Fire
Andrew Fire, Stanford, CA US
Patent application number | Description | Published |
---|---|---|
20100234445 | Patterns of known and novel small RNAS in human cervical cancer - Small RNA sequences that are differentially expressed in SCCC cells are provided. The sequences find use in diagnosis of cancer, and classification of cancer cells according to expression profiles. The methods are useful for detecting cervical cancer cells, facilitating diagnosis of cervical cancer and the severity of the cancer (e.g., tumor grade, tumor burden, and the like) in a subject, facilitating a determination of the prognosis of a subject, and assessing the responsiveness of the subject to therapy. | 09-16-2010 |
20120220466 | Measurement and Monitoring of Cell Clonality - Methods are provided for the detection and analysis of clonality in a cell population, where parallel sequencing is applied to a nucleic acid sample obtained from the cell population, optionally a population of lymphocytes. Replicate samples are amplified, and sequenced, where identification of coincident sequences in two or more replicates is indicative of clonal expansion. | 08-30-2012 |
20130149699 | Translation Kinetic Mapping, Modification and Harmonization - The profile of translation elongation rate along an mRNA is modulated in a directed manner by locally altering codon usage, in particular utilizing differences in ribosomal dwell times among pairs of synonymous codons translated by a single tRNA through wobble base pairing. Unlike codon optimization based on organism-specific codon frequencies or tRNA pools, the methods of the invention need not change the tRNA that translates the codon, rather modulating the interaction between a given tRNA and the mRNA coding sequence. | 06-13-2013 |
20140235477 | Measurement and Monitoring of Cell Clonality - Methods are provided for the detection and analysis of clonality in a cell population, where parallel sequencing is applied to a nucleic acid sample obtained from the cell population, optionally a population of lymphocytes. Replicate samples are amplified, and sequenced, where identification of coincident sequences in two or more replicates is indicative of clonal expansion. | 08-21-2014 |
20140273225 | NUCLEOSOME-EXCLUDING SEQUENCES (NES) AS A DNA SPACER IN VECTORS RESULTS IN PROLONGED TRANSGENE EXPRESSION IN EUKARYOTIC CELLS - The silencing effect of a spacer sequence, for example a bacterial backbone sequence in a plasmid or other episomal vector, on transgene expression is reversed by engineering of the spacer to include nucleosome exclusion sequences. | 09-18-2014 |
Andrew Fire, Washington, DC US
Patent application number | Description | Published |
---|---|---|
20080248576 | Genetic Inhibition of double-stranded RNA - A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods. | 10-09-2008 |
20090311786 | Levels and/or Sustainability of DNA-based Gene Expression - The invention encompasses methods for improving the level and/or sustainability of expression for a target nucleic acid in a eukaryotic cell comprising: (a) modifying the target nucleic acid to introduce or to comprise signals that limit or constrain the positions of nucleosome cores, and (b) introducing the modified target nucleic acid into the eukaryotic cell, wherein the modified target nucleic acid has improved levels and/or sustainability of expression compared to original unmodified nucleic acid. | 12-17-2009 |
20140350083 | Genetic Inhibition by Double-Stranded RNA - A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods. | 11-27-2014 |
Andrew Fire, Baltimore, MD US
Patent application number | Description | Published |
---|---|---|
20080305543 | RNA interference pathway genes as tools for targeted genetic interference - Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity. | 12-11-2008 |
20130029425 | Genetic Inhibition by Double-Stranded RNA - A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods. | 01-31-2013 |
20130230492 | GENETIC INHIBITION BY DOUBLE-STRANDED RNA - A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods. | 09-05-2013 |
Luke Fire, Cambridge, MA US
Patent application number | Description | Published |
---|---|---|
20110288054 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I) as described herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof. | 11-24-2011 |
20110288077 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES - This invention relates to compounds of the Formula (I)-(IX):, as defined herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α combinations thereof. | 11-24-2011 |
20120010181 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof. | 01-12-2012 |
20120015926 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof. | 01-19-2012 |
Michael Fire, Nethanya IL
Patent application number | Description | Published |
---|---|---|
20140150109 | METHOD FOR PROTECTING USER PRIVACY IN SOCIAL NETWORKS - A method for protecting user privacy in an online social network, comprising the steps of defining, for a given primary user of an online social network who is authorized to post multimedia information in an account of the social network, a personal profile type that characterizes a level of desired privacy and that is selected from a group of predetermined profile types; defining a personal profile type selected from the group for each of a plurality of secondary users who are interested in accessing posted multimedia information of the primary user while functioning as a friend thereof; and denying a request for friendship initiated by one of the plurality of secondary users when the profile type of the primary user and of the one of the plurality of secondary users are incompatible as defined by predetermined rules, that may be stored in the privacy setting module. | 05-29-2014 |
Michael Fire, Netanya IL
Patent application number | Description | Published |
---|---|---|
20150082448 | Method for Detecting Spammers and Fake Profiles in Social Networks - A method for protecting user privacy in an online social network, according to which negative examples of fake profiles and positive examples of legitimate profiles are chosen from the database of existing users of the social network. Then, a predetermined set of features is extracted for each chosen fake and legitimate profile, by dividing the friends or followers of the chosen examples to communities and analyzing the relationships of each node inside and between the communities. Classifiers that can detect other existing fake profiles according to their features are constructed and trained by using supervised learning. | 03-19-2015 |