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Fernández

Alberto Fernandez, Montevideo UY

Patent application numberDescriptionPublished
20110130765Coplanar X-Ray Guided Aiming Arm for Locking of Intramedullary Nails - A novel coplanar X-ray guided method and device for insertion of distal locking screws in intramedullary bone nails. The device has coplanar holes, which allow insertion of protective sleeves. A drill and bone screws can be inserted through the protective sleeves. Radiopaque target markers in the aiming arm enable the easy positioning of an X-ray source such that an X-ray beam is coplanar with the aiming arm transverse holes. After the X-ray source is accurately oriented, a single X-ray snapshot is enough to assess the exact distortion of the implanted intramedullary nail. The X-ray beam need not be coaxial with the intramedullary nail holes. The aiming arm has a mobile portion and a fixed portion fastened to the nail, wherein said aiming arm can be adjusted, displacing the mobile portion over the fixed portion, to compensate for the distortion of the intramedullary nail after implantation. Once the aiming arm is precisely positioned, the aiming arm transverse holes and intramedullary nail holes are accurately aligned, protective sleeves are inserted through aiming arm holes, bone drills are drilled through the intramedullary nail holes and surrounding bone material, and bone screws are inserted, locking the intramedullary nail to the bone.06-02-2011

Patent applications by Alberto Fernandez, Montevideo UY

Alberto Angel Fernandez, Montevideo UY

Patent application numberDescriptionPublished
20090131951Coplanar X-Ray Guided Aiming Arm for Locking of Intramedullary Nails - A novel coplanar X-ray guided method and aiming arm device for insertion of distal locking screws in intramedullary bone nails. Radiopaque target markers in the aiming arm enable the easy positioning of an X-ray source such that an X-ray beam is coplanar with the aiming arm transverse holes. After the X-ray source is accurately oriented, a single X-ray snapshot is enough to assess the exact distortion of the implanted intramedullary nail. The X-ray beam need not be coaxial with the nail holes. The aiming arm includes a mobile portion and a fixed portion fastened to the nail, and the aiming arm can be adjusted, displacing the mobile portion over the fixed portion, to compensate for the distortion of the intramedullary nail caused by implantation in bone.05-21-2009
20100076496Variable Angle Locked Bone Fixation System - A bone fixation assembly for securing a fixation device such as a bone plate, to bone includes a fixation device, including at least a through hole with isolated protrusions (such as pegs or spikes); and locking bone engaging members such as screws.03-25-2010
20110190771Two Members Cerclage Tool - A method for placing a fixation member around a bone for internal fixation of the bone includes (a) inserting a first member of a cerclage tool through an incision and into a vicinity of the bone, the first member extending from a first proximal end comprising a first handle portion and along a first central portion to a first distal end comprising a first bent tube portion; (b) inserting a second member of the cerclage tool through the incision and into the vicinity of the bone, the second member extending from a second proximal end comprising a second handle portion and along a second central portion to a second distal end comprising a second bent tube portion; (c) joining the first and second members together to form a continuous tube with the first bent tube portion and the second bent tube portion that encircles the bone, wherein the first bent tube portion and the second bent tube portion cross over one another to form a non-zero angle at a location that is proximal of the bone when viewed from a direction extending perpendicularly into a plane comprising the first and second members, wherein the continuous tube is configured and dimensioned to receive the fixation member; (d) disassembling the joined first and second members; and (e) removing the disassembled first and second members from the vicinity of the bone and from the incision.08-04-2011
20120232561COPLANAR X-RAY GUIDED AIMING ARM FOR LOCKING OF INTRAMEDULLARY NAILS - A novel coplanar X-ray guided method and aiming arm device for insertion of distal locking screws in intramedullary bone nails. Radiopaque target markers in the aiming arm enable the easy positioning of an X-ray source such that an X-ray beam is coplanar with the aiming arm transverse holes. After the X-ray source is accurately oriented, a single X-ray snapshot is enough to assess the exact distortion of the implanted intramedullary nail. The X-ray beam need not be coaxial with the nail holes. The aiming arm includes a mobile portion and a fixed portion fastened to the nail, and the aiming arm can be adjusted, displacing the mobile portion over the fixed portion, to compensate for the distortion of the intramedullary nail caused by implantation in bone.09-13-2012

