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Fisher, PA

Andrew Fisher, Pittsburgh, PA US

Patent application numberDescriptionPublished
20100158815Biological Cell Tracking With Ultrasound - This invention addresses the clinical problem of how to optimize biological cell based therapies, such as stem cell therapy. Currently, cell therapies administered by intravenous, intra-arterial, and/or direct tissue injection are limited by the lack of clinically available imaging methods to detect the in vivo fate of the administered cells. There are many efforts underway to develop imaging strategies for stem cells in vivo, including radionuclide and MRI-based approaches. However, these approaches are limited by potential safety issues (e.g. radioactive exposure of stem cells, toxicity of iron particles used for MRI) and difficulty in serial tracking due to complex instrumentation and/or the requirement for repetitive radiation exposure.06-24-2010
20110208113Directed Cell-Based Therapy Using Microbubble Tagged Cells - The disclosed technology describes compositions and methods useful for providing cell based therapy. For example, one embodiment of cell based therapy involves the regeneration of injured tissue and/or promoting wound healing. Certain embodiments provide improved therapeutic compositions using microbubbles by delivering biological progenitor cells to the injured tissues. The administration of the microbubbles is directed by acoustic radiation forces that interact with embodiments of microbubbles comprising an acoustically active gas. As such, a high efficiency of progenitor cell delivery to injured tissue is realized. One advantage of this technique over targeted delivery of pharmaceutical compounds, is that the delivered progenitors cells may be derived from the patient (i.e., personalized therapy), thereby avoiding side effects, allergic reactions, and overall problems associated with refractive drug responses.08-25-2011

Brian Fisher, Greenville, PA US

Patent application numberDescriptionPublished
20090165267Clip for transportation of ladders and method - A clip for maintaining a first side rail of a first ladder adjacent to a second side rail of a second ladder which is in series with the first side rail. The clip includes a first portion connected to a support element and a second portion connected to the support element. The first portion, second portion and support element are one continuous piece. The first portion defines a hooking engagement with the first side rail and the second portion defines a receiving engagement with the second side rail. The first and second portion opening from opposite sides of the support element, respectively, which conform to the portion of the respective side rail that it receives for removably and frictionally holding the respective side rails in a self-gripping and form-fitting manner such that the side rails are maintained adjacent and in series to each other so that no damage is possible to the ladders by relative movement of the side rails under dynamic conditions brought about by motion during transportation. A method for securely transporting a first ladder which defines a first plane for climbing and at least a second ladder which defines a second plane for climbing.07-02-2009

Dusti Fisher, Pennsburg, PA US

Patent application numberDescriptionPublished
20100129318CYNOMOLGUS IL-13 MUTEIN PROTEINS, ANTIBODIES, COMPOSITIONS, METHODS AND USES - The present invention relates to at least one novel cynomolgus IL-13 muteins (Mut-IL-13) proteins, antibodies, including isolated nucleic acids that encode at least one Mut-IL-13 protein or antibody, Mut-IL-13 vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.05-27-2010

Edward T. Fisher, East Norriton, PA US

Patent application numberDescriptionPublished
20100132813VALVE LEAKBY DIAGNOSTICS - A method is disclosed for determining leakby in a flow controller (06-03-2010

Gail A. Fisher, North Catasauqua, PA US

Patent application numberDescriptionPublished
20110195163MCC/Hydrocolloid Stabilizers and Edible Compositions Comprising the Same - Stabilizers comprising co-processed MCC and a hydrocolloid, edible compositions comprising the stabilizers, and processes for making the edible compositions are described. Edible compositions may be prepared from a stabilizer comprising MCC and a hydrocolloid, along with a protein source and/or juice. Compositions of the invention may include low pH beverages comprising the MCC stabilizer, a protein source and/or a fruit or vegetable juice or other fruit-flavored liquid, optionally with an additional amount of hydrocolloid and acidulant, sweetener, buffering agents, pH modifiers, or stabilizing salts.08-11-2011

