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Fisher, MA
Carl Fisher, Watertown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110028384 | RAP VARIANTS FOR DRUG DELIVERY - The present invention relates to stabilized RAP variants and methods of use thereof. Conjugates of stabilized RAP variants to therapeutic compounds and stabilized RAP fusion proteins comprising therapeutic polypeptides are also presented. | 02-03-2011 |
David E. Fisher, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080213772 | USE OF MICROPHTHALMIA FOR DIAGNOSIS, PROGNOSIS AND/OR TREATMENT OF MELANOMA - Microphthalmia (Mi) while present in melanocytes, a cells and osteoclast, is not normally present in other cells. We have found that Mi is present in the nucleus of melanoma cells. Melanoma can be diagnosed by contacting a malignant cell with a probe for Mi. If the probe identities Mi in the nucleus of the cell, the cell is a melanoma. | 09-04-2008 |
| 20090176726 | METHODS FOR TREATING MITF-RELATED DISORDERS - Methods for treating melanoma and other MITF-related disorders by administering a compound that causes an increase in HIF-1 level or activity (e.g., by increasing the level of HIF-1I in a cell) within cells. Such methods include administration of a compound that is a hydroxylase inhibitor, e.g., a prolyl hydroxylase inhibitor that reduces hydroxylation of HIF-1I thereby causing an increase in HIF-1I in the cell. Such treatment can lead to a decrease in MITF activity or expression. | 07-09-2009 |
David W. Fisher, Woburn, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100203945 | Chance-board game method and system - A method and system for a chance-board-game with a board presentation and numerical matrix to define position and focus for chance game. The apparatus (G-Box) is a portable gaming device which includes an addressable touch screen with advanced networking, security and video graphics enabling a player to concurrently participate in multiple games of chance. Menu driven with an imbedded matrix processor, the device allows a player to actively or passively participate in multiple games, including CHINGO WORLD™ Games, Bingo, Keno, Roulette, Slot Machines and with an imbedded Alert and Notification Processor (ANP) that empowers a chance player to not only accurately play hundreds of game “cards” but also automatically monitor complex games and thus not miss any “wins” while complying with all game win notification requirements. The 6×6 matrix CHINGO game may be played using the apparatus (G-Box) for active or passive gaming or CHINGO games may be played using traditional manual cards and sheets of cards. The apparatus (G-Box) is designed to facilitate gaming within a gaming facility (Casino) or to participate in controlled open gaming through a standard cable and a national CHINGO gaming network. | 08-12-2010 |
Freeman Hendrickson Fisher, Charlestown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100128396 | LOCATING FEATURE FOR MOUNTING A COMPONENT TO A BASE - The present disclosure provides an apparatus for mounting an object to a base. In one example, the apparatus includes a base and a protuberant feature extending from the base. The protuberant feature includes a datum surface sized to matingly engage a corresponding surface of an object to precisely position the object with respect to the base. | 05-27-2010 |
Greg Fisher, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110017206 | APPARATUS AND METHODS FOR DIRECT INHALATION OF SCENTS AND MEDICINES - An intranasal tab may provide temporary, controlled and direct inhalation of scents and/or medicine into the nose, thereby increasing the overall effectiveness and velocity of impact that scents and/or medicine may have on the mind and/or body. The tabs may provide increased convenience, speed, comfort and effectiveness of mobile aromatherapy and medicinal therapy. The tabs may be substantially flat, triangular, and designed from various types of absorbent materials. The center of the tab may be comprised of highly absorbent material compared to the perimeter and external surfaces of the tab which remain relatively dry to the touch. The tabs are adapted to be inserted separately into either nostril of the nose without falling out. | 01-27-2011 |
Harvey Fisher, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090088845 | TITANIUM TANTALUM OXYGEN ALLOYS FOR IMPLANTABLE MEDICAL DEVICES - The present disclosure relates to alloys of titanium, tantalum, and oxygen that include from greater than 0 to about 60 weight % tantalum, from greater than or equal to about 0.10 weight % oxygen, and the balance titanium and other impurities. Also disclosed are methods of making such alloys. In addition, articles of manufacture including such alloys, such as biomedical implants, are disclosed. | 04-02-2009 |
| 20110233057 | HOMOGENEOUS TITANIUM TUNGSTEN ALLOYS PRODUCED BY POWDER METAL TECHNOLOGY - The present disclosure is related to homogeneous alloys comprising titanium and 9% to less than 20% by weight of tungsten, wherein the alloy has a yield strength of at least 120,000 psi and ductility of least 20% elongation; and with further alloying an ultimate tensile strength of at least 200,000 psi and useful ductility of at least 2% elongation; and with the addition of ceramic particulate reinforcements can exhibit an ultimate tensile strength of at least 180,000 psi. Products and metal matrix composites comprising such homogeneous alloys are also disclosed. The metal matrix composites further comprise a discontinuous reinforcement chosen from TiC, TiB | 09-29-2011 |
