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Flockhart
David Flockhart, Indianapolis, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20120088247 | MATERIALS AND METHODS FOR TREATING PATIENTS WITH TAXOXIFEN - A pathway for the metabolism of tamoxifen is identified including the activity of at least 2 different isoforms of UGY2B7. This pathway includes isozymes of CYP3A which convert tamoxifen (TAM) to N-desmethyl-TAM, which is then converted to endoxifen by the action of CYP2D6. Once formed, endoxifen may be degraded by at least one isozyme of UGT2B7. Patients that have highly active isoforms of CYP2D6 and slow acting isoforms of UGT2B7 accumulate high levels of endoxifen and are good candidates for treatment with tamoxifen. Also disclosed are methods for screening patients with a high likelihood of benefiting from treatment with tamoxifen. These methods include testing patients for various alleles of genes known to be involved in tamoxifen metabolism and treating patients accordingly. | 04-12-2012 |
David A. Flockhart, Indianapolis, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20110111510 | METHODS TO EVALUATE CYTOCHROME P450 2C19 ISOENZYME ACTIVITY USING A BREATH TEST - The present invention relates, generally to a method of determining and assessing cytochrome P450 2C19-related (CYP2C19) metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of | 05-12-2011 |
Gordon M.h. Flockhart, Glasgow GB
| Patent application number | Description | Published |
|---|---|---|
| 20100271623 | Method and Apparatus for Characterizing a Multilayered Structure - An apparatus and method for characterizing the complex coupling coefficient of a multilayered periodic structure either during or after inscription is described. This apparatus is capable of continuously measuring the complex reflectivity at single or multiple wavelengths to a resolution limited by Rayleigh scattering in the waveguide section where the structure is inscribed. The apparatus is also capable of rejecting undesired signals associated with stray reflections in the system and unwanted environmentally induced change in optical path lengths during the inscription procedure. The complex coupling coefficient of the multilayered periodic structure can be derived from the measured complex reflectivity and can reveal errors present in the structure. The complex coupling coefficient can also be used to derive an error signal to enable implementation of a closed loop inscription system capable of inscribing error free multilayer structures. | 10-28-2010 |
Gordon M.h. Flockhart, Kirkintilloch GB
| Patent application number | Description | Published |
|---|---|---|
| 20090102474 | FIBER LASER MAGNETIC FIELD SENSOR - The device includes two supports and a primary conductive strip. The primary conductive strip includes a neutral surface, a first side, and a second side. The primary conductive strip is connected one of directly and indirectly on the first side to the two supports such that the primary conductive strip is constrained in two dimensions and movable in one dimension. The device also includes a primary distributed feedback fiber laser. The primary distributed feedback fiber laser includes a fiber axis. The primary distributed feedback fiber laser is connected to the primary conductive strip along one of the first side and the second side such that there is a positive distance between the neutral surface of the primary conductive strip and the fiber axis of the primary distributed feedback fiber laser. | 04-23-2009 |
Ian Flockhart, Woodmansey GB
| Patent application number | Description | Published |
|---|---|---|
| 20100168448 | Methods of Preparing Cannabinoids From Plant Material - The invention relates to methods of preparing cannabinoids in substantially pure form starting from plant material. Also described are substantially pure preparations of various cannabinoids and cannabinoid acids, and also extracts enriched in cannabinoids and cannabinoid acids. | 07-01-2010 |