Gary Fisher, Huntingdon Valley, PA US

Patent application numberDescriptionPublished
20120072054SYSTEM AND METHOD FOR PRODUCING MADE-TO-ORDER DESIGNS ON THE SURFACE OF AN EXTRATERRESTRIAL BODY - A method for producing designs involves receiving a request to create a design on the surface of an extraterrestrial body, transmitting a control signal to a device on a vehicle on the extraterrestrial body, the control signal causing the device to create the design, and receiving an image signal providing an image of the design created on the surface. A device for producing the designs includes a surface altering tool configured to rearrange material on the surface. The tool may be provided as a configurable-tread rover wheel that includes a wheel hub having radially-extending channels, and tread elements supported in the channels that are selectively articulatable under the control of a control module to form a tread pattern corresponding to a design intended to be produced. The tread elements may be selectively extended or retracted by operation of an array of solenoids controlled by the control module.03-22-2012

Gary Fisher, Huntington Valley, PA US

Patent application numberDescriptionPublished
20080284289SPACE-SUIT MATABLE ENCLOSURE PROVIDING WORKSPACE FOR ASTRONAUTS - An enclosure providing a workspace for astronauts, deep-sea divers, etc. wearing pressurized suits includes a housing providing a substantially-closed chamber, a port providing access to the chamber, and a connector circumscribing the port. The enclosure's connector is configured to mate with, and form an airtight seal with, a complementary connector of the suit to close the chamber. A pressure control system may be provided to pressurize and depressurize the chamber. After connecting the enclosure to the suit, the closed chamber may be pressurized to balance pressures internal and external to the suit to facilitate manual operations. Any mated connectors of suit portions internal to the enclosure may be decoupled to expose a human limb, etc., and yet the pressure in the chamber may be maintained. The suit may include a limb-engaging seal resisting intermixing of chamber gases with suit gases while matable connectors of the suit are decoupled.11-20-2008

Jody Fisher, Yardley, PA US

Patent application numberDescriptionPublished
20110225009SYSTEM AND METHOD FOR PROVIDING GEOGRAPHIC PRESCRIPTION DATA - A system for providing geographic prescription data includes an input device, a presentation device, at least one database for storing electronic claims data and a computing platform in communication with the input device, the presentation device, and the at least one database. The input device receives user selections for at least one a portion of a region, a pharmaceutical, a category of pharmaceuticals, and a group of patients. The presentation device presents a report to the user comparing information about the selected portion of the region to another portion of the region. The computing platform receives a persons of interest list, correlates the stored electronic claims data with the persons of interest list such that all electronic claims data related to a person on the persons of interest list are correlated to the person, and provides the report for the selected portion of the region and the selected group of patients based on the correlation of the stored electronic claims data with the persons of interest list. The report includes prescriptions for the selected pharmaceutical, a comparison of the prescriptions for the selected pharmaceutical to the prescriptions for the same selected pharmaceutical for the other portion of the region, and a projected change in the prescriptions for the selected pharmaceutical based on at least one of a change in the patients prescribed the selected pharmaceutical and a change in the prescriptions per patients prescribed the selected pharmaceutical.09-15-2011

John E. Fisher, Swarthmore, PA US

Patent application numberDescriptionPublished
20090301902PROCESS FOR PRODUCING NANOPOROUS CARBIDE-DERIVED CARBON WITH INCREASED GAS STORAGE CAPABILITY - Methods for producing and using nanoporous carbide-derived carbon in applications involving gas storage are provided.12-10-2009

Judith L. Fisher, Pittsburgh, PA US

Patent application numberDescriptionPublished
20080202098Exhaust Gas Purifying Method and Purifier - An exhaust gas purification system (08-28-2008
20100168890Three-Dimensional Data Extraction Using Ray Casting - Methods are provided for solid free-form fabrication of an article without using a slice stack file. These apply ray casting a number of times to an electronic representation of the article to create data objects for use directly as printing instructions or which are convertible into printing instructions. The data objects may be utilized as they is generated or after they are created for a portion or all of the article. After utilization, the data objects may be discarded or stored for later use. Layer-specific layer thickness and other-direction resolution parameters may be input and utilized in selecting the number of rays to be cast, their origination points, and their directions, thus permitting controllable variation in detail precision in any direction. Error diffusion techniques may be used to improve fabricated part integrity. Improved intermachine portability is provided. Method, system, code, and media claims are included.07-01-2010

