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Fleming, MA
Alison Fleming, Attleboro, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080199530 | ABUSE-DETERRENT PHARMACEUTICAL COMPOSITIONS OF OPIOIDS AND OTHER DRUGS - An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, a drug is modified to increase its lipophilicity. In preferred embodiments the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and preferably organic solvent insoluble, but enzymatically degradable by enzymes present in the human gastrointestinal tract. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion. | 08-21-2008 |
Alison B. Fleming, Attleboro, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080260819 | SUSTAINED RELEASE COMPOSITIONS OF DRUGS - A sustained release pharmaceutical composition has been developed. The composition resists dose dumping when broken, crushed or chewed, which enhances the safety of the dosage form should it be accidentally or intentionally physically compromised. In the preferred embodiment, a drug is modified to increase its lipophilicity. In preferred embodiments the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles coated with one or more coating layers. The sustained release composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chewing or crushing) and the resulting material is placed in 0.1N HCl. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of diffusion, surfactant action of bile acids, mechanical erosion, and in some embodiments, enzymatic degradation. | 10-23-2008 |
| 20090297617 | ABUSE-DETERRENT PHARMACEUTICAL COMPOSITIONS OF OPIOIDS AND OTHER DRUGS - An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. In a preferred embodiment, a drug is modified to increase its lipophilicity. In some embodiments the modified drug is homogeneously dispersed within spherical microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and/or organic solvent insoluble. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract. | 12-03-2009 |
Alison B. Fleming, North Attleboro, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110142943 | TAMPER-RESISTANT PHARMACEUTICAL COMPOSITIONS OF OPIODS AND OTHER DRUGS - Tamper-resistant pharmaceutical compositions have been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. The tamper-resistant compositions retard the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract. | 06-16-2011 |
Alison B. Fleming, Mansfield, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100260834 | ABUSE-DETERRENT DRUG FORMULATIONS - An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, the drug is modified to increase its lipophilicity by forming a salt between the drug and one or more fatty acids wherein the concentration of the one or more fatty acids is one to 15 times the molar amount of the active agent, preferably two to ten times the molar amount of the active agent. In one embodiment the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and preferably organic solvent insoluble. The abuse-deterrent composition prevents the immediate release of a substantial portion of drag, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion. | 10-14-2010 |
Christine Fleming, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110292400 | APPARATUS, SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM FOR SPECTRAL ANALYSIS OF OPTICAL COHERENCE TOMOGRAPHY IMAGES - According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for generating information for at least one structure. For example, using at least one first arrangement, it is possible to receive at least one first radiation from the at least one structure and at least one second radiation from a reference, and interfere the first and second radiations to generate at least one third radiation. Further, with at least one second arrangement, it is possible to generate spectroscopic data as a function of the at least one third radiation, and reduce at least one scattering effect in the spectroscopic data to generate the information. In addition or as an alternative, according to a further exemplary embodiment of the present disclosure, it is possible to classify a type of the structure based on the spectroscopic data to generate the information. | 12-01-2011 |
Mark Fleming, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090036654 | Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof - The present invention relates to human Rho-kinase I (ROCK I), ROCK I binding pockets, ROCK I-like binding pockets. More particularly, the present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ROCK I protein or ROCK I protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising ROCK I kinase domain and ROCK I kinase domain complexed with an inhibitor of that domain. The invention also relates to methods of identifying inhibitors of the ROCK I kinase domain. | 02-05-2009 |
Paul E. Fleming, Weston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110245203 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID - The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases. | 10-06-2011 |
Paul E. Fleming, Wellesley, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100081633 | Derivatives of 1-amino-2-cyclobutylethylboronic acid - The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases. | 04-01-2010 |
| 20100093713 | BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE - This invention provides beta-carboline compounds of formula | 04-15-2010 |
| 20110071134 | 2-(AMINO-SUBSTITUTED)-4-ARYL PYRIMIDINES AND RELATED COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES - A heterocyclic inhibitor having the formula I, with the variables defined herein, which is useful for treating inflammatory and other physiological disorders in which PKC-theta isoform plays a role: | 03-24-2011 |
Paul J. Fleming, Needham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090276370 | COMPUTER SYSTEM ARCHITECTURE AND COMPUTER IMPLEMENTED METHODS FOR ENHANCED CUSTODY AND PRINCIPAL LENDING OF SECURITIES - A computer system executes a principal lending to lend the securities from lending accounts of an entity to borrowing accounts of the entity, in which the entity acts as a principal. The system includes a computer database storing securities availability information indicating availability of the securities available for borrowing from lending accounts of the entity, and a computer server system implemented by a principal lending computer system. The principal lending computer system configured to receive a short sale indication of a security for a borrowing account, electronically transmit a first transfer instruction to a custody-control computer system to transfer custody of the shorted security from at least one lending account to the principal, and electronically transmit a second transfer instruction to the custody-control computer system to transfer custody of the shorted security from the principal to the borrowing account. A computer implemented method and various alternative embodiments are also disclosed. | 11-05-2009 |
| 20100274703 | COMPUTER SYSTEM ARCHITECTURE AND COMPUTER IMPLEMENTED METHODS FOR DOMESTIC AND INTERNATIONAL ENHANCED CUSTODY AND PRINCIPAL LENDING OF SECURITIES - A computer system executes a principal lending transaction to lend international securities from lending accounts of a global entity to borrowing accounts of the entity, in which the entity acts as a principal. The system includes a computer database storing securities availability information indicating availability of the international securities available for borrowing from lending accounts of the global entity, and a computer server system implemented by a principal lending computer system. The principal lending computer system configured to receive a short sale indication of a security for a borrowing account, electronically generate a transfer instruction to a custody-control computer system to transfer custody of the international shorted security from at least one lending account to the borrowing account of the same global entity as the global entity of the at least one lending account, electronically transmit the transfer instruction, and electronically transmit a second transfer instruction to the custody-control computer system to transfer custody of the shorted security from the principal to the borrowing account. A computer implemented method and various alternative embodiments are also disclosed. | 10-28-2010 |
Paul Robert Fleming, Waltham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100179150 | ANTIBACTERIAL PIPERDINE DERIVATIVES - Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. | 07-15-2010 |
Robert Fleming, Lynnfield, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090216532 | Automatic Extraction and Dissemination of Audio Impression - A method of creating a voice message is described. A dictated audio input is converted by automatic speech recognition to produce a structured text report that includes report fields with report field data extracted from the dictated audio input. A report message is created for transmission over an electronic communication system to a message recipient. The report message has message fields with message field data based on corresponding report field data. A message audio extract is automatically extracted from a portion of the dictated audio input and attached to the report message. And the report message with the message audio extract attachment is forwarded over the electronic communication system to the message recipient | 08-27-2009 |
Tony Fleming, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100233177 | MOLECULES AND METHODS FOR MODULATING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) - Epitopes of Proprotein convertase subtilisin/kexin type 9 (PCSK9), compositions that bind to PCSK9 and PCSK9 epitopes, and methods of using the compositions are described herein. | 09-16-2010 |
Tony J. Fleming, Waltham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100144058 | B-LYMPHOCYTE STIMULATOR BINDING POLYPEPTIDES AND METHODS BASED THEREON - Binding polypeptides that specifically bind B lymphocyte stimulator protein or B lymphocyte stimulator-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate function of B lymphocyte stimulator or B lymphocyte stimulator receptor, comprising B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate B lymphocyte stimulator function or B lymphocyte stimulator receptor function, comprising administering to an animal, preferably a human, an effective amount of one or more B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator. | 06-10-2010 |