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| 20080241831 | Methods for detecting small RNA species - The invention provides a method of detecting small target nucleotide sequences, in particular, small RNA species that are present in a sample. The method generally comprises a poly-A polymerization step or a ligation step to add a universal sequence to the 3′-end of all RNA molecules, followed by a universal primer-mediated cDNA synthesis, solid-phase selection, assay oligo annealing, extension and PCR amplification/labeling. The method of the invention can be practiced to amplify and label a small amount of miRNA or other ncRNA. The resulting amplification product can be read out on a universal array or an array with miRNA-specific or ncRNA-specific probes. The invention has multiple embodiments, including methods, compositions, and kits. In general, the nucleic acids, compositions, and kits comprise materials that are useful in carrying out the methods of the invention or are produced by the methods, and that can be used to detect small target nucleic acid sequences present in samples, in particular, small RNA species. | 10-02-2008 |
| 20080242555 | MULTIPLEX NUCLEIC ACID REACTIONS - The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously. | 10-02-2008 |
| 20100015626 | MULTIPLEX NUCLEIC ACID REACTIONS - The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously. | 01-21-2010 |
| 20100311064 | MULTIPLEX NUCLEIC ACID REACTIONS - The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously. | 12-09-2010 |
| 20110152111 | MULTIPLEX NUCLEIC ACID ANALYSIS USING ARCHIVED OR FIXED SAMPLES - The present invention is directed to compositions and methods for multiplex analyses of nucleic acids from archival tissues. | 06-23-2011 |
| 20110153534 | Expression Profiles to Predict Relapse of Prostate Cancer - The present invention provides a method for preparing a reference model for cancer relapse prediction that provides higher resolution grading than Gleason score alone. The method encompasses obtaining from different individuals a plurality of prostate carcinoma tissue samples of known clinical outcome representing different Gleason scores; selecting a set of signature genes having an expression pattern that correlates positively or negatively in a statistically significant manner with the Gleason scores; independently deriving a prediction score that correlates gene expression of each individual signature gene with Gleason score for each signature gene in said plurality of prostate carcinoma tissue samples; deriving a prostate cancer gene expression (GEX) score that correlates gene expression of said set of signature genes with the Gleason score based on the combination of independently derived prediction scores in the plurality of prostate cancer tissue samples; and correlating said GEX score with the clinical outcome for each prostate carcinoma tissue sample. A set of signature genes is provided that encompasses all or a sub-combination of GI_2094528, KIP2, NRG1, NBL1, Prostein, CCNE2, CDC6, FBP1, HOXC6, MKI67, MYBL2, PTTG1, RAMP, UBE2C, Wnt5A, MEMD, AZGP1, CCK, MLCK, PPAP2B, and PROK1. Also provided a methods for predicting the probability of relapse of cancer in an individual and methods for deriving a prostate cancer gene expression (GEX) score for a prostate carcinoma tissue sample obtained from an individual. | 06-23-2011 |
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| 20100190787 | Modulators of Mitotic Kinases - The invention relates to compounds of Formula (I), a prodrug, a polymorph, a tautomer, an enantiomer, a stereoisomer, a solvate, an N-oxide, or a pharmaceutically acceptable salt thereof: (formula should be inserted here) which have inhibitory effect on one or more protein kinases that are involved in cell mitosis. | 07-29-2010 |
| 20100249067 | Modulators of Mitotic Kinases - The invention relates to compounds of Formula (I), a polymorph, an enantiomer, a stereoisomer, a solvate, an N-oxide derivative, or a pharmaceutically acceptable salt thereof: Formula (I), which have inhibitory effect on one or more protein kinases that are involved in cell mitosis. | 09-30-2010 |
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| 20090161746 | RECEIVER ADJUSTMENT BETWEEN PILOT BURSTS - A receiver may train its equalizer using consecutive pilot bursts, divide the traffic between the consecutive pilot bursts into multiple sub-segments, and interpolate the trained equalizer coefficients to obtain the coefficients for equalizing one or more of the sub-segments. The receiver may also determine signal to interference and noise ratio (SINR) values based on each of the consecutive pilot bursts, and interpolate the SINR for decoding one or more of the sub-segments. The receiver may be an access terminal receiver operating in a code division multiple access (CDMA) cellular system. | 06-25-2009 |
| 20090252099 | INTERFERENCE MANAGEMENT IN A WIRELESS COMMUNICATION SYSTEM USING FREQUENCY SELECTIVE TRANSMISSION - Interference that occurs during wireless communication may be managed by determination of a selected transmit waveform exhibiting a preferred channel quality. A method, apparatus and medium of communication determine a transmit waveform from among a plurality of allocated waveforms of an unplanned access point to an associated access terminal. The transmit waveform exhibiting a highest channel quality with an associated access terminal over others of the plurality of allocated waveforms is determined. Signals are transmitted according to the transmit waveform from the unplanned access point to the associated access terminal. | 10-08-2009 |