Patent applications by Judith L. Fisher, Pittsburgh, PA US

Levi S. Fisher, Bird-In-Hand, PA US

Patent application numberDescriptionPublished
20100000161Snow Guard and Method of Attaching the Same - A snow guard and a method of attaching a snow guard to a seam of a metal roof wherein the snow guard includes a base having a first side wall, a second side wall, and a top wall that define a seam receiving channel. The first side wall is provided with at least one opening. The second side wall has at least one fixed projection extending from the second side wall into the seam receiving channel and toward the opening. At least one moveable fastener extends through the opening into the seam receiving channel and toward the projection, and a blade is attached to a base receiving end of the base.01-07-2010

Lonnie L. Fisher, Hallstead, PA US

Patent application numberDescriptionPublished
20090257722Plural fiber optic interconnect - A fiber optic connector for connecting a plurality of optical fibers comprising a plurality of fiber optic assemblies, each assembly including at least one optical fiber coupled to a ferrule, the ferrule being coupled to a spring. A connector housing is configured to support the plurality of optical fibers. The connector housing includes first and second mating connector portions. A plurality of channels support each of the plurality of fiber optic assemblies, respectfully, disposed between the first and second mating connector portions. A plurality of apertures are formed in at least one of end the housing. The plurality of fiber optic assemblies are supported between the first mating connector portion and the second mating connector portion by the channels such that the springs are disposed between the first and second mating connector portions and the ferrules of the plurality of fiber optic assemblies extend through the apertures at the one end of the connector housing in a spring loaded fashion.10-15-2009

Orin B. Fisher, Butler, PA US

Patent application numberDescriptionPublished
20090043231Electromagnetic device, method and apparatus for selective application to vertebrates - A multifunction device for selective application to the body of a vertebrate is disclosed. The device includes an electromagnetic generator supported by an bobbin like member which has a bore therethrough for reciprocally receiving an elongated magnetizable member. A permanent magnet is disposed near one end of the bore. The magnetic poles of the permanent magnet are arranged to magnetically attract the elongated magnetizable member. When energized, the electromagnetic generator produces a magnetic field magnetically polarizing the elongated magnetizable member establishing a repelling magnetic force with the permanent magnet which is additive to the electromagnetic force caused by the electromagnetic generator moving the elongated magnetizable member away from the permanent magnet.02-12-2009

Rick Fisher, Langhorne, PA US

Patent application numberDescriptionPublished
20120130242SYSTEMS AND METHODS FOR CONCURRENTLY DISPLAYING A PLURALITY OF IMAGES USING AN INTRAVASCULAR ULTRASOUND IMAGING SYSTEM - An intravascular ultrasound imaging system includes an imaging core insertable into a catheter lumen. The imaging core includes at least one transducer disposed at a distal end of a driveshaft. The at least one transducer transmits acoustic signals and transforms received echo signals to electrical signals. The at least one transducer rotates about a longitudinal axis of the catheter and moves longitudinally along a patient blood vessel as the at least one transducer transmits the acoustic signals. A control module is coupled to the imaging core. The control module includes a processor that processes received electrical signals from the at least one transducer. The processor uses the received electrical signals to generate a plurality of cross-sectional images captured along least a portion of the patient blood vessel. A display coupled to the processor concurrently displays at least two of the plurality of cross-sectional images.05-24-2012

Seth Fisher, Harrisburg, PA US

Patent application numberDescriptionPublished
20100009577BALLAST MOUNTED CONNECTOR RECEPTACLE - A connector, method of connecting, and connector assembly preventing potting from disrupting the physical and electrical connection of a mated electrical connector assembly that can be connected and/or disconnected without cutting wires and with a single hand.01-14-2010

