Patent application number | Description | Published |
20090136086 | Spray data acquisition system - A spray data acquisition system includes a spray pump actuator that is capable of providing a pumping force to a pumping device to generate an aerosol spray plume along a spray axis. The system also includes an illumination device that illuminates the aerosol spray plume along at least one first geometric plane that intersects the aerosol spray plume. The system further includes an imaging device that acquires data representative of an interaction between the illumination and the aerosol spray plume along at least one geometric plane. | 05-28-2009 |
20100116070 | Method and Apparatus for Measuring Manual Device Actuation - An assembly that provides operational information about operation of a device, such as a nasal spray pump or metered dose inhaler. A linkage adapted to extend between a mounting assembly, connected to a stationary part of the device, and an adapter assembly, connected to a movable part of the device, is in operational relationship with a transducer to enable the transducer to indicate a mechanical relationship between the movable and stationary parts of the device corresponding to the operation of the device. A data collection and processing system may be connected to the transducer for determining information that may be used to program an automated actuation system. | 05-13-2010 |
20100271477 | Spray Angle Measurement Apparatus and Method - Direction of material emitted from orifices is directly related to the effectiveness of spray devices to deliver the material to an intended location area. Improper emission direction results in material, such as medication, paint, or fuel, not reaching its intended target and causes cascading effects, such as improper patient dosing, compromised patient relief, waste, poor target coverage, missed target penetration, poor engine performance, and other safety/performance problems. An apparatus for inspecting operation of an orifice according to an example embodiment measures actual material emission direction relative to an expected material emission direction determined as a function of position and orientation of an orifice. The apparatus may confirm whether the emission direction is within an expected emission direction and accepted tolerance range. Through use of the apparatus, accurate screening of production products can be performed efficiently and manufacturing defects can be diagnosed and eliminated. | 10-28-2010 |
Patent application number | Description | Published |
20100055180 | Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof - An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose and a binder, and optionally a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API. | 03-04-2010 |
20110092598 | Driectly Compressible High Functionality Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof - An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API. | 04-21-2011 |
20110136921 | SUSTAINED RELEASE COMPOSITION - A sustained release composition comprising spray dried particles of at least one polysaccharide gum and at least one polyhydric sugar alcohol, as well as methods of making the sustained released composition are provided. A sustained release pharmaceutical solid dosage form, and a method of making the solid dosage form by compression are also provided. | 06-09-2011 |
20110229527 | DIRECTLY COMPRESSIBLE HIGH FUNCTIONALITY GRANULAR DIBASIC CALCIUM PHOSPHATE BASED CO-PROCESSED EXCIPIENT - An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular dibasic calcium phosphate based excipient is provided. The improved excipient comprises dibasic calcium phosphate, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the components. The improved excipient provides enhanced flowability/good flow properties, an increased API loading and blendability and higher compactibility as compared to the individual components, and as compared to excipients formed from the same materials by conventional methods. | 09-22-2011 |
20110288146 | DIRECTLY COMPRESSIBLE GRANULAR MICROCRYSTALLINE CELLULOSE BASED, EXCIPIENT, MANUFACTURING PROCESS AND USE THEREOF - An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose and a binder, and optionally a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API. | 11-24-2011 |
20120100211 | MATERIAL AND PROCESS FOR INCORPORATION OF LOW DOSAGE ACTIVE PHARMACEUTICAL INGREDIENTS AND USE THEREOF - A low dose API pharmaceutical tablet having excellent content uniformity is provided. The tablet is formed by spray coating a support excipient with the API. The resulting composition is suitable for direct compression tablet formulation without the need for an additional granulation step to uniformly coat the API onto the support excipient. The support excipient comprises microcrystalline cellulose, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the support excipient components. | 04-26-2012 |
Patent application number | Description | Published |
20100178194 | Powder extrusion of shaped sections - The present invention provides a continuous powder extrusion method for making an article having a profile including an outer shape and optionally including one or more inner hollows. One or more bulk material powders and one or more binders are provided, and the bulk material powders and the binders are mixed to form a mixture. A die is provided, the die optionally including a mandrel having one or more shapes. The mixture is extruded through the die and the optional mandrel to produce a green form. The green form is debound to produce a brown form and the brown form is sintered to produce a densified form. The densified form is optionally processed using thermal, mechanical, and/or thermomechanical processing to produce a wrought form. The densified or wrought form is optionally cut to a length and/or finished using traditional metal finishing processes. | 07-15-2010 |
20120225989 | MATERIAL PROCESSING SYSTEMS - Material processing systems are disclosed. Some systems include methods of eliminating or reducing defects in elongate workpieces that can undergo large deformations during processing. Some systems include apparatus configured to facilitate such large deformations while maintaining internal stresses (e.g., tensile stresses) below a threshold stress. Some disclosed systems pertain to powder extrusion techniques. Continuous and batch processing systems are disclosed. | 09-06-2012 |
20130218281 | PRESSURE FORMING OF METAL AND CERAMIC POWDERS - A method of pressure forming a brown part from metal and/or ceramic particle feedstocks includes: introducing into a mold cavity or extruder a first feedstock and one or more additional feedstocks or a green or brown state insert made from a feedstock, wherein the different feedstocks correspond to the different portions of the part; pressurizing the mold cavity or extruder to produce a preform having a plurality of portions corresponding to the first and one or more additional feedstocks, and debinding the preform. Micro voids and interstitial paths from the interior of the preform part to the exterior allow the escape of decomposing or subliming backbone component substantially without creating macro voids due to internal pressure. The large brown preform may then be sintered and subsequently thermomechanically processed to produce a net wrought microstructure and properties that are substantially free the interstitial spaces. | 08-22-2013 |