Patent applications by Alberto Angel Fernandez, Montevideo UY

Alvaro Fernandez, Nivelles BE

Patent application numberDescriptionPublished
20130030132PROCESS FOR PREPARING POLYOLEFIN - The invention relates to a process for preparing polyolefin in a loop reactor. The polymer is prepared by polymerizing olefin monomers in the presence of a catalyst to produce a polyolefin slurry while pumping said slurry through said loop reactor by means of a pump. The present process is characterized in that the catalyst is fed in the loop reactor at a distance to the pump. The invention allows production of the polymer with advantageous properties while leading to fewer blockages of the reactor.01-31-2013

Álvaro Acebrón Fernández, Madrid ES

Patent application numberDescriptionPublished
20090041860ORALLY-DISPERSIBLE PHARMACEUTICAL COMPOSITIONS - The invention relates to oral pharmaceutical compositions which take the form of orally-dispersible tablets containing calcium and, optionally, vitamin D and/or fluorine together with pharmaceutically-acceptable excipients and which can be used for the treatment or prevention of osteoporosis and other diseases characterised by loss of bone mass.02-12-2009
20090318401USE OF ESTRIOL IN LOW DOSES - The invention relates to the use of low doses of estriol by vaginal route for treatment and/or prevention of urogenital atrophy due to estrogen deficit in women.12-24-2009

Angel Luis Andres Fernandez, Birmingham GB

Patent application numberDescriptionPublished
20100198461METHOD AND APPARATUS FOR CONTROLLING AN ELECTRIC ASSIST MOTOR USING A MODIFIED BLENDING FILTER - A method for controlling an electric assist motor for providing steering assist in response to a sensed torque signal includes the step of filtering the sensed torque signal to provide a low frequency torque signal and a high frequency torque signal. A low frequency assist torque signal is determined as a function of the low frequency torque signal. A high frequency assist gain signal is determined as a function of the sensed torque signal and a sensed vehicle speed. The high frequency assist gain signal is applied to the high frequency torque signal to determine a high frequency assist torque signal. A torque command signal is determined as a function of the low frequency assist torque signal and the high frequency assist torque signal. The electric assist motor is commanded to provide steering assist in accordance with the torque command signal.08-05-2010

Patent applications by Angel Luis Andres Fernandez, Birmingham GB

Anne Marie Fernandez, Brussels BE

Patent application numberDescriptionPublished
20090110753Enzyme-cleavable prodrug compounds - The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention.04-30-2009

Anne-Marie Fernandez, Bruxelles BE

Patent application numberDescriptionPublished
20100035799METHOD FOR THE SYNTHESIS OF ANTHRACYCLINE-PEPTIDE CONJUGATES - The present invention relates to a method for the preparation of a compound of formula (I) or pharmaceutically acceptable salts thereof and intermediates thereof, comprising the steps of:02-11-2010

Damian Antonio Fernandez, Oldham UK

Patent application numberDescriptionPublished
20100168634MULTI DIRECTIONAL STRETCH TUBULAR BANDAGES - A stretchable bandage comprises a knitted fabric comprising a plurality of yarns (b), (c) of a first inelastic material, e.g. viscose knitted together with yarns (a}, (d), of a second elastically extensible material (e.g. elastane). As shown, the yarns may be knitted from a pair of yarns, one viscose (c) and one elastane (d) fed together and occupying a common yarn path, and separated from the next such pair of yarns by a viscose yarn (b) and an elastane yarn (a) fed separately as single yarns.07-01-2010

Eduardo Roberto Fernandez, Pcia. De Buenos Aires AR

Patent application numberDescriptionPublished
20100236816INSULATOR FOR ELECTRIFIED ELEMENTS - An insulator member comprises a set of passages (09-23-2010
20100237302SIDE ANCHOR STRETCHER FOR FILIFORM ELEMENTS AND METHOD OF PRODUCTION OF SAID STRETCHER - An anchor stretcher device includes a wind up reel (09-23-2010

Elstan Anthony Fernandez, Singapore SG

Patent application numberDescriptionPublished
20110097848Method for Connecting a Die Assembly to a Substrate in an Integrated Circuit and a Semiconductor Device Comprising a Die Assembly - A semiconductor device includes a substrate, a die assembly attachable to the substrate and a flexible strip extending over the substrate and the die assembly. The flexible strip has one or more routing circuits carried thereon. The die assembly and the substrate are arranged to be electrically connected through the one or more routing circuits carried on the flexible strip.04-28-2011

