| Patent application number | Description | Published |
|---|
| 20080254523 | Methods for the Production of Products in Host Cells - The invention provides methods and host cells for the production of ascorbic acid intermediates. The invention also provides host cells having a modification in a polynucleotide that uncouples the catabolic pathway from the oxidative pathway by deleting the encoding for an endogenous enzymatic activity that phosphorylates D-glucose at its 6th carbon and/or a polynucleotide that has deleted the encoding for endogenous enzymatic activity that phosphorylates D-gluconate at its 6th carbon. Such host cells are used for the production of products, such as, ascorbic acid intermediates. Nucleic acid and amino acid sequences with inactivated enzymatic activity which phosphorylates D-glucose at its 6th carbon and inactivated enzymatic activity which phosphorylates D-gluconate at its 6th carbon are provided. | 10-16-2008 |
| 20080293124 | Multimeric Oxidoreductases - The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof. | 11-27-2008 |
| 20080299614 | Metabolically Engineered Bacterial Strains Having Non-Functional Endogenous Gluconate Transporters - The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes. | 12-04-2008 |
| 20090142843 | Glucose Transport Mutants For Production Of Biomaterial - A method is disclosed for restoring a Glu | 06-04-2009 |
| 20090156430 | PROMOTER AND PLASMID SYSTEM FOR GENETIC ENGINEERING - This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a terminator sequence, the plasmids containing variants of glucose isomerase promoters for varying levels of protein expression. The materials and methods are useful for genetic engineering in microorganisms, especially where multiple genetic insertions are sought. | 06-18-2009 |
| 20090203102 | COMPOSITIONS AND METHODS FOR PRODUCING ISOPRENE - The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells. | 08-13-2009 |
| 20100257778 | PRODUCTION OF FATTY ACID DERIVATIVES - Methods and compositions for producing fatty acid derivatives, for example, fatty esters, are described. | 10-14-2010 |
| 20100274033 | PRODUCTION OF FATTY ACID ESTERS - Methods of producing fatty acid esters, such as fatty acid ethyl esters, from genetically engineered microorganisms are described. | 10-28-2010 |
| 20100285567 | TAT SIGNAL PEPTIDES FOR PRODUCING PROTEINS IN PROKARYOTES - This invention provides polynucleotides encoding TAT fusion proteins, and methods for producing proteins of interest in a host cell. In particular, the present invention relates to polynucleotides, vectors, polypeptides and methods for expressing organophosphate-degrading enzymes e.g. organophosphorus hydrolase (OPH) in host cell, such as a | 11-11-2010 |
| 20110000125 | PRODUCTION OF FATTY ALCOHOLS WITH FATTY ALCOHOL FORMING ACYL-COA REDUCTASES (FAR) - The disclosure relates to methods of producing fatty alcohols from recombinant host cells comprising genes encoding heterologous fatty acyl-CoA reductase (FAR) enzymes. The disclosure further relates to FAR enzymes and functional fragments thereof derived from marine bacterium and particularly marine gamma proteobacterium such as | 01-06-2011 |
| 20110003353 | Multimeric Oxidoreductases - The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof. | 01-06-2011 |
| 20110046014 | PROMOTER AND PLASMID SYSTEM FOR GENETIC ENGINEERING - This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a terminator sequence, the plasmids containing variants of glucose isomerase promoters for varying levels of protein expression. The materials and methods are useful for genetic engineering in microorganisms, especially where multiple genetic insertions are sought. | 02-24-2011 |
