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Feldman, MA
Adam S. Feldman, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090239245 | METHOD FOR DIAGNOSIS AND PROGNOSIS OF EPITHELIAL CANCERS - The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy. | 09-24-2009 |
Bart C. Feldman, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100169167 | Computer Implemented System for Determining a Distribution Policy for a Single Period Inventory System, Optimization Application Therefor, and Method Therefor, and Decision Support Tool for Facilitating User Determination of a Distribution Policy for a Single Period Inventory System - Computer implemented system for determining a distribution policy for a single period inventory system on the basis of the relative merit of allocating a draw unit of one of a multitude of different consumer items to one of a multitude of different locations in accordance with an allocation decision criterion subject to one or more constraints, an optimization application therefor, and method therefor, and including a Decision Support Tool for facilitating user determination of a distribution policy for a single period inventory system. | 07-01-2010 |
Henry Feldman, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100105071 | METHODS FOR PREDICTING THE ONSET OF MENARCHE - Embodiments of the invention provide methods for predicting the onset of menarche, i.e. a females first menstrual period, through the measurement of salivary hormone levels (e.g. 17-β estradiol, testosterone, progesterone, and/or 17 hydroxy-progesterone (17-OHP)). In particular, the methods described herein enable a reliable determination that menarche will, or will not occur, within varied time intervals, e.g. 1 to 30 days, 1 to 45 days, 1 to 60 days and 1 to 90 days. Diagnostic kits and products of manufacture comprising the kits are also provided. | 04-29-2010 |
Jeffrey Feldman, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100158924 | Expression of the cysteine protease legumain in vascular and inflammatory diseases - The present invention provides isolated and purified polynucleotides, polypeptides, and antibodies related to mammalian (e.g., mouse and human) legumain and the novel legumain splice variant, ZB-1. The invention further relates to the use of these isolated and purified polynucleotides, polypeptides, and antibodies, as well as other legumain and ZB-1 agonists and antagonists, in modulating legumain and/or ZB-1 activity, expression, and/or secretion in a cell or cell population, e.g., monocytes, macrophages, foam cells, vascular endothelial cells, kidney proximal tubule cells, arterial endothelial cells, sites of inflammatory cell invasion into a vessel intima, and neointimal lesional areas of an artery. The invention also provides legumain and ZB-1 antagonists, e.g., antagonistic small molecules, antibodies and antibody fragments to legumain and ZB-1, legumain and ZB-1 inhibitory polypeptides, and legumain and ZB-1 inhibitory polynucleotides. The present invention is also directed to novel methods for diagnosing, prognosing, monitoring, treating, ameliorating and/or preventing vascular disorders/diseases and inflammatory disorders/diseases. | 06-24-2010 |
Jeffrey L. Feldman, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090017019 | METHODS AND COMPOSITIONS FOR MODULATING BMP-10 ACTIVITY - Methods and compositions for modulating cardiac, renal and vascular cell function and homeostasis using agonists and antagonists of BMP-10 are disclosed. In particular, methods for treating, preventing and/or diagnosing BMP-10-associated vascular, renal, fibrotic and cardiac conditions and/or disorders are disclosed. Screening methods for evaluating BMP-10 modulators, e.g., agonists and antagonists, are also disclosed. | 01-15-2009 |
| 20090202474 | EXPRESSION OF ORPHAN GPR64 IN INFLAMMATORY DISEASES - Methods of screening for agents for treating inflammatory diseases are provided. The methods involve screening for agents that modulate the activity or expression of GPR64, which has been discovered herein to play a role in inflammatory diseases. Methods for treating an inflammatory disease, as well as methods of modulating the activity or expression of GPR64, methods of screening for an inflammatory disease in a subject, pharmaceutical compositions, a nucleic acid variant, and antibodies are also provided. | 08-13-2009 |
Jeffrey Lawrence Feldman, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080247955 | Inflammation treatment, detection and monitoring via TREM-1 - The present invention provides methods of treating inflammatory diseases/disorders in a subject by inhibiting/antagonizing TREM-1 expression/activity/signal transduction and/or DAP12/TyroBP expression and/or activity. Methods of detecting the presence of inflammatory disease in a subject by detecting TREM-1 and/or DAP12/TyroBP expression and/or activity in the subject or a sample obtained therefrom, wherein increased expression or activity is indicative of the inflammatory disease are also included. The present invention further provides methods for assessing the efficacy of a TREM-1-modulating agent administered to a patient by detecting levels of secreted phosphoprotein 1 (SPP1) and/or one or more other biomarkers in the patient or in a sample from the patient. | 10-09-2008 |