Patent applications by Elstan Anthony Fernandez, Singapore SG

Emilio Fernandez, Santiago CL

Patent application numberDescriptionPublished
20110244464IDENTIFICATION OF GENES OR POLYPEPTIDES THE EXPRESSION OF WHICH CORRELATES TO FERTILITY, OVARIAN FUNCTION AND/OR FETAL/NEWBORN VIABILITY - A genetic means of determining whether a female subject produces “pregnancy competent” oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level, or pattern referred to herein as the “pregnancy signature”, also can be used to identify subjects with underlying conditions that impair or prevent the development of a viable pregnancy, e.g., pre-menopausal condition, other hormonal dysfunction, ovarian dysfunction, ovarian cyst, cancer or other cell proliferation disorder, autoimmune disease and the like. Microarrays containing “pregnancy signature” genes or corresponding polypeptides provide another preferred aspect of the invention. Still further, the subject invention can be used to derive animal models, e.g., non-human primate animal models, for the evaluation of the efficacy of putative female fertility treatments.10-06-2011

Fabiana Fernandez, Unterengstringen CH

Patent application numberDescriptionPublished
20110097357BIOCONJUGATES MADE FROM RECOMBINANT N-GLYCOSYLATED PROTEINS FROM PROCARYOTIC CELLS - The present invention is directed to a bioconjugate vaccine, such as an 01-bioconjugate vaccine, comprising: a protein carrier comprising a protein carrier containing at least one consensus sequence, D/E-X—N—Z—S/T, wherein X and Z may be any natural amino acid except proline; at least one antigenic polysaccharide from at least one pathogenic bacterium, linked to the protein carrier; and, optionally, an adjuvant. In another aspect, the present invention is directed to a method of producing an O1-bioconjugate in a bioreactor comprising a number steps.04-28-2011

Fernando Ferreira Fernandez, Sao Jose Dos Campos BR

Patent application numberDescriptionPublished
20090266936AIRCRAFT FUSELAGE STRUCTURAL COMPONENTS AND METHODS OF MAKING SAME - Aircraft fuselage structures have reinforcement members in the vicinity of the stringer openings formed in frame members and are rigidly lap joined to a surface region of the frame members by a friction stir weld region. Such aircraft fuselage structural components may thus be provided with plural longitudinally spaced-apart frame members defining a transversal cross-section of an aircraft fuselage section, the frame members having a plurality of stringer holes therethrough, and plural longitudinally oriented stringers each being positioned within a respective one of the stringer holes of the frame member. The reinforcement members are lap joined to corresponding surfaces of frame members in the vicinity of the stringer holes such that the reinforcement members are joined rigidly to the corresponding surfaces of the frame members by a friction stir weld region.10-29-2009
20090311549FRICTION STIR WELDING (FSW) METHODS AND SYSTEMS AND FRICTION STIR WELDED COMPONENTS MADE THEREBY - Friction stir welding (FSW) processes, systems and the resulting friction stir welded components are disclosed whereby first and second workpieces are welded to one another using a first workpiece having mutually orthogonal structural components and a junction region therebetween which defines a bearing surface of predetermined geometry. A shoulder of a FSW tool may be brought into bearing contact with the bearing surface so that a pin extending from the shoulder of the FSW tool may be advanced into and through the one structural component of the first workpiece at an angle relative thereto so as to thereby form a friction stir weld region between the first and second workpieces. Some preferred embodiments will provide a bearing surface which defines an arcuately concave geometry, in which case the shoulder of the FSW tool defines an arcuately convex geometry conformably mateable with the bearing surface. According to other preferred embodiments, the bearing surface defines an arcuately convex geometry, in which case the shoulder of the FSW tool defines an arcuately concave geometry conformably mateable with the bearing surface. According to yet other preferred embodiments, the bearing surface and the shoulder of the FSW tool are each planar.12-17-2009
20110079339FRICTION STIR WELDING SPINDLE DOWNFORCE AND OTHER CONTROL TECHNIQUES, SYSTEMS AND METHODS - Friction stir welding equipment control force spindle for mounting in an orbital head housing uses a coaxial sensor to measure downforce. Simultaneously, an axial electrical actuator is controlled to dynamically correct the axial tool position during the welding, by a direct axial force system control, in order to maintain controlled downforce according to parameters previously set, based on numerical control. The equipment also sets up, monitors and controls spindle rotation speed, welding speed, acceleration speed and downforce using for example closed loop control functions. A laser system may scan the backing surface before welding and correct original tool path, in order to get an offset tool path. A precision alarm system may provide safe welding while preventing the tool from colliding with the backing surface.04-07-2011

