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Feldheim
Daniel Feldheim, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100000881 | Electrochemical detection of nucleic acid hybridization - A nucleic acid hybridization detection assay is carried out at an electrode. A solid electrode, such as an indium tin oxide electrode, is modified by capture probes comprising single-stranded oligonucleotides immobilized to the surface of the electrode. In some embodiments using sandwich assay methodology, the capture probes hybridize complementary target nucleic acid sequences, which in turn are bound to detection probes comprising nanoparticle-oligonucleotide conjugates comprising target-complementary oligonucleotides. In some embodiments, detection probes comprise nanoparticles attached to molecules comprising one partner of a ligand-binding pair (e.g., streptavidin), while target sequences comprise the other partner of the ligand-binding pair (e.g., biotin). When the assay is carried out in the presence of a redox mediator, redox reactions catalyzed, and/or facilitated and/or enhanced by the presence of nanoparticles generate electrons that are transferred to the electrode, resulting in a detectable electrical signal. | 01-07-2010 |
Daniel L. Feldheim, Boulder, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20100255194 | GRADIENT FABRICATION TO DIRECT TRANSPORT ON A SURFACE - The present invention discloses gradients and methods of forming gradients. The gradients can form a component of a molecular machine, such as those disclosed herein. The molecular machines of the present invention can perform a range of tasks including nanoparticle heterostructure assembly, derivatization of a nanoparticle and synthesis of biomolecules, to name just a few applications. | 10-07-2010 |
Daniel L. Feldheim, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080199529 | NANOPARTICLE DELIVERY VEHICLE - A nanoparticle delivery vehicle, comprising a nanoparticle, an active agent and a nuclear localization signal and methods of modulating gene expression and protein expression employing the nanoparticle delivery vehicle. A representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter of about 30 nm or less, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the nucleus of a target cell. Another representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter greater than or equal to about 30 nm, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the cytoplasm of a cell. | 08-21-2008 |