John S. Fisher, Medford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110210763 | COMMON-MODE INSENSITIVE SAMPLER - An approach to rejecting input common-mode voltage variations in a sampler/converter that avoids the use of a differential amplifier in the signal path, and without introducing added distortion or noise. In one embodiment, the input common-mode variations are sensed on a pair of matched resistors that straddle the common mode analog inputs, on a node ‘Vcmi’. An alternative, switched-capacitor-based sensing scheme is also possible. Using this measured Vcmi, adjustments are then made to the rest of the sampler/converter to take out any variations observed at Vcmi. | 09-01-2011 |
Jonathan Fisher, Dartmouth, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120032833 | RADAR COHERENT PROCESSING INTERVAL SCHEDULING VIA AD HOC NETWORK - Techniques disclosed herein include systems and methods for accurately scheduling radar and radio events against each other. Specifically, a scheduling manager can schedule radar events based on scheduled radio events (wireless network communication events). A given radio schedule for a compact radar sensor can be a relatively complicated schedule, especially when the compact radar sensor operates as part of an ad hoc network. In certain embodiments, the scheduling manager identifies a radio transmission schedule of neighboring radar nodes or compact radar sensor units. Such a radio transmission schedule of neighboring nodes can include information on when neighboring nodes will be receiving or transmitting data. The scheduling manager then schedules radar events to be executed by the radar device at available times, or at times that do not overlap with scheduled radio events. | 02-09-2012 |
Kirk L. Fisher, Groton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090142073 | METHOD AND APPARATUS FOR MAINTAINING A COHERENT COMBINED BEAM DURING ARBITRARY STEERING - A method and apparatus for accounting for phase differences in a transmit path of an optical system is provided. A transmit control system nullifies phase errors in signals propagating from a coherent source to phase samplers and back to a transmitter sensor. A small time-dependent length modulation is applied to a feed fiber of each aperture and this modulation enables a hill-climbing servo loop to increase, or in some cases even maximize, a detected intensity. This results in a particular relationship between the phases at all the phase-sampling points. The optical system is then calibrated so that this relationship corresponds to in-phase beams when the optical system is aimed at boresight. | 06-04-2009 |
Marc Fisher, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120070403 | USE OF G-CSF FOR THE EXTENSION OF THE THERAPEUTIC TIME-WINDOW OF THROMBOLYTIC STROKE THERAPY - The present invention relates to the use of G-CSF and derivatives thereof for extending the therapeutic window of subsequent thrombolytic treatment of acute stroke, and thereby, allowing the diagnostic examinations which are necessary prior to the thrombolytic treatment in order to avoid hemorrhagic and other severe adverse side effects of the thrombolysis. | 03-22-2012 |
Michael Alan Fisher, Middleborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080234758 | INTRA-FACET FIXATION DEVICE AND METHOD OF USE - A implantable interference device configured for intra-facet placement within a facet joint is provided. The device includes a shank capable of engaging opposing faces of the facet joint. The shank can further include a head extending from a proximal end of the shank wherein the head is configured to engage and/or buttress opposing faces of the joint, and also configured for preventing over-insertion of the device. Optionally, at least a portion of the shank can include or be formed of a fusion-promoting bioactive material. Further, a method for providing fixation of a facet joint by intra-facet placement of an interference device within the facet joint is provided. | 09-25-2008 |
| 20080255618 | ARTICULATING FACET FUSION SCREW - A spinal implant is provided having an elongate member with a longitudinal axis and threads extending over at least a portion of the outer surface thereof. The implant includes a stabilization feature associated with the elongate member that is selectively configurable between a delivery configuration and a deployed configuration in which the stabilization feature is oriented at an angle with respect to the longitudinal axis of the elongate member. Also, at least a portion of the implant can include a fusion-promoting bioactive material. In another aspect, the invention includes methods for providing stabilization within a facet joint by delivery of an articulating intra-facet screw. | 10-16-2008 |
| 20080255622 | FACET FIXATION AND FUSION SCREW AND WASHER ASSEMBLY AND METHOD OF USE - A spinal implant including a stabilization member coupled to an elongate member is herein provided. The implant can be configured for placement within a facet joint in an intra-facet or trans-facet configuration. Also, the implant can include a fusion-promoting bioactive material thereby providing a single device capable of spinal stabilization and/or fusion. Furthermore, a method of placing such an implant within a facet joint in an intra-facet or trans-facet orientation is hereby provided. | 10-16-2008 |