Ferrando Ferrera Fernandez, Sao Paulo BR

Patent application numberDescriptionPublished
20100072261FRICTION STIR WELDING SPINDLE DOWNFORCE AND OTHER CONTROL TECHNIQUES, SYSTEMS AND METHODS - Friction stirred welding equipment, developed according to requirements of high reliability, robustness, precision and low cost, weld lap and butt joints in complex surfaces with fixed pin tool under controlled downforce. Exemplary equipment comprises a control force orbital spindle, wherein a coaxial sensor measures the downforce and simultaneously the axial electrical actuator corrects axial tool position along the welding, by a direct axial force system control, in order to maintain controlled downforce according to previously set parameters. The equipment sets up, monitors and controls the spindle rotation speed, welding speed, acceleration speed and downforce and can record in a database the downforce and tool welding position during the welding. The exemplary equipment may also comprise a laser system that scans the backing surface before welding and corrects original tool path, in order to provide an offset tool path and precision alarm system to get a safe welding, avoiding tool collision with the backing.03-25-2010

Francesca Fernandez, Singapore SG

Patent application numberDescriptionPublished
20120004266DOPAMINE-BETA-HYDROXYLASE GENETIC POLYMORPHISM AND MIGRAINE - The invention provides a method of determining whether or not an individual has a predisposition to migraine including the step of determining whether an isolated nucleic acid obtained from the individual comprises a nucleotide sequence corresponding to at least a fragment of a dopamine β-hydroxylase (DBH) gene promoter, wherein the presence of a −1021C→T single nucleotide polymorphism (SNP) in said nucleotide sequence indicates whether or not said individual has an increased predisposition to migraine compared to an individual without the polymorphism. DBH −1021C/C homozygotes are particularly susceptible to migraine. The −1021T allele may exert a protective effect. The method is particularly suited to detection of a predisposition to migraine with aura in females. The invention also provides a diagnostic kit for detecting a −1021C→T SNP associated with migraine. The method and kit may facilitate selection of individuals for migraine therapy which targets the dopaminergic system.01-05-2012

Francisco Garcia Fernandez, Guanajuato MX

Patent application numberDescriptionPublished
20080293559Process and Plant for Converting Hazardous Waste Containing Chromium VI Into Non-Hazardous Waste - The instant invention relates to a process and plant for the transformation of dangerous wastes containing chromium six as contaminant into non dangerous wastes that can be stored without special care and will be degraded in the environment without time limit. The process basically consists of milling, extracting chromium six in liquid phase and under controlled conditions of stirring, time and temperature, proceeding then, through reduction, to transform the chromium six in chromium three and then precipitating as chromium trioxide, through gasification.11-27-2008
20120107200PROCESS AND PLANT FOR CONVERTING HAZARDOUS WASTE CONTAINING CHROMIUM VI INTO NON-HAZARDOUS WASTE - The instant invention relates to a process and plant for the transformation of dangerous wastes containing chromium six as contaminant into non dangerous wastes that can be stored without special care and will be degraded in the environment without time limit.05-03-2012

Gustavo Fernandez, Bocholt DE

Patent application numberDescriptionPublished
20120106740DEFAULT ENCODING - The invention relates to a method for encoding a connection between a base (05-03-2012

Hector Fernandez, Ciudad Autonoma De Buenos Aires AR

Patent application numberDescriptionPublished
20120005916PROCESS FOR DRYING BREWER'S SPENT GRAINS - A process for drying brewer's spent grains, so as to obtain a product with moisture lower than or equal to 15% by weight, biologically stable in time, with high nutritional value, commercially profitable, and environmentally safe, the process comprising two phases: the first one is a mechanical pressing operation for diminishing the initial moisture of brewer's spent grains from at least 75-80% by weight, up to a lower moisture value of 70% by weight; the liquid obtained is carried to an effluent treatment plant; the solid obtained undergoes a second phase; said second phase consists of thermal drying, having two sub-phases: during the first one, the product is transported through a hot air current while during the second one, it is transported by an air current at room temperature; this way, a final product with a moisture content lower of 15% or less by weight is obtained.01-12-2012

