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Fernandez, MA

Cecilia Fernandez, Jamaica Plain, MA US

Patent application numberDescriptionPublished
20100267041SERIAL ANALYSIS OF BIOMARKERS FOR DISEASE DIAGNOSIS - The present invention generally relates to serial analysis of biomarkers for disease diagnosis. In certain embodiments, the invention provides methods for diagnosing a disease including obtaining a sample from a subject, conducting a first assay to determine whether a first biomarker in the sample is positive or negative for a disease, and conducting a second assay to determine whether a second biomarker in the sample is positive or negative for the disease if the first assay produced a negative result.10-21-2010

Cecilia A. Fernandez, Jamaica Plain, MA US

Patent application numberDescriptionPublished
20100284992Phospholipase C and Method of Use - The present invention provides a method for reducing angiogenesis using a phospholipase C.11-11-2010

Gary Fernandez, Concord, MA US

Patent application numberDescriptionPublished
20100217783COMMUNICATING WITH DATA STORAGE SYSTEMS - In some aspects, a method includes connecting over a network to a data storage system, the data storage system storing data objects. A dataflow graph that includes nodes representing data processing components connected by links that represent flows of data access an interface of the data storage system. The interface provides functions for accessing the data objects. At least one of the data processing components performs operations on a received input flow of data that enable the functions provided by the interface to modify one or more stored data objects, and performs operations in response to functions provided by the interface to generate an output flow of data.08-26-2010

Jason E. Fernandez, Brookline, MA US

Patent application numberDescriptionPublished
20100137213FORMULATIONS OF SINGLE DOMAIN ANTIGEN BINDING MOLECULES - The invention relates to formulations of single domain antigen binding molecules, e.g., nanobody molecules, in particular formulations of TNF-binding nanobody molecules. The single domain antigen binding molecules can include one or more single binding domains that interact with, e.g., bind to, one or more target proteins. The formulations are useful, e.g., as pharmaceutical formulations. Method of preparing, and using the formulations described herein, to treat, e.g., TNF-associated disorders, are also disclosed.06-03-2010

Luis Fernandez, Somerville, MA US

Patent application numberDescriptionPublished
20100193898METHOD FOR FORMING TRENCH ISOLATION USING GAS CLUSTER ION BEAM PROCESSING - A method of forming shallow trench isolation on a substrate using a gas cluster ion beam (GCIB) is described. The method comprises generating a GCIB, and irradiating the substrate with the GCIB to form a shallow trench isolation structure by depositing a dielectric layer in at least one region on the substrate.08-05-2010

Rafael Fernandez, Jamaica Plain, MA US

Patent application numberDescriptionPublished
20090130703Methods of Detection of Changes in Cells - Methods are provided to detect changes in cells without the use of detection labels.05-21-2009
20090137422Methods for Identifying Modulators of Ion Channels - The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.05-28-2009
20090305304High Resolution Label Free Analysis of Cellular Properties - The invention provides methods of detecting a change in cell growth patterns.12-10-2009
20100273185Detection of Biased Agonist Activation - The invention provides single assay methods to detect the activity of biased agonists or agonists that are less than full agonists on cells.10-28-2010