Steven M. Fisher, West Chester, PA US

Patent application numberDescriptionPublished
20090273796PEELING IMAGED MEDIA FROM A SUBSTRATE - A method for imaging a media is provided which includes supporting a substrate and the media in a layered configuration. An imaging head is operated to image the media by directing radiation beams towards a surface of the imaged media while effecting relative movement between the imaging head and the support. A roller is brought into contact with the imaged media. The roller can be brought into contact with an un-imaged region of the surface of the imaged media, the un-imaged region corresponding to a region of the surface of the imaged media that is not impinged by the radiation beams. The un-imaged region could be an edge portion of the media. Relative movement is effected between an axis of rotation of the roller and the support to cause the roller to roll on the regions of the surface of the imaged media impinged by the radiation beams.11-05-2009

Thorsten E. Fisher, Hatfield, PA US

Patent application numberDescriptionPublished
20080287394Hiv Integrase Inhibitors - Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I) wherein R11-20-2008
20100087419HIV INTEGRASE INHIBITORS - Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication:04-08-2010
20100216834HIV INTEGRASE INHIBITORS - Stereoisomers of compounds of Formula I are disclosed: wherein V08-26-2010

Patent applications by Thorsten E. Fisher, Hatfield, PA US

William T. Fisher, Schwentsville, PA US

Patent application numberDescriptionPublished
20090292276SYSTEM AND METHOD OF USE FOR AGENT DELIVERY AND REVASCULARIZING OF GRAFTS AND VESSELS - A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter.11-26-2009

William T. Fisher, Schwenksville, PA US

Patent application numberDescriptionPublished
20100145259THROMBECTOMY AND SOFT DEBRIS REMOVAL DEVICE - A device suitable for removing material from a living being is provided, featuring an infusate pump, and an aspiration pump, both powered by a motor. The aspiration pump and infusate pump preferably feature a helical pumping mechanism, and operate at a high rate of rotation, thereby ensuring adequate pumping performance and flexibility. Additionally, a narrow crossing profile is maintained, ensuring that the device may reach more tortuous regions of the vasculature. In one embodiment, the system comprises a wire-guided mono-rail catheter with a working head mounted on a flexible portion of the catheter that can laterally displace away from the guide wire to facilitate thrombus removal. The working head may be operated to separate and move away from the guide wire to come within a closer proximity of the obstructive material to more effectively remove it from the vessel.06-10-2010
20100152720OFFSET CATHETER - Various embodiments of an offset catheter are provided. In some embodiments, an offset catheter includes a guidewire tube and a catheter coupled with an elastic and/or compressible rib. The compressible rib provides an offset or separation between the catheter and the guidewire tube in its resting state. The rib has an initial resting state, but may be forced into a compressed state. When released from the compressed state, the rib returns to its resting state. An offset catheter may be compressed and slid through a sheath. When the offset catheter emerges from the sheath, the distal tip will return to its resting state providing an operation offset.06-17-2010
20100228152Catheter for conducting a procedure within a lumen, duct or organ of a living being - In an embodiment, the invention provides a catheter suitable for use in performing a procedure within a vessel, lumen or organ of a living having a distal end which is steerable, such as upon the application of compression. The catheter may be of the over the wire type, or alternatively may be a rapid exchange catheter. The catheter may provide for a rotating element which may be used to open a clogged vessel, or alternatively to provide information about adjacent tissues, such as may be generated by imaging or guiding arrangements using tissue detection systems known in the art, e.g., ultrasound, optical coherence reflectometry, etc. For rapid exchange catheters having a rotating element, there is provided an offset drive assembly to allow the rotary force to be directed from alongside the guidewire to a location coaxial to and over the guidewire.09-09-2010
20120129674CENTRIFUGE - A single use, sterile, self-contained, compact, easy to use centrifugal separation unit provides for quick, reliable platelet concentration from whole blood. Anti-coagulated blood is injected through an elastomeric seal into a separation chamber featuring a tapered barrel and an end cap. At least one port is located in the end cap, at a desired radius from the longitudinal axis. The centrifugal field created by rotation of the chamber stratifies the blood radially, with red blood cells adjacent the wall of the barrel, and plasma found closest to the longitudinal axis. Opening the port causes the pressure of the centrifugal field to eject red blood cells or plasma, thereby increasing the concentration of platelets remaining in the chamber. After ceasing chamber rotation, the concentrated platelets are recovered.05-24-2012
20120129675CENTRIFUGE - Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.05-24-2012

Patent applications by William T. Fisher, Schwenksville, PA US