Iraima Fernández, San Antonio De Los Altos VE

Patent application numberDescriptionPublished
20110021387REVERSIBLE GELLING SYSTEM AND METHOD USING SAME DURING WELL TREATMENTS - An all-oil reversible gelling system includes a polymer, a crosslinker, a gel accelerator, and an oxidant, wherein temperature activates the crosslinker so as to cause the system to form a gel, and the oxidant subsequently decomposes the gel. This gel is designed to seal temporarily portions of oil-producing or water or gas injecting subterranean formations.01-27-2011

Jara Fernandez, Freiburg DE

Patent application numberDescriptionPublished
20100193002SEMICONDUCTOR COMPONENT, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF - The invention relates to a semiconductor component which contains one semiconductor layer containing germanium. On the rear-side, i.e. on the side orientated away from the incident light, the semiconductor layer has at least one layer containing silicon carbide which serves, on the one hand, for the reflection of radiation and also as rear-side passivation or as diffusion barrier. A method for the production of semiconductor components of this type is likewise described. The semiconductor components according to the invention are used in particular as thermophotovoltaic cells or multiple solar cells based on germanium.08-05-2010

Javier Garcia Fernandez, Vancouver CA

Patent application numberDescriptionPublished
20130045204FLUORINATED BISPHENOL ETHER COMPOUNDS AND METHODS FOR THEIR USE - Compounds having a structure of Formula I:02-21-2013

Javier Jimenez Fernández, Navarra ES

Patent application numberDescriptionPublished
20110104341METHOD FOR CLOSING THE END OF FOLDED TUBULAR CASINGS - The invention relates to a method for closing the end of shirred tubular casings which comprises deshirring a terminal portion of the tubular casing in the direction of the axis of the stick, turning over the deshirred terminal portion in order to insert same inside the casing, securing the deshirred terminal portion from inside the casing, rotating the terminal portion and flattening the rotated terminal portion.05-05-2011

Jorge Damaso Fernandez, Markham CA

Patent application numberDescriptionPublished
20090287920METHOD FOR ESTABLISHING BI-DIRECTIONAL MESSAGING COMMUNICATIONS WITH WIRELESS DEVICES AND WITH REMOTE LOCATIONS OVER A NETWORK - A method, server, device and computer readable medium for establishing a bi-directional communication session between a first device and a server is provided. During the method, a first transport layer connection between the first device and the server is established. The first device is then authenticated with the server over the first transport layer connection. In the event that authenticating the first device is successful, the server and the first device establish a persistent, bi-directional communication session over the first transport layer connection.11-19-2009

Jose Cruz Kissler Fernandez, Bad Abbach DE

Patent application numberDescriptionPublished
20090005913Method and Device for Determining a PWM Signal on Which a Dither Frequency is Superimposed in Order to Control a Solenoid Valve - A PWM signal on which a dither signal is superimposed is used for adjusting a central position when controlling a solenoid valve. To improve this type of control process in which the amplitude of the dither signal depends on the current of the solenoid valve and thus on the PWM signal, the PWM signal and the dither signal are generated in a computer unit independently of the power regulation process. Forming the signals separately has the advantage of generating a constant amplitude for the dither signal each time a triggering signal is generated for the solenoid valve such that the armature of the solenoid valve can oscillate specifically about the central position and thereof at constant small vibrations. This allows frictional forces to be reliably reduced and the solenoid valve to be switched more rapidly while the load on the main computer is reduced.01-01-2009

José Javier Fernández, Ortuella ES

Patent application numberDescriptionPublished
20100140447MULTI-PURPOSE PART - A multi-purpose part (06-10-2010

