Inventors list |
Assignees list |
Classification tree browser |
Top 100 Inventors |
Top 100 Assignees |
Fire
Andrew Fire, Stanford, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100234445 | Patterns of known and novel small RNAS in human cervical cancer - Small RNA sequences that are differentially expressed in SCCC cells are provided. The sequences find use in diagnosis of cancer, and classification of cancer cells according to expression profiles. The methods are useful for detecting cervical cancer cells, facilitating diagnosis of cervical cancer and the severity of the cancer (e.g., tumor grade, tumor burden, and the like) in a subject, facilitating a determination of the prognosis of a subject, and assessing the responsiveness of the subject to therapy. | 09-16-2010 |
Andrew Fire, Washington, DC US
| Patent application number | Description | Published |
|---|---|---|
| 20080248576 | Genetic Inhibition of double-stranded RNA - A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods. | 10-09-2008 |
| 20090311786 | Levels and/or Sustainability of DNA-based Gene Expression - The invention encompasses methods for improving the level and/or sustainability of expression for a target nucleic acid in a eukaryotic cell comprising: (a) modifying the target nucleic acid to introduce or to comprise signals that limit or constrain the positions of nucleosome cores, and (b) introducing the modified target nucleic acid into the eukaryotic cell, wherein the modified target nucleic acid has improved levels and/or sustainability of expression compared to original unmodified nucleic acid. | 12-17-2009 |
Andrew Fire, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080305543 | RNA interference pathway genes as tools for targeted genetic interference - Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity. | 12-11-2008 |
Luke Fire, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110288054 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I) as described herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof. | 11-24-2011 |
| 20110288077 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES - This invention relates to compounds of the Formula (I)-(IX):, as defined herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α combinations thereof. | 11-24-2011 |