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Farrar
Daniel James Farrar, Ontario CA
| Patent application number | Description | Published |
|---|---|---|
| 20100114843 | Index Compression In Databases - Systems, methods and computer program products for compression of database indexes are described herein. A system embodiment includes a sequence determiner to scan a database index and to determine a start of a range and end of a range of consistently changing values in one or more index pages of said database index and an index updater to update said database index based on a sequence determined by said sequence determiner, while suspending writing of one or more values that lie within start of said range and end of said range of values. A method embodiment includes scanning an index, determining a pattern of changing values in one or more index pages of said index and selectively updating said index based on said determining step to minimize index insertions. The method embodiment further includes determining a start of a range of values and an end of said range of values in an index page, setting appropriate bits to identify said start of range of values and end of range of values, determining if an entry to be inserted can appended to at the end of said range of values, and compressing said index by suspending writing of one or more values that occur between said start of range of values and said end of range of values. | 05-06-2010 |
Gwenyth Jane Farrar, Monkstown IE
| Patent application number | Description | Published |
|---|---|---|
| 20090197336 | SUPPRESSION OF POLYMORPHIC ALLELES - Methods and agents for suppressing expression of a mutant allele of a gene having a polymorphism are provided. The methods of the invention provide suppression effectors such as antisense nucleic acids or ribozymes, that bind to nucleic acid regions having a polymorphism within a gene such that one allele of a gene is exclusively or preferentially suppressed. The method also provides the administration of a replacement nucleic acid, if required. The invention has the advantage that the same suppression strategy, when directed to polymorphisms, could be used to suppress, in principle, many mutations in a polymorphic gene. This is particularly relevant when large numbers of mutations within a single gene cause disease pathology. | 08-06-2009 |
| 20110190371 | GENETIC SUPPRESSION AND REPLACEMENT - Methods and agents for suppressing expression of a mutant allele of a gene and providing a replacement nucleic acid are provided. The methods of the invention provide suppression effectors such as, for example, antisense nucleic acids, ribozymes, or RNAi, that bind to the gene or its RNA. The invention further provides for the introduction of a replacement nucleic acid with modified sequences such that the replacement nucleic acid is protected from suppression by the suppression effector. The replacement nucleic acid is modified at degenerate wobble positions in the target region of the suppression effector and thereby is not suppressed by the suppression effector. In addition, by altering wobble positions, the replacement nucleic acid can still encode a wild type gene product. The invention has the advantage that the same suppression strategy could be used to suppress, in principle, many mutations in a gene. Also disclosed is a transgenic mouse that expresses human rhodopsin (modified replacement gene) and a transgenic mouse that expresses a suppression effector targeting rhodopsin. Also disclosed in intraocular administration of siRNA. | 08-04-2011 |
Gwenyth Jane Farrar, Dublin IE
| Patent application number | Description | Published |
|---|---|---|
| 20110229439 | COMPLEMENT PROTEINS - The present invention relates to classical pathway complement proteins and their use in the prognosis and prevention of diseases involving cone photoreceptor degeneration. Specifically, the present invention is directed to the use of one or more classical pathway complement proteins, preferably involved in the recognition phase, in the maintenance of cone photoreceptor cell viability in a degenerating retina. The invention is also directed to a method for determining the susceptibility, risk of development and/or progression of diseases involving cone photoreceptor degeneration in a subject. | 09-22-2011 |
Gwyneth Jane Farrar, Co Dublin IE
| Patent application number | Description | Published |
|---|---|---|
| 20100190841 | GENETIC SUPPRESSION AND REPLACEMENT - The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid. | 07-29-2010 |
Gwyneth Jane Farrar, Monkstown IE
| Patent application number | Description | Published |
|---|---|---|
| 20090233368 | ALLELE SUPPRESSION - A strategy for suppressing expression of one allele of an endogenous gene is provided comprising providing suppression effectors such as antisense nucleic acids able to bind to polymorphisms within or adjacent to a gene such that one allele of a gene is exclusively or preferentially suppressed and if required of a replacement gene can be introduced. | 09-17-2009 |
Stephen Farrar, Telopea AU
| Patent application number | Description | Published |
|---|---|---|
| 20090003601 | ALPHA-MASKED IMAGE MATCHING - A method and system is disclosed for authenticating a physical medium ( | 01-01-2009 |