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Feng Yan
Feng Yan, Grand-Lancy CH
| Patent application number | Description | Published |
|---|---|---|
| 20110070165 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 03-24-2011 |
| 20110097275 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 04-28-2011 |
| 20110150778 | Assembly of Gas-Filled Microvesicle With Active Component For Contrast Imaging - Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC comprises a targeting ligand a diagnostic agent or any combination thereof. Optionally a bioactive agent can further be associated to the MAC. The assembly of the invention can be formed from gas-filled microbubbles or microballoons and a MAC having preferably nanometric dimensions, e.g. a micelle, and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging. | 06-23-2011 |
| 20110208115 | Composition Comprising Gas-Filled Microcapsules For Ultrasound Mediated Delivery - Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein. | 08-25-2011 |
| 20110236320 | Ultrasound Contrast Agents And Process For The Preparation Thereof - Injectable aqueous suspension of microbubbles filled with a biocompatible gas and a method of preparation thereof. At least 10% of the total volume of gas contained in the microbubbles is contained in microbubbles with a diameter of 1.5 μm or less. The microbubbles can be obtained by preparing an emulsion comprising an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and then reconstituted in an aqueous suspension of gas-filled microbubbles. | 09-29-2011 |
| 20110245663 | Automatic Liquid Injection System and Method - A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds. | 10-06-2011 |
| 20110262366 | COMPOUNDS FOR TARGETING ENDOTHELIAL CELLS, COMPOSITIONS CONTAINING THE SAME AND METHODS FOR THEIR USE - The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy. | 10-27-2011 |
| 20120093732 | ULTRASOUND CONTRAST AGENTS AND METHODS OF MAKING AND USING THEM - The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents. | 04-19-2012 |
Feng Yan, La Jolla, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100234400 | COMPOUNDS THAT MAINTAIN PLURIPOTENCY OF EMBRYONIC STEM CELLS - The present invention relates to methods and compositions for culturing embryonic stem (ES) cells. The methods relate to growing the ES cells in the presence of small molecules of formula (I) that maintain the pluripotency/self-renewal of the cells without feeder cells and LIF in serum-free conditions. These methods in part facilitate much more consistency in embryonic stem cell production, providing, for example, new avenues in the practical applications of embryonic stem cells in regenerative medicine. | 09-16-2010 |
Feng Yan, Plan-Les-Ouates CH
| Patent application number | Description | Published |
|---|---|---|
| 20090041833 | Composition comprising gas-filled microcapsules for ultrasound mediated delivery - Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein. | 02-12-2009 |
| 20090263330 | GAS-FILLED MICROVESICLES WITH POLYMER-MODIFIED LIPIDS - Image enhancing contrast agents for use in diagnostic and/or therapeutic methods, particularly in the form of gas-filled microvesicles, with enhanced stability. The gas-filled microvesicles are stabilized by a layer of amphiphilic material and comprise from 0.15% to 1.0% by moles of a lipid bearing a hydrophilic polymer. The lipid bearing a hydrophilic polymer is preferably a phospholipid linked to polyethyleneglycol. | 10-22-2009 |
Feng Yan, Geneva CH
| Patent application number | Description | Published |
|---|---|---|
| 20090253986 | Detection of Immobilized Contrast Agent in Medical Imaging Applications Based on Flow Dynamics Analysis - A system for facilitating the detection of an immobilized contrast agent in medical imaging applications is proposed. The system includes means for providing a sequence of a total number of input images obtained at corresponding acquisition instants by imaging a body-part of a patient subjected to an administration of a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target, each input image including a plurality of input values each one indicative of a response to an interrogation signal of a corresponding portion of the body-part possibly including said contrast agent, and means for reducing a contribution of the circulating contrast agent within the body-part in at least one selected input image; the means for reducing includes means for creating a filtered image corresponding to each selected input image by replacing a set of input values of the selected input image with a set of corresponding filtered values, each filtered value being representative of the lowest response of the corresponding portion of the body-part in a set of multiple input images including the selected input image, the set of multiple input images consisting of a number of input images lower than the total number. | 10-08-2009 |
