Famili
Amin Famili, Denver, CO US
Patent application number | Description | Published |
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20150094641 | ANTIPROLIFERATIVE SURFACE MODIFICATIONS AND METHODS OF USE - This invention is in the field of medicinal intervention. The present invention relates to a device constructed from metals, polymers or other materials that are amenable to precise surface modifications and coupling with erodible agents methods for its use, wherein (1) the erodible agents, which contain active ingredients (medications), provide for acute control of cellular proliferation and (2) a pattered surface having milli, micron, and/or nano-sized micro-patterning characteristics imparts anti-proliferative properties over the long-term. | 04-02-2015 |
20160051469 | BIODEGRADABLE COPOLYMERS, SYSTEMS INCLUDING THE COPOLYMERS, AND METHODS OF FORMING AND USING SAME - Therapeutic agent delivery systems, which include a thermally-sensitive copolymer and optionally a therapeutic agent, are disclosed. The copolymer is water soluble and biodegradable and, in accordance with exemplary embodiments, includes hydrophobic and hydrophilic portions. The systems may include supplemental compounds, such as polymeric nanoparticles, micelle compounds, or a combination thereof, to further provide sustained release of the therapeutic agent. | 02-25-2016 |
Imandohkt Famili, San Diego, CA US
Patent application number | Description | Published |
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20120185226 | MAMMALIAN CELL LINE MODELS AND RELATED METHODS - The invention provides models and methods useful for optimizing cell lines. The invention provides methods and computer readable medium or media containing such methods. Such a computer readable medium or media can comprise commands for carrying out a method of the invention. The methods of the invention can be utilized to model improved characteristics of a cell line, for example, improved product production, improved growth, improved culture characteristics, and the like. | 07-19-2012 |
Imandokht Famili, San Diego, CA US
Patent application number | Description | Published |
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20100280803 | Compositions and Methods for Modeling Saccharomyces cerevisiae Metabolism - The invention provides an in silico model for determining a | 11-04-2010 |
20120191434 | ARTICLES OF MANUFACTURE AND METHODS FOR MODELING CHINESE HAMSTER OVARY (CHO) CELL METABOLISM - The invention provides a Chinese Hamster Ovary (CHO) cell model and methods of using such a model. The invention provides methods and computer readable medium or media containing such models and methods. | 07-26-2012 |
20120196321 | SELECTABLE MARKERS AND RELATED METHODS - The invention relates to newly identified selectable marker systems, cells for use in a selectable marker system, and methods for using the selectable marker systems. | 08-02-2012 |
20150302141 | MULTICELLULAR METABOLIC MODELS AND METHODS - The invention provides a computer readable medium or media, having: (a) a first data structure relating a plurality of reactants to a plurality of reactions from a first cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (b) a second data structure relating a plurality of reactants to a plurality of reactions from a second cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (c) a third data structure relating a plurality of intra-system reactants to a plurality of intra-system reactions between said first and second cells, each of said intra-system reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (d) a constraint set for said plurality of reactions for said first, second and third data structures, and (e) commands for determining at least one flux distribution that minimizes or maximizes an objective function when said constraint set is applied to said first and second data structures, wherein said at least one flux distribution is predictive of a physiological function of said first and second cells. The first, second and third data structures also can include a plurality of data structures. Additionally provided is a method for predicting a physiological function of a multicellular organism. The method includes: (a) providing a first data structure relating a plurality of reactants to a plurality of reactions from a first cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (b) providing a second data structure relating a plurality of reactants to a plurality of reactions from a second cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (c) providing a third data structure relating a plurality of intra-system reactants to a plurality of intra-system reactions between said first and second cells, each of said intra-system reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (d) providing a constraint set for said plurality of reactions for said first, second and third data structures; (e) providing an objective function, and (f) determining at least one flux distribution that minimizes or maximizes an objective function when said constraint set is applied to said first and second data structures, wherein said at least one flux distribution is predictive of a physiological function of said first and second cells. | 10-22-2015 |
Nader Famili, Los Angeles, CA US
Patent application number | Description | Published |
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20160056540 | MODULAR DESIGN OF A HIGH POWER, LOW PASSIVE INTERMODULATION, ACTIVE UNIVERSAL DISTRIBUTED ANTENNA SYSTEM INTERFACE TRAY - A modular high power, low passive intermodulation, active, universal, distributed antenna system interface tray that includes one or more front-end RF frequency duplexers instead of a high power, low passive intermodulation attenuator to achieve superior FIM performance. A cable switch matrix allows for the use of the system among varying power levels and accomplishes the above in a modular architecture. | 02-25-2016 |