Patent application number | Description | Published |
20130198888 | METHODS AND COMPOSITIONS FOR GENERATING COMPLEX TRAIT LOCI - Compositions and methods are provided for stacking multiple independent transgenic loci into the genome of a plant. Compositions include plants, seeds or plant cells comprising at least one transgenic target site and at least one genomic locus of interest integrated at different genomic sites within a genomic window. Plant breeding techniques can be employed such that the transgenic target site and the genomic locus of interest can be bred together. In this way, multiple independent transgene integrations can be generated within a genomic window to create a complex trait locus. The complex trait locus is designed such that the transgenic target sites and/or genomic loci of interest can segregate independently of each other, thus providing the benefit of altering a complex trait locus by breeding-in and breeding-away specific elements. Various methods can also be employed to modify the target sites such that they contain a variety of polynucleotides of interest. | 08-01-2013 |
20130263324 | METHODS FOR PRODUCING A COMPLEX TRANSGENIC TRAIT LOCUS - Methods for producing in a plant a complex transgenic trait locus comprising at least two altered target sequences in a genomic region of interest are disclosed. The methods involve the use of two or more double-strand-break-inducing agents, each of which can cause a double-strand break in a target sequence in the genomic region of interest which results in an alteration in the target sequence. Also disclosed are complex transgenic trait loci in plants. A complex transgenic trait locus comprises at least two altered target sequences that are genetically linked to a polynucleotide of interest. Plants, plant cells, plant parts, and seeds comprising one or more complex transgenic trait loci are also disclosed. | 10-03-2013 |
20150184194 | METHODS AND COMPOSITIONS FOR PRODUCING MALE STERILE PLANTS - Methods of making a targeted modification in a male fertility gene in the genome of a plant are disclosed. The methods involve contacting a plant cell with an engineered double-strand-break-inducing agent capable of inducing a double-strand break in a target sequence in the male fertility gene and identifying a cell comprising an alteration in the target sequence. Also disclosed are plants, plant cells, plant parts, and seeds comprising a male fertility gene with an alteration in a male fertility gene. Nucleic acid molecules comprising male fertility genes with at least one targeted modification therein, optimized nucleic acid molecules encoding endonucleases that are engineered double-strand-break-inducing agents and expression cassettes, host cells, and plants comprising one or more of the nucleic acid molecules are further disclosed. | 07-02-2015 |
Patent application number | Description | Published |
20110274747 | C-Terminal Fragments of Glucagon-Like Peptide-1 (GLP-1) - C-Terminal Fragments of Glucagon-Like Peptide-1 (GLP 1), and methods of use thereof, e.g., for the treatment of obesity and obesity-related disorders, e.g., diabetes and the metabolic syndrome. | 11-10-2011 |
20130288961 | METHODS FOR TREATING STEATOTIC DISEASE - Methods for treating fatty liver disease, e.g., hepatic steatosis, using peptide fragments of the C-terminal end of glucagon-like peptide-1 (GLP-1), e.g., GLP-1(28-36). | 10-31-2013 |
20140212472 | Methods of Treatment Using A Pentapeptide Derived From The C-Terminus Of Glucagon-Like Peptide 1 (GLP-1) - Methods of treating obesity, metabolic syndrome, hepatic and non-hepatic steatosis, and diabetes using a pentapeptide, LVKGRamide, derived from the C-terminus of Glucagon-Like Peptide 1 (GLP-1). | 07-31-2014 |
20150133384 | C-Terminal Fragments of Glucagon-Like Peptide-1 (GLP-1) - C-Terminal Fragments of Glucagon-Like Peptide-1 (GLP 1), and methods of use thereof, e.g., for the treatment of obesity and obesity-related disorders, e.g., diabetes and the metabolic syndrome. | 05-14-2015 |
Patent application number | Description | Published |
20120197822 | SYSTEM AND METHOD FOR USING CLUSTER LEVEL QUORUM TO PREVENT SPLIT BRAIN SCENARIO IN A DATA GRID CLUSTER - A system and method is described for use with a data grid cluster, which uses cluster quorum to prevent split brain scenario. The data grid cluster includes a plurality of cluster nodes, each of which runs a cluster service. Each cluster service collects and maintains statistics regarding communication flow between its cluster node and the other cluster nodes in the data grid cluster. The statistics are used to determine a status associated with other cluster nodes in the data grid cluster whenever a disconnect event happens. The data grid cluster is associated with a quorum policy, which is defined in a cache configuration file, and which specifies a time period that a cluster node will wait before making a decision on whether or not to evict one or more cluster nodes from the data grid cluster. | 08-02-2012 |
