M. Flores, Lansdale, PA US

Osvaldo A. Flores, North Wales, PA US

Patent application numberDescriptionPublished
20110250628Hcv replicons containing ns5b from genotype 2b - The present invention features methods for enhancing the ability of a genotype 2b NS5B sequence to function in a replicon, for producing replicons containing a functional genotype 2b NS5B, and for using replicons to measure the ability of a compound to affect HCV replication that is sustained with the genotype 2b polymerase. Also featured is a genotype 1b NS4B adaptive mutation. The ability to produce replicons containing a functional genotype 2b NS5B is illustrated by the production of chimeric replicons based on HCV genotype 1b where substantially all the NS5B sequence is replaced with a genotype 2b NS5B.10-13-2011