20150044462 | MATERIAL PROCESSING SYSTEMS - Material processing systems are disclosed. Some systems include methods of eliminating or reducing defects in elongate workpieces that can undergo large deformations during processing. Some systems include apparatus configured to facilitate such large deformations while maintaining internal stresses (e.g., tensile stresses) below a threshold stress. Some disclosed systems pertain to powder extrusion techniques. Continuous and batch processing systems are disclosed. | 02-12-2015 |
Patent application number | Description | Published |
20130311789 | BLOCK-LEVEL DATA STORAGE SECURITY SYSTEM - A secure storage appliance is disclosed, along with methods of storing and reading data in a secure storage network. The secure storage appliance is configured to present to a client a virtual disk, the virtual disk mapped to the plurality of physical storage devices. The secure storage appliance is capable of executing program instructions configured to generate a plurality of secondary blocks of data by performing splitting and encrypting operations on a block of data received from the client for storage on the virtual disk and reconstitute the block of data from at least a portion of the plurality of secondary blocks of data stored in shares on corresponding physical storage devices in response to a request from the client. | 11-21-2013 |
20140108796 | STORAGE OF CRYPTOGRAPHICALLY-SPLIT DATA BLOCKS AT GEOGRAPHICALLY-SEPARATED LOCATIONS - A secure storage appliance is disclosed, along with methods of storing and reading data in a secure storage network. The secure storage appliance is configured to present to a client a virtual disk, the virtual disk mapped to the plurality of physical storage devices. The secure storage appliance is capable of executing program instructions configured to generate a plurality of secondary data blocks by performing splitting and encrypting operations on a primary data block received from the client for storage on the virtual disk. For security, the secondary data blocks are stored at geographically-distributed locations. The secure storage appliance is also capable of executing program instructions configured to reconstitute the primary data block from at least a portion of the plurality of secondary data blocks stored in shares on corresponding physical storage devices in response to a request from the client. | 04-17-2014 |
20140108797 | STORAGE COMMUNITIES OF INTEREST USING CRYPTOGRAPHIC SPLITTING - Methods and systems of presenting data in a secure data storage network are disclosed. One method includes defining a community of interest capable of accessing data stored in a secure data storage network, the community of interest including a plurality of users desiring access to a common set of data. The method also includes associating the community of interest with a workgroup key. and, upon identification of a client device as associated with a user from among the plurality of users in the community of interest, presenting a virtual disk to the client device, the virtual disk associated with the workgroup key and a volume containing the common set of data, the volume including a plurality of shares stored on a plurality of physical storage devices. | 04-17-2014 |
20140129844 | STORAGE SECURITY USING CRYPTOGRAPHIC SPLITTING - Methods and systems for storing data securely in a secure data storage network are disclosed. One method includes receiving at a secure storage appliance a block of data for storage on a volume, the volume associated with plurality of shares distributed across a plurality of physical storage devices. The method also includes cryptographically splitting the block of data received by the secure storage appliance into a plurality of secondary data blocks. The method further includes encrypting each of the plurality of secondary data blocks with a different session key, each session key associated with at least one of the plurality of shares. The method also includes storing each data block and associated session key at the corresponding share, remote from the secure storage appliance. | 05-08-2014 |
Patent application number | Description | Published |
20150120459 | INTERCONNECTED PLATFORMS FOR PROVIDING ADVERTISEMENTS - Systems and methods for selling unsold ad (advertisement) avails as individual ad avails or as bundled with other unsold ad avails in a demographic bin. Ad avails and ad demographic bins may be sold to an ad buyer and may represent a variety of parameters and/or terms to which the ad demographic bin seller may have to perform. The ad demographic bins may specify a number of views, a targeted geography of those views, and/or a targeted demographic of those views. The unsold ad avails may be offered for sale without indicating the content, content providers, or the time slot associated with the ad avail. These ad avails may be offered for sale if it is determined that the ad avails are about to expire, such as within a threshold number of days. In the cases, where the ad avails are sold as a demographic bin (i.e. bundled with other ad avails), the aggregate demographic parameters associated with the demographic bin may be indicated when offering the ad avails for sale. Once an ad demographic bin is sold, one or more ad avails, spots, and/or other ad assets may be acquired, such as from media and/or content providers for the purpose of rendering one or more ads on behalf of the ad buyer. The ad avails, spots, and/or other ad assets may be selected and/or acquired in a manner as to perform to the parameters of the ad demographic bin. | 04-30-2015 |
20150120464 | INTERCONNECTED PLATFORM FOR PROVIDING ADVERTISEMENTS - Systems and methods for generating, selling, executing terms of ad demographic bins are disclosed. Ad demographic bins may be sold to ad buyer and may represent a variety of parameters and/or terms to which the ad demographic bin seller may have to perform. The ad demographic bins may specify a number of views, a targeted geography of those views, and/or a targeted demographic of those views. Once an ad demographic bin is sold, one or more ad avails, spots, and/or other ad assets may be acquired, such as from media and/or content providers for the purpose of rendering one or more ads on behalf of the ad buyer. The ad avails, spots, and/or other ad assets may be selected and/or acquired in a manner as to perform to the parameters of the ad demographic bin. | 04-30-2015 |
20150334433 | Zone Signal Targeting and Analytics - Systems and methods for targeting advertisements to particular zones within a content distribution region are disclosed. One or more zone signals may be generated and distributed by combining media content with a respective advertisement corresponding to each of the zones within the distribution region. In some example cases, the media content may be received from a broadcaster. The systems and methods may further include the capability to determine zone based and/or advertisement based viewing metrics for one or more of the zones within the content distribution region by polling client devices within the one or more zones. | 11-19-2015 |