| 20080255666 | FACET FIXATION AND FUSION WEDGE AND METHOD OF USE - A spinal implant including an at least one screw disposed within a wedge body is herein provided. The implant can be configured for placement with a facet joint in an intra-facet delivery. Furthermore, the implant can include a fusion-promoting bioactive material thereby providing a single device capable of spinal stabilization and/or fusion. Furthermore, a method of placing such an implant within a facet joint in an intra-facet orientation is hereby provided. | 10-16-2008 |
Michael Alan Fisher, Middleboro, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080288073 | Self-Distracting Cage - Various spinal implants and methods for stabilizing the spine are provided. In one exemplary embodiment, a spinal implant is provided having an expandable container with an interior volume that is selectively expandable between a compressed condition and an expanded condition. The expandable container is coupled to a superior endplate member having a bone-contacting surface and an engagement surface effective to mate with a superior surface of the expandable container, and an inferior endplate member having a bone-contacting surface and an engagement surface effective to mate with an inferior surface of the expandable container. In addition, at least one inlet port is formed in the expandable container and is effective to communicate a fluid to at least one cavity disposed within the interior volume of the expandable container. | 11-20-2008 |
| 20090088809 | Anti-Microbial Implant - Non-load-bearing, drug-eluting components that can be added to load bearing spinal implants. | 04-02-2009 |
Peter Fisher, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110284059 | THERMOPHOTOVOLTAIC ENERGY GENERATION - Inventive systems and methods for the generation of energy using thermophotovoltaic cells are described. Also described are systems and methods for selectively emitting electromagnetic radiation from an emitter for use in thermophotovoltaic energy generation systems. In at least some of the inventive energy generation systems and methods, a voltage applied to the thermophotovoltaic cell (e.g., to enhance the power produced by the cell) can be adjusted to enhance system performance. Certain embodiments of the systems and methods described herein can be used to generate energy relatively efficiently. | 11-24-2011 |
Richar Fisher, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110182948 | METHOD FOR TREATING DISEASE CHARACTERIZED BY PLAQUE - The present invention relates to the use of a filamentous agent other than a filamentous bacteriophage to disaggregate aggregated proteins in plaque or to treat a patient suffering from or susceptible to a disease characterized by the presence of plaque. | 07-28-2011 |
Robert John Fisher, West Roxbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090269250 | Apparatus and Methods For Nanoparticle Generation and Process Intensification of Transport and Reaction Systems - Apparatus, systems and methods are provided that utilize microreactor technology to achieve desired mixing and interaction at a micro and/or molecular level between and among feed stream constituents. Feed streams are fed to an intensifier pump at individually controlled rates, e.g., based on operation of individually controlled feed pumps. The time during which first and second feed streams are combined/mixed prior to introduction to the microreactor is generally minimized, thereby avoiding potential reactions and other constituent interactions prior to micro- and/or nano-scale interactions within the microreactor. Various microreactor designs/geometries may be employed, e.g., “Z” type single or multi-slot geometries and “Y” type single or multi-slot geometries. Various applications benefit from the disclosure, including emulsion, crystallization, encapsulation and reaction processes. | 10-29-2009 |
Stephen D. Fisher, Belmont, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080300836 | Self-Perpetuation of a Stochastically Varying Resource Pool - A computer-readable medium has encoded thereon software for maintaining a steady-state worth of an inhomogenous renewable resource pool. The software includes instructions for causing a data-processing system to evaluate an indicator of a historical worth of the resource pool, to determine a draw amount at least in part on the basis of this indicator, and to output data representative of that draw amount. | 12-04-2008 |
| 20100179924 | Controlled Depletion of a Stochastically Varying Resource Pool - A method for controlling resource pool depletion includes, at a first time, determining a first remainder of a depletion interval; on the basis of the first remainder, determining a first depletion rate for urging the pool to reach a selected state at the end of the depletion interval; on the basis of the first depletion rate, partially depleting the pool; and at a second time following the first time, determining a second remainder of the depletion interval; receiving state information indicative of a difference between a state of the pool at the first time and a state of the resource pool at the second time; on the basis of the second remainder and the state information, determining a second depletion rate for urging the pool to reach a selected state at the end of the depletion interval; and on the basis of the second depletion rate, partially depleting the pool. | 07-15-2010 |