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Farson

Debbie Farson, San Francisco, CA US

Patent application numberDescriptionPublished
20110028694METHODS TO EXPRESS RECOMBINANT PROTEINS FROM LENTIVIRAL VECTORS - Lentivector constructs for expression of recombinant proteins, polypeptides or fragments thereof and methods of making the same are described. The lentivectors typically have a self-processing cleavage sequence between a first and second protein or polypeptide coding sequence allowing for expression of a functional protein or polypeptide under operative control of a single promoter and may further include an additional proteolytic cleavage sequence which provides a means to remove the self-processing cleavage sequence from the expressed protein or polypeptide. The vector constructs find utility in methods relating to enhanced production of biologically active proteins, such as immunoglobulins or fragments thereof in vitro and in vivo.02-03-2011

Deborah Farson, Oakland, CA US

Patent application numberDescriptionPublished
20080241929METHOD AND MEANS FOR PRODUCING HIGH TITER, SAFE, RECOMBINANT LENTIVIRUS VECTORS - Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production. The vectors can contain inducible or conditional promoters.10-02-2008

Deborah A. Farson, Oakland, CA US

Patent application numberDescriptionPublished
20080286836METHOD AND MEANS FOR PRODUCING HIGH TITER, SAFE RECOMBINANT LENTIVIRUS VECTORS - Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production.11-20-2008

Max Robert Farson, Greenville, SC US

Patent application numberDescriptionPublished
20100329863METHOD FOR REDUCING TIP RUB LOADING - A method for reducing tip rub loads in a rotor blade is described having the steps of selecting a location of contact between the rotor blade and a static structure; selecting a location on the blade for incorporating a tip-cutter; selecting a cutter-profile for the tip-cutter; and incorporating the tip-cutter on the selected location on the blade such that tip-cutter is capable of removing a portion of the static structure during a tip rub such that tip rub loads are facilitated to be reduced.12-30-2010
20100329875ROTOR BLADE WITH REDUCED RUB LOADING - An airfoil for use in a rotor assembly is disclosed, the airfoil having a tip-cutter located on a sidewall near a tip portion, wherein the tip-cutter is capable of removing a portion of an abradable material during a tip rub. In another embodiment, an airfoil has a tip-grinder located on the tip portion, wherein the tip-grinder capable of removing a portion of an abradable material during a tip rub. In another embodiment, an airfoil has a tip-rake that facilitates reducing loading induced to said airfoil during tip rubs.12-30-2010