Feng Yan, Suzhou CN
| Patent application number | Description | Published |
|---|---|---|
| 20090176915 | NANOPOROUS AND MICROPOROUS SOLVOGELS AND NONOLATEXES BY MICROEMULSION POLYMERIZATION - The present invention relates to microemulsions of immiscible fluids stabilized by reactive ionic liquid surfactant wherein the ionic liquid surfactant has a melting point less than 80° C. The invention also relates to composite materials comprising a copolymer of ethylenically reactive species, wherein one of the species is a reactive ionic liquid surfactant having a melting point less than 80° C., and wherein the material also comprises non-reactive Class I fluid. The invention further relates to methods for synthesizing the composite materials comprising preparing a microemulsion of immiscible Class I fluid and Class II fluid stabilized by reactive ionic liquid surfactant wherein the ionic liquid surfactant has a melting point less than 80° C., and polymerizing the microemulsion to form a composite material. | 07-09-2009 |
Feng Yan, Meyrin CH
| Patent application number | Description | Published |
|---|---|---|
| 20090076477 | Automatic Liquid Injection System and Method - A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds. | 03-19-2009 |
Feng Yan, Plan-Les-Quates CH
| Patent application number | Description | Published |
|---|---|---|
| 20110200530 | TARGETING CONSTRUCT COMPRISING ANTI-POLYMER ANTIBODY AND CONTRAST/THERAPEUTIC AGENTS BINDING TO THE SAME - Pharmaceutical kit comprising (i) a targeting construct which comprises a targeting ligand and an anti-polymer antibody and (ii) a polymer-containing liposome or gas-filled microvesicle capable of binding or associating to said construct. Also disclosed are methods of preparing and of administering said assembly, as well as an assembly comprising said targeting construct and said liposome or gas-filled microvesicle. | 08-18-2011 |
Feng Yan, Jiangsu CN
| Patent application number | Description | Published |
|---|---|---|
| 20110215227 | Photosensitive Detector with Composite Dielectric Gate MOSFET Structure and Its Signal Readout Method - The present invention relates to a photosensitive detector with a composite dielectric gate MOSFET structure and its signal readout method. The MOSFET structure detector is formed on a p-type semiconductor substrate. N-type semiconductor regions locate on the two sides of the top part of the p-type semiconductor substrate to form a source and a drain. An underlying dielectric layer, a photo-electron storage layer, a top dielectric layer, and a control gate are stacked on the substrate in sequence. The top insulating dielectric layer can prevent the photoelectrons stored in the photo-electron storage layer from leaking into the control gate. The source and the drain are floating when photoelectrons are collected and injected into the photoelectron storing layer to be held therein. There is a transparent or semi-transparent window for detecting incident light forming on the substrate or gate surface. This invented detector has excellent scalability, basic compatibility with the flash memory fabricating technology, low leakage current, higher imaging speed than CCD, non-sensitivity to processing defects, larger dynamic range than other structures and higher accuracy of signal readout. | 09-08-2011 |
Feng Yan, West Lafayette, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20120117008 | Parallel Processing Of Data Sets - Systems, methods, and devices are described for implementing learning algorithms on data sets. A data set may be partitioned into a plurality of data partitions that may be distributed to two or more processors, such as a graphics processing unit. The data partitions may be processed in parallel by each of the processors to determine local counts associated with the data partitions. The local counts may then be aggregated to form a global count that reflects the local counts for the data set. The partitioning may be performed by a data partition algorithm and the processing and the aggregating may be performed by a parallel collapsed Gibbs sampling (CGS) algorithm and/or a parallel collapsed variational Bayesian (CVB) algorithm. In addition, the CGS and/or the CVB algorithms may be associated with the data partition algorithm and may be parallelized to train a latent Dirichlet allocation model. | 05-10-2012 |