Joseph Fernandez, Hong Kong CN

Patent application numberDescriptionPublished
20090213572INTERACTIVE ACTUATABLE WEARABLE DISPLAY - A display apparatus that can be worn by a user, attached to a surface, and/or comprise a stand-alone display containing a light source that emits light and is positioned so as to illuminate a design on the surface of the display apparatus, and/or that incorporates a lighted surface or video-capable technology and that may be connected to a microprocessor and/or light, sound or motion sensor functionalities connected to a microprocessor that can interpret external stimulus and modify the display according to various criteria to attract viewers. The display apparatus also is connected to or in the case of a wearable display contains a power supply that provides power to the light source or lighted display technology and microprocessor and/or sensor functionalities. In some embodiments, the invention may also include a promotional display member that displays advertising or sponsoring information. This promotional display member is configured to attach to display apparatus and surround the design on the front surface of the display apparatus.08-27-2009

Juan Carlos Fernandez, Distrito Federal MX

Patent application numberDescriptionPublished
20130017300Method of Preparing an Oat-Containing Dairy Beverage - A process for preparing an oat and milk beverage includes processing taking place under chilled conditions. Moreover, the oat product used in accordance with aspects of this invention is hydrolyzed oat flour.01-17-2013

Lucas Fernandez, Toronto CA

Patent application numberDescriptionPublished
20100314382CONTROL SYSTEM FOR OPERATING AUTOMOTIVE VEHICLE COMPONENTS - There is disclosed a control system for operating automotive vehicle components. The control system typically includes at least a control module programmed with instructions for controlling a heater, a ventilator or both.12-16-2010

Patent applications by Lucas Fernandez, Toronto CA

Marcus Codrington Fernandez, London GB

Patent application numberDescriptionPublished
20110143871CRICKET SPORTS BAT - A cricket sports bat comprising an elongate handle and a truncate blade, the blade comprising a front playing face the majority of which is substantially planar across its face, an opposing rear surface, sides extending between the front face and rear surface, a toe and a pair of shoulders extending one each side of the handle/blade to the sides, characterized in that the ratio of the length of the blade to the width of the blade is in the range of 4:1-3.25:1. The present invention relates to a bat for use in cricket.06-16-2011

Marija Fernandez, Lausanne CH

Patent application numberDescriptionPublished
20130020646MULTI-CHANNEL HOMOGENOUS PATH FOR ENHANCED MUTUAL TRIGGERING OF ELECTROSTATIC DISCHARGE FINGERS - Mutual triggering of electrostatic discharge (ESD) fingers is improved by creating a base contact in each individual finger and connecting all of these base contacts in parallel. The local base contact in each ESD finger is located at a position where the base voltage significantly increases when the ESD current increases. Thus when an ESD finger is triggered its local base voltage will tend to significantly increase. Since all of the ESD finger bases are connected in parallel this local voltage increase will forward bias the base-emitter junctions of the other ESD fingers, thus triggering them all. By sharing the triggering current from the fastest ESD finger with the slower ones ensures that all ESD fingers are triggered during an ESD event.01-24-2013

Melissa Laura Fernandez, Fitzgibbon AU

Patent application numberDescriptionPublished
20120219536PURINE-TARGETED DIAGNOSIS AND THERAPY OF WOUNDS - Methods of treating a wound, an ulcer and/or a burn responsive to inhibition of xanthine oxidoreductase to thereby reduce uric acid in an animal are provided wherein the methods include topical administration of a therapeutic agent effective for treatment of the wound, the ulcer and/or the burn wherein the therapeutic agent inhibits xanthine oxidoreductase to thereby reduce uric acid in the wound, ulcer and/or burn. Also provided are methods and kits for determining the severity of a wound, a burn and/or an ulcer including the step of detecting one or more of (i) a level of uric acid; (ii) a level of one or more uric acid precursors; and (iii) a presence, or absence of or level of xanthine oxidoreductase.08-30-2012

N. Fernandez, Ciudad De Buenos Aires AR

Patent application numberDescriptionPublished
20090187999Process for Producing Exogenous Protein in the Milk of Transgenic Mammals and a Process For Purifying Proteins Therefrom - The invention relates to a non-human transgenic mammal that is useful for the production of a protein of interest that may be toxic to the mammal. The mammal is characterized by the fact that it is transgenic for the production in its milk of an inactive form of the protein of interest, preferably recombinant human insulin. It is not possible to produce recombinant human insulin in transgenic mammals since this molecule has a certain degree of biological activity in the mammals and could be toxic to the mammal. Thus, the invention involves cloning a genetic construct comprising a sequence encoding a modified human insulin precursor under the control of a beta casein promoter in an expression vector. It also involves transfecting the expression plasmid into fetal bovine somatic cells, such as fibroblasts, and enucleating bovine oocytes by nuclear transfer to generate transgenic embryos. The invention gives rise to transgenic bovine that will be able to produce a modified human insulin precursor in their mammary glands. Afterwards, the milk of these transgenic mammals can be collected, the modified human insulin precursor can be converted in vitro into recombinant human insulin, and the recombinant human insulin can be purified to homogeneity as a pure biopharmaceutical product.07-23-2009

