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Fanara
Domenico Fanara, Brussels BE
| Patent application number | Description | Published |
|---|---|---|
| 20110021786 | Pharmaceutical Solutions, Process of Preparation and Therapeutic Uses - The present invention concerns a stable pharmaceutical solution, a process of the preparation thereof and therapeutic uses thereof. | 01-27-2011 |
| 20110091547 | Pharmaceutical Compositions Comprising Brivaracetam - The present invention relates to a pharmaceutical composition comprising brivaracetam as active ingredient, the invention relates specifically to a prolonged release formulation. | 04-21-2011 |
Domenico Fanara, Wanze BE
| Patent application number | Description | Published |
|---|---|---|
| 20080206331 | TABLET COMPRISING EFLETIRIZINE AND PSEUDOEPHEDRINE - The present invention concerns a tablet comprising two distinct segments. More particularly the invention relates to combinations of two pharmaceutical substances and methods of treatment of allergic disorders. | 08-28-2008 |
| 20090047344 | Formulations - The present invention relates to pharmaceutical compositions for oral administration of active compounds. | 02-19-2009 |
| 20110027359 | Novel Pharmaceutical Compositions Comprising Levetiracetam - The present invention relates to a pharmaceutical composition comprising levetiracetam as active ingredient, the invention relates specifically to a prolonged release formulation. | 02-03-2011 |
Patrizia Fanara, Oakland, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110076236 | COMPOSITIONS AND METHODS OF TREATMENT USING MODULATORS OF MOTONEURON DISEASES - The invention disclosed herein describes a novel therapeutic target for motoneuron diseases (altered dynamics of microtubules in neurons); methods for measuring the state of activity of this therapeutic target in subjects with established, incipient, or potential motoneuron disease; the discovery of drug agents that modulate neuronal microtubule dynamics in living subjects with motoneuron diseases; the discovery that administration of such agents, alone or in combinations, can improve MT-mediated transport of “synaptic vesicle cargo” molecules along and through axons; the discovery that such modulation of altered microtubule dynamics and improvement in MT-transport of molecules along axons can provide marked neuroprotective therapy for living subjects with motoneuron diseases, including delay in symptoms and prolongation of survival; and the discovery that monitoring of neuronal microtubule dynamics in response to therapeutic interventions in subjects with motoneuron diseases, allows diagnostic monitoring, to optimize therapeutic regimens and treatment strategies in individual subjects or in drug trials. The monitoring involves measuring isotope enrichment in secreted synaptic vesicle cargo molecules. | 03-31-2011 |
Patrizia A. Fanara, Oakland, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090197279 | MICROTUBULE SYNTHESIS AS A BIOMARKER - Stable isotope labeling was used to measure dynamics of tubulin incorporation into microtubule subpopulations representing different neuronal compartments in the murine hippocampus. Neuronal microtubules were largely static. Basal turnover was highest in tau-associated (axona) and growth cone), lower in MAP2-associated (somatodendritic), and lowest in cold stable (axonal shaft) subpopulations. Intracerebroventricular glutamate injection stimulated label incorporation into axonal shaft and somatodendritic microtubules, the latter dependent on cAMP-PKA. Hippocampus-dependent memory formation after contextual fear conditioning was accompanied by increased assembly of MAP2- and cold stable-microtubules. Both microtubule assembly and memory formation were inhibited by the microtubule depolymerizing drug, nocodazole. This approach allows for correlation with behavioral measures of learning and memory and for the screening of candidate agents for stimulatory activities on learning memory. | 08-06-2009 |