| 20100080189 | METHOD AND APPARATUS FOR PLUG-AND-PLAY VENUE-CAST CO-CHANNEL WITH WIDE-AREA NETWORK - A system, method, and apparatus for providing venue-cast service in a wireless access network are disclosed. A local transmitter can request reservation of air link resources on the wireless access network for a venue-cast transmission. The local transmitter can receive a forward link signal with a timing reference for data transmitted on the wireless access network such as, for example, the forward link signal in an EV-DO network or a FLO-based media distribution system. Based on the timing reference, the local transmitter can transmit venue-cast information in a same frequency band as the forward link signal utilizing the reserved air link resources. Optionally, the venue-cast system can include a collocated network repeater and the local transmitter can synchronize its timing and transmit power to the forward link signal from the repeater. | 04-01-2010 |
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| 20090134046 | INSTRUMENTS AND METHODS FOR MIXING THE CONTENTS OF A DETECTION CHAMBER - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle. | 05-28-2009 |
| 20090136913 | Gravity-Assisted Mixing Methods - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle. | 05-28-2009 |
| 20090136963 | METHODS OF CONCENTRATING AN ANALYTE - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle. | 05-28-2009 |
| 20090142745 | INSTRUMENTS AND METHODS FOR EXPOSING A RECEPTACLE TO MULTIPLE THERMAL ZONES - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle. | 06-04-2009 |
| 20090142771 | Methods and Instruments for Processing a Sample in a Multi-Chambered Receptacle - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle. | 06-04-2009 |
| 20100196908 | SYSTEMS AND METHODS FOR DETECTING A SIGNAL AND APPLYING THERMAL ENERGY TO A SIGNAL TRANSMISSION ELEMENT - A signal detection system configured for detecting a signal emitted by the contents of a reaction receptacle is also configured to apply thermal energy to a portion of the reaction receptacle to affect a reaction occurring within the reaction receptacle. More particularly, a system for detecting electromagnetic radiation emitted by the contents of a reaction receptacle includes a transmission element configured for transmitting electromagnetic radiation from the contents of the receptacle, a thermal element associated with the transmission element and configured to apply thermal energy to at least a portion of the receptacle, and a detector configured to receive electromagnetic radiation from the transmission element and to generate a signal corresponding to a characteristic of the electromagnetic radiation received by the detector. | 08-05-2010 |
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| 20100052817 | Integrated Circuit Inductor with Transverse Interfaces - An integrated circuit (IC) inductor structure is provided with transverse electrical interfaces. The inductor structure is formed on at least one IC circuit layer and has a first axis planar to a circuit layer surface, bisecting the inductor into opposite first and second sides. An input interface is formed on the circuit layer and connected to the inductor first side, parallel to a second axis, which is perpendicular to the first axis. An output interface is formed on the circuit layer and connected to the inductor second side, parallel to the second axis. In one aspect, the inductor has a center tap electrical interface parallel to the axis. In another aspect, the inductor includes a three-dimensional (3D) loop formed over a plurality of the circuit layers. | 03-04-2010 |
| 20100052837 | Integrated Circuit Multilevel Inductor - An integrated circuit (IC) multilevel inductor structure is provided. The IC multilayer inductor structure is made from an IC including a plurality of circuit layers, where the inductor is a three-dimensional (3D) loop formed over a plurality of the circuit layers. In a simple example, if the IC includes a first circuit layer and a second circuit layer, then the inductor 3D loop includes a first partial loop portion formed on the first circuit layer, a second partial loop portion formed on the second circuit layer, and a via connecting the first and second partial loop portions. More generally, the inductor typically includes a plurality of 3D loops. A first plurality of 3D loops is formed between the input and an nth circuit layer, and a second plurality of 3D loops is formed between the nth circuit layer and the output. | 03-04-2010 |
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| 20080279170 | METHOD AND APPARATUS FOR MULTIPLEXING CDM PILOT AND FDM DATA - Techniques for sending control information in a wireless communication system are described. In an aspect, a user equipment (UE) may send data for control information in a resource block with frequency division multiplexing (FDM) and may send pilot in the resource block with frequency-domain code division multiplexing (CDM). The UE may determine multiple groups of subcarriers to use to send data in multiple symbol periods of the resource block based on a predetermined pattern or a pseudo-random hopping pattern. Each group may include consecutive subcarriers to support localized FDM. The multiple groups may include different subcarriers to provide frequency diversity and possibly interference averaging. The UE may send modulation symbols for data (e.g., in the time domain) on the multiple groups of subcarriers in the multiple symbol periods. The UE may send a reference signal sequence for pilot on multiple subcarriers in each symbol period for pilot. | 11-13-2008 |
| 20090141690 | METHOD AND APPARATUS FOR UPLINK CONTROL SIGNALING - A transmitter in a wireless network transmits joint channel quality indicator (CQI) and data packet acknowledgement (Ack) or just CQI within the same subframe without uplink data transmission that can be readily detected at a receiver. When a short cyclic prefix (CP) is appropriate, a first approach utilizes a pilot aided signaling by using two different Walsh covers for the pilots to signal CQI vs. CQI+ACK. When a long CP is appropriate with one pilot, two different code designs are provided for CQI and CQI+ACK that only optimize the code book for each mode separately, but also maximize the distance between these two code spaces. Various coset based approaches are described to search for such linear block codes. Initial results showed good codes can be found based on the coset based approach to minimize the false alarm and misdetection. | 06-04-2009 |
| 20090196247 | SIMULTANEOUS TRANSMISSION OF ACKNOWLEDGEMENT, CHANNEL QUALITY INDICATOR AND SCHEDULING REQUEST - Systems and methodologies are described that facilitate simultaneous transmission of control information in a single sub-frame. For instance, simultaneous transmission can maintain single carrier waveforms for a control channel even when a plurality of information types is scheduled in concurrently. Channel quality indicators, scheduling requests and acknowledgement messages can be jointly coded. In addition, reference symbols in a sub-frame can be modulated to indicate values associated with a scheduling request or an acknowledgement message. Moreover, in situations where channel quality indicators, scheduling requests and or acknowledgement messages are simultaneously scheduled, one or more can be dropped. Further, a single carrier constraint can be relaxed to enable simultaneous transmission of information in the sub-frame at different frequencies. | 08-06-2009 |
| 20090245284 | ENCODING AND DECODING OF CONTROL INFORMATION FOR WIRELESS COMMUNICATION - Techniques for sending control information in a wireless communication system are described. In one design, a user equipment (UE) may map first information (e.g., CQI information) to M most significant bits (MSBs) of a message and may map second information (e.g., ACK information) to N least significant bits (LSBs) of the message if the second information is sent, where M≧1 and N≧1. The UE may encode the message with a block code, e.g., encode the M MSBs with the first M basis sequences of the block code and encode the N LSBs with the next N basis sequences of the block code. The second information may include N ACK bits. The UE may set each ACK bit to a first value for an ACK or to a second value for a NACK. The second value may also be used for discontinuous transmission (DTX) of ACK information. | 10-01-2009 |
| 20090296850 | ENCODED CONTROL CHANNEL INFORMATION INTERLEAVING - Systems and methodologies are described that facilitate interleaving encoded control channel information for transmission over an uplink channel. The encoded control channel information, for example, can include encoded Channel Quality Indicator (CQI) information, encoded Precoding Matrix Indicator (PMI) information, and/or Rank Indicator (RI) information. CQI information, PMI information, and/or RI information can be encoded at an access terminal, for instance, by applying a punctured Reed Muller block code to generate a sequence of encoded bits. The encoded bits can be interleaved to reorder the sequence utilizing one or more interleaving approaches. Examples of interleaving approaches that can be leveraged include prime number based interleaving, generalized bit reversal interleaving, column-row interleaving with column bit reversal, and/or M-sequence based interleaving. Further, the reordered sequence of encoded bits can be transmitted to a base station over an uplink channel. | 12-03-2009 |
| 20100232311 | CONCURRENT TRANSMISSION OF ACK/NACK, CQI AND CQI FROM USER EQUIPMENT - A wireless communications method is provided. The method includes providing a multi-codeword transmission that includes ACK/NACK and discontinuous transmission (DTX) information. The method also includes ordering reference signal (RS) symbols in proximity to at least one other reference signal symbol to facilitate signaling of additional states and enabling spreading gain to be increased. | 09-16-2010 |
| 20110044269 | METHODS AND APPARATUS FOR BLIND INTERFERENCE DECREASE/CANCELLATION TECHNIQUES - A method, an apparatus, and a computer program product for wireless communication are provided in which one or more semi-static parameters associated with at least one neighboring eNode B (eNB) and an interfering user equipment (UE) are detected, at an eNB, and a blind interference reduction scheme based on the one or more detected semi-static parameters to reduce a signal from the interfering UE is applied. | 02-24-2011 |