Nuria Parés Fernández, Vilanova I La Geltru (barcelona) ES

Patent application numberDescriptionPublished
20100252582LOW HEIGHT PRECOMPRESSION PUMP - Low height precompression pump. The pump comprises: 10-07-2010

Oscar Fernandez, Great Cambourne GB

Patent application numberDescriptionPublished
20120062109Organic Electroluminescent Device and Method of Fabrication - An organic electroluminescent device comprises an anode; a cathode; a first electroluminescent layer between the anode and the cathode comprising an electron transporting material; and a second electroluminescent layer between the first electroluminescent layer and the anode. The second electroluminescent layer comprises a hole transporting material and an electroluminescent electron trapping material. The first electroluminescent layer may comprises a polymer having an electron transporting material and an electroluminescent material, and may include an optionally electroluminescent hole-transporting material. The electron transporting material and one or both of the hole transporting material of the first electroluminescent layer and the electroluminescent material of the first electroluminescent layer are part of the same molecule or polymer. Preferably, the electron transporting material comprises a plurality of adjacent arylene repeat units.03-15-2012

Pablo Serrano Fernandez, Szczecin PL

Patent application numberDescriptionPublished
20110105342METHOD FOR DETERMINING REDUCED PREDISPOSITION TO CANCER BASED ON GENETIC PROFILE - The invention provide methods for early detection of a reduced risk of developing cancer, which comprises detecting the absence of a series of genetic polymorphisms associated with a predisposition of developing cancer, including the polymorphisms of the genes BRCA1, BRCA2, CARD15 (NOD2), CHEK2, CDKN2A (P16), CYP1B1, FGFR2 (KGFR2), MAP3K1 (MEKK1), p53 (TP53), TNRC9, XPD (ERCC2) and the genetic marker Rs6983267, in a biological sample from the analyzed subject, wherein the absence of the genetic polymorphisms is indicative of significantly decreased risk of developing, at least, breast cancer.05-05-2011

Reynold Morales Fernandez, Ciudad De La Habana CU

Patent application numberDescriptionPublished
20090176703NEUROPEPTIDES FOR AQUATIC ORGANISMS CULTURE - The present invention is related to the use of variants of the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) to stimulate the growth and to improve the immunological system of aquatic organisms. The variants of the peptide were provided by immersion, injection or as a food additive.07-09-2009

Roberto G. Fernandez, Canoas BR

Patent application numberDescriptionPublished
20080197206Refrigerant System With Water Heating - A heat pump system (08-21-2008

Roberto G. Fernandez, Buenos Aires AR

Patent application numberDescriptionPublished
20090013702REFRIGERANT CHARGE CONTROL IN A HEAT PUMP SYSTEM WITH WATER HEATER - A heat pump system includes a compressor, a reversing valve, an outdoor heat exchanger and an indoor heat exchanger in a circuit, and a refrigerant-to-water heat exchanger. In the air cooling with water heating mode, the air heating with water heating mode and the water heating only mode, water from a water reservoir is passed through refrigerant-to-water heat exchanger. A refrigerant reservoir may be provided for use in refrigerant charge control. A refrigerant line (01-15-2009
20090049857HEAT PUMP SYSTEM HAVING AUXILIARY WATER HEATING AND HEAT EXCHANGER BYPASS - A heat pump system (02-26-2009

Rocky Anthony Fernandez, Wadala East, Mumbai IN

Patent application numberDescriptionPublished
20100216396Integrated System and Method for Enabling Mobile Commerce Transactions using "Contactless Identity Modules in Mobile Handsets" - The invention relates to a smart integration of dual Architecture Contact-less SIM into mobile devices and describes the method of performing various economic transactions more efficiently using a smart and interactive poster device.08-26-2010