Patent application number | Description | Published |
20080314114 | FLUORESCENCE CALIBRATOR FOR MULTIPLE BAND FLAT FIELD CORRECTION - A fluorescence reference plate for a fluorescence spectroscopic instrument is arranged with fluorescent layers having different excitation and emission characteristics. The fluorescent layers are ordered in the form of a stack for providing a flat-field calibration standard over multiple bands of wavelengths. | 12-25-2008 |
20090067582 | IMAGING TARGET FOR TESTING QUALITY OF MULTIPLE-MAGNIFICATION FOCUS AND IMAGE CO-REGISTRATION - An imaging target, suited for use in multi-modal imaging systems, includes test patterns for testing quality of both focus and co-registration for multiple magnifications and multiple modalities of operation of a multimodal imaging system. | 03-12-2009 |
20090080608 | METHOD AND APPARATUS FOR MEASURING LONG BONE DENSITY OF SMALL-ANIMALS - A method and apparatus are disclosed for measuring long bone density of small animals. A phosphor screen or plate is provided of a type that transduces incident ionizing radiation to emitted light. A small animal is positioned before the phosphor screen or plate and exposed to soft X-radiation having an energy level in the range of 11 to 16 Kev. Light emitted by the phosphor screen or plate is captured using a digital camera and a digital X-ray image is prepared of a long bone of the animal. The X-ray image is transformed into an X-ray density image and a region of interest is defined on the long bone in the X-ray density image. At least one row of pixels is scanned within the region of interest of the X-ray density image. A nonlinear least squares analysis of data obtained from the scanning step is conducted using a cylindrical model for the long bone within the region of interest. | 03-26-2009 |
20090273944 | VARIABLE CONDENSER FOR DELIVERY OF ILLUMINATION INCLUDING RECURSIVELY NESTED CIRCLE-TO-LINE FIBER OPTIC CONVERTER CABLE - A variable condenser for delivery of illumination, including a recursively nested circle-to-line fiber optic shape-converting cable and a focusable input lens system. At the input of the fiber optic cable, sets of individual optical fibers comprise successively smaller annuli recursively nested about a common center. At the output of the fiber optic cable, the sets of individual optical fibers comprise pairs of line segments recursively nested about the line midpoint, whereby the nesting level of the pairs of line segments has an exact or an approximate correspondence to the nesting level of the annuli. The output may be split into a plurality of lines, whereby the sets of individual optical fibers are distributed among the plurality of lines. The input lens system has a single adjustable focus means to vary the radius of an illumination spot incident upon the input of the fiber optic cable circle input. | 11-05-2009 |
20100022866 | TORSIONAL SUPPORT APPARATUS AND METHOD FOR CRANIOCAUDAL ROTATION OF ANIMALS - A torsional support apparatus is disclosed for craniocaudal rotation of test animals to enable multiple-view imaging. The animal is supported in a U-shaped loop of optically transparent material and the loop is moved to apply torsion to the animal to rotate it about its craniocaudal axis. Methods of imaging also are disclosed that use the torsional support technique. | 01-28-2010 |
Patent application number | Description | Published |
20130217583 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS - The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds. | 08-22-2013 |
20140256595 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS - The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | 09-11-2014 |
20140323317 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS - The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | 10-30-2014 |
Patent application number | Description | Published |
20100208348 | TUNABLE SPECTRAL FILTRATION DEVICE - A tunable spectral filtration device comprises at least one optical filter for intersecting a first path of converging or diverging light comprising an axis at a first angle of incidence and at least one device positioned to enable a second path of the converging or diverging light to pass through the at least one optical filter at a second angle of incidence. The optical filter comprises at least one coating and is tiltable over a plurality of angles with respect to the axis. The first angle of incidence is opposite in sign to the second angle of incidence, such that the positioning of the at least one optical filter and the at least one device substantially cancels angle-of-incidence dependent spectral broadening and/or polarization dependent spectral broadening of the converging or diverging light. | 08-19-2010 |
20100218140 | GRAPHICAL USER INTERFACE FOR MULTI-MODAL IMAGES AT INCREMENTAL ANGULAR DISPLACEMENTS - A method for forming a sequence of images of a subject obtains at least first and second image sets of the subject, each image set having a given angular displacement relative to an axis of rotation of the subject, each image set having at least a first component image of a first diagnostic modality at the given angular displacement and a second component image that is co-registered to the first component image at the given angular displacement. The first image set is selected as the selected image set for display. A synthesized image is formed by combining image data for the at least first and second component images of the selected image set and the synthesized image is displayed. | 08-26-2010 |
20100220836 | APPARATUS AND METHOD FOR MULTI-MODAL IMAGING - An imaging system and method for imaging an immobilized object. The imaging system includes a support member adapted to receive the object in an immobilized state. The system also includes first means for imaging the immobilized object in a first imaging mode to capture a first image, and second means for imaging the immobilized object in a second imaging mode to capture a second image. The first imaging mode is selected from the group: x-ray mode and radio isotopic mode. The second imaging mode is selected from the group: bright-field mode and dark-field mode. The first and second means for imaging may be included in a capture system having a camera, a first mirror on a first side of the support member for reflecting light to capture the first and second images and a second mirror on a second, opposite side of the support member for reflecting light to capture a third image from an opposite side of the object. A movable phosphor screen is employed when the first image is captured and not employed when the second image is captured. The phosphor screen is adapted to be movable without moving the immobilized object and support member. The system can further include means for generating a third image comprised of the first and second images. | 09-02-2010 |
20120008742 | APPARATUS AND METHOD FOR MULTI-MODAL IMAGING - An imaging system and method for imaging an immobilized object. The imaging system includes a support member adapted to receive the object in an immobilized state. The system also includes means for imaging the immobilized object in various imaging modes to capture images of the object. The imaging system further includes a movable phosphor screen. The phosphor screen is adapted to be movable without moving the immobilized object and support member. | 01-12-2012 |
20120106702 | APPARATUS AND METHOD FOR MULTI-MODAL IMAGING USING MULTIPLE X-RAY SOURCES - An imaging system for imaging at least a first and a second subject has a support stage to support the subjects. An imaging system has an ionizing radiation imaging section with at least a first ionizing radiation source for directing ionizing radiation within a first zone that includes the first subject and a second ionizing radiation source for directing ionizing radiation within a second zone that lies substantially outside the first zone and that includes the second subject. At least one imaging receiver forms an image of the subject within each zone. A camera system obtains at least one image of the at least first and second subjects. A computer is in signal communication with the imaging system and energizable to form a combined image from two or more images of the same subjects. | 05-03-2012 |
20140066819 | LUMINESCENCE-GUIDED FOCUSED ULTRASOUND APPARATUS AND METHOD - A luminescence-guided focused ultrasound apparatus, comprising at least one focused ultrasound transducer that delivers focused ultrasound energy to at least one focal region within the subject, at least one luminescence detector that detects a luminescence signal generated within the subject, and at least one guiding element that guides the at least one focused ultrasound transducer to deliver focused ultrasound energy to the at least one focal region wherein the at least one guiding element is influenced by the detected luminescence signal. The at least one focused ultrasound transducer may be configured in operate in a plurality of modes, including a low-intensity mode for delivering low-intensity focused ultrasound energy and a high-intensity mode for delivering high-intensity focused ultrasound energy. | 03-06-2014 |
20140086567 | IMAGING ENCLOSURE APPARATUS AND METHODS - An imaging apparatus for imaging an object has an enclosure chassis that defines an enclosed imaging volume and that provides an imaging aperture to a camera apparatus that mounts against the chassis and that further provides at least a first lateral access opening for access to the object. A light-obstructing gasket is coupled to the enclosure chassis and has at least a first foldable lateral access leaf that folds to a first position against the first lateral access opening to block ambient light through the first lateral access opening and that folds away from the first lateral access opening to a second position to allow access to the object. | 03-27-2014 |
20140240468 | FRAME-SEQUENTIAL MULTIWAVELENGTH IMAGING SYSTEM AND METHOD - A frame-sequential multiwavelength imaging system comprises a wavelength switching device for producing a repeated series of different wavelength profiles, a detector for detecting the dynamic scene and a signal processing unit for synthesizing a dynamic multiwavelength image of the dynamic scene. The signal processing unit may comprise at least one input device at least one logic device and at least one output device. The system can be used in a method to perform multiwavelength imaging of a dynamic scene, typically for surgical purposes. | 08-28-2014 |