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Fitzgerald, Cambridge
James Fitzgerald, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20110021943 | NEURAL INTERFACE - This invention relates to the neural interface comprising one or more electrode-coupled microchannels. Each electrode-coupled microchannel comprises a microchannel for accommodating regenerating nerve axons; and one or more electrodes exposed to the interior of said microchannel. The one or more electrodes may comprise (i) a stimulation array suitable for generating an extracellular stimulus current which induces an action potential in an axon in the microchannel; and/or (ii) a recording array which detects an extracellular signal in the microchannel indicative of an action potential in an axon in the microchannel. Interfaces as described may be useful in blocking pain, treating misrouted motor nerves; repair or treating nerve injury; or controlling or providing sensation and/or proprioception from a prosthesis. | 01-27-2011 |
John B. Fitzgerald, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20090108210 | NEUTRON LOGGING TOOL HAVING SOURCE AND TARGET WITH DEUTERIUM-TRITIUM GAS ADMIXTURE - An accelerator-based neutron tool is provided. The tool includes a deuterium-tritium gas mixture such that the tool outputs a desired ratio of 2.45 MeV and 14 MeV neutrons. | 04-30-2009 |
John Barry Fitzgerald, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20090026359 | METHOD TO SIMULTANEOUSLY DETERMINE PORE HYDROCARBON DENSITY AND WATER SATURATION FROM PULSED NEUTRON MEASURMENTS - A method comprising using inelastic and capture gamma-ray count rates from two detectors in a borehole logging tool and determining formation water saturation. In this method the formation water saturation is determined without prior knowledge of the carbon density in the pore hydrocarbons. | 01-29-2009 |
Jonathan Basil Fitzgerald, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110027291 | METHODS, SYSTEMS AND PRODUCTS FOR PREDICTING RESPONSE OF TUMOR CELLS TO A THERAPEUTIC AGENT AND TREATING A PATIENT ACCORDING TO THE PREDICTED RESPONSE - The invention provides methods for treating patients which methods comprise methods for predicting responses of cells, such as tumor cells, to treatment with therapeutic agents. These methods involve measuring, in a sample of the cells, levels of one or more components of a cellular network and then computing a Network Activation State (NAS) or a Network Inhibition State (NIS) for the cells using a computational model of the cellular network. The response of the cells to treatment is then predicted based on the NAS or NIS value that has been computed. The invention also comprises predictive methods for cellular responsiveness in which computation of a NAS or NIS value for the cells (e.g., tumor cells) is combined with use of a statistical classification algorithm. Biomarkers for predicting responsiveness to treatment with a therapeutic agent that targets a component within the ErbB signaling pathway are also provided. | 02-03-2011 |
| 20110125468 | USING RESPONSE SURFACES FOR SCREENING INHIBITOR COMBINATIONS AND DIGITAL PROCESSING METHODS - A method for selecting a combination of therapeutic agents can include: providing a response surface having data that relates network activation states of a downstream component of a biological network with activation states of at least two upstream components of the network; identifying a desired network activation state of the downstream component from the response surface; identifying the corresponding activation states of the upstream components and identifying at least two therapeutic agents that modulate the upstream components and that are capable of obtaining the desired network activation state. The response surface can be visual or virtual. Optionally, the desired network activation state is an optimal network activation state. | 05-26-2011 |
Rebecca C. Fitzgerald, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20090286237 | Diagnostic Kits and Methods for Oesophageal Abnormalities - The invention relates to kits and methods for aiding the diagnosis of Barrett's oesophagus or Barrett's associated dysplasia. Preferred is a method comprising assaying cells from the surface of a subject's oesophagus for a non-squamous cellular marker, wherein detection of such a marker indicates increased likelihood of the presence of Barrett's or Barrett's associated dysplasia, preferably wherein said sample of cells is not directed to a particular site within the oesophagus. The invention also encompasses a method comprising sampling the cellular surface of the oesophagus of said subject. The invention also relates to a kit comprising a swallowable device comprising abrasive material capable of collecting cells from the surface of the oesophagus, together with printed instructions for its use in detection of Barrett's oesophagus or Barrett's associated dysplasia. Preferably said device comprises a capsule sponge. | 11-19-2009 |
Shaun D. Fitzgerald, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20080254730 | Passive Ventilation Stack - A passive ventilation stack for a room, building or the like comprises an interior space and first and second openings providing fluid communication between the interior space and a room to be ventilated, and the outside atmosphere. A control system is provided for varying the size of the openings, so as to cause natural heat exchange between relatively cool ventilation air entering the stack from outside and relatively warm air entering the stack from a room or building to be ventilated. | 10-16-2008 |
Stephen Fitzgerald, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20080226640 | C1q Related Protein - This invention relates to a novel protein, termed INSP162, herein identified as a secreted protein containing c1q and collagen domains and to the use of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease. | 09-18-2008 |
Stephen Noel Fitzgerald, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20080213286 | Mam Domain Containing Protein - This invention relates to a novel protein, termed INSP152, herein identified as a secreted protein, in particular, as a MAM domain containing protein and to the use of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment. | 09-04-2008 |