20120198055 | SYSTEM AND METHOD FOR USE WITH A DATA GRID CLUSTER TO SUPPORT DEATH DETECTION - A system and method is described for use with a data grid cluster to support death detection. A network ring is formed by connecting a plurality of process nodes in the data grid, wherein each node in the network ring watches another node. A death of a first process node in the network ring can be detected by a second process node, when the second process node notices that its connection to the first process node has closed. The first process node then informs other process cluster nodes in the network ring that the first node is dead. In accordance with an embodiment, machine level death detection can also be supported in the data grid cluster by using an Internet Protocol (IP) monitor. | 08-02-2012 |
20120198455 | SYSTEM AND METHOD FOR SUPPORTING SERVICE LEVEL QUORUM IN A DATA GRID CLUSTER - A system and method is described for use with a data grid cluster, for supporting service level quorum in the data grid cluster. The data grid cluster includes a plurality of cluster nodes that support performing at least one service action. A quorum policy, defined in a cache configuration file associated with the data grid cluster, can specify a minimum number of service members that are required in the data grid cluster for performing the service action. The data grid cluster uses the quorum policy to determine whether the service action is allowed to be performed, based on a present state of the plurality of cluster nodes in the data grid cluster. | 08-02-2012 |
20120297056 | EXTENSIBLE CENTRALIZED DYNAMIC RESOURCE DISTRIBUTION IN A CLUSTERED DATA GRID - A centralized resource distribution is described where the decision portion of partitioning data among cluster nodes is made centralized while the actual mechanics to implement the partitioning remain a distributed algorithm. A central distribution coordinator is used to create an extensible central strategy that controls how the data will be partitioned across the cluster. The work to implement this strategy is performed by all of the members individually and asynchronously, in accordance with a distributed algorithm. The central strategy can be communicated to all cluster members and each member can perform the partitioning as it relates to itself. For example, in accordance with the distributed algorithm, one node may decide that it needs to obtain a particular partition in light of the central strategy and carry out the necessary steps to obtain that data, while other nodes may be asynchronously performing other individual partition transfers relevant to those particular nodes. | 11-22-2012 |
20130041969 | SYSTEM AND METHOD FOR PROVIDING A MESSAGING APPLICATION PROGRAM INTERFACE - A system and method for providing a message bus component or version thereof (referred to herein as an implementation), and a messaging application program interface, for use in an enterprise data center, middleware machine system, or similar environment that includes a plurality of processor nodes together with a high-performance communication fabric (or communication mechanism) such as InfiniBand. In accordance with an embodiment, the messaging application program interface enables features such as asynchronous messaging, low latency, and high data throughput, and supports the use of in-memory data grid, application server, and other middleware components. | 02-14-2013 |
20130097615 | SYSTEM AND METHOD FOR PROVIDING A MESSAGING APPLICATION PROGRAM INTERFACE - A system and method for providing a message bus component or version thereof (referred to herein as an implementation), and a messaging application program interface, for use in an enterprise data center, middleware machine system, or similar environment that includes a plurality of processor nodes together with a high-performance communication fabric (or communication mechanism) such as InfiniBand. In accordance with an embodiment, the messaging application program interface enables features such as asynchronous messaging, low latency, and high data throughput, and supports the use of in-memory data grid, application server, and other middleware components. | 04-18-2013 |
20140075071 | SYSTEM AND METHOD FOR SUPPORTING MESSAGE PRE-PROCESSING IN A DISTRIBUTED DATA GRID CLUSTER - A system and method can support message pre-processing in a distributed data grid. The system can associate a message bus with a service thread on a cluster member in the distributed data grid. Furthermore, the system can receive one or more incoming messages at the message bus using an input/output (I/O) thread, and pre-process said one or more incoming messages on the I/O thread before each said incoming message is delivered to a service thread in the distributed data grid. Additionally, the system can take advantage of a pool of input/output (I/O) threads to deserialize inbound messages before they are delivered to the addressed service, and can relieve the bottleneck that is caused by performing all message deserialization in a single threaded fashion before the message type can be identified and offloaded to the thread-pool within the distributed data grid. | 03-13-2014 |
20140075078 | SYSTEM AND METHOD FOR SUPPORTING A SCALABLE MESSAGE BUS IN A DISTRIBUTED DATA GRID CLUSTER - A system and method can a scalable message bus in a distributed data grid. The system can provide a plurality of message buses in the distributed data grid, wherein the distributed data grid includes a plurality of cluster members and provides a plurality of services. Furthermore, the system can associate each said service in the distributed data grid with a said message bus, and use the plurality of message buses to support data transferring between different services on different cluster members in the distributed data grid. Additionally, the system can use a datagram layer to support clustering in the distributed data grid, and bypass the datagram layer in the distributed data grid for data transferring. | 03-13-2014 |
20140108533 | SYSTEM AND METHOD FOR SUPPORTING OUT-OF-ORDER MESSAGE PROCESSING IN A DISTRIBUTED DATA GRID - A system and method can support out-of-order message processing in a distributed data grid. A cluster node in the distributed data grid can receive a plurality of messages at a cluster node in the distributed data grid. The distributed data grid allows each message in the plurality of messages to determine whether it needs to be handled in a particular order on a first thread. The cluster node can dispatch one or more of said messages that do not need to be handled in the particular order on the first thread to one or more different threads. | 04-17-2014 |
20140108645 | SYSTEM AND METHOD FOR SUPPORTING A SELECTION SERVICE IN A SERVER ENVIRONMENT - A system and method can support socket programming in a server environment, such as a distributed data grid. The server environment can include a selection service that operates to register a plurality of sockets, wherein each said socket is associated with a handler in a plurality of handlers. Furthermore, the selection service can listen for one or more incoming connection requests on the plurality of sockets, and invoke a pluggable callback provided by a said handler associated with a registered socket in the plurality of sockets, when said registered socket receives an incoming connection request. | 04-17-2014 |
20140108664 | SYSTEM AND METHOD FOR SUPPORTING PORT MULTIPLEXING IN A SERVER ENVIRONMENT - A system and method can support port multiplexing in a server environment, e.g. in a distributed data grid. The server environment can comprise a port to receive one or more request, wherein the port is adapted to be associated with different port address values and the port operates to receive one or more connection requests. Additionally, the server environment allows a plurality of sockets to utilize the different port address values to support multiplexing of sockets over the port, and a multiplexed socket provider can be used to provide the plurality of sockets. | 04-17-2014 |
20140108681 | SYSTEM AND METHOD FOR PROVIDING A FLEXIBLE BUFFER MANAGEMENT INTERFACE IN A DISTRIBUTED DATA GRID - A system and method can provide a flexible buffer management interface in a distributed data grid. The buffer manager in the distributed data grid can receive a request from a requester for a buffer in the distributed data grid, wherein the request contains at least one parameter that provides an indication on the size of the requested buffer. Then, the buffer manager can allocate a buffer based on the indication in the request and provide the allocated buffer to the requester, wherein an actual size of the buffer is determined by the buffer manager. | 04-17-2014 |
20140108760 | SYSTEM AND METHOD FOR SUPPORTING SMART BUFFER MANAGEMENT IN A DISTRIBUTED DATA GRID - A system and method can support smart buffer management in a distributed data grid. A buffer manager in the distributed data grid can provide a plurality of buffers in a buffer pool in the distributed data grid, wherein the plurality of buffers are arranged in different generations and each buffer operates to contain one or more objects. The buffer manager can prevent a garbage collector from directly recycling the memory associated with each individual object in the buffer pool, and can allow the garbage collecting of one or more objects in one or more buffers in a particular generation to be performed together. | 04-17-2014 |
Patent application number | Description | Published |
20100300460 | EARPLUG - An earplug is provided and includes a tip for use in forward and lateral sealing, which is formed to define a rearward recessed cavity, and a stem. The stem includes a user graspable elongate portion configured with a stiffness in a first direction that is greater than a stiffness in a second direction, which is transverse to the first direction, and a member, disposed at a forward end of the elongate portion and configured to be insertable into the cavity, the member including a surface to be adhered to an interior facing surface of the cavity and on which a channel is defined to allow for outflow from the cavity, and the member being formed with a shape to complement that of the cavity to axially and circumferentially align the tip and the stem. | 12-02-2010 |
20130019880 | EARPLUG - An earplug is provided and includes a tip for use in forward and lateral sealing, which is formed to define a rearward recessed cavity, and a stem. The stem includes a user graspable elongate portion configured with a stiffness in a first direction that is greater than a stiffness in a second direction, which is transverse to the first direction, and a member, disposed at a forward end of the elongate portion and configured to be insertable into the cavity, the member including a surface to be adhered to an interior facing surface of the cavity and on which a channel is defined to allow for outflow from the cavity, and the member being formed with a shape to complement that of the cavity to axially and circumferentially align the tip and the stem. | 01-24-2013 |
Patent application number | Description | Published |
20080229457 | S-ADENOSYL-L-METHIONINE SYNTHETASE PROMOTER AND ITS USE IN EXPRESSION OF TRANSGENIC GENES IN PLANTS - A constitutive plant S-adenosyl-L-methionine synthetase (SAMS) promoter and subfragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in plants are described. | 09-18-2008 |
20090054247 | POLYNUCLEOTIDES ENCODING PROTEINS INVOLVED IN PLANT METABOLISM - The invention provides isolated pyruvate dehydrogenase kinase nucleic acids and their encoded polypeptides. The present invention provides methods and compositions relating to altering pyruvate dehydrogenase kinase levels in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. | 02-26-2009 |
20100162436 | SITE-SPECIFIC INTEGRATION AND STACKING OF TRANSGENES IN SOYBEAN VIA DNA RECOMBINASE MEDIATED CASSETTE EXCHANGE - A targeting method is described that allows precise cassette replacement at a previously characterized genetic locus. A target DNA construct containing a pair of incompatible FRT sites flanking a target cassette was introduced into soybean by regular biolistic transformation. Transgenic events containing a single complete copy of the target site were then selected and retransformed with a donor DNA construct containing the identical pair of incompatible FRT sites flanking a donor cassette. Precise DNA cassette exchange happened between the target cassette and the donor cassette via recombinase mediated cassette exchange (RMCE) so that the donor cassette was introduced at the exact genomic site previously occupied by the target cassette. Through repeated RMCE using additional incompatible FRT sites, multiple groups of transgenes can be stacked at the same genomic locus. | 06-24-2010 |
20100242137 | POLYNUCLEOTIDES ENCODING PROTEINS INVOLVED IN PLANT METABOLISM - The invention provides isolated pyruvate dehydrogenase kinase nucleic acids and their encoded polypeptides. The present invention provides methods and compositions relating to altering pyruvate dehydrogenase kinase levels in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. | 09-23-2010 |
20110030090 | Disease resistance genes - The invention provides isolated peptide-methionine sulfoxide reductase nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering peptide-methionine sulfoxide reductase levels in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. | 02-03-2011 |
20110061127 | S-ADENOSYL-L-METHIONINE SYNTHETASE PROMOTER AND ITS USE IN EXPRESSION OF TRANSGENIC GENES IN PLANTS - A constitutive plant S-adenosyl-L-methionine synthetase (SAMS) promoter and subfragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in plants are described. | 03-10-2011 |
20110214204 | POLYNUCLEOTIDES ENCODING PROTEINS INVOLVED IN PLANT METABOLISM - The invention provides isolated pyruvate dehydrogenase kinase nucleic acids and their encoded polypeptides. The present invention provides methods and compositions relating to altering pyruvate dehydrogenase kinase levels in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. | 09-01-2011 |
20130007912 | POLYNUCLEOTIDES ENCODING PROTEINS INVOLVED IN PLANT METABOLISM - The invention provides isolated pyruvate dehydrogenase kinase nucleic acids and their encoded polypeptides. The present invention provides methods and compositions relating to altering pyruvate dehydrogenase kinase levels in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. | 01-03-2013 |
20130014294 | SITE-SPECIFIC INTEGRATION AND STACKING OF TRANSGENES IN SOYBEAN VIA DNA RECOMBINASE MEDIATED CASSETTE EXCHANGE - A targeting method is described that allows precise cassette replacement at a previously characterized genetic locus. A target DNA construct containing a pair of incompatible FRT sites flanking a target cassette was introduced into soybean by regular biolistic transformation. Transgenic events containing a single complete copy of the target site were then selected and retransformed with a donor DNA construct containing the identical pair of incompatible FRT sites flanking a donor cassette. Precise DNA cassette exchange happened between the target cassette and the donor cassette via recombinase mediated cassette exchange (RMCE) so that the donor cassette was introduced at the exact genomic site previously occupied by the target cassette. Through repeated RMCE using additional incompatible FRT sites, multiple groups of transgenes can be stacked at the same genomic locus. | 01-10-2013 |
20140020131 | METHODS AND COMPOSITIONS FOR PRODUCING MALE STERILE PLANTS - Methods of making a targeted modification in a male fertility gene in the genome of a plant are disclosed. The methods involve contacting a plant cell with an engineered double-strand-break-inducing agent capable of inducing a double-strand break in a target sequence in the male fertility gene and identifying a cell comprising an alteration in the target sequence. Also disclosed are plants, plant cells, plant parts, and seeds comprising a male fertility gene with an alteration in a male fertility gene. Nucleic acid molecules comprising male fertility genes with at least one targeted modification therein, optimized nucleic acid molecules encoding endonucleases that are engineered double-strand-break-inducing agents and expression cassettes, host cells, and plants comprising one or more of the nucleic acid molecules are further disclosed. | 01-16-2014 |
20140130206 | POLYNUCLEOTIDES ENCODING PROTEINS INVOLVED IN PLANT METABOLISM - The invention provides isolated pyruvate dehydrogenase kinase nucleic acids and their encoded polypeptides. The present invention provides methods and compositions relating to altering pyruvate dehydrogenase kinase levels in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. | 05-08-2014 |
20140223606 | COMPOSITIONS AND METHODS COMPRISING SEQUENCES HAVING MEGANUCLEASE ACTIVITY - Compositions and methods comprising polynucleotides and polypeptides having meganuclease activity are provided. Further provided are nucleic acid constructs, yeast, plants, plant cells, explants, seeds and grain having the meganuclease sequences. Various methods of employing the meganuclease sequences are provided. Such methods include, for example, methods for producing a meganuclease with increased activity at a wide range of temperatures, methods for producing a yeast, plant, plant cell, explant or seed comprising a meganuclease with increased activity. | 08-07-2014 |
20140338070 | METHODS AND COMPOSITIONS FOR TARGETED INTEGRATION IN A PLANT - Compositions and methods are provided for the targeted integration of a polynucleotide sequence of interest into the genome of a plant or plant cell. The methods and compositions employ recognition sites for endonucleases and endonucleases in combination with site-specific recombination sites/recombinases to provide an effective system for establishing target sites within the genome of a plant, plant cell or seed. Once such target sites are established, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. | 11-13-2014 |
20150082478 | PLANT GENOME MODIFICATION USING GUIDE RNA/CAS ENDONUCLEASE SYSTEMS AND METHODS OF USE - Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification of a nucleotide sequence in the genome of a cell or organism, for gene editing, and/or for inserting or deleting a polynucleotide of interest into or from the genome of a cell or organism. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Breeding methods and methods for selecting plants utilizing a two component RNA guide and Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell. | 03-19-2015 |
20150184173 | COMPOSITIONS AND METHODS COMPRISING SEQUENCES HAVING MEGANUCLEASE ACTIVITY - Compositions and methods comprising polynucleotides and polypeptides having meganuclease activity are provided. Further provided are nucleic acid constructs, yeast, plants, plant cells, explants, seeds and grain having the meganuclease sequences. Various methods of employing the meganuclease sequences are provided. Such methods include, for example, methods for producing a meganuclease with increased activity at a wide range of temperatures, methods for producing a yeast, plant, plant cell, explant or seed comprising a meganuclease with increased activity